- Griffen Campbell - Colby
- Juliette Goglia - Meadow
- Nicole Sullivan - Alexis
- Malik S. - Trey
- Maurice LaMarche - HandyRandy79
- Gary Anthony Williams - Ernie
- Danny Brown - Lisa
- Denny Love - Young Man
- Staci Lynn Fletcher - Lil’ Hatchet
- David Parkman - Teddy
- Earthquake - Que
- Joshua Triplett - Jeremiah
- Marilu Henner - Paula
- Alexandra Chando - Chloe
- Amir O'Neil - Jamaal
- Duane R. Shepard Sr. - Abe
- Jeris Poindexter - Tommy
- Mandell Maughan - Lyndsay
- Lauren Plaxco - Pyper
- Erin Young - Greer
- Jim Meskimen - Dr. Bancroft
- Daniela Nyffenegger - Fundraiser Patient
- Brandon Claybon - Promoter
- Marla Gibbs - Miss Simpson
- Josh Brener - Trevor
- Grace Demarco - Violet
- Yemi Cole - Ebony
- Kevin Will - Coach McCluskey
- Burt Grinstead - Climber
- Geoff Stults - Logan #2
- Euanton Dotson - Security
- Jim O'Heir - Maynard
- Dee Jay Jackson - Older Guest
- Jordyn Curet - Kayla Watkins
- Will Green - Paul
- Matt Romano - Danny
- Mark Anthony Williams - Melvin
- Ashleigh Morghan - Vanessa
- Brian Thomas Smith - Ed
- Aynsley Bubbico - Jennifer
- Eliza Shin - Lorraine
- Eric Normington - Bill
- Tian Richards - Daryl
- Nick George - Chef Mitchell
- Angelique Maurnae - Hostess
- Scott Cooper Ryan - Host
- John Gloria - Husband
- Zee James - Nail Artist #1
- Kym Whitley - LaTonya
- Cocoa Brown - Regina
- Edy Ganem - Sofia
- Charlie Hankin - Bartender
- David Terrell - Roy
- Tony Winters - Johnny
- Rhomeyn Johnson - Lou
- Casey Sander - Santa
- Deborah Baker Jr. - Brittany
- Victor Williams - Pastor Don
- Ashleigh Crystal Hairston - Keira
- Tracey Ashley - Wanda
- Erica Vittina Phillips - Renee
- Greg Romero Wilson - Norm
- Tahir Moore - Lenny
- Jonathan Slavin - Jeffery
- Sarah Jane MacKay - Claudia
- Nicola Lambo - Cynthia
- Jared Wernick - Waiter
- Riki Lindhome - Kristen
- Richard Gant - Walter
- Wayne Brady - Isaiah Evans
- Tim Powell - Desk Sergeant
- Asante Jones - Moderator
- Suzy Nakamura - Dr. Chen
- David Goryl - Oscar
- Milan Carter - Wyatt
- Brian Posehn - Clem
- Patricia Belcher - Sister Sabrina
- Mike Schiff - Marco
- Brian Nelson Jr. - Husband
- Bianca Lopez - Wife #1
- Rashawn Nadine Scott - Wife #2
- Bob Clendenin - Stan
- Chloé Wepper - Nurse Chris
- Shawn Parikh - Danny
- Michael Gladis - Dr. Fisher
- Samm Levine - Jerry
- William Lee Scott - Brett
- Matt Kaminsky - Phil
- Marieve Herington - Deborah
- Dion LaMarr Harvey - Eddie
- Jack Guzman - Carlos
- George Lopez - Victor
- Abigail Marlowe - Diane
- Scott Lawrence - Pastor Williams
- Jasmine Hester - Kerry
- Christian Prentice - Human Robot
- Margaret Avery - Aunt Desiray
- Michel Estime - Victor
- Joi Liaye - Keisha
- Richard Whiten - Riley
- Danny Woodburn - Mayor Clyborne
- Jahdai Pickett - Butch
- David Proffitt - Police Officer
- Jaiden McLeod - Kid
- Napiera Groves - Devona
- Kimberley Drummond - Ariel
- Jackie Osorio - Tegan
- Skye Lucas - Emily
- Liam Martinez - Joey
- Jerome Bettis - Jerome Bettis
- Amber Chardae Robinson - Whitney
- Cosima Cabrera - Jay
- Samantha Cutaran - Lynn
- Jeremiah King - Eli
- Kyle Howard - Josh
- Rebeka Montoya - Daisy
- Lily Sanchez - Thatcher
- Joy Rovaris - Jasmine
- Jill Remez - D.A. Benton
- Thomas Ochoa - Xander
- Jeffrey Sun - Judge Pineda
- Bridger Buckley - Pizza Guy
- Chelsea Harris - Necie
- Wayne Lopez - Javier
- Chase Yi - Dante
- Ryan Klarenbach - Lil’ Satan
- Annie Sertich - Jackie
- Alycia Pascual-Peña - Yoli
- Dana Daurey - Aria
- Dawn Drake - Linda
- Jason Rogel - Alejandro
- Joey Medina - Umpire
- Bill Bellamy - Lorenzo
- Terri J. Vaughn - Claire
- Tracy Morgan - Curtis
- Anosh McAdam - Tyler
- Phil Morris - Terrence
- Tommy Davidson - Jordan
- Nefetari Spencer - Janelle
- Nefetari Spencer - Francine
- Eric Allan Kramer - Barry
- Patti LaBelle - Marilyn
- Jordan Belfi - Stan
- Shaun Dixon - Isaiah
- Juliet Rusche - Eden
- Chaz Ingram - Frank
- Shanola Hampton - Nikki
- Brely Evans - Janice
- Joseph DeBona - Stage Manager
- Gina Yashere - Chika
- Warren Burke - Parker
- Shondrella Avery - Demi
- Rizi Timane - Akin
- Kiều Chinh - Tuyen
- Andrew Brian Carter - Thad
- Hayden Lam - Quan
- Kelsey McKean - Not Gemma
- Colin McGurk - Mike
- Ashley Hogan - Maria
- Vadim Brunell - Percy
- Fray Forde - Donovan
- John Ross Bowie - Gregory
- Chris Aquilino - Mr. Ryan
- Courtney Nichole - Ms. Davis
- Katlyn Carlson - Linzie
- Troy Winbush - Kenny
- Issac Ryan Brown - Peter
- Mary Sohn - Virginia
- Kevin Pollak - Lamar Johnson
- D.L. Hughley - Self
- Joseph A. Garcia - Manuel
- Alan Brooks - Doug
- Dominique Washington - FBI Agent
- Jill Marie Jones - Zenay
- Matthew Keith - Stew
- Rashmi Rustagi - Fiona
- Gabriel Iglesias - Luis Cabrera
- Jay Phillips - Julian
- Blanca Araceli - Antonia
- Jerry O'Connell - Jerry O'Connell
- Daniel DiMaggio - Kiefer
- Skye Townsend - Courtney
- Patrick Cox - Big Shovel
- Nicholas Anthony Reid - Hugo
- Sheryl Underwood - Sheryl Underwood
- Akbar Gbaja-Biamila - Akbar Gbajabiamila
- Amanda Kloots - Amanda Kloots
- Natalie Morales - Natalie Morales
- Dia La Ren Nash - Violet
- Casey Ford Alexander - Dr. Pinkler
- Noah Weisberg - Pat
- Julie Claire - Ingrid
- Cara Santana - Emilia
- Peter Breitmayer - Judge Lampin
- Garrett Bales - Derek
- Denzel Johnson - Larry
- Russell Peters - Joe
- Brenden Solomon - Server
- Danny De Lloyd - Don
- Maggie Gwin - Sandi
- Tom Lommel - Thomas
- Zack Colonna - Ronnie
- Meg Cashel - Passenger
- Ronin Lee - Jake
- Brian George - Mr. Friendly
- Miya Kodama - Hope
- John Eddins - Neighbor
- Pegah Rashti - Neighbor
- Ever Carradine - Ashley
- Ricarlo Flanagan - Security Guard
- Rob James - Terrell
- Anjali Bhimani - Suraya
- James Wong - Officer Yang
- David Weisenberg - Clerk
- Bobby McGee - Groundskeeper
- Ariel Eliaz - Tod
- Paul Culos - Scot
- Vincent Ventresca - Throckmorton
- Chivonne Michelle - Sheri
- Ian Stanley - Officer Hitchcock
- Tony Gonzalez - Derrick
- Maya Lynne Robinson - Lorraine
- Toni Braxton - Toni Braxton
- Soma Mitra - Doctor Galazkiewicz
- Kari Lee Cartwright - Doctor Chilligan
- Ken Whittingham
- Jenny Nolan Bailey
- Marian Deaton
- Victor Gonzalez
- Eric Dean Seaton
- Jacob Brown
- Ryan Raddatz
- Jay Phillips
- Raynelle Swilling
- Erica Montolfo-Bura
- Devon Shepard
- Alyssa Litman
- Kendall Johnson
- Teri Schaffer
- Don D. Scott
- Aaron Kaplan
- Cedric the Entertainer
- Carly Hallam Tosh
- Jack Donato
- Ashley Neumeister
- Jesse Peck
- Charlie McDaniel
- Kurt Farquhar
Cedric the Entertainer interpreta a Calvin Butler en la serie.
Riki Lindhome interpreta a Kristen en la serie.
Jerry O'Connell interpreta a Jerry O'Connell en la serie.
Max Greenfield interpreta a Dave Johnson en la serie.
Tichina Arnold hace el papel de Tina Butler.
Beth Behrs interpreta a Gemma Johnson en la serie.
Sheaun McKinney interpreta a Malcolm Butler en la serie.
Marcel Spears interpreta a Marty Butler en la serie.
Hank Greenspan hace el papel de Grover Johnson.
Skye Townsend interpreta a Courtney en la serie.
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