- John Beasley - Janitor at NuGenesis
- Tyler Christopher - Ethan Clausen / Mirage
- Dan Bucatinsky - Emery
- Ulysses Cuadra - Kid
- Joe Unger - Eldridge Hailey
- Melora Hardin - Wendy Dawson
- Jay Harrington - Det. Maxwell
- Channon Roe - Pat Rush
- Ron Roggé - Orderly
- Julia Campbell - Kristi Kincaid
- Stuart Stone - Chris
- Mia Korf - Anna
- Rockmond Dunbar - Joe Taylor
- Bobby Edner - Ryan Wells
- Bert Remsen - Father Moore
- Sullivan Walker - Mutumbo
- Alex Carter - Craig Winston
- Emile Hirsch - Bryce Banks
- Nancy O'Dell - News Reporter
- Bryan Cranston - Neil Roberts
- Tim DeKay - Eddie Fontenot
- Don Keith Opper - Lester
- Francis Guinan - George Harper
- Leslie Jordan - Pat
- Marshall Bell - Warden Michaels
- Louis Ferreira - Scotty Boyd
- Cyia Batten - Erica Green
- Raphael Sbarge - Jeffrey Baytos
- Alex Nevil - Comic Book Kid
- Tava Smiley - Chloe
- Richard Riehle - Graham Hawkes
- Lindsay Felton - Hostage Daughter
- John Pleshette - Sean Flanagan
- Nancy Sullivan - News Reporter
- Stefan Gierasch - Congressman Leon Beckwith
- Kyla Pratt - Tracy Johnson
- Christopher Masterson - Chris Conti
- Andrea Roth - Gibbs
- John Diehl - Sheriff Delmont
- Roxana Zal - Carla Parks
- Lilyan Chauvin - Mrs. Nikkos, the Greek Lady
- Janet Hubert - Madam Director
- Marjorie Monaghan - Martha Poole
- Ron Yuan - Ken Watanabe
- Brian Tee - Male Agent
- Anthony Starke - Michael Patrick
- Chris Williams - Derek Kobey
- Tony Plana - Det. Guerra
- Robert Carradine - Sheriff Dwight Kunkle
- Christopher Allport - Lt. Cmdr. Chris Nashton
- Reggie Hayes - Froman
- Gailard Sartain - Tug Beaulieu
- Mike Starr - Axe
- Lois Nettleton - Gloria
- Cindy Pickett - Dr. Shafton
- Kelli Maroney - Reporter
- Jeffrey Meek - Agent Gerald Linden
- Kathy Evison - Lt. Molly Kimbrell
- Tobin Bell - Mr. White
- Ryan Bollman - Kessler
- Anthony Guidera - Vince
- Casey Sander - Luke
- Heidi Lenhart - Shea / Carrie Goltz
- Cali Timmins - Rebecca Simons (uncredited)
- Peter Onorati - Roland Pritchard
- Geoffrey Blake - Dr. Jason Earl
- Thom Barry - Leonard
- Linda Carlson - Harriet Tashman
- James Tolkan - FBI Special Agent Korkos
- Jeff Coopwood - Raymond
- Gary Farmer - Vincent LaPahie
- Ken Clark - Sweeper
- Travis Tedford - Ryan Blake
- Michael Des Barres - Douglas Willard, The Blue Moon Killer
- Catherine Dent - Dr. Carla Goetz
- Michael Reilly Burke - Harold 'Harry' Kincaid
- Marguerite MacIntyre - Deborah Clark
- Jesse Head - J.R. Miller
- Greg Serano - Manny
- Robia LaMorte - Cindy Wells
- Caitlin Wachs - Faith Parker
- Zack Ward - Theodore Reed / Little Joshua
- John Cothran - Earl Dupree
- Jason Brooks - Thomas Gates
- Clyde Kusatsu - Li Ho
- Travis Fine - Brian Stoffel
- Peter Murnik - Bobby Cain
- Sam Whipple - Sheldon Fein
- Jennifer Aspen - Anna Roemer
- John Bolger - Agent Morton
- Alex Datcher - Jessica Kline
- John Fleck - Ray
- Lawrence Pressman - Ben Sloane
- Stephanie Faracy - Joyce Cullman
- Theodore Bikel - Martin Zeller / Dr. Werner Krieg
- Robert Peters - Dave Dugger
- David Labiosa - Officer Tom Mooney
- Michael Angarano - Patrick Harper
- Tracey Needham - Rachel Daly
- Matt Clark - Lyle Bowman
- Paul Perri - Frank K. Isaac
- Seth Adkins - Nicky Parks
- Peter Michael Goetz - Dr. Miles Hendricks
- Pat Crawford Brown - Millie Reynolds
- Deanne Bray - Deaf Woman
- Lanei Chapman - Julie Thorton
- Gregg Henry - Peter Morgan
- William Sanderson - Roy Abbot
- Michael Gilden - Elf
- Chris Ellis - Daniel Crockett
- Matthew Carey - High School Student
- Wayne Newton - Self
- Leon Russom - Captain Paul Nagel
- William Lucking - Lt. Chomsky
- Lisa Rieffel - Jeanette Connelly
- Maury Sterling - Donny Beaulieu
- Kiami Davael - Simone Bien Aime
- Marisa Ryan - Helen Diggs
- Michael Dorn - Col. Lee Dance
- Albie Selznick - Agent Tympson
- Chad Doreck - Duppy Demetrius
- E.J. Callahan - Fisherman
- Eric Bruskotter - Donny
- Enrique Murciano - Tony
- Ian Paul Cassidy - Zed
- Dana Ashbrook - Cam Larsen
- Luna Lauren Velez - Emily Sadler
- Carrie Hamilton - Jill Arnold
- Haley Joel Osment - Davey Simpkins
- Erika Christensen - Leigh Wright
- Susan Gibney - Kim
- Kirsten Nelson - ATF Agent Beth Swik
- Robert Madrid - Raul Zenega
- Anne-Marie Johnson - Lt. Alison Fawkes
- Brad William Henke - Jimbo
- Aaron Lustig - Atty. Tom Byner
- Tamara Braun - Claire Dunning
- Jessica Steen - Rachel
- Paul Eiding - Bernie Baxley
- Clint Howard - Smitty
- Scott William Winters - Ray
- Aisha Tyler - Angela Somerset
- Beth Grant - Mrs. Haring
- Daniel von Bargen - Captain Prentiss McClaren
- Denis Arndt - Nick Avani
- Patrick Fischler - Toby
- Joseph D. Reitman - Spencer
- M.C. Gainey - Sharpton
- Ricco Ross - Larron
- Robby Gordon - Indy Car Driver
- Troy Winbush - Agent Grimm
- Joel Polis - Agent Russell Gillson
- Taylor Negron - Max Vargas, Tax Official
- John Maynard - Howard Cullman
- Lise Simms - Reporter Danielle Canepa
- Scott Jaeck - Martin Benton
- Nancy Parsons - Martha Bowman
- Courtney Peldon - Kaley Isaac
- Larry Joshua - Special Agent Roger Bingham
- L. Scott Caldwell - Gwen Porter
- Terence Knox - Tom Matthews
- Judith Hoag - Gail Reese
- Judith Hoag - Captain Angela Wiley
- Kara Zediker - Ivy
- Kara Zediker - Ivy (archive footage)
- Michael B. Silver - Chris Rockwell
- Sean O'Bryan - Bradley DuMonte
- Isabel Glasser - Lt. Nancy Gleason
- Kate Hodge - Carol Bates
- Leonard Lightfoot - Reb McElroy
- Brock Peters - Henry Cockran
- Natalie Canerday - Christine
- Virginia Capers - Mr. Herbert's Former Assistant
- Bradley Gregg - Eugene Diggs
- Laura Cayouette - Agent Jenna McGann
- Lombardo Boyar - Seelye
- Alyson Croft - Leslie Johnson
- Rena Riffel - Mona Jeffries
- Phil Fondacaro - Doorman
- Clare Carey - Dr. Melissa Blass
- Howard Hesseman - Landlord
- Rex Linn - Agent Ellis Talbot
- Kirk Fox - Huey
- Barbara Tyson - Robin Gantry
- Kevin Weisman - Mr. Abel
- George Lazenby - Major Charles
- Jeremy Roberts - Efram Bartlett
- Zelda Rubinstein - Pawn Shop Lady
- Phina Oruche - Doctor
- Diana Maria Riva - Lupe Harmon
- Leigh Taylor-Young - Michelle Lucca Stamatis
- Inday Ba - Emma
- Eric Pierpoint - Sheriff Randall Carver
- Grand L. Bush - Det. Rusk
- Kenneth Mars - Benny
- William Shockley - Luther Ecksley
- Elizabeth Morehead - Nora Banks
- Peter Holden - Radio Station Manager
- Chaka Forman - Computer Sketch Artist
- Dean Norris - Sheriff Whalen
- Dean Norris - Tommy Larson
- Jacob Vargas - Javi Padillo
- Lisa Lackey - Cindy Thomas
- Matt Corboy - Chris Welman
- Orlando Brown - Bruno
- Mario Andretti - Mario Andretti
- Vanessa Williams - Denise Clements
- Salli Richardson-Whitfield - Cynthia Sloan
- Justin Kirk - Horace Strickland
- Jeff Kober - Clavell Dane
- Keene Curtis - Mr. Fenigor
- Miguel Sandoval - Manny Alomar
- Zachary Browne - Young Kyle
- Danny Woodburn - Jumbo Jim
- Stephen Tobolowsky - Dr. Alan Trader
- Steve Eastin - Cedar Point Sheriff
- William Wellman Jr. - USAF General
- Felton Perry - Buddy
- Kevin Patrick Walls - Petty Officer Mike Baker
- Kevin Cooney - Mr. Chambers
- Trevor Morgan - Kid
- Kyle Colerider-Krugh - Building Manager
- Jake Lloyd - Young Angelo / Timmy
- Jake Lloyd - Young Angelo
- Jake Lloyd - Ronny Collins
- Philip Lenkowsky - Junior
- Amy Wheaton - Jessica Bracken
- Marji Martin - Waitress
- John Billingsley - Kenny
- John Billingsley - Kenny (archive footage)
- Silas Weir Mitchell - Luke Carlo
- Jamie Luner - Rachel Burke
- Jon Polito - Ben Hansel
- Jon Polito - Constantin Falzone
- Aaron Meeks - Kevin
- Melinda Clarke - Miss Eve
- Jim Haynie - Ben Miller
- Jonathan Hernandez - Billy Lomax
- Jonathan Hernandez - Billy Lomax (archive footage)
- Kim Myers - Jarod's Mother
- Jay Acovone - Det. Stan Wilkins
- Lenny Von Dohlen - Mr. Cox
- Jenny Gago - Warden Anita Esparza
- Cliff DeYoung - Dr. Samson Dane
- Jennifer Garner - Billie H. Vaughn / Dupree
- Pamela Brull - Kitty Morgan
- Drake Bell - Shawn Boyd
- Tom Everett - Grant Roemer
- Wendel Meldrum - Dr. Lizabeth Drake
- Kimber Sissons - Knockout
- Gregory Itzin - Phil Campbell
- Daniel Dae Kim - Lenny Duc
- Earl Houston Bullock - Marlan Marcantel
- Antonio David Lyons - Todd Healy
- Dennis Keiffer - Thug #1
- James Pickens Jr. - Clark Thomas
- Ray Laska - Lieutenant Row
- Sam McMurray - Morris Clancy
- Ellen Travolta - Dara's Mother
- Rosemary Alexander - Mrs. Rion
- Max Martini - Todd Baxter
- Michael Welch - Eric Gantry
- Robert Curtis Brown - Mr. Brewster
- Barbara Babcock - Edna Raines
- Dendrie Taylor - Mary Blake
- Connie Ray - Deputy Miller (archive footage)
- Connie Ray - Deputy Marilyn Miller
- Betty Murphy - Doris the Housekeeper
- James Sutorius - Dr. Christopher Fein
- James Whitmore Jr. - Captain Russ Osborne (archive footage)
- James Whitmore Jr. - Captain Russ Osborne
- Mailon Rivera - Detective
- Rick Hoffman - Photographer
- David Dunard - Detective Harold Evans
- Michael Andretti - Michael Andretti
- Joseph Fuqua - Agent Dean Clark
- Bryan Matsuura - Le Xuan Duc
- Brad Greenquist - Frank Linden
- Dann Florek - Don Larson
- Tony Pierce - Dave
- Kimiko Gelman - Dr. Kim Fugimora
- Dorothy Fielding - Mrs. Chambers
- David Proval - Carl Will
- Pato Hoffmann - Ronny Tiger
- Kay E. Kuter - Mr. Kleinman
- Gregory Cruz - Mike Bodie
- Phill Lewis - Detective Meyers
- Gail Strickland - Grace Carter-Welman
- Nigel Gibbs - Dewey
- Simon Templeman - Darrin Faxon
- Brian Gaskill - Jimmy Roemer
- Don Harvey - Joey Melino
- Don Harvey - Mr. Job
- Don Mirault - Don the Sweeper
- Marisa Petroro - Emily
- Marisa Petroro - Emily (uncredited)
- Kerrie Keane - Faye
- Jay Karnes - Brad Anderson
- Juanita Jennings - Alice Evans
- David Denman - Daniel Falk
- Bruce Wright - Commander Davis
- Dwayne L. Barnes - D-Mac
- Sal Landi - Reggie Esposito
- Nancy Everhard - Dr. Cynthia deWitt
- Brent Roam - Wade Dawson
- Elayn J. Taylor - Judge T. Halpern
- Darcas Macopson - Master Sgt. Rob Hancock
- Joel Stoffer - Jude Dane
- Scott Burkholder - Det. David Geary
- Dan Cashman - Jacob Stand-in
- Dan Martin - Dr. Fletcher
- Jonathan Osser - Younger Jarod
- James Hong - Mr. Lee
- Ally Walker - Dr. Samantha 'Sam' Waters
- Georgia Emelin - Dr. Kara Hargadon
- James Wellington - Guard in Blue
- Michael Krawic - Drug Addict Detective
- Daniel Hansen - Albert Williams
- June Kyoto Lu - Grandmother
- Kelsey Mulrooney - Debbie Broots
- Kelsey Mulrooney - Debbie Broots (archive footage)
- Kelsey Mulrooney - Angel
- Steven Flynn - R.J. Roemer
- Michael Yama - Grandfather
- George Buck Flower - Motel Manager
- William James Jones - C.J. Wocheck
- Tony Carreiro - District Attorney Mitch Meyers
- Peggy Doyle - Clare Dumont
- Lisa Howard - Annie Lambert
- Charles Lucia - Elijah
- Rachel Winfree - Realtor
- Rachel Winfree - Nurse
- Richard Marcus - Mr. Raines (archive footage)
- James Dalesandro - Monk
- Ashley Peldon - Young Miss Parker (archive footage)
- Elpidia Carrillo - Nia
- John Mahon - Eugene Clark
- Jeffrey Hutchinson - Brandon Larson
- Joel McCrary - Butch
- Elizabeth Sampson - Kelli
- Mary Beth McDonough - Mrs. Falk
- Lynn Blades - Reporter
- Craig W. Van Sickle
- Steven Long Mitchell
- Juan Carlos Coto
Don Harvey hace el papel de Mr. Job.
Stephen Tobolowsky interpreta a Dr. Alan Trader en la serie.
James Tolkan hace el papel de FBI Special Agent Korkos.
Antonio David Lyons interpreta a Todd Healy en la serie.
Brock Peters interpreta a Henry Cockran en la serie.
Harve Presnell hace el papel de Mr. Parker.
Gailard Sartain interpreta a Tug Beaulieu en la serie.
Trevor Morgan interpreta a Kid en la serie.
William Sanderson hace el papel de Roy Abbot.
Elpidia Carrillo interpreta a Nia en la serie.
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