- Carter Hudson - Attorney in Line
- Mohammad Bakri - Tariq
- Chris Perfetti - Lawyer
- Sofia Black-D'Elia - Andrea Cornish
- Paul Sparks - Don Taylor
- Michael Kenneth Williams - Freddy Knight
- Glenne Headly - Alison Crowe
- Amara Karan - Chandra Kapoor
- Paulo Costanzo - Ray Halle
- Afton Williamson - Officer Cass Wiggins
- Joshua Bitton - Officer Robert Maldonado
- Victor Verhaeghe - CSI Turley
- Nabil Elouahabi - Yusuf
- Mustafa Shakir - Victor
- Esau Pritchett - Mr. Day
- J.D. Williams - Trevor Williams
- Aaron Moten - Petey
- Frank Wood - Medical Examiner
- Lord Jamar - Tino
- Jeff Wincott - Detective Lucas
- Sticky Fingaz - Rikers Inmate
- Pernell Walker - Rikers PO
- Scott Menville - Rikers Latino Prisoner
- Chris McKinney - Rikers Head CO
- Nikiya Mathis - Rikers Check-in Assistant
- Kymbali Craig - Rikers Strip Search Guard
- Glenn Fleshler - Judge Roth
- Don Harvey - Detective Tomalikis
- Trudie Styler - Jean Rothman
- Ben Shenkman - Sergeant Klein
- Eric D. Hill Jr. - Basketball Player
- Riti Sachdeva - Aunty
- Sam Gilroy - Shunned Passenger
- Garrett Basch - Ivan
- Steve Cirbus - Police Patrolman
- Charlie Hudson III - Duane Reade
- Steven Randazzo - Andrea's Neighbor
- Skipp Sudduth - Cop at crime scene
- Mike Figueroa - Officer Frank Hernandez
- Kevin Dunn - Detective Daniel Lang
- Donté Bonner - Bell
- Kris Eivers - Woods
- Frank De Julio - Pauline
- Jason Furlani - Anti-Crimer
- Lennie Loftin - Detective Lieberman
- Ned Eisenberg - Lawrence Felder
- Nicholas Turturro - Detective
- Ray Abruzzo - Eddie
- Tijuana Ricks - Morgue Attendant
- Russell G. Jones - Detective
- Jonny Coyne - Detective Fitzroy
- Jimmy Palumbo - 12th Precinct Cop
- Mike DiGiacinto - 12th Precinct Cop
- Joseph Latimore - Bailiff
- Terron Jones - Tamar Gee
- Adam LeFevre - Judge
- Simon Feil - Gurwitz
- Manny Perez - Inspector McCaffrey
- Quincy Chad - Tombs Officer
- Jimmy Gary Jr. - Tombs Officer
- Andre Ware - Tombs Officer
- Saycon Sengbloh - Tombs Officer
- Renoly Santiago - Tombs Junkie
- Aubrey Joseph - Dwight Gooden Stone
- LaChanze - Dwight's Mom
- Don Guillory - ADA
- Catherine A. Callahan - ADA Assistant
- Cliff Moylan - Arraignment Bailiff
- Nicholas J. Coleman - Detective McPherson
- Albert Jones - District Attorney
- Jeremy Shamos - Dermatologist
- Michelle Duffy - Reporter
- Michael Rivera - Police Impound Lot Officer
- Alexis Suarez - 87th Street Cop
- Bobby Di Cicco - Eczema Help Group Member
- Michael Buscemi - Steve
- Patch Darragh - Eczema Help Group Member
- Sean Ringgold - Pound Employee
- Bryan Burton - Shelter Volunteer
- Ashley Thomas - Calvin Hart
- Babs Olusanmokun - Marvin
- Damien Lemon - Defendant
- Jennifer Onvie - Janine
- Aida Turturro - Rehab Worker
- Max Casella - Edgar
- Erik McKay - DeVaughn
- Roosevelt Davis - Holding Cell Guard
- Wallace Smith - Holding Cell Inmate
- Daniel J. Watts - Holding Cell Inmate
- Jack Gilpin - Doctor
- Fisher Stevens - Saul the Pharmacist
- Paul Carafotes - Rose
- Brian Tarantina - Bar Patron
- Chip Zien - Dr. Katz
- Skyler Fortgang - Student
- Barrington Walters Jr. - Student
- Yvonne Zima - Teacher
- Erica Cho - ADA
- Maren Lord - ADA
- Joe Egender - Cutty
- Treach - Willy John
- Otoja Abit - Willy John's Friend
- Richard Price - 'Viagra' Dealer
- Jeff Chena - Ciara's John
- Frank Ridley - Jerry
- Ivan Camilo - Bodega Clerk
- Nayab Hussain - Employee Clerk
- Chris Cafero - Facebook Cop
- Joseph Badalucco Jr. - Detective
- Donovan Christie Jr. - Nation of Islam Inmate
- Susan Blackwell - Drug Intoxication Expert
- Andrew Stewart-Jones - Coach Harris
- James L. Ward - Trial Bailiff
- Allen Enlow - Biologist
- Pallavi Sastry - Khan's Neighbor
- Daniel Gadi - Trainer
- Danny Flaherty - Copy Store Clerk
- Michael J. Burg - Bar Owner
- Robert C. Kirk - John O'Hara
- Monette McKay - Court Stenographer
- Charles Brice - Terry
- Donnetta Lavinia Grays - Nurse
- Michael Braun - Dr. Nelson
- Roscoe Orman - Jury Foreman
- Garrett Basch
- Peter Moffat
- James Gandolfini
- Jane Tranter
- Richard Price
- Steven Zaillian
- Jeff Russo
Riz Ahmed interpreta a Nasir "Naz" Khan en la serie.
John Turturro interpreta a John Stone en la serie.
Bill Camp interpreta a Dennis Box en la serie.
Payman Maadi hace el papel de Salim Khan.
Poorna Jagannathan interpreta a Safar Khan en la serie.
Sofia Black-D'Elia hace el papel de Andrea Cornish.
Paul Sparks hace el papel de Don Taylor.
Jeannie Berlin interpreta a Helen Weiss en la serie.
Michael Kenneth Williams interpreta a Freddy Knight en la serie.
Glenne Headly interpreta a Alison Crowe en la serie.
Capítulo disponible en las siguientes plataformas:
