- Bette Midler - Hadassah Gold
- Gwyneth Paltrow - Georgina Hobart
- Jessica Lange - Dusty Jackson
- Benjamin Barrett - Ricardo
- David Corenswet - River Barkley
- Brandon Win - Connor
- Tracy S. Lee - Vicki
- Courtney Taylor Burness - Hostess
- Adam Wang - Mr. Anselm
- Andrew Patrick Ralston - Dean Lawrence
- Laura Patalano - Lupe
- Jeff Allen - Thomas Eagleton
- Andre Hotchko - Hubert Humphrey
- Blaine Gray - Ted Kennedy
- Chris Flanders - Walter Mondale
- Rick Holmes - Cooper
- Tanner Thomason - John Judson
- Richard Wharton - Thomas
- Troy Blendell - Mr. Happ
- Louise Bennett - Nancy Grace-Type
- Russell Posner - Elliot Beachman
- Koby Kumi-Diaka - Pierre Toussaint
- Graham Clarke - Freddy
- Macy Friday - Chippy
- Kevin Gardner - Mr. Hapswell
- AJ Achinger - Derek
- Paloma Esparza Rabinov - Trina
- Elise Luthman - Shelley
- Terry Sweeney - Buddy Broidy
- Marshall Fox - Ray
- Eric Nenninger - Detective
- Justiin A. Davis - Dabney
- Joseph Runningfox - Shaman George
- January Jones - Lizbeth Sloan
- Taylan Tural - Dina
- Martina Navratilova - Brigitte
- Dylan McDermott - Theo Sloan
- Ty Chen - Khai Zhi
- Miles Fisher - Thad
- Natasha Ofili - Principal Vaughn
- Kelly Fulton - Alison
- Jake Tapper - Himself
- Trey Eason - Luther Hobart
- Trevor Eason - Martin Hobart
- Joe Carroll - David
- John Scott-Richardson - Native American Chief
- Valerie Sue Love - Waitress
- Joe Morton - Marcus Standish
- Sam Jaeger - Tino McCutcheon
- Heather Burns - Mary McCutcheon
- Josh Bonzie - Randal
- Jackie Hoffman - Sherry Dougal
- Ava Eisenson - Riva Mandel
- Robin Weigert - Andi Mueller
- Susannah Perkins - Jayne Mueller
- Krystin Goodwin - Tiffany Albrecht
- Alix Elias - Elderly Volunteer
- Clark Carmichael - Pat Carney
- Mitch Greenberg - Male Patron
- Chris Kipiniak - Bryce Edgmon
- Robert James Hickey - Carl Moses
- Michael Simon Hall - David Yancy
- Cate Bottiglione - Shelly Simmonds
- Ryan J. Haddad - Andrew Cashman
- Mallory Ann Wu - Taryn
- Daryl Edwards - J. Tank Brown
- Michael Hartney - Manager
- B.K. Cannon - Chris
- David J. Cork - Franklin
- Jake Johnson - Student
- Teddy Sears - William Ward
- Michael Graham - Gaylord Nelson
- Timothy Scott - Student (uncredited)
- Rudy Pankow - Other Kid
Jessica Lange hace el papel de Dusty Jackson.
Joe Morton interpreta a Marcus Standish en la serie.
Ben Platt interpreta a Payton Hobart en la serie.
Judith Light interpreta a Dede Standish en la serie.
Lucy Boynton interpreta a Astrid Sloan en la serie.
Zoey Deutch hace el papel de Infinity Jackson.
Julia Schlaepfer interpreta a Alice Charles en la serie.
Laura Dreyfuss interpreta a McAfee Westbrook en la serie.
Theo Germaine interpreta a James Sullivan en la serie.
Rahne Jones interpreta a Skye Leighton en la serie.
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