- Ivan Dixon - Wick
- Keir Dullea - Frank
- Stafford Repp - Lt. Howard Cline
- Joan Staley - Sophie
- Gary Merrill - Karl Lippert
- Telly Savalas - Dr. Buel Reed
- Lynn Bari - Mrs. Grace
- Eileen Heckart - Harriet Dawson
- Mike Kellin - Moran
- Richard Arlen - Willits
- Leif Erickson - Dr. Eric Thor
- Virginia Gregg - Georgine
- Robert Redford - Arthur Honniger - Hitchhiker
- Ralph Taeger - Tad Calloway
- Patricia Breslin - Ruth Wollock
- Joan Hackett - Angie
- Betsy Jones-Moreland - Claire Arnet
- Jack Klugman - Floyd Blaylock
- Natalie Trundy - Inge Halverson
- Alberta Nelson - Anna
- Ben Wright - Frank Andrews
- Les Tremayne - Garland
- Cecil Kellaway - Mr. Weltschmerz
- Nehemiah Persoff - Louis Morley
- Robert Blake - Bobby Madero
- Ann B. Davis - Elizabeth MacBaine
- Eddie Albert - Walter Cowley
- Dina Merrill - Ruth Kingman
- John Larkin - Chuck Graffer
- Arthur O'Connell - Peter Capples
- James Gregory - Father Al
- Charles Aidman - Dr. Ted Reisman
- Norman Burton - Poulos
- Barbara Baxley - Eve Lippert
- Peter Whitney - Matson
- Wendell Corey - Roger Dawson
- Robert Middleton - Stanley Mannis
- Royal Dano - Harry Tilden
- Paul Carr - Johnny
- Martin Balsam - Frank Eberhardt
- Charles McGraw - Dr. Cameron Hill
- Keenan Wynn - Ronson
- Doro Merande - Miss Stewart
- Peter Falk - Lopez
- Judi Meredith - Florence Charron
- Barney Phillips - Sergeant Steiner
- Brett Somers - Dorothy Blaylock
- Arlene Martel - Maria Danielo
- Peter Helm - Lennie Rath
- Nan Martin - Margaret
- Stanley Adams - Larry Gruber
- Josephine Hutchinson - Nettie
- Frank Silvera - John Hernandez
- Beatrice Kay - Joy Miggins
- Linda Watkins - Wilma Donnelly
- Ron Howard - Tommy Simms
- Peter Fonda - Ronnie Bryson
- Virginia Christine - Annabelle
- Phyllis Love - Mrs. Capples
- Parley Baer - Pop O'Shea
- Fritz Weaver - Arthur Grissom
- Simon Oakland - Felix Pascal
- Chris Robinson - Clifford Forbes
- Barry Morse - Morgan Dolgelly
- Barry Morse - Virgil Payne
- Michael Constantine - Oscar Holloway
- Jeanne Cooper - Helen
- Jack Oakie - Ham Tucker
- Paul Richards - Hobbins
- Sherry Jackson - Ellen Talltree
- Burt Brinckerhoff - Willis
- Anne Francis - Phyllis Eberhardt
- Gloria Grahame - Nurse Nora Springer
- Charles Bronson - Jerry Bergason
- Amanda Randolph - Mattie
- Joseph Ruskin - Donnell
- Margaret Hayes - Eve Steiner
- Kevin Hagen - Arne Halverson
- Eduardo Ciannelli - Tulio Rossi
- Paula Raymond - Andrea Beauvoir
- Sydney Pollack - Bert Masters
- Sydney Pollack - Austin Rogers
- Margo - Mrs. Madero
- Joseph Wiseman - Clayton Grimes
- Laraine Day - Vivian Cowley
- Milton Selzer - Dr. Harmon
- Joanne Linville - Grace Kegler
- Hope Summers - Mrs. McCurtin
- John Larch - John Clark
- William Windom - Warren Giles
- Virginia Field - Iris
- William Schallert - Gilbert Condon
- Edward Binns - Crafts
- Diana Millay - Connie Weems
- Bartlett Robinson - Victor Kredenza
- Bartlett Robinson - Farnum
- Nelson Leigh - Dr. Halsted
- Victor Buono - Manrique
- Andrew Prine - Werner Muelich
- Laura Devon - Ann Fetterson
- James Doohan - Dr. Lennon
- Miriam Colon - Dolores Madero
- Henry Beckman - Sergeant Rayless
- Bea Benaderet - Miss Horne
- Don Taylor - Fred Kingman
- Lin McCarthy - John Kegler
- James Flavin - Moose
- Ed Begley - Masters
- Mario Alcalde - Frank Danielo
- Mario Alcalde - Barney Talltree
- Susan Gordon - Muffin Reisman
- Vic Morrow - Belman
- Oscar Beregi Jr. - Howard Pressman
- Oscar Beregi Jr. - Karl Muelich
- Iphigenie Castiglioni - Carla Rossi
- Henry Jones - Davidson
- Vaughn Taylor - Felix Wainwright
- John Fiedler - Perkins
- Cloris Leachman - Elsie Condon
- Victor Jory - Deacon Lee
- Tina Louise - Stella Knowland
- Jack Hogan - Jerry Wells
- David Lewis - Maury Keeler
- David Lewis - Townsend
- Robert Karnes - Fred Clinton
- Yvonne Craig - Louise Pittman / Edna Pittman
- Ed Nelson - Roger Sykes
- Ed Nelson - Jefty Bright
- Strother Martin - Benny Kohler
- Edward Andrews - Hutch Hutchins
- Sandra Warner - Mrs. Flyer
- Sandra Warner - Sandy Demarest
- Bryan O'Byrne - Cannon
- Ilka Chase - Cynthia Webster
- Quinn Martin
Peter Falk hace el papel de Lopez.
Robert Redford interpreta a Arthur Honniger - Hitchhiker en la serie.
Vaughn Taylor interpreta a Felix Wainwright en la serie.
Josephine Hutchinson interpreta a Nettie en la serie.
Les Tremayne interpreta a Garland en la serie.
Nehemiah Persoff interpreta a Louis Morley en la serie.
Arthur O'Connell hace el papel de Peter Capples.
Edward Binns interpreta a Crafts en la serie.
Charles Bronson interpreta a Jerry Bergason en la serie.
Miriam Colon interpreta a Dolores Madero en la serie.
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