- Haley Tju - Little Girl
- Phil Abrams - Dr. Barr
- Isaak Presley - Wilbur
- Jessica Lu - Tabitha
- Leslie Grossman - Melissa
- Edi Patterson - Wilbur's mom
- Edward Barbanell - Roger
- Christopher Wolfe - Jason
- Sarah Buehler - Women's services worker
- Brandon Johnson - Tripp
- Trilby Glover - Dede
- Paul Mabon - Joey
- Jolene Anderson - Sabrina
- Michael Chernus - Paul
- Barry Bostwick - Marty
- Sterling Sulieman - Clint
- Shannen Doherty - Self / Brenda
- James Urbaniak - Mr. Blakeney
- Ravi Patel - Amir
- Marlo Thomas - Nancy Niles
- Cheri Oteri - Carla
- Rob Reinis - Officer Runey
- Matt Bomer - Monty
- Mark Consuelos - Chris
- Sarah Burns - Megan
- Kerri Kenney - Dr. Howell
- Stacie Greenwell - Mrs. White
- Peter Porte - Mr. Rodriguez
- Mel Rodriguez - Gerald
- Milton T.J. Taylor - Malcolm
- Nicole Richie - Self
- George Takei - Sam
- Erik Weiner - Ian
- Brooke Bloom - Debra
- Will Green - Frank
- Lenny Jacobson - Ben
- Kevin Christy - Freddie
- Greg Pitts - Pat
- Maddy Caddell - Blog
- Hemky Madera - Luis
- John Stamos - Brice
- Indrajit Sarkar - Dr. Venkatashar
- John Benjamin Hickey - Father Michael
- Toby Huss - Farmer Mark
- Willam Belli - Nana Drag Queen
- Shree Crooks - Avery
- Antoinette Abbamonte - Deaf Mom
- Debbie Lee Carrington - Little Person Mom
- Andrea Helene - Lady Buyer
- Marieve Herington - Heather
- Sara Lassner - Sheryl
- Kelly Mantle - Aubrey
- Ellen Ratner - 50-Year-Old Woman
- Yolanda Snowball - Nurse
- Michael Anthony Spady - Deaf Dad
- Haley Strode - Waitress
- John Vance - Juror
- AlgeRita Wynn - Judge
- Marshall Hilliard - Party Guest
- Merit Leighton - Large Girl
- David Lewis - Young Gay Dude
- Sandy Martin - Miss Pepper
- Dre Matthews - Go-Go Boy
- Charlie Weirauch - Buck
- Kurt Scholler - Suburban Dad
- Kyla Kenedy - Rebecca
- Gurinder Sindher - Equinox Employee
- Ashlee Füss - Young Jane
- Jolene Andersen - Sabrina
- Jeff Harlan - Edgar
- Kelly Keaton - Charity
- Julia Prud'homme - Billie
- Ryan Scharoun - Hot Young Guy
- June Kyoto Lu - Korean Woman
- Van Epperson - White Man
- Aria Noelle Curzon - Waitress
- Brighton Sharbino - Sarah
- Leisha Hailey - Victoria
- Constance Zimmer - Tiffany
- Ryan Bittle - Mitch Madison
- Briana Lane - Clea
- Ely Henry - Devin
- Anjini Taneja Azhar - Jenna
- Anjini Taneja Azhar - Reagan
- Alexandra Gold Jourden - Bianca
- Alexandra Gold Jourden - Talia
- Emily Kosloski - Lorraine
- Staci Lawrence - Kate
- Thomas Barbusca - Donny
- Matthew Jacob Wayne - Ethan
- Jordenn Thompson - Mary Todd Lincoln
- Nolan Gross - Son
- Julie Brister - Sandy Greenberg
- Reggie De Leon - Tuan
- Jasmine Masters - Rocky Drag Queen
- Phoebe Neidhardt - Young Woman
- Madison Dae Clarion - Classmate
- Elisha Yaffe - Noel
- Wendy Benson-Landes - Courtney
- Jackie Joyner - Tasha
- Angela Matemotja - Nanny
- Sarah Stouffer - Sienna
- Rakefet Abergel - Pilar
- Moshe Kasher - Writer
- Layla Crawford - Young Rocky
- Timothy E. Goodwin - Crew Member
- Lais Pedroso - Babysitter
- Jason Boegh - Rayburn
- Nikki McKenzie - Natasha
- Michael Lanahan - Manager
- Jen Ray - Violet
- Kelly Rohrbach - Amber
- Nick Gore - Brandon
- Rachel DeGenaro - Frances (young)
- Peggy Dunne - Technician
- Jon Baggio - Cat Man
- Drue Delio - Goldfish Man
- Dana Daurey - Lauren
- Connor Clayton - Bryan / David's Son
- Asjha Cooper - Nikki (17 Yrs)
- Laura Chinn - Amy
- Noah Weisberg - Joel
- Sara Van Horn - Cat Lady
- Becky Feldman - Odd Looking Woman
- Darryl Alan Reed - Dashing Man
- Cathy Chang - Sobbing Woman
- Erin Affourtit - Health Nut Mom
- Phil Kruse - Cody
- Amor Sanchez - Mrs. Vega
- Frantz Y. Delsoin - Burly Man
- Tiffany Abney - Wardrobe Stylist
- Abby Linden - Kid
- Ali Adler
- Dante Di Loreto
George Takei hace el papel de Sam.
Justin Bartha hace el papel de David Murray.
Andrew Rannells interpreta a Bryan Collins en la serie.
Georgia King interpreta a Goldie Clemmons en la serie.
Bebe Wood interpreta a Shania Clemmons en la serie.
NeNe Leakes interpreta a Rocky en la serie.
Jayson Blair interpreta a Clay Clemmons en la serie.
Ellen Barkin interpreta a Jane Forrest en la serie.
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