- Tori Spelling - Self
- Ray Romano - Self - Guest
- Kirsten Dunst - Self - Guest
- Ben Affleck - Self
- Jim Belushi - Self - Guest
- Steven Weber - Self - Guest
- Dennis Franz - Self
- Topher Grace - Self
- Dave Grohl - Self
- Dane Cook - Self
- Jon Favreau - Self
- Amy Brenneman - Self - Guest
- Jimmy Kimmel - Self
- John Cleese - Self
- Kevin Nealon - Self
- Elizabeth Perkins - Self - Guest
- Malcolm McDowell - Self - Guest
- Piper Perabo - Self
- Chris Isaak - Self
- Samantha Mathis - Self - Guest
- David Cassidy - Self
- Famke Janssen - Self
- Bridget Fonda - Self - Guest
- Patricia Heaton - Self - Guest
- Thora Birch - Self - Guest
- Kevin Pollak - Self - Guest
- Illeana Douglas - Self - Guest
- Ben Stein - Self
- Kelli Williams - Self - Guest
- Leah Remini - Self - Guest
- Martin Mull - Self
- Farrah Fawcett - Self - Guest
- Jeri Ryan - Self
- Kari Wuhrer - Self
- Paula Abdul - Self
- Mary McCormack - Self - Guest
- Natasha Henstridge - Self
- Buddy Hackett - Self
- Carmen Electra - Self - Guest
- Andy Dick - Self
- Bill Pullman - Self
- Alice Cooper - Self
- Pauly Shore - Self
- Vince Vaughn - Self - Guest
- Will Ferrell - Self - Guest
- Jason Ritter - Self
- Zach Braff - Self
- Melissa George - Self - Guest
- Christina Ricci - Self - Guest
- Estella Warren - Self
- Janeane Garofalo - Self
- Melanie Chisholm - Self
- George Clooney - Self - Guest
- Meat Loaf - Self
- Clint Black - Self
- Peter Fonda - Self - Guest
- Laetitia Casta - Self - Guest
- Elisa Donovan - Self
- Maria Sharapova - Self
- Michael Boatman - Self
- Ice Cube - Self - Guest
- Sylvester Stallone - Self - Guest
- Andrew Dice Clay - Self
- Sting - Self - Guest
- Paul Shaffer - Self
- Kevin James - Self - Guest
- Ron Howard - Self - Guest
- Page Falkinburg Jr. - Self
- Alessandro Nivola - Self - Guest
- Al Franken - Self
- Kim Delaney - Self
- Lou Diamond Phillips - Self
- Lauren Ambrose - Self - Guest
- Beth Orton - Self
- Jennifer Esposito - Self - Guest
- Shaggy - Self
- Coolio - Self
- Dennis Rodman - Self - Guest
- Jacqueline Bisset - Self
- Kristin Davis - Self - Guest
- Cybill Shepherd - Self - Guest
- Kathy Kinney - Self
- Eric McCormack - Self - Guest
- Mimi Rogers - Self - Guest
- Padma Lakshmi - Self
- William Shatner - Self - Guest
- Tim Robbins - Self - Guest
- J.C. Brandy - Self
- Jerri Manthey - Self
- Garry Marshall - Self - Guest
- Stacy Keach - Self - Guest
- Jonathan Silverman - Self
- Tim Roth - Self - Guest
- Tricky - Self
- Dave Winfield - Self
- Richard T. Jones - Self
- Elizabeth Berkley - Self - Guest
- Gena Lee Nolin - Self
- Robin Tunney - Self - Guest
- Freddie Prinze Jr. - Self
- Terry Bradshaw - Self - Guest
- Virginia Madsen - Self - Guest
- Diana Krall - Self
- Wendie Malick - Self - Guest
- Ted Danson - Self - Guest
- Alyson Hannigan - Self - Guest
- Scott Bakula - Self - Guest
- Delbert McClinton - Self
- Suzanne Vega - Self
- Mira Sorvino - Self - Guest
- Jason Alexander - Self - Guest
- Boz Scaggs - Self
- James Marsden - Self - Guest
- Bianca Lawson - Self
- Jacinda Barrett - Self - Guest
- Eric Szmanda - Self
- Sarah Chalke - Self
- Jonathan Lipnicki - Self
- Serena Altschul - Self
- Lea Thompson - Self - Guest
- Tom Green - Self
- Alison Eastwood - Self - Guest
- Andy Roddick - Self
- Jewel - Self
- Asia Argento - Self
- Tim Blake Nelson - Self - Guest
- Paulina Rubio - Self - Guest
- Ryan Belleville - Stand-up
- Cyndi Lauper - Self - Guest
- Jaime Bergman - Self
- Reggie Miller - Self
- Juliette Lewis - Self - Guest
- John Corbett - Self - Guest
- Luke Perry - Self - Guest
- Jessica Simpson - Self
- Tony Rock - Self
- Poppy Montgomery - Self - Guest
- Reba McEntire - Self - Guest
- Melissa Peterman - Self
- Pat Benatar - Self
- Hayden Christensen - Self
- Christine Baranski - Self
- Vanessa Marcil - Self
- James 'Jimmy Jam' Harris III - Self
- Cole Hauser - Self
- Jon Voight - Self - Guest
- Bic Runga - Self
- Leslie Nielsen - Self
- Kate Mulgrew - Self - Guest
- Jennifer Garner - Self - Guest
- Tyrese Gibson - Self
- Yancy Butler - Self
- Adam Carolla - Self
- Craig Ferguson - Self - Guest
- Vin Diesel - Self - Guest
- Jeffrey Tambor - Self
- Clint Eastwood - Self - Guest
- Mark Burnett - Self
- Roma Downey - Self - Guest
- Majandra Delfino - Self
- Jerry O'Connell - Self
- Kelly Hu - Self
- Tara Reid - Self
- Joely Fisher - Self
- Pam Grier - Self - Guest
- Mena Suvari - Self
- Peter Boyle - Self
- Alex Meneses - Self
- Wilmer Valderrama - Self
- Kevin Bacon - Self - Guest
- Erik Palladino - Self - Guest
- Drew Pinsky - Self
- Paul Sorvino - Self - Guest
- Gina Philips - Self - Guest
- Ron Livingston - Self
- Tom Everett Scott - Self - Guest
- Dennis Prager - Self
- James Cromwell - Self - Guest
- Natasha Gregson Wagner - Self
- Robert Urich - Self
- Heather Dubrow - Self
- Seth Rogen - Self - Guest
- Ming-Na Wen - Self - Guest
- Christian Bale - Self - Guest
- Drew Carey - Self - Guest
- Keb' Mo' - Self
- Gavin Rossdale - Self
- Bill Bellamy - Self
- Brooke Burns - Self
- Geraldo Rivera - Self
- Bebe Neuwirth - Self - Guest
- David Hyde Pierce - Self - Guest
- Ryan Seacrest - Self
- Carla Gugino - Self
- Megyn Price - Self
- Robert Evans - Self - Guest
- Rosario Dawson - Self - Guest
- Paul Rudd - Self - Guest
- Vincent Pastore - Self
- Rachel Roberts - Self
- Katey Sagal - Self
- Anna Nicole Smith - Self
- Susan Sarandon - Self - Guest
- Anastacia - Self - Guest
- Craig David - Self
- Alexis Bledel - Self
- Maz Jobrani - Self
- Jami Gertz - Self
- Dennis Farina - Self
- Diane Kruger - Self - Guest
- Michael Rosenbaum - Self
- Charisma Carpenter - Self
- Michael Ian Black - Self - Guest
- Slash - Self
- Adam Goldberg - Self
- Hector Elizondo - Self
- David Boreanaz - Self
- The Angel - Self
- Dana Delany - Self - Guest
- Christine Lahti - Self - Guest
- Jeremy Piven - Self - Guest
- Murphy Lee - Self (uncredited)
- Tim Matheson - Self
- Scott Cohen - Self
- Connie Nielsen - Self - Guest
- Damon Wayans - Self
- George Lopez - Self
- John Larroquette - Self
- Bob Saget - Self - Guest
- Kaley Cuoco - Self - Guest
- Carl Reiner - Self - Guest
- Lauren Graham - Self - Guest
- Adam West - Self
- Soleil Moon Frye - Self
- Melissa Joan Hart - Self - Guest
- Scarlett Johansson - Self - Guest
- Ashley Judd - Self - Guest
- Kim Smith - Self
- Kevin Garnett - Self
- Lesley Stahl - Self
- Julius Sharpe
Cybill Shepherd hace el papel de Self - Guest.
Peter Boyle hace el papel de Self.
Elizabeth Perkins interpreta a Self - Guest en la serie.
Lea Thompson interpreta a Self - Guest en la serie.
Christian Bale interpreta a Self - Guest en la serie.
Stacy Keach interpreta a Self - Guest en la serie.
Tim Roth hace el papel de Self - Guest.
Vince Vaughn interpreta a Self - Guest en la serie.
Alessandro Nivola hace el papel de Self - Guest.
Jeffrey Tambor interpreta a Self en la serie.
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