- John Beasley - Janitor at NuGenesis
- Tyler Christopher - Ethan Clausen / Mirage
- Dan Bucatinsky - Emery
- Ulysses Cuadra - Kid
- Joe Unger - Eldridge Hailey
- Melora Hardin - Wendy Dawson
- Jay Harrington - Det. Maxwell
- Channon Roe - Pat Rush
- Ron Roggé - Orderly
- Julia Campbell - Kristi Kincaid
- Stuart Stone - Chris
- Mia Korf - Anna
- Rockmond Dunbar - Joe Taylor
- Bobby Edner - Ryan Wells
- Bert Remsen - Father Moore
- Sullivan Walker - Mutumbo
- Alex Carter - Craig Winston
- Emile Hirsch - Bryce Banks
- Nancy O'Dell - News Reporter
- Bryan Cranston - Neil Roberts
- Tim DeKay - Eddie Fontenot
- Don Keith Opper - Lester
- Francis Guinan - George Harper
- Leslie Jordan - Pat
- Marshall Bell - Warden Michaels
- Louis Ferreira - Scotty Boyd
- Cyia Batten - Erica Green
- Raphael Sbarge - Jeffrey Baytos
- Alex Nevil - Comic Book Kid
- Tava Smiley - Chloe
- Richard Riehle - Graham Hawkes
- Lindsay Felton - Hostage Daughter
- John Pleshette - Sean Flanagan
- Nancy Sullivan - News Reporter
- Stefan Gierasch - Congressman Leon Beckwith
- Kyla Pratt - Tracy Johnson
- Christopher Masterson - Chris Conti
- Andrea Roth - Gibbs
- John Diehl - Sheriff Delmont
- Roxana Zal - Carla Parks
- Lilyan Chauvin - Mrs. Nikkos, the Greek Lady
- Janet Hubert - Madam Director
- Marjorie Monaghan - Martha Poole
- Ron Yuan - Ken Watanabe
- Brian Tee - Male Agent
- Anthony Starke - Michael Patrick
- Chris Williams - Derek Kobey
- Tony Plana - Det. Guerra
- Robert Carradine - Sheriff Dwight Kunkle
- Christopher Allport - Lt. Cmdr. Chris Nashton
- Reggie Hayes - Froman
- Gailard Sartain - Tug Beaulieu
- Mike Starr - Axe
- Lois Nettleton - Gloria
- Cindy Pickett - Dr. Shafton
- Kelli Maroney - Reporter
- Jeffrey Meek - Agent Gerald Linden
- Kathy Evison - Lt. Molly Kimbrell
- Tobin Bell - Mr. White
- Ryan Bollman - Kessler
- Anthony Guidera - Vince
- Casey Sander - Luke
- Heidi Lenhart - Shea / Carrie Goltz
- Cali Timmins - Rebecca Simons (uncredited)
- Peter Onorati - Roland Pritchard
- Geoffrey Blake - Dr. Jason Earl
- Thom Barry - Leonard
- Linda Carlson - Harriet Tashman
- James Tolkan - FBI Special Agent Korkos
- Jeff Coopwood - Raymond
- Gary Farmer - Vincent LaPahie
- Ken Clark - Sweeper
- Travis Tedford - Ryan Blake
- Michael Des Barres - Douglas Willard, The Blue Moon Killer
- Catherine Dent - Dr. Carla Goetz
- Michael Reilly Burke - Harold 'Harry' Kincaid
- Marguerite MacIntyre - Deborah Clark
- Jesse Head - J.R. Miller
- Greg Serano - Manny
- Robia LaMorte - Cindy Wells
- Caitlin Wachs - Faith Parker
- Zack Ward - Theodore Reed / Little Joshua
- John Cothran - Earl Dupree
- Jason Brooks - Thomas Gates
- Clyde Kusatsu - Li Ho
- Travis Fine - Brian Stoffel
- Peter Murnik - Bobby Cain
- Sam Whipple - Sheldon Fein
- Jennifer Aspen - Anna Roemer
- John Bolger - Agent Morton
- Alex Datcher - Jessica Kline
- John Fleck - Ray
- Lawrence Pressman - Ben Sloane
- Stephanie Faracy - Joyce Cullman
- Theodore Bikel - Martin Zeller / Dr. Werner Krieg
- Robert Peters - Dave Dugger
- David Labiosa - Officer Tom Mooney
- Michael Angarano - Patrick Harper
- Tracey Needham - Rachel Daly
- Matt Clark - Lyle Bowman
- Paul Perri - Frank K. Isaac
- Seth Adkins - Nicky Parks
- Peter Michael Goetz - Dr. Miles Hendricks
- Pat Crawford Brown - Millie Reynolds
- Deanne Bray - Deaf Woman
- Lanei Chapman - Julie Thorton
- Gregg Henry - Peter Morgan
- William Sanderson - Roy Abbot
- Michael Gilden - Elf
- Chris Ellis - Daniel Crockett
- Matthew Carey - High School Student
- Wayne Newton - Self
- Leon Russom - Captain Paul Nagel
- William Lucking - Lt. Chomsky
- Lisa Rieffel - Jeanette Connelly
- Maury Sterling - Donny Beaulieu
- Kiami Davael - Simone Bien Aime
- Marisa Ryan - Helen Diggs
- Michael Dorn - Col. Lee Dance
- Albie Selznick - Agent Tympson
- Chad Doreck - Duppy Demetrius
- E.J. Callahan - Fisherman
- Eric Bruskotter - Donny
- Enrique Murciano - Tony
- Ian Paul Cassidy - Zed
- Dana Ashbrook - Cam Larsen
- Luna Lauren Velez - Emily Sadler
- Carrie Hamilton - Jill Arnold
- Haley Joel Osment - Davey Simpkins
- Erika Christensen - Leigh Wright
- Susan Gibney - Kim
- Kirsten Nelson - ATF Agent Beth Swik
- Robert Madrid - Raul Zenega
- Anne-Marie Johnson - Lt. Alison Fawkes
- Brad William Henke - Jimbo
- Aaron Lustig - Atty. Tom Byner
- Tamara Braun - Claire Dunning
- Jessica Steen - Rachel
- Paul Eiding - Bernie Baxley
- Clint Howard - Smitty
- Scott William Winters - Ray
- Aisha Tyler - Angela Somerset
- Beth Grant - Mrs. Haring
- Daniel von Bargen - Captain Prentiss McClaren
- Denis Arndt - Nick Avani
- Patrick Fischler - Toby
- Joseph D. Reitman - Spencer
- M.C. Gainey - Sharpton
- Ricco Ross - Larron
- Robby Gordon - Indy Car Driver
- Troy Winbush - Agent Grimm
- Joel Polis - Agent Russell Gillson
- Taylor Negron - Max Vargas, Tax Official
- John Maynard - Howard Cullman
- Lise Simms - Reporter Danielle Canepa
- Scott Jaeck - Martin Benton
- Nancy Parsons - Martha Bowman
- Courtney Peldon - Kaley Isaac
- Larry Joshua - Special Agent Roger Bingham
- L. Scott Caldwell - Gwen Porter
- Terence Knox - Tom Matthews
- Judith Hoag - Gail Reese
- Judith Hoag - Captain Angela Wiley
- Kara Zediker - Ivy
- Kara Zediker - Ivy (archive footage)
- Michael B. Silver - Chris Rockwell
- Sean O'Bryan - Bradley DuMonte
- Isabel Glasser - Lt. Nancy Gleason
- Kate Hodge - Carol Bates
- Leonard Lightfoot - Reb McElroy
- Brock Peters - Henry Cockran
- Natalie Canerday - Christine
- Virginia Capers - Mr. Herbert's Former Assistant
- Bradley Gregg - Eugene Diggs
- Laura Cayouette - Agent Jenna McGann
- Lombardo Boyar - Seelye
- Alyson Croft - Leslie Johnson
- Rena Riffel - Mona Jeffries
- Phil Fondacaro - Doorman
- Clare Carey - Dr. Melissa Blass
- Howard Hesseman - Landlord
- Rex Linn - Agent Ellis Talbot
- Kirk Fox - Huey
- Barbara Tyson - Robin Gantry
- Kevin Weisman - Mr. Abel
- George Lazenby - Major Charles
- Jeremy Roberts - Efram Bartlett
- Zelda Rubinstein - Pawn Shop Lady
- Phina Oruche - Doctor
- Diana Maria Riva - Lupe Harmon
- Leigh Taylor-Young - Michelle Lucca Stamatis
- Inday Ba - Emma
- Eric Pierpoint - Sheriff Randall Carver
- Grand L. Bush - Det. Rusk
- Kenneth Mars - Benny
- William Shockley - Luther Ecksley
- Elizabeth Morehead - Nora Banks
- Peter Holden - Radio Station Manager
- Chaka Forman - Computer Sketch Artist
- Dean Norris - Sheriff Whalen
- Dean Norris - Tommy Larson
- Jacob Vargas - Javi Padillo
- Lisa Lackey - Cindy Thomas
- Matt Corboy - Chris Welman
- Orlando Brown - Bruno
- Mario Andretti - Mario Andretti
- Vanessa Williams - Denise Clements
- Salli Richardson-Whitfield - Cynthia Sloan
- Justin Kirk - Horace Strickland
- Jeff Kober - Clavell Dane
- Keene Curtis - Mr. Fenigor
- Miguel Sandoval - Manny Alomar
- Zachary Browne - Young Kyle
- Danny Woodburn - Jumbo Jim
- Stephen Tobolowsky - Dr. Alan Trader
- Steve Eastin - Cedar Point Sheriff
- William Wellman Jr. - USAF General
- Felton Perry - Buddy
- Kevin Patrick Walls - Petty Officer Mike Baker
- Kevin Cooney - Mr. Chambers
- Trevor Morgan - Kid
- Kyle Colerider-Krugh - Building Manager
- Jake Lloyd - Young Angelo / Timmy
- Jake Lloyd - Young Angelo
- Jake Lloyd - Ronny Collins
- Philip Lenkowsky - Junior
- Amy Wheaton - Jessica Bracken
- Marji Martin - Waitress
- John Billingsley - Kenny
- John Billingsley - Kenny (archive footage)
- Silas Weir Mitchell - Luke Carlo
- Jamie Luner - Rachel Burke
- Jon Polito - Ben Hansel
- Jon Polito - Constantin Falzone
- Aaron Meeks - Kevin
- Melinda Clarke - Miss Eve
- Jim Haynie - Ben Miller
- Jonathan Hernandez - Billy Lomax
- Jonathan Hernandez - Billy Lomax (archive footage)
- Kim Myers - Jarod's Mother
- Jay Acovone - Det. Stan Wilkins
- Lenny Von Dohlen - Mr. Cox
- Jenny Gago - Warden Anita Esparza
- Cliff DeYoung - Dr. Samson Dane
- Jennifer Garner - Billie H. Vaughn / Dupree
- Pamela Brull - Kitty Morgan
- Drake Bell - Shawn Boyd
- Tom Everett - Grant Roemer
- Wendel Meldrum - Dr. Lizabeth Drake
- Kimber Sissons - Knockout
- Gregory Itzin - Phil Campbell
- Daniel Dae Kim - Lenny Duc
- Earl Houston Bullock - Marlan Marcantel
- Antonio David Lyons - Todd Healy
- Dennis Keiffer - Thug #1
- James Pickens Jr. - Clark Thomas
- Ray Laska - Lieutenant Row
- Sam McMurray - Morris Clancy
- Ellen Travolta - Dara's Mother
- Rosemary Alexander - Mrs. Rion
- Max Martini - Todd Baxter
- Michael Welch - Eric Gantry
- Robert Curtis Brown - Mr. Brewster
- Barbara Babcock - Edna Raines
- Dendrie Taylor - Mary Blake
- Connie Ray - Deputy Miller (archive footage)
- Connie Ray - Deputy Marilyn Miller
- Betty Murphy - Doris the Housekeeper
- James Sutorius - Dr. Christopher Fein
- James Whitmore Jr. - Captain Russ Osborne (archive footage)
- James Whitmore Jr. - Captain Russ Osborne
- Mailon Rivera - Detective
- Rick Hoffman - Photographer
- David Dunard - Detective Harold Evans
- Michael Andretti - Michael Andretti
- Joseph Fuqua - Agent Dean Clark
- Bryan Matsuura - Le Xuan Duc
- Brad Greenquist - Frank Linden
- Dann Florek - Don Larson
- Tony Pierce - Dave
- Kimiko Gelman - Dr. Kim Fugimora
- Dorothy Fielding - Mrs. Chambers
- David Proval - Carl Will
- Pato Hoffmann - Ronny Tiger
- Kay E. Kuter - Mr. Kleinman
- Gregory Cruz - Mike Bodie
- Phill Lewis - Detective Meyers
- Gail Strickland - Grace Carter-Welman
- Nigel Gibbs - Dewey
- Simon Templeman - Darrin Faxon
- Brian Gaskill - Jimmy Roemer
- Don Harvey - Joey Melino
- Don Harvey - Mr. Job
- Don Mirault - Don the Sweeper
- Marisa Petroro - Emily
- Marisa Petroro - Emily (uncredited)
- Kerrie Keane - Faye
- Jay Karnes - Brad Anderson
- Juanita Jennings - Alice Evans
- David Denman - Daniel Falk
- Bruce Wright - Commander Davis
- Dwayne L. Barnes - D-Mac
- Sal Landi - Reggie Esposito
- Nancy Everhard - Dr. Cynthia deWitt
- Brent Roam - Wade Dawson
- Elayn J. Taylor - Judge T. Halpern
- Darcas Macopson - Master Sgt. Rob Hancock
- Joel Stoffer - Jude Dane
- Scott Burkholder - Det. David Geary
- Dan Cashman - Jacob Stand-in
- Dan Martin - Dr. Fletcher
- Jonathan Osser - Younger Jarod
- James Hong - Mr. Lee
- Ally Walker - Dr. Samantha 'Sam' Waters
- Georgia Emelin - Dr. Kara Hargadon
- James Wellington - Guard in Blue
- Michael Krawic - Drug Addict Detective
- Daniel Hansen - Albert Williams
- June Kyoto Lu - Grandmother
- Kelsey Mulrooney - Debbie Broots
- Kelsey Mulrooney - Debbie Broots (archive footage)
- Kelsey Mulrooney - Angel
- Steven Flynn - R.J. Roemer
- Michael Yama - Grandfather
- George Buck Flower - Motel Manager
- William James Jones - C.J. Wocheck
- Tony Carreiro - District Attorney Mitch Meyers
- Peggy Doyle - Clare Dumont
- Lisa Howard - Annie Lambert
- Charles Lucia - Elijah
- Rachel Winfree - Realtor
- Rachel Winfree - Nurse
- Richard Marcus - Mr. Raines (archive footage)
- James Dalesandro - Monk
- Ashley Peldon - Young Miss Parker (archive footage)
- Elpidia Carrillo - Nia
- John Mahon - Eugene Clark
- Jeffrey Hutchinson - Brandon Larson
- Joel McCrary - Butch
- Elizabeth Sampson - Kelli
- Mary Beth McDonough - Mrs. Falk
- Lynn Blades - Reporter
- Craig W. Van Sickle
- Steven Long Mitchell
- Juan Carlos Coto
Don Harvey hace el papel de Mr. Job.
Stephen Tobolowsky hace el papel de Dr. Alan Trader.
James Tolkan hace el papel de FBI Special Agent Korkos.
Antonio David Lyons interpreta a Todd Healy en la serie.
Brock Peters hace el papel de Henry Cockran.
Harve Presnell interpreta a Mr. Parker en la serie.
Gailard Sartain interpreta a Tug Beaulieu en la serie.
Trevor Morgan hace el papel de Kid.
William Sanderson interpreta a Roy Abbot en la serie.
Elpidia Carrillo interpreta a Nia en la serie.
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