- J. Anthony Pena - Carl
- Michael Malarkey - Sam Foster
- Elisabeth Röhm - Agent Aria Price
- Dilshad Vadsaria - Anaya Sodhi
- Rafa Sánchez - Bank Manager
- Rainier Quintana - Paramedic
- Markice Moore - Cornell Barnes
- Blas Sien Diaz - Inmate #1
- John Wu - Lew
- José Luis Oyola - Buyer
- Matt Gerald - Kilvinski
- Gilluis Pérez - EMT
- Wanda Rovira - Neighbor
- Jeffrey Holsman - Doctor
- Alexander Blaise - Harrison Fields
- Brian Tester - Dr. Faraday
- Amber Rivera - Reporter #3
- Oscar Morales - Budtender
- Carolyn Michelle Smith - Sonia Gardener
- Linda Purl - Gwenn
- Ryan Christiansen - Rollins
- Jeremy Landon Hays - Keller
- Jeremy Landon Hays - Jennings
- Kyle Bary - Brian
- Mariana Monclova - Girl
- Sarah Dumont - Kate Miller
- Michael Filipowich - Vasily Andropov
- Clint James - Sanders
- Mike Whaley - Sergeant
- Oscar Guerrero - Pablo
- Yetta Gottesman - Priya Gupta
- Yetta Gottesman - Suit
- Norman Grant - Security Guard Helixa
- Kwame Patterson - Neckbone
- Billy Malone - Frank
- Brendan Clack - FBI Agent #4
- Sebastian Vázquez - Grandson Assassin
- Sebastian Vázquez - Son Assassin
- Robert Gossett - Charles Ryder
- Aaron Abrams - Shankman
- Edward Lee Thompson - Businessman
- LaToya Tonodeo - Tara Byrd
- Ash Christian - Driver
- Gordon Danniels - Grandfather
- Essex O'Brien - Tyson
- Julitza Berberena - Victim of the Jailbreak
- Kevin Connolly - James Hoke
- Rey Hernandez - Tristan James
- Rich Paul - Eli
- Christopher Burns - Detective
- Jorge Antares - Father Assassin
- Jorge Blanco Muñoz - Young Ignacio
- Alejandra Purcell - Young Carmen
- Leonardo Castro Sitiriche - Trabajador
- Marian Pabón - Pearl
- Audrey Neal - Bartender
- Ashley Pickett - Medical Examiner #2
- James Edward Thomas - Sheriff's Spokesman
- Khotan Fernández - Tito
- Carrie Walrond Hood - Ms Schulz
- Sarah Rich - Student #2
- Jean Pierre Prats - Cartel Dignataries
- Carlos Sanz - Ignacio Velasquez
- Leona Lewis - Amber Hall
- Erik King - Pastor Greg
- Joshua Leary - Jones
- Jahzir Bruno - Tommy
- Aurelio Lima - Reynaldo
- Karen-Eileen Gordon - Isabel Williams
- Isaac Keys - G
- Martin Bats Bradford - Clinton
- Russell Wong - Michael Everett
- Jock McKissic - George Pearson
- Cara Mantella - Case Worker
- Isaac Santiago - Raven #1
- Anika C. McFall - Neighbor #1
- Brandon Engman - Male Student #1
- Chandler Lovelle - Female Student #1
- Leah Pressman - Sarah
- Jessie Vaughn - Girl
- Ashley Song - Female Pastor
- Isabel Arraiza - Lourdes
- Isabella Rivera-Gandulla - Veronica Ramos
- Braulio Castillo Jr. - Victor Moreno
- Kim Delaney - Abigail
- Andrew Howard - Kraley
- Richard Burgi - Nathan Andrews
- Gerrard Lobo - Rajiv
- Rafa Alvarez - Hector
- Ricardo Álvarez - Samuel
- Linette Torres - Mother
- Miranda Purcell - Sofia
- Eve Mauro - Teresa Winters
- Sara Jarque - Sylvia Moreno
- Jaime Irizarry - Homeless Guy
Sean Bean interpreta a Tom Hammond en la serie.
Ryan Kwanten interpreta a Steve Hammond en la serie.
Katrina Law interpreta a Karen Beach en la serie.
Cory Hardrict interpreta a Cole Hammond en la serie.
J. J. Soria hace el papel de Pete Ramos.
Christina Milian interpreta a Christine Parks en la serie.
Zulay Henao interpreta a Carmen Velasquez en la serie.
Sebastián Zurita interpreta a Ricardo Velazquez en la serie.
J. Anthony Pena interpreta a Carl en la serie.
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