- Karen Pittman - Mia Jordan
- Bel Powley - Claire Conway
- Jon Hamm - Paul Marks
- Desean Terry - Daniel Henderson
- Jack Davenport - Jason Craig
- Ruairí O'Connor - Ty Fitzgerald
- Steve Carell - Mitch Kessler
- Kathy Najimy - Sylvia Portman
- Tony von Halle - Phil
- Mark Totty - Jeremy Brian
- David Bowe - Clyde Canter
- Guy Garner - Darwin Martin
- Judy Kain - Adelle Waters
- Jay Jackson - Vernon Worrell
- Krystin Goodwin - Tabitha Roberts
- Alexandra Fatovich - Michelle Conners
- Steve Kuzj - Andrew Falk
- Dwayne Colbert - Fan
- Tyee Tilghman - Cory's Driver
- Craig Cox - New Orleans Head-Licking Guy
- Patrick Fabian - Jeff
- Terryn Westbrook - Fay Ohoa
- Marie-Françoise Theodore - Melissa
- Kristina Hayes - Sally
- Rebecca Klingler - Tammy
- Ryan Alexander Holmes - Ian
- Erika Ringor - Mandy Schaeffer
- Danni Wang - Jun
- Krishna Smitha - Noorean Gill
- Jesse Wang - Chinese Conductor
- Lee Chen - Traveler
- Hayley Keown - Female Assistant
- Dave Grohl - Dave Grohl
- Taylor Hawkins - Taylor Hawkins
- Nate Mendel - Nate Mendel
- Chris Shiflett - Chris Shiflett
- Pat Smear - Pat Smear
- Rami Jaffee - Rami Jaffee
- Violet Grohl - Foo Fighters' Background Vocalist
- Zak Lee - Professore Viola
- Michael Gallagher - Paparazzo #1
- Barbara Gruska - Foo Fighters' Background Vocalist
- Hasan Minhaj - Eric Nomani
- Stephen Friedrich - Jeffrey Gordon
- Brad Lee Wind - Kenny
- Marisa Echeverria - Robin
- Casey Adams - NY Pedestrian
- David Paymer - Mr. Shoenfeld
- Jack Conley - Earl
- Brian Stelter - Carl Richardson
- Ron Gilbert - Tom Ballantine
- J. Anthony McCarthy - Weaver
- Stefan Chase - Corrine Patterson
- Mark Ivanir - Al
- Peter Arpesella - Vincenzo
- Meredith Scott Lynn - Linda
- Matt Adler - Shane Card Services (voice)
- Jim Pirri - Luca Romano (voice)
- Dina Morrone - ER Receptionist
- Katie Aselton - Madeleine
- Dan Gilvezan - Wendell (voice)
- Stephen Apostolina - Clay Becker (voice)
- Dave Foley - Peter Bullard
- Tara Karsian - Gayle Burns
- Patrick Bristow - Gordon
- James Gleason - Uncle Mike
- Taylor Cooper - Meredith
- Patti Tippo - Lauren Kessler
- Elaine Ann Hu - Sasha Press Coordinator
- Alex Alcheh - Harry Hotel Bellman
- Countrified Wedman - Paparazzo #2 / Paparazzo
- Paul Norwood - Randall
- Will Arnett - Doug Klassen
- Sohm Kapila - Desiree Bowers ACSN Anchor
- Holland Taylor - Cybil Richards
- Valeria Golino - Paola Lambruschini
- Damon Dayoub - Glen Corn
- Markus Flanagan - Gerald Drummond
- Sean Alexander James - Security Guard / Jimbo
- Theo Iyer - Kyle
- Aflamu Johnson - Aflamu
- Guilford Adams - Curt Savage
- Catherine Dyer - Teresa Bonner
- Noah Blake - Brian Boso
- Arianna Ortiz - Pamela
- Candice Ramirez - Jasmyn
- John Gloria - Dr. Vincent Botz
- Anneris Mercedes - Blaine E.R. Receptionist
- Stephen L. Wilson - Sick Man
- Joe Daru - Angry Husband
- Midnight White - DJ Dennis
- Hank Northrop - Unruly Protestor
- Andrew Leeds - Alan
- John Marshall Jones - Noah
- Allan Graf - Joe
- Jake Broder - Nate
- J.D. Hinton - Bob Stephens
- Nancy Stone - Jenna Macantire
- Deborah Geffner - Crisis Specialist
- Jacqueline Mazarella - Trisha Marino
- Zuri Hall - E! Reporter
- Elizabeth Greer - Lisa Paushter
- Julie Goldman - TMS Desk Security Guard
- Ellen Gerstein - Woman
- Hank Cheyne - Disgraced Director
- Choni Francis - RJ Smith
- Angelo Vacco - Gary
- Jordan Seigel - Musician
- Hannah Marshall - Veronique
- Pramod Kumar - Cab Driver
- Adina Porter - Sarah Gravele
- Fred Melamed - Mitch's Agent
- Kerry Gutierrez - Marcy
- Kelly Clarkson - Kelly Clarkson
- Harley Graham - Young Bradley
- Zakary Risinger - Young Hal
- Kelly Sullivan - Vicki Manderly
- Clayton Farris - Segment Producer
- Jack Armstrong - Beau
- Shelley Robertson - Janet
- Ahna O'Reilly - Ashley Brown
- Natalia Warner - Cecily
- Brett Butler - Sandy Jackson
- Edie Mirman - E.R. Phone Nurse (voice)
- John Patrick Jordan - Tom
- Nikhil Pai - Research Expert
- Jaco Caraco - Guitarist
- Ephraim López - Shopkeeper
- Jason Halbert - Pianist
- David Morse - Mr. Jackson
- Janina Gavankar - Alison Namazi
- Kate Vernon - Geneva Micklen
- Philip Anthony-Rodriguez - Gabriel
- Ali Astin - Meagan Walters-Clarke
- James Urbaniak - Backstage Manager
- Robert Cicchini - Robert
- Carolyn Zeller - Jane
- Michelle Kim McCoy - Hostess
- Andre Boyer - Host
- Julian Morris - Andrew
- Cory Tucker - Guy at Table
- David Jahn - Desk Clerk
- Cheyenne Jackson - Cheyenne Jackson
- T.J. Alvarado - Barista
- Mark Harelik - Richard
- Christian Jacob - Pianist
- Mike O'Malley - Tim Eavers
- Chris Dougherty - Eric
- Buckley Sampson - Kate
- Al Coronel - Mike
- Alain Uy - Jimmy
- Alice Lin - Jimmy's Grandmother
- Carrie Armstrong - Woman
- Ivan Fuchs - Man in Pilot
- Candice Marie Bennett - Woman in Pilot
- Romy Rosemont - Sheila
- Dendrie Taylor - Yvette
- Shane Munson - Samantha
- Tom Irwin - Fred Micklen
- Paul Witten - Austin
- Roman Mitichyan - Sam Rudo
- Mindy Kaling - Audra
- Andre M. Johnson - Stage Manager
- Kristel Kovner - Madison Kane (uncredited)
- Paul Guilfoyle - Reid
- Martin Short - Dick Lundy
- Judah Mackey - Teddy Kessler
- Embeth Davidtz - Paige Jacobs
- Nanrisa Lee - Local News Reporter
- Richard Whiten - Paul
- Ethan Cohn - Jared
- Jeff Pomerantz - Drew
- Dana Davis - Christine
- Ferly Prado - Dancer
- Rachael Markarian - Dancer
- Meagan Kong - Dancer
- Hannah Douglass - Dancer
- Traci Swartz - Dancer
- Ashley Everett - Dancer
- Cassie Dzienny - Dancer
- Kristin Johnson - Dancer
- Maria Sharapova - Maria Sharapova
- Christopher Rivaro - Security Guard Bill
- Hayes MacArthur - Marlon Tate
- Lisa London - Landlord
- Andrew Bridges - Male Tenant
- Kelli Dawn Hancock - Woman at Bar
- Tommy Buck - Tourist
- Oona Roche - Lizzy Craig
- Ian Gomez - Greg
- Victoria Tate - Rena Robinson
- Augustus Prew - Sean
- Shari Belafonte - Julia
- Joe Marinelli - Donny Spagnoli
- Amber Friendly - Layla Bell
- Andrea Bendewald - Valerie
- Katherine Ko - Dhillon Reece-Smit
- Eli Bildner - Joel Rapkin
- Michelle Meredith - Lindsey Sherman
- Marcia Gay Harden - Maggie Brener
- Christian Zuber - Fred's Assistant
- Joe Tippett - Hal Jackson
- Joe Pacheco - Bart Daley
- Amanda Anka - Party Guest (uncredited)
- Audrey Douglass - Dancer
- Tig Notaro - Amanda Robinson
- Virginia Tran - Assistant Director
- Ashley Platz - Lena
- Moe Bertran - Mel Sidewalk Vendor
- Adam Kang - Photographer
- Andrew Patrick Ralston - Elmer
- Josh Breslow - Dylan
- Damien Luvara - Cop
- Mike Ostroski - Victor
- Clive Standen - Andre Ford
- Maria Canals-Barrera - Mercedes
- Armie Hicks Jr. - Tech Guy
- Stephen Fry - Leonard Cromwell
- June Diane Raphael - Eagle News Anchor
- Alano Miller - Marcus Hunter
- Sachin Bhatt - Geoffrey
- Retta - Retta
- Fortune Feimster - Fortune Feimster
- Anthony DeVito - Coney Island Vendor
- Brent Bailey - Zach
- Sam Boxleitner - Drew
- Emmie Nagata - Erica
- Ilia Volok - Pavlo (voice)
- Brian Byrnes - Reed
- Paull Walia - Sahil
- Natalie Morales - Kate Danton
- Sasha Alexander - Salma
- T.V. Carpio - Emma
- Daniel Kash - Seth
- Stacey Swift - Sam
- Zeke Alton - Concierge Doctor
- Leslie Thurston - Jackie
- Eliza Shin - Roberta
- Samantha Sloyan - Cheryl
- Scott Peat - Ryder Flynt
- Anne Berger - Stage Manager
- Lindsay Duncan - Martha Ellison
- Eyal Podell - Larry Pane
- Ari Beverly Carter - Maya
- Peggy Dunne - Sue Bridges
- Corey Martin Craig - Carter
- Sean Muramatsu - Reporter (Rui Tanaka)
- Shannon Woodward - Jess Bennett
- Jamal Lloyd Johnson - Preston
- Ricky Titus-Lam - Baker 2
- Elizabeth Perkins - Elena
- Marita de Lara - Sarah
- Rafael Cabrera - Vincent
- Aven Lotz - Young Bradley
- Jeremy Denzlinger - Desk Officer
- Paul Chirico - Bradley's Father
- Joanne Baron - Brenda Litchfield
- Jason Wong - Maitre D'
- John Hartmann - Interviewer
- Ingrid Walters - Simone
- Matthew Downs - Officer #2
- Pierpaolo Piccioli - Pierpaolo Piccioli (uncredited)
- Mimi Leder
- Kristin Hahn
- Michael Ellenberg
- Reese Witherspoon
- Jennifer Aniston
- Kristan Berona
- Carter Burwell
Martin Short hace el papel de Dick Lundy.
Elizabeth Perkins interpreta a Elena en la serie.
David Morse hace el papel de Mr. Jackson.
Valeria Golino hace el papel de Paola Lambruschini.
Reese Witherspoon hace el papel de Bradley Jackson.
Marcia Gay Harden interpreta a Maggie Brener en la serie.
Jennifer Aniston interpreta a Alex Levy en la serie.
Steve Carell interpreta a Mitch Kessler en la serie.
Paul Guilfoyle interpreta a Reid en la serie.
Jack Davenport hace el papel de Jason Craig.
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