- Rachael Harris - Claire
- Brenda Blethyn - Angela Kimble
- Jennifer Elise Cox - Natalie
- Constance Zimmer - Amy Hunter
- Dave Florek - The Douche
- Barry Livingston - Director
- Tim Meadows - Dr. Volk
- Sally Pressman - Melanie
- Don Lake - Carl
- Lee Tergesen - Todd Watski
- Mary Beth McDonough - Mrs. Wilhoite
- Matt Letscher - Burton Schaefer
- Blair Underwood - Daniel Harris
- Charles Esten - Joe Campbell
- Ashley Williams - Store Clerk Amy
- Ben Feldman - Timmy
- Jim Meskimen - Bernie
- Kevin Kilner - Charles Ehrhardt
- Femi Emiola - Hostess
- Wendy Raquel Robinson - Anita Lawrence
- Tim DeKay - Patrick Harris
- Jason Alexander - Dr. Palmer
- Scott Bakula - Jeff Hunter
- Sandra Bernhard - Audrey
- Megan Mullally - Margaret
- Jeffrey Tambor - Neil
- Eric McCormack - Dr. Max Kershaw
- Bob Clendenin - Mr. Tuttle
- Mary Gross - Mrs. Orr
- Kathleen Wilhoite - Mrs. Dee Sellick
- Stefanie Scott - Britney Burke
- Ernie Grunwald - Salesman
- Kristen Johnston - Francie
- Roxanne Beckford - Gym Member
- Jennifer Baxter - Amy
- Helen Slater - Liz
- P.J. Byrne - Doug
- Crista Flanagan - Andrea
- Patrick Breen - Edmund
- Alicia Ziegler - Amber
- Ed Begley Jr. - Pastor Ed
- Patrick Fischler - David
- Andy Richter - Stan
- Jim Hanna - Man
- Jamie Kaler - Hugh
- Ana Ortiz - Belinda
- Jennifer Grey - Tracey
- Gigi Rice - Shelley
- James Lesure - Dave
- Katie Walder - Hannah
- Michaela Watkins - Lucy
- Stephen Tobolowsky - Principal James Merrow
- Stephanie Faracy - Dr. Jacobson
- Clea Lewis - Emily
- Parker Goris - Justin
- Dan Gauthier - Brian
- Amy Farrington - Ali
- Amy Sedaris - Frances 'Frankenstein' Stein
- Tim Bagley - Dr. Mike
- Rachel Quaintance - Beth
- Jane Lynch - Ms. Hammond
- Patrick Kerr - Peter
- Lauren Tuerk - Cathy
- Dave Foley - Tom
- Portia Realer - Regina
- Molly Shannon - Jeannie
- Rachel G. Fox - Gretchen (non créditée)
- Jordan Baker - Mrs. Belt
- Michael Medico - Cute Guy
- Nancy Lenehan - Principal Marcie Nunley
- Nancy Lenehan - Kit
- Scott Klace - Jeff
- Saxon Trainor - Samantha
- Kerry Carney - Swim Instructor
- Anthony Holiday - Pete Baran
- Tria Katz - Kim
- Mary Alexandra Stiefvater - Cerise
- Tommy Savas - Mark
- Shi Ne Nielson - Spa Girl
- James Huang - Waiter
- Scott Lawrence - Nate Lawrence
- Lily Goff - Ashley Ehrhardt
- Marissa N. Blanchard - Kelsey
- Jillian Boyd - Woman
- Keeshan Giles - Young Man
- Maya Goodwin - Young Woman
- Kurt Doss - Jack
- Rebecca Creskoff - Hilary
- Jack Kehler - Scalper
- Edward James Gage - Bouncer
- Craig Welzbacher - Arena Employee
- Lisa Cole - Mom
- Lauren Bowles - Patty
- Kelly Hare - Sherri
- Amy Landers - Pretty Christine
- Rachel Cannon - Denise
- Benjamin Bryan - Benji
- Brendan Patrick Connor - Man
- Fred Maske - Waiter
- JoAnn Willette - Tanya
- Emily Rose Everhard - Julie
- Logan Jay Stern - Madison
- Miranda Frigon - Tori
- Eileen Fogarty - Liz
- Aalok Mehta - Peter
- Alex Splendore - Lutz
- Tate Hanyok - Waitress
- Jesse Heiman - Waiter
- Allen Lulu - Man in Line
- Tara Karsian - Dot
- Matthew Glave - Ben Michael
- Stefan Marks - Bartender
- Josh Phillips - Seth
- Marty Ryan - Pharmacist
- Ben Bode - Dr. Gurwich
- Ali Hillis - Denise
- Miranda Kent - Receptionist
- Indira G. Wilson - Nurse
- Tom Papa - Mike
- Lindsey Fields - Myrna Jones
- Denise Gossett - Cell Phone Mom
- David Goryl - Man
- Marcy McCusker - Bree
- Jennifer Rau - Waitress
- Steven Hack - Mr. Dupont
- Amy Tolsky - Heidi Baker
- Elaine Loh - Receptionist
- Kimberly Daugherty - Amber
- Kelly Mantle - Sparkle
- Silvia Curiel - Paola
- Ryan Sparks - Teenager
- Barry Alan Levine - Lew
- Robert Corvin - Funeral Family Mourner
- Mark Daneri - Doctor
- Paula Newsome - Principal Diane Slater
- Katrina Nelson - Beautiful Girl
- Debra Azar - Sarah
- Alison White - Jamie
- Jeanette O'Connor - Candy
- Wayne Nickel - Larry Babotts
- Chris Gartin - Glenn
- Kulap Vilaysack - Nurse
- Terryn Westbrook - Mother of 2-hour-old Baby
- Ross Mackenzie - Painter
- Corbin Bernsen - Howard
- John Apicella - Judge
- Steven Lee Allen - Process Server
- Marion Ross - Agnes
- Michael Spound - Doug the Landlord
- Erica Shaffer - Mrs. Bethany Burke
- Kelsey Crane - Cute Girl
- Wendy Johnson - Crying Patient
- Shira Scott Astrof - Lynn
- Daniel Roebuck - Josh
- Adrienne Barbeau - Adrienne Barbeau
- Michael Patrick McGill - Man in Parking Garage
- Jessica Belkin - Isabelle
- Rodney J. Hobbs - Unkind Passerby
- Brian Chenoweth - Another Passerby
- Lou DiMaggio - Security Person
- Peggy Blow - Ticket Agent
- Travis Willingham - Massage Guy
- Al Coronel - Border Guard
- Joel McKinnon Miller - Immigration Officer Dutton
- Alexandra Ella - Marcie
- Jeff Witzke - Frank
- Leo Marks - Ken
- Julia Lehman - Heidi
- Josh Randall - Officer Johnson
- Beth Littleford - Tony Kershaw
- Drew Wicks - Party Guest
- Eddie Diaz - Jesse, Home Depot Clerk
- Jack Burditt
- Jackie Filgo
- Jeff Filgo
- Kari Lizer
- Sherry Bilsing
- Jeff Astrof
- Julia Louis-Dreyfus
- Andy Ackerman
- Holli Gailen
- Lisa Helfrich
- Adam Barr
Julia Louis-Dreyfus hace el papel de 'Old' Christine Campbell.
Stephen Tobolowsky interpreta a Principal James Merrow en la serie.
Brenda Blethyn interpreta a Angela Kimble en la serie.
Jeffrey Tambor interpreta a Neil en la serie.
Sandra Bernhard interpreta a Audrey en la serie.
Scott Bakula interpreta a Jeff Hunter en la serie.
Jason Alexander interpreta a Dr. Palmer en la serie.
Jennifer Grey hace el papel de Tracey.
Jack Kehler interpreta a Scalper en la serie.
Clark Gregg hace el papel de Richard Campbell.
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