- Amy Hill - Suji
- Chris Elliott - Bradley Crosby
- Jim Rash - Harris Van Doren
- Robert Donner - Mr. Clench
- Colleen McDermott - Prostitute #1
- Sally Kellerman - Felicia Dane
- Anna Nicole Smith - Anna Nicole Smith
- Tom Hanks - Tom Hanks
- Betty White - Betty White
- Dyan Cannon - Mitzi Wilde
- Bob Saget - Bob Saget
- D.W. Moffett - Dylan Michael Michaels
- Steven Eckholdt - Daniel
- Sheryl Crow - Sheryl Crow
- Rob Lowe - Rob Lowe
- Larry Poindexter - Dr. Mike
- George Hamilton - George Hamilton
- Tim DeKay - John Marshall
- Peter Jason - Senator Wilburn
- Tom Arnold - Tom Arnold
- Mo Gaffney - Fern, the Cat Lady
- Billy Campbell - Luke
- Mark Fite - The Repairman
- Ken Hudson Campbell - Roland
- Yasmine Bleeth - Natalie
- Paula Cale - Lizzie Wilde
- Jon Lovitz - Acer Predburn
- John Del Regno - Perkins
- Kelly Lange - Kelly Lange
- Stephen Tobolowsky - Vincent Hartford
- Carol Leifer - Sissy Daniels-Polonsky
- David Huddleston - Ulysses
- Mary Tyler Moore - Catherine Wilde
- David Lee Smith - Mark
- Norman Fell - Norman Fell
- Charo - Charo
- Morgan Fairchild - Morgan Fairchild
- Garry Marshall - Garry Marshall
- Virginia Mayo - Virginia Mayo
- Ian McShane - Leland Banks
- Carolyn Hennesy - Flight Attendant
- John Tesh - John Tesh
- Sarah Silverman - Ali Walters
- Matt Huhn - Jason
- Lyle Waggoner - Lyle Waggoner
- Mark Capri - Dr. Martin Talley
- Conchata Ferrell - Maxine Mansfield
- Matt Champagne - Peter Henley
- Danny Dayton - Irv Goodwin
- Gary Coleman - Gary Coleman
- Trisha Yearwood - Trisha Yearwood
- Tim Curry - Sir Rudolph Haley
- George Segal - Fred Wilde
- George Segal - Douglas Wilde
- Don Sparks - Dr. Chuck
- Rachel York - Christy
- Fred Stoller - Leo
- Jack Coleman - Colin Terell
- Michael York - Leland Banks
- Christopher Darga - Bo Bo
- Barry Diamond - Carmine
- Joy Rinaldi - Nurse
- Lisa Kaminir - Prostitute
- Peter White - Mr. Hillerman
- Summer Knight - Charree Cola
- Larry Drake - Dr. Bryce Fromm
- Brighton Hertford - Lizzy
- Kat Cressida - Leland's Fiancée
- Barry Heins - Barry
- Rip Taylor - Papa Jack Judkins
- Chris Bonno - Ernie
- Sarah Purcell - Sarah Purcell
- Raymond Singer - Johnnie Cochran
- Tawny Kitaen - Tawny Kitaen
- Cameron Watson - Josh Cullen
- Michael Alaimo - Waiter
- Nicholas Cascone - Newt
- Gerry McIntyre - Bessie
- Christine Romeo - Wendy Dawson
- Tricia Vessey - Kyle
- Melora Griffis - Cindy Leaper
- Zoaunne LeRoy - Bikini Waxer
- Christy L. Medrano - Maya
- Robert Curtis Brown - Jed
- Wendy Cutler - Mr. Haley's Assistant
- Wendy Cutler - Joyce Marshack
- Todd Merrill - Ned Perlow
- Steve Kehela - Ed Perlow
- Victoria Jackson - Darla
- Catherine Bell - Dylan's Mistress
- Vince Melocchi - Comet Employee
- Christian J. Meoli - Vanjacker
- Stacey Travis - Sister Katherine O'Farrell
- Larry Hankin - Stan
- David Wells - Priest
- Peter Berg - David
- Maury Sterling - Barfighter
- Dean Fortunato - Ricky Columbus
- Heather James - Nurse
- Jeffrey von Meyer - Doctor
- Carole Androsky - Blind Woman
- Dot-Marie Jones - Officer Debbie Tadzekian
- Dot-Marie Jones - Sheila
- Carmen Thomas - Nurse
- Traci Adell - Sugar
- Devika Parikh - T.J.'s Girl
- Scott LaRose - Skip
- June Gable - Theresa
- Robert Costanzo - Skip's father
- Philippe Bergeron - Mr. Gilbert
- Maggie Baird - French Filmmaker's Wife
- Timothy Elwell - Gene
- Mark Tymchyshyn - Troy
- J. Patrick McCormack - The Maitre'd
- Julianne Christie - Penelope
- John Bradley - Jack
- Michael Kagan - The Pound Attendant
- Robert Cohen - Delivery Man
- Robert Cohen - UPS Guy
- Frankie J. Allison - The Dealer
- Bill Ferrell - The Pit Boss
- Richmond Harrison - Man
- Keythe Farley - Waiter
- Robert Mailhouse - Pete
- Joseph D. Reitman - Billy, the homeless man
- Susan Wood - Carla
- Patrick Thomas O'Brien - Lab Man
- Jimmy Pardo - Detective
- Alex Nevil - The Server
- Tasha Taylor - Hotel Guest
- Krikor Satamian - The Janitor
- Alex Trebek - Alex Trebek
- Krissy Carlson - The Naked Girl
- Bradford English - Trucker
- Kevin Fry-Bowers - Guard
- Kenneth Mars - Judge
- Blaire Baron - The Well Dressed Woman
- Eric Fleeks - Server
- John Mansfield - The Comet's Lawyer
- Steve Kramer - Duchovny's Lawyer
- Christopher Michael Moore - Policeman
- Paul Parducci - Doug
- Kayla Murphy - Lucy
- Brooke Garrett - Meg
- Shannon Kenny - Liesl
- Rachel Reenstra - Laura
- Cindy Katz - Nancy Glickman
- Jo Deodato Clark - Doree Ziskin
- Christopher Neame - Dr. Schmekler
- John Hawkes - Duane Baldwin
- Frank Stallone Jr. - Frank Stallone
- Antony Alda - Antony Alda
- Christopher Carroll - Good Samaritan
- Bill Daily - Doc
- Doris Hess - Passenger
- Debra Mooney - Eleanor
- John Reilly - King
- Bill Erwin - Victor
- Basil Langton - Alf
- Linda Porter - Edwina
- Harper Roisman - Nigel
- Kevin Brief - Bartender
- Steven M. Porter - Frankie Zimmer
- Barry Wiggins - Jim the Anchorman
- Vince Lozano - Orderly
- Brent Hinkley - Lomax
- Barry Del Sherman - The Clerk
- Alison Martin - Bonnie
- Sarah Ann Morris - Denise
- Mark Barrett - The Temp Worker
- Jeri Gaile - Margaret Taylor
- Christopher M. Dukes - Pool Player
- Ana Auther - Renata
- Pauley Perrette - Ilana
- David Jay Willis - Waiter
- Steve Nevil - Dr. Conway
- Peggy Miley - Shirley
- Cheryl Bianchi - Patrice
- Wendy Pitts - Sherry Fisher
- Mark Hoffman - EMT
- Jonathan McMurtry - The Counselor
- Lissa Negrin - Cherre
- Geoffrey Lower - Edward Dane
- Chris Thompson
- Brad Grey
- Bernie Brillstein
Stephen Tobolowsky hace el papel de Vincent Hartford.
Tom Hanks hace el papel de Tom Hanks.
Rob Lowe interpreta a Rob Lowe en la serie.
Conchata Ferrell hace el papel de Maxine Mansfield.
Catherine Bell interpreta a Dylan's Mistress en la serie.
Garry Marshall interpreta a Garry Marshall en la serie.
George Hamilton interpreta a George Hamilton en la serie.
David Huddleston interpreta a Ulysses en la serie.
Téa Leoni interpreta a Nora Wilde en la serie.
Holland Taylor hace el papel de Camilla Dane.
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