- Karen Pittman - Mia Jordan
- Bel Powley - Claire Conway
- Jon Hamm - Paul Marks
- Desean Terry - Daniel Henderson
- Jack Davenport - Jason Craig
- Ruairí O'Connor - Ty Fitzgerald
- Steve Carell - Mitch Kessler
- Kathy Najimy - Sylvia Portman
- Tony von Halle - Phil
- Mark Totty - Jeremy Brian
- David Bowe - Clyde Canter
- Guy Garner - Darwin Martin
- Judy Kain - Adelle Waters
- Jay Jackson - Vernon Worrell
- Krystin Goodwin - Tabitha Roberts
- Alexandra Fatovich - Michelle Conners
- Steve Kuzj - Andrew Falk
- Dwayne Colbert - Fan
- Tyee Tilghman - Cory's Driver
- Craig Cox - New Orleans Head-Licking Guy
- Patrick Fabian - Jeff
- Terryn Westbrook - Fay Ohoa
- Marie-Françoise Theodore - Melissa
- Kristina Hayes - Sally
- Rebecca Klingler - Tammy
- Ryan Alexander Holmes - Ian
- Erika Ringor - Mandy Schaeffer
- Danni Wang - Jun
- Krishna Smitha - Noorean Gill
- Jesse Wang - Chinese Conductor
- Lee Chen - Traveler
- Hayley Keown - Female Assistant
- Dave Grohl - Dave Grohl
- Taylor Hawkins - Taylor Hawkins
- Nate Mendel - Nate Mendel
- Chris Shiflett - Chris Shiflett
- Pat Smear - Pat Smear
- Rami Jaffee - Rami Jaffee
- Violet Grohl - Foo Fighters' Background Vocalist
- Zak Lee - Professore Viola
- Michael Gallagher - Paparazzo #1
- Barbara Gruska - Foo Fighters' Background Vocalist
- Hasan Minhaj - Eric Nomani
- Stephen Friedrich - Jeffrey Gordon
- Brad Lee Wind - Kenny
- Marisa Echeverria - Robin
- Casey Adams - NY Pedestrian
- David Paymer - Mr. Shoenfeld
- Jack Conley - Earl
- Brian Stelter - Carl Richardson
- Ron Gilbert - Tom Ballantine
- J. Anthony McCarthy - Weaver
- Stefan Chase - Corrine Patterson
- Mark Ivanir - Al
- Peter Arpesella - Vincenzo
- Meredith Scott Lynn - Linda
- Matt Adler - Shane Card Services (voice)
- Jim Pirri - Luca Romano (voice)
- Dina Morrone - ER Receptionist
- Katie Aselton - Madeleine
- Dan Gilvezan - Wendell (voice)
- Stephen Apostolina - Clay Becker (voice)
- Dave Foley - Peter Bullard
- Tara Karsian - Gayle Burns
- Patrick Bristow - Gordon
- James Gleason - Uncle Mike
- Taylor Cooper - Meredith
- Patti Tippo - Lauren Kessler
- Elaine Ann Hu - Sasha Press Coordinator
- Alex Alcheh - Harry Hotel Bellman
- Countrified Wedman - Paparazzo #2 / Paparazzo
- Paul Norwood - Randall
- Will Arnett - Doug Klassen
- Sohm Kapila - Desiree Bowers ACSN Anchor
- Holland Taylor - Cybil Richards
- Valeria Golino - Paola Lambruschini
- Damon Dayoub - Glen Corn
- Markus Flanagan - Gerald Drummond
- Sean Alexander James - Security Guard / Jimbo
- Theo Iyer - Kyle
- Aflamu Johnson - Aflamu
- Guilford Adams - Curt Savage
- Catherine Dyer - Teresa Bonner
- Noah Blake - Brian Boso
- Arianna Ortiz - Pamela
- Candice Ramirez - Jasmyn
- John Gloria - Dr. Vincent Botz
- Anneris Mercedes - Blaine E.R. Receptionist
- Stephen L. Wilson - Sick Man
- Joe Daru - Angry Husband
- Midnight White - DJ Dennis
- Hank Northrop - Unruly Protestor
- Andrew Leeds - Alan
- John Marshall Jones - Noah
- Allan Graf - Joe
- Jake Broder - Nate
- J.D. Hinton - Bob Stephens
- Nancy Stone - Jenna Macantire
- Deborah Geffner - Crisis Specialist
- Jacqueline Mazarella - Trisha Marino
- Zuri Hall - E! Reporter
- Elizabeth Greer - Lisa Paushter
- Julie Goldman - TMS Desk Security Guard
- Ellen Gerstein - Woman
- Hank Cheyne - Disgraced Director
- Choni Francis - RJ Smith
- Angelo Vacco - Gary
- Jordan Seigel - Musician
- Hannah Marshall - Veronique
- Pramod Kumar - Cab Driver
- Adina Porter - Sarah Gravele
- Fred Melamed - Mitch's Agent
- Kerry Gutierrez - Marcy
- Kelly Clarkson - Kelly Clarkson
- Harley Graham - Young Bradley
- Zakary Risinger - Young Hal
- Kelly Sullivan - Vicki Manderly
- Clayton Farris - Segment Producer
- Jack Armstrong - Beau
- Shelley Robertson - Janet
- Ahna O'Reilly - Ashley Brown
- Natalia Warner - Cecily
- Brett Butler - Sandy Jackson
- Edie Mirman - E.R. Phone Nurse (voice)
- John Patrick Jordan - Tom
- Nikhil Pai - Research Expert
- Jaco Caraco - Guitarist
- Ephraim López - Shopkeeper
- Jason Halbert - Pianist
- David Morse - Mr. Jackson
- Janina Gavankar - Alison Namazi
- Kate Vernon - Geneva Micklen
- Philip Anthony-Rodriguez - Gabriel
- Ali Astin - Meagan Walters-Clarke
- James Urbaniak - Backstage Manager
- Robert Cicchini - Robert
- Carolyn Zeller - Jane
- Michelle Kim McCoy - Hostess
- Andre Boyer - Host
- Julian Morris - Andrew
- Cory Tucker - Guy at Table
- David Jahn - Desk Clerk
- Cheyenne Jackson - Cheyenne Jackson
- T.J. Alvarado - Barista
- Mark Harelik - Richard
- Christian Jacob - Pianist
- Mike O'Malley - Tim Eavers
- Chris Dougherty - Eric
- Buckley Sampson - Kate
- Al Coronel - Mike
- Alain Uy - Jimmy
- Alice Lin - Jimmy's Grandmother
- Carrie Armstrong - Woman
- Ivan Fuchs - Man in Pilot
- Candice Marie Bennett - Woman in Pilot
- Romy Rosemont - Sheila
- Dendrie Taylor - Yvette
- Shane Munson - Samantha
- Tom Irwin - Fred Micklen
- Paul Witten - Austin
- Roman Mitichyan - Sam Rudo
- Mindy Kaling - Audra
- Andre M. Johnson - Stage Manager
- Kristel Kovner - Madison Kane (uncredited)
- Paul Guilfoyle - Reid
- Martin Short - Dick Lundy
- Judah Mackey - Teddy Kessler
- Embeth Davidtz - Paige Jacobs
- Nanrisa Lee - Local News Reporter
- Richard Whiten - Paul
- Ethan Cohn - Jared
- Jeff Pomerantz - Drew
- Dana Davis - Christine
- Ferly Prado - Dancer
- Rachael Markarian - Dancer
- Meagan Kong - Dancer
- Hannah Douglass - Dancer
- Traci Swartz - Dancer
- Ashley Everett - Dancer
- Cassie Dzienny - Dancer
- Kristin Johnson - Dancer
- Maria Sharapova - Maria Sharapova
- Christopher Rivaro - Security Guard Bill
- Hayes MacArthur - Marlon Tate
- Lisa London - Landlord
- Andrew Bridges - Male Tenant
- Kelli Dawn Hancock - Woman at Bar
- Tommy Buck - Tourist
- Oona Roche - Lizzy Craig
- Ian Gomez - Greg
- Victoria Tate - Rena Robinson
- Augustus Prew - Sean
- Shari Belafonte - Julia
- Joe Marinelli - Donny Spagnoli
- Amber Friendly - Layla Bell
- Andrea Bendewald - Valerie
- Katherine Ko - Dhillon Reece-Smit
- Eli Bildner - Joel Rapkin
- Michelle Meredith - Lindsey Sherman
- Marcia Gay Harden - Maggie Brener
- Christian Zuber - Fred's Assistant
- Joe Tippett - Hal Jackson
- Joe Pacheco - Bart Daley
- Amanda Anka - Party Guest (uncredited)
- Audrey Douglass - Dancer
- Tig Notaro - Amanda Robinson
- Virginia Tran - Assistant Director
- Ashley Platz - Lena
- Moe Bertran - Mel Sidewalk Vendor
- Adam Kang - Photographer
- Andrew Patrick Ralston - Elmer
- Josh Breslow - Dylan
- Damien Luvara - Cop
- Mike Ostroski - Victor
- Clive Standen - Andre Ford
- Maria Canals-Barrera - Mercedes
- Armie Hicks Jr. - Tech Guy
- Stephen Fry - Leonard Cromwell
- June Diane Raphael - Eagle News Anchor
- Alano Miller - Marcus Hunter
- Sachin Bhatt - Geoffrey
- Retta - Retta
- Fortune Feimster - Fortune Feimster
- Anthony DeVito - Coney Island Vendor
- Brent Bailey - Zach
- Sam Boxleitner - Drew
- Emmie Nagata - Erica
- Ilia Volok - Pavlo (voice)
- Brian Byrnes - Reed
- Paull Walia - Sahil
- Natalie Morales - Kate Danton
- Sasha Alexander - Salma
- T.V. Carpio - Emma
- Daniel Kash - Seth
- Stacey Swift - Sam
- Zeke Alton - Concierge Doctor
- Leslie Thurston - Jackie
- Eliza Shin - Roberta
- Samantha Sloyan - Cheryl
- Scott Peat - Ryder Flynt
- Anne Berger - Stage Manager
- Lindsay Duncan - Martha Ellison
- Eyal Podell - Larry Pane
- Ari Beverly Carter - Maya
- Peggy Dunne - Sue Bridges
- Corey Martin Craig - Carter
- Sean Muramatsu - Reporter (Rui Tanaka)
- Shannon Woodward - Jess Bennett
- Jamal Lloyd Johnson - Preston
- Ricky Titus-Lam - Baker 2
- Elizabeth Perkins - Elena
- Marita de Lara - Sarah
- Rafael Cabrera - Vincent
- Aven Lotz - Young Bradley
- Jeremy Denzlinger - Desk Officer
- Paul Chirico - Bradley's Father
- Joanne Baron - Brenda Litchfield
- Jason Wong - Maitre D'
- John Hartmann - Interviewer
- Ingrid Walters - Simone
- Matthew Downs - Officer #2
- Pierpaolo Piccioli - Pierpaolo Piccioli (uncredited)
- Mimi Leder
- Kristin Hahn
- Michael Ellenberg
- Reese Witherspoon
- Jennifer Aniston
- Kristan Berona
- Carter Burwell
Martin Short interpreta a Dick Lundy en la serie.
Elizabeth Perkins interpreta a Elena en la serie.
David Morse hace el papel de Mr. Jackson.
Valeria Golino interpreta a Paola Lambruschini en la serie.
Reese Witherspoon hace el papel de Bradley Jackson.
Marcia Gay Harden interpreta a Maggie Brener en la serie.
Jennifer Aniston interpreta a Alex Levy en la serie.
Steve Carell interpreta a Mitch Kessler en la serie.
Paul Guilfoyle interpreta a Reid en la serie.
Jack Davenport interpreta a Jason Craig en la serie.
Capítulo disponible en las siguientes plataformas:
