- John F. O'Donohue - Max Dumas
- Jazzmun - Pat
- Timothy Stack - Irv Feinberg
- Dirk Blocker - Tom Tuttle
- Wendy Schaal - Brenda
- Beah Richards - Emma
- Rue McClanahan - Rue McClanahan
- Ted Shackelford - Jim Matthews
- James Greene - Mike O'Donnel
- Marion Ross - Ruth Eggers
- Kevin Michael Richardson - Curtis
- Mayim Bialik - Rachel Hemingway
- Ralph Manza - Rudy
- Lenny Wolpe - Dr. Lewis
- Furley Lumpkin - Customer
- David Crosby - Chester
- Matthew Perry - Steven
- Len Lesser - Preacher
- William Utay - Christpher
- Art LaFleur - Al
- Christine Dunford - Con Woman
- Doris Roberts - Mrs. Shenker
- Deezer D - The Robber
- John Bellucci - Mike
- Martin Garner - Leonard Shenker
- Glenn Shadix - Walker
- Peter Murnik - Bob
- Darwyn Carson - Woman
- Anthony Russell - Louis
- Micah Dyer - Sailor
- Kathleen York - Lisa
- Jack Kenny - Todd
- June Lockhart - John's Mother
- Slappy White - Slappy
- Cu Ba Nguyen - Kevin
- Cu Ba Nguyen - Passenger
- Patricia Childress - Lori
- Louis Mustillo - Thief
- Abdul Salaam El Razzac - Clyde
- Kathleen Campbell - Woman
- Clifton Davis - Jada Sweet
- Chris Stacy - Dennis
- Andy Garrison - Businessman
- Bumper Robinson - The Iceman
- Art Metrano - Jim
- Bill Erwin - Man
- Ernie Lee Banks - Man
- Jason Stuart - Chris
- Eric Christmas - Felix
- Eric Christmas - Man in Phone Booth
- Lee Ryan - Bill
- Victor Wilson - Steven
- Michael McDonald - Phil
- Tudi Roche - Karen
- Tyler Gurciullo - Timmy
- Peter Crombie - Ted Slattery
- Don McManus - Steve Hitler
- David Byron - Firpo
- Zak Knutson - Hanz
- Jonathan Schmock - Customer in Men's Room
- Jonathan Schmock - Man
- Jonathan Schmock - Sailor
- Donna Mills - Carol
- Ryan Stiles - CIA Agent Kinkaid
- Ryan Stiles - Mac
- Ryan Stiles - Dave
- Omri Katz - Tony Hemingway
- Joe Namath - Joe Montana
- Dinah Manoff - Kelly
- Adele Malis-Morey - Carol
- Matt Borlenghi - Bobby
- Dion DiMucci - Dion
- Robert Miranda - Morrie
- Chris Spencer - Marine
- Sarah Martineck - Mary Sue
- Michelle Simms - Yvonne
- Nita Talbot - Woman
- Bobcat Goldthwait - Bob Barker
- Dean Hill - Man
- Steve Sheridan - Man
- Richard Venture - Simmons
- Patti D'Arbanville - Big Linda
- Bertila Damas - Consuela
- Mark Blankfield - Carl Pfaff
- Richard Schiff - Wilson
- Gracie Harrison - Polly
- Fred Asparagus - Tarok
- Edward Hibbert - Winston
- Miguel Pérez - Stewie Sr.
- Molly Shannon - Vivian
- Ellen Albertini Dow - Old Woman
- Lane Davies - Artie Fogle
- Thomas Kopache - Sal DalBazzo
- Humberto Ortiz - Dante
- O-Lan Jones - Helen
- Ed Marques - Lunatic
- Marsha Warfield - Tawny
- Jack Kehler - Dave
- Joe Pesci - Joe Pesci
- Eugene Roche - Mr. Hampton
- F.X. Vitolo - Harvey
- Lea DeLaria - Lorelei
- Mike Starr - David Coltrane
- Nicholas Hormann - Mr. Collier
- Cheryl 'Salt' James - Ronnette
- Sean Whitesell - Man
- Graham Jarvis - Dr. Kaufman
- John Vargas - Albert Garcia
- T'Keyah Crystal Keymáh - Sara Jones
- Jane Lynch - Mary Travers
- Nathan Morris - Self - Boyz II Men
- Shawn Stockman - Self - Boyz II Men
- Michael McCary - Self - Boyz II Men
- Wanya Morris - Self - Boyz II Men
- John Diehl - Chris
- Don Hepner - Man
- Tim Daly - Thor Merrick
- Harper Roisman - Mr. Fishburn
- Kimberly Russell - Johnnie Hemingway
- Dick Martin - Bill Eggers
- Roscoe Lee Browne - Mr. Davis
- Michael Colyar - Lou Friedman
- Larry Coven - Customer
- Charles Emmett - Black Cop
- Kinky Friedman - Kinky Friedman
- Janine Jordae - Lady
- Mila Kunis - Lucy Sanchez
- David Cassidy - Jefferson Kelly
- Michael Worth - Uri
- John Apicella - Husband
- Joey Lawrence - Sonny Watkins
- Courtney Chase - Marjorie
- Bob Clendenin - Lefty Martin
- Kathy Brett - Waitress
- Cheryl Tiegs - Lola Valenti
- Rick Hurst - Richard
- Rip Torn - Bernard Galvin
- David "Puck" Rainey - Richie
- Karyn Parsons - Annie
- Henry Gibson - Priest
- Kimberly Campbell - Tiffany Younger
- David Pressman - Michael Walker
- Charles C. Stevenson Jr. - Dave Wilson
- Bette Rae - Woman
- Vickilyn Reynolds - Woman
- Stan Ivar - David McKenna
- Roger Eschbacher - Tommy
- Phil Hartman - Otto Friedling
- Dennis Miller - Dennis Miller
- Ben Meyerson - Charles
- Victor Raider-Wexler - Man
- Victor Raider-Wexler - Samson
- Cynthena Sanders - Young Woman
- John Caponera - John Johnson
- Jeff Austin - Maitre D'
- Ron Litman - Shady Character
- Ted McGinley - Karl Reese
- Yvette Freeman - Mrs. Wilson
- Richard Assad - Mr. Soulaymanulo
- Patrick Rowe - Watch Vendor
- Richard Mulligan - Richard Hemingway
- Brant von Hoffman - Sky Diving Instructor
- Dann Florek - Winters Lennox
- Lisa Mende - Stenographer
- Ellis Williams - Security Guard
- Sid Melton - Sweetcakes
- Fort Atkinson - Army General
- Mark Roberts - Gary
- Warren Frost - Professor Nolfi
- Brenda Strong - Christine Taylor
- J.P. Manoux - Student
- Christina Solis - Woman
- Alex Meneses - Venus
- April Ortiz - Maria
- Paul Parducci - Big Moe Lyman
- Don Reed - Announcer
- Nikki Tyler-Flynn - Woman
- Nikki Tyler-Flynn - Teller
- Charles Robinson - Norm Jones
- Time Winters - Patient
- Will Jeffries - Congressman
- Victor Contreras - Best Man
- Mark Morante - Head Usher
- Helen Keaney - Tracy
- Jerry Lambert - Pierre
- Jerry Lambert - Kevin
- Jerry Lambert - Policeman
- Jerry Lambert - Marco
- Ann Magnuson - Amanda Cox
- Jo De Winter - Louise Merrick
- Frank Novak - Fireman
- Harry Anderson - Dr. Gates
- George Hamilton - George Hamilton
- Kathleen Garrett - Linda Armstrong
- Nancy Linehan Charles - Carol
- Joe Lando - Todd
- Holly Fulger - Penelope
- Jacqueline Obradors - Myra Fuentes
- Max Wright - Jackson Bishop
- Fabiana Udenio - Paulina Bishop
- Betty White - Betty White
- Estelle Getty - Estelle Getty
- David Landsberg - Man
- Larry Poindexter - Dr. Tim
- Juliana Donald - Isabella
- Carlos Lacámara - Armando
- Robert Covarrubias - Tomas
- Jhoanna Flores - 5th Grader
- Ria Pavia - Amy
- Donnie Jeffcoat - Kyle
- Bill Macy - Charlie
- Nestor Carbonell - Felicio
- Michael B. Silver - Scott
- Robertson Dean - Editor
- Paul Collins - Moderator
- Rob LaBelle - Dr. Kinney
- Michael Quill - Reporter
- Jill Talley - Woman
- Michael Halpin - Gary
- Jerry Hauck - Minister
- Bruce Thomas - David
- Gary Beach - Dan Caffee
- Mary Jo Keenen - Sweetie Jo Caffee
- William Hubbard Knight - Doctor
- Mary Kay Adams - Bunny Abelson
- Mario Montez - Elsa
- Mirron E. Willis - Umba!Wa
- Patrick Thomas O'Brien - Mr. Hunter
- Essence Atkins - Jocelyn
- Ray Charles - Ray Charles
- Gretchen German - Dr. Lisa Snee
- Rick Batalla - Pa'ab
- Andrew J. Ferchland - Jason Hoodak
- Marcelo Tubert - Pa'ab's Uncle
- Jimmie Walker - Slyde Wilson
- Paul Willson - Harrison Leeworth
- Fred Sanders - Lance The EPA Guy
- Richard Vidan - Susan
- Pat Crawford Brown - Chris' Mom
- Philip Baker Hall - Mr. Frank
- Ryan Reynolds - Tony Hemingway
- Erick Avari - Targ
- Malinda Williams - Shanelle
- Murphy Dunne - Mr. Salinger
- Francis X. McCarthy - Fred
- Don Reo
- Paul Junger Witt
- Tony Thomas
Kimberly Campbell interpreta a Tiffany Younger en la serie.
John Diehl interpreta a Chris en la serie.
O-Lan Jones interpreta a Helen en la serie.
Philip Baker Hall interpreta a Mr. Frank en la serie.
Joe Pesci hace el papel de Joe Pesci.
George Hamilton interpreta a George Hamilton en la serie.
Jack Kehler hace el papel de Dave.
John Larroquette interpreta a John Hemingway en la serie.
Liz Torres hace el papel de Mahalia Sanchez.
Daryl Mitchell hace el papel de Dexter Wilson.
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