- Tina Fey - Self - Panelist
- Eva Longoria - Self - Panelist
- Madonna - Self - Panelist
- Larry David - Self - Panelist
- Maria Menounos - Self - Fact checker
- Martha Stewart - Self - Panelist
- Jason Alexander - Self - Panelist
- Alec Baldwin - Self - Panelist
- Kirstie Alley - Self - Panelist
- Sheryl Crow - Self - Panelist
- Jimmy Fallon - Self - Panelist
- Nathan Lane - Self - Panelist
- Adam Carolla - Self - Panelist
- Gloria Estefan - Self - Panelist
- Donald Trump - Self - Panelist
- Sarah Silverman - Self - Panelist
- Matthew Broderick - Self - Panelist
- Martin Short - Self - Panelist
- Gwyneth Paltrow - Self - Panelist
- Greg Giraldo - Self - Panelist
- Howie Mandel - Self - Panelist
- Bette Midler - Self - Panelist
- Craig Robinson - Self - Panelist
- Demi Moore - Self - Panelist
- Kelly Ripa - Self - Panelist
- Ricky Gervais - Self - Panelist
- Julianne Moore - Self - Panelist
- Jerry Seinfeld - Self - Panelist
- Tracy Morgan - Self - Panelist
- Susie Essman - Self - Panelist
- Regis Philbin - Self - Panelist
- Kathy Griffin - Self - Panelist
- Ellen Pompeo - Self - Panelist
- Brian Regan - Self - Panelist
- Seth Meyers - Self - Panelist
- Denise Richards - Self - Panelist
- George Wallace - Self - Panelist
- Lauren Graham - Self - Panelist
- Colin Quinn - Self - Panelist
- Mary J. Blige - Self - Panelist
- Rachael Ray - Self - Panelist
- Larry Miller - Self - Panelist
- J.B. Smoove - Self - Panelist
- Cedric the Entertainer - Self - Panelist
- Rachel Dratch - Self - Panelist
- Joel McHale - Self - Panelist
- Judah Friedlander - Self - Panelist
- Will.i.am - Self - Panelist
- Nick Cannon - Self - Panelist
- Caroline Rhea - Self - Panelist
- Jim Breuer - Self - Panelist
- Bill Maher - Self - Panelist
- Patti LaBelle - Self - Panelist
- Ali Wentworth - Self - Panelist
- Beth McCarthy-Miller
- Chuck Martin
- Jeff Cesario
- Tom Papa
- Cyndi Owgang
- Jennifer O'Connell
- George Shapiro
- Jason Brugnatelli
- Nick Emmerson
- Al Berman
- Tony Bandelato
- Michael Bové
- David Vanacore
Kirstie Alley interpreta a Self - Panelist en la serie.
Martin Short hace el papel de Self - Panelist.
Madonna hace el papel de Self - Panelist.
Kathy Griffin interpreta a Self - Panelist en la serie.
Demi Moore hace el papel de Self - Panelist.
Tom Papa interpreta a Self - Host en la serie.
Matthew Broderick interpreta a Self - Panelist en la serie.
Jason Alexander interpreta a Self - Panelist en la serie.
Larry Miller interpreta a Self - Panelist en la serie.
Julianne Moore hace el papel de Self - Panelist.
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