- Harold Gould - Miles Webber
- Bea Arthur - Dorothy Hollingsworth
- Bobcat Goldthwait - Gordon M. Cosay
- George Burns - George Burns
- Ned Beatty - Tad Hollingsworth
- Barry Bostwick - Nick DeCarlo
- Ken Kercheval - Charlie
- Bruce A. Young - George Wilson
- Amzie Strickland - Sylvia
- Eric Christmas - Gerald Davenport
- Brooke Theiss - Charlene
- Monte Landis - Mr. Ricchutti
- Robert Rockwell - Mr. Cochran
- Joe Alaskey - Mr. Smith #3
- Margaret Cho - Fong
- Hansford Rowe - Mr. Seigel
- Ricardo Montalban - Lawrence Gentry
- Dick Van Patten - Taylor
- Gregory Sierra - Rubin
- Nanette Fabray - Fern
- Earl Boen - Priest
- Gibby Brand - Mr. McGowan
- Anne Haney - Vivian
- Carol Leifer - Meredith
- Henry Polic II - Dining Room Guest
- Steve Hytner - Mr. Burrows
- Tim Conway - Milton
- Bill Engvall - Matthew Devereaux
- Joyce Meadows - Mrs. Pinkerman
- Stephen Root - Mr. Tucker
- Pamela Dunlap - Dr. Ursula
- Harvey Korman - Bill
- Eddie Albert - Bill Douglas
- Joely Fisher - Paula Webb
- Jack Black - Cab Driver
- Charles Napier - Mr. Smith #1
- Miguel Sandoval - Ramone
- Herb Edelman - Stan Zbornak
- Furley Lumpkin - Security Guard
- Mark Kubr - Brick
- Bertila Damas - Beverly
- Abraham Alvarez - Herb Jenkins
- Jennifer Barlow Grodsky - Bambi
- Catherine MacNeal - Kimberle
- Tom La Grua - The Thief
- Lee Ryan - Man #1
- Mary Pat Gleason - Lost and Found Woman
- Robert Beecher - Older Man
- Marty Brinton - Dining Room Guest
- Michael Francis Clarke - Officer #1
- Kelly Cinnante - Officer #2
- Annie O'Donnell - Charlene
- Christopher Collins - Angel
- Kim Fields - Trisha
- Monica Allison - Joanne
- Phil Proctor - Vincent Vale
- Ja'net DuBois - Louise Wilson
- Edward Penn - Man #1
- Camille Ameen - Mrs. Smith #1
- Arthur Eckdahl - Mr. Smith #2
- Susan Norfleet - Wanda
- Isaac Ocampo - Young Chuy
- Nick Toth - Dr. Norman Charles
- Hartley Silver - Man #1
- Charles Bouvier - Mr. Fisk
- Alexander Folk - The Cop
- David Jay Willis - Mr. Wormer
- Stephen James Carver - Brad the Pool Guy
- Josef Cannon - Josef
- Bill Morey - Mr. Mitchelson
- Jeanne Mori - Marion Kim
- Daryl Keith Roach - Man #1
- Bob Barker - Bob Barker (voice) (uncredited)
- Rod Roddy - Rod Roddy (voice) (uncredited)
- Georgie Cranford - The Kid
- Patrick Culliton - Taxi Driver
- Adam Biesk - Benson
- Robert Cavanaugh - Rick
- Micah Dyer - Kid #1
- Richard Gautier - Bobby Lee
- Cynthia Frost - First Woman
- Debra Engle - Rebecca Devereaux
- Jim Vallely
- Mitchell Hurwitz
- Marc Cherry
- Susan Harris
- Paul Junger Witt
- Tony Thomas
- George Aliceson Tipton
- Andrew Gold
Ricardo Montalban interpreta a Lawrence Gentry en la serie.
Bruce A. Young hace el papel de George Wilson.
Joely Fisher interpreta a Paula Webb en la serie.
Earl Boen hace el papel de Priest.
Betty White hace el papel de Rose Nylund.
Rue McClanahan interpreta a Blanche Devereaux en la serie.
Estelle Getty hace el papel de Sophia Petrillo.
Don Cheadle interpreta a Roland Wilson en la serie.
Cheech Marin interpreta a Chuy Castillos en la serie.
Billy L. Sullivan hace el papel de Oliver Webb.
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