- Ashley Brooke - Riley
- Chris Cafero - Tad
- Phillip Johnson Richardson - Hakim
- Julio Torres - Jordan
- Jackie Hoffman - Lorraine
- Kate Berlant - Pitzi Pyle
- Kate Simses - Brittlyn
- Tinsley Mortimer - Tinsley Mortimer
- Andrew Ridings - Matt
- Hoda Kotb - Hoda Kotb
- Mario López - Mario López
- Greta Lee - Genevieve Kim
- Aidy Bryant - Aidy Bryant
- Patrick Wilson - Patrick Wilson
- Andy Cohen - Andy Cohen
- Daniel K. Isaac - Jeremy Delonpre
- Kathie Lee Gifford - Kathie Lee Gifford
- Beck Bennett - Jeff
- Ryan Farrell - Dr. Nick
- Richard Kind - Skip Schamplin
- Tim Rogan - The Shirtless Vet
- Zosia Mamet - Zosia Mamet
- Ali Ahn - Jo
- Justin Sylvester - Justin Sylvester
- Debi Mazar - Debi Mazar
- Tuc Watkins - Troy
- Noah Galvin - Eddie
- Jimmy Fowlie - Cameron Colby
- Wanda Sykes - Shuli Kucerac
- Ian Ziering - Ian Ziering
- Alison Rich - Melanie
- Shauna Bloom - Tamra
- Gideon Glick - Jess
- Michael Che - Michael Che
- Nick Adams - Dallas Drake
- Helen Goldsby - Ranessa Boley Braun
- Dylan O'Brien - Dylan O'Brien
- Justin Bartha - Justin Bartha
- Lukas Gage - Lukas Gage
- Kiernan Shipka - Kiernan Shipka
- Fin Argus - Lucas Lambert Moy
- Stephen Cofield Jr. - Damian Davis
- KeiLyn Durrel Jones - Frank
- Emily Berman - Amida
- Andrea Boehlke - Reporter
- Joseph Lymous - Reporter
- Anu Valia - Night Nurse Director
- Lori Funk - NIght Nurse COVID Officer
- Imani Love - Woman
- Helena Betancourt - Nurse
- Kelsey Bailey - Gwen
- Dante Jeanfelix - Social Media Rep
- Samy Nour Younes - Rich
- Arnie Burton - Theo
- Asmeret Ghebremichael - Lead Stylist
- Kathy Searle - Suse
- Gregory Perri - Gavin
- Gibson Frazier - Dr. Wiegland
- Ava Sofia Mattox - Receptionist
- Nadia Dajani - Mackenzie
- Johnny M. Wu - Paramount Casting
- Alex E. Harris - Trish
- Leah McSweeney - Leah
- Vanessa Cozart - Hailey
- Kathryn Boswell - Julia
- David Neal Levin - Doug
- Alex Webb - Producer
- Justin Adams - Agent
- Gurinder Sindher - Rep
- Cicily Daniels - Woman at Cafe
- Chris Wendelken - Friendly Man
- Matthew Laureano - Hot Actor
- Dana Delany - Emily Overruled
- Miles G. Jackson - Ethan
- Katie Hartman - A.D.
- Blair Sams - Stenographer
- Zuhdi Boueri - Victor
- NaTonia Monét - June
- Ka-Ling Cheung - Yuri
- Sebastian Barba - P.A.
- Mike Carlsen - Mike
- Jarvis D. Matthews - Usher
- David Moreland - Broadway Angry Man
- Genesis Oliver - Broadway Doctor
- Laura Esterman - Broadway Older Woman
- Sarah Hayon - Patron
- Marcus Raye Pérez - Flower Delivery Man
- Tim Young - Caveman
- Erinn Ruth - Interviewer
- Bill Dawes - Billionaire
- Nick Rehberger - Exec
- Josh Tobin - Exec
- Ricardo Vázquez - Steve
- Monique Holt - Seamstress
- Lisa Dennett - Seamstress Interpreter
- Nat DeWolf - Head of GLAAD
- Adam DeCarlo - GLAAD #2
- Tracy Westmoreland - Head of Westboro
- Brenny Rabine - Westboro #2
- Simu Liu - Simu Liu
- Ann Dowd - Paula Davies
- Lusia Strus - Sheila
- Woody Fu - Applebee's A.D.
- Katie Lee Hill - Katrina
- Kwabena Ampofo - Passing Grip
- Brenna Palughi - Applebee's Hostess
- Meghan Manning - Dancer
- Elliott Fullam - Super Fan
- Ben Platt - Ben Platt
- Eddie Leavy - Max
- Cameron Kasky - Cameron Kasky
- Maddie Corman - Pat's Friend
- Henny Russell - Lisa
- Finnerty Steeves - Line Producer
- Dylan Guerra - Moviegoer
- Adam Keane - Movie Fan
- Harsh Nayyar - Vishant
- Susan Blackwell - Casting Director
- Tarik Davis - Nuts4Nuts Guy
- Amr El-Bayoumi - Qatari Businessman
- Ekow Brown - Dancer
- Christine Chang - Meredith
- Lily Chee - Model Girl
- Rosa Gilmore - Rep. Elena Diaz-Coleman
- Sudi Green - Bagel Bites Reporter
- John Michael Lyles - Kevin
- Rachel Zeiger-Haag - Kendra
- Ben Jaeger-Thomas - Man
- Sophia Rose - Yendani
- Abena Mensah-Bonsu - Ashlee
- Becky Chicoine - Renee
- Tori Feinstein - Rachel Klein
- Gilli Nissim - Nurse
- Sophie Zucker - Numbers Person
- Josie Totah - Elijah
- Bettina Bilger - Lisa
- Twinkle Burke - Principal
- Sydney Mae Diaz - Swoopy Hair Kid
- Donshea Hopkins - Ebony
- Ryan Willard - DJ
- Mark Gessner - Director
- Kathryn Burns - Dancer
- Ilia Jessica Castro - Dancer
- Laura Jordan - Deborah
- Ariana Madix - Ariana Madix
- John Mondin - Carl
- Tom Sandoval - Tom Sandoval
- Brock Yurich - Trainer
- David Arquilla - Gym Receptionist
- Olivia Cipolla - Dancer
- Meagan Kong - Dancer
- Shannon O'Neill - Assistant Director
- Saamer Usmani - Paul Mago
- Cindy Katz - Acting Teacher
- Navaris Darson - Drake Cameron
- Will Jacobs - Nerdy Date
- Heidi Gardner - Mona
- Sophie Faulkenberry - Hot Blonde
- Nick Fondulis - Photographer
- Noelle Franco - Party Girl
- Rony Clanton - Cab Driver
- Caden Asher Mazurek - Young Cary
- Violet Krumbein - Amanda (voice)
- Kaylin Hedges - Ava
- Molly Camp - Cat Owner
- Erica Hernandez - Waitress
- Eva Kaminsky - (voice)
- Nozipho McLean - Stage Manager
- Kara Young - VMA Announcer (voice)
- Nischelle Turner - Nischelle Turner
- Gage Banister - Ezra
- Fredi Bernstein - Lorin
- Richard Bekins - Judge
- Richard Bekins - Terrence
- Richard Busser - Ray
- Germar Terrell Gardner - Pietro
- Erin Noel Grennan - Grieving Widow
- Rachel Pegram - Jackie
- Kim Ramirez - Cindy
- James David Rich - Passing Man
- Marcia DeBonis - Kathy
- Jenny Lester - Stephanie
- Liz McCartney - Sweet Midwestern Lady
- Noam Ash - Grindr Guy
- Cate Bottiglione - Manager
- Iliana Inocencio - Kirsten
- Heidi Germaine Schnappauf - Drunk Friend
- Lou Gonzalez - Peter
- Brandon Salerno - Friend
- Constantine Rousouli - Nooner
- April Armstrong - Nurse
- Devin Bockrath - Amy
- Venida Evans - Elderly Woman
- Viveca Chow - Girl
- Adam David Thompson - Pastor Jax Dag
- Blake Baumgartner - Young Brooke
- Joe Castle Baker - Vincent
- Suzen Baraka - Beth
- Alex Boniello - Indie Rock Band Singer
- Winslow Bright - Jagger
- Steve Blanchard - Priest
- George Deihl Jr. - Producer
- Tommy Do - Tony
- Geraldine Leer - Leanne
- Caleb Reese Paul - Young Carey
- Liz Priestley - Tourist
- Natalie Walker - Seinfeld
- Tavi Gevinson - Tavi Gevinson
- Alexandria Benford - Make-Up Artist
- Waliek Crandall - Security Guard
- Nora Hummel - Phyllis
- Donovan Mitchell - Ethan
- Regina Ohashi - Audience Member
- Alex Wyse - Elliott
- Antu Yacob - Dina
- Mike Dobbins - Grip
- Andrea Negrete - Shopper
- Tina Benko - Phoebe McInerny Purmont
- Isabelle Barbier - Ashly
- Denia Brache - Female Patient
- Jeanette Branch - Nurse Finch
- Pat Labez - Nurse Akiyama
- Maria Elena Ramirez - Dalia Solomon King
- Jay Santiago - Mr. Gutierrez
- Aneesh Sheth - Rhadika Kamini Patel
- Melinda Tanner - Cynthia
- Rick Younger - Ted
- Joe Sabia - 73 Questions Man
- Michael Campayno - Dean Brennan
- James Anderson - James
- Andrew Keenan-Bolger - Andrew Keenan-Bolger
- Charles Everett - Tic Tac Toe A.D.
- Julia Harnett - Reporter
- Juri Henley-Cohn - Philip Price
- Xavier Rodney - Sound Technician
- Matthew Saldivar - Hank
- Meagan Kimberly Smith - Leah
- Alessia Cara - Alessia Cara
- Bowen Yang - Bowen Yang
- Diego Calinawan - Bouncer
- Matthew Atherton - Tourist Man
- Shannon DeVido - Linda
- Eileen Galindo - Aunt Connie (voice)
- Reggie De Leon - Hollis
- Ashley Austin Morris - Flight Attendant
- Patrick Reilly - Rob
- Valerie Smaldone - CNN Anchor
- Clifton J. Adams - Waiter
- Kevin Curtis - Devin
- Dave Mizzoni - Chorus Boy
- Oraldo Austin - Nurse
- Jennifer Allen - Kathy
- Denise Bessette - Theresa
- Maya Deshmukh - Mary
- Randi Kaplan - Gail
- Erin Quill - Mom
- Eric Satterberg - Chef Eric
- Mary Stout - Kathy
- Jennifer Tsay - Carissa
- Claire Burgi - Ticker
- Daniel Rios Jr. - DJ
- Esteban Suero - Even Cuter Gay
- Jonathan Villanueva - Officer
- Chris Morris - Applebee's Diner
- Rachel Paula Green - Applebee's Diner
- Theis Weckesser - Elf Man
- Mario D'Leon - Elf Man
- Mikaela Izquierdo - Alicia
- Deya Danielle Drake - Jess
- Julian Gavilanes - Terry
- Mike Menendez - Mike
- Jessica DiGiovanni - Melissa
- Alexander Blaise - CEO
- Lori Hammel - Robin
- Tyler Bunch - Gas Station Attendant
- Edie Falco - Edie Falco
- Lane Napper - Paparazzo
- Jamar Greene - Doorman
- Mansoor Najee-Ullah - Mc. McMurtry
- Shravan Amin - NYT Reporter
- Derrick Delgado - Little Kid
- Anthony Ruiz - Uncle Hector
- Elisa de La Roche - Tia Paula
- Adrienne Acevedo Lovette - Cousin Marta
- Todd Cerveris - Improv Teacher
- Sandra Berrios - Aunt Connie
- Latrisha Talley - EMT
- Erick McAllister - Firefighter
- Sam Faulkner - Connor
- Lawrence O'Donnell - Lawrence O'Donnell
- David Lascher - Travis
- Reade Kelly - Neighbor
- Adam Enright - Buzzfeed Reporter
- Charmaine Reedy - Older Woman
- Laurel Casillo - Judy
- Desmond Richardson - Ted
- Spike Einbinder - Jules
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