- Coby Bell - Jace Turner
- Grace Byers - Reeva Payge
- Toks Olagundoye - Carla Jackson
- Dale Godboldo - Ted Baird
- Fin Argus - Jack
- Pierce Foster Bailey - Trevor
- Billy Blair - Trucker Driver
- Folake Olowofoyeku - Scar
- Chris Butler - Dr. Watkins
- Dalton E. Gray - Jake
- Christian Adam - Obnoxious Guy #1
- Roscoe Johnson - Guard
- Aerli Austen - Amber
- Dave Blamy - Father
- Scott Parks - Passenger Cop
- Jacinte Blankenship - Mutant Mom
- David Alessi - Cop
- Matthew Tompkins - Cal Jameson
- Ava Culpepper - Daughter
- Dayna Beilenson - Pedestrian #1
- Michelle Kim McCoy - Chloe Tan
- Jordan Eli Arellano - Young Boy
- Paul Cooper - Andreas von Strucker
- Ryan Czerwonko - Angry Looking Man
- Courtney Dietz - Angry Mutant Girl
- Tony DeMil - Guard #2
- Caitlin Mehner - Andrea von Strucker
- Michelle Veintimilla - Carmen Guerra
- Katelyn Farrugia - Nurse
- Matt Doman - SS McAuley
- Eric Hunter - Mutant Amputee
- Christine Dunford - DOJ Official
- Steve Alderfer - SS Agent
- Barbara Hawkins-Scott - Desk Nurse
- Jaxon Rose Moore - Grace
- Justin Matthew Smith - Thomas
- Tom Glynn - SS Guard #2
- Bobby Hernandez - Cartel Soldier #1
- Jim Dougherty - Pastor
- Josh Henry - Ben
- Jason-Jamal Ligon - Side-Eye
- Josué Gutierrez - Francisco
- Brooke Jaye Taylor - SS Tactical Commander
- Aden Stay - Man in Truck
- Liza Fagin - Norah
- Cynthea Mercado - Latina Prisoner
- Erin Way - Shelia
- Elena Satine - Sonya Simonson / Dreamer
- Kristopher Charles - SS Tech
- Kristopher Charles - SS Tech #1
- Van Marten - Elixir
- Bob Jennings - Lodo
- Gino Vento - Juan
- Stephan Jones - Driver
- Darren Goldstein - Chuck
- Anthony Nguyen - Joshua
- Marco Schittone - Young Boy
- Aaron Quick Nelson - SS Winkler
- Cooper Roth - Scott
- DJames Jones - Harry / Trader
- Tess Malis Kincaid - Campaign Manager
- Elizabeth Davidovich - Tough Woman #1
- Scarlett Blum - Dominique
- Forrest Briggs - Diner Patron
- Forrest Briggs - Rally Attendee
- Jesse O'Neill - SS Guard #3
- Gabriel Manak - Lab Tech
- Monique Yvette Grant - Guard #1
- Joe Nemmers - Agent Weeks
- Jayvo Scott - Gangbanger
- Glenn Magee - Another Man
- Charlie Parrish - Gate Guard
- Lloyd Pitts - SS Stunt Agent #2
- Adam Boyer - Trask Security Guard
- Vanessa Aranegui - SS Tech #2
- Danny Ramirez - Wes
- Frieda Jane - Young Ellen Strucker
- Jason Burkey - Nate
- Mike Senior - Substation Guard
- Robert Bryan Davis - Purifier
- Omer Mughal - Crying SS Agent #1
- Andrew Benator - Aide (Hound)
- Sharon Gless - Ellen Strucker
- Javier Vazquez Jr. - Crying SS Agent #2
- Alex Collins - Jack Campbell
- Charles Green - Political Strategist
- Cristian Gonzalez - Insurance Agent
- Andrew Masset - Franklin Bennett
- Kurt Yue - Trask Employee
- David Norona - Senator Matthew Montez
- Vishesh Chachra - Agent Novak
- Matthew Cornwell - Hound Tech
- Mimi Fletcher - Nurse
- Michael Aaron Milligan - Gravity Hound
- Kate MacCallum - Inertia Hound
- Elliott Grey - Director Wolcott
- David Shae - Molecule Hound
- Angela Oh - Chief of Staff
- Robert C. Treveiler - Dan
- Faith Dillon - Nurse
- Troy Parker - Cop #1
- Jordan Patrick - Loitering Mutant
- Ray Campbell - William
- Brad Carter - Wire
- Denise Arribas - Mother
- Demi Castro - Father
- Rick Espaillat - Indignant Mutant
- Diesel Madkins - Sentinel Service Officer
- Matthew Rimmer - Furious Mutant
- Mia Ella Clyburn - Jazmine
- Mia Ella Clyburn - Jazmin
- Bianca Berry Tarantino - Dawn
- Raymond J. Barry - Otto Strucker
- Danube R. Hermosillo - Cristina
- Mark Rowe - Facility Owner
- Mark Rowe - David Hine
- Mahdi Cocci - Security Guard
- Kamar de los Reyes - Sebastian Diaz
- Robert G. McKay - Sergeant Lopez
- Rose Bianco - Nun
- Paden Fallis - Doctor
- Jennifer A. Martin - Worker #1
- Adam Murray - Worker #2
- Clark Sarullo - Waitress
- Diane Villegas - Nurse
- Adam David Thompson - Graph
- Aaron Beelner - Small Mutant
- Spence Maughon - Hospital Administrator
- William Mark McCullough - Michael
- Noelle Messier - Screaming Mutant
- Margo Moorer - OBGYN
- Sumalee Montano - Dr. Taylor
- Saree Mcintosh - Young Frost Sisters
- Vince Pisani - Dr. Kelsey
- Bryan Brendle - Terrified Mutant
- Michael Chandler - Dr. John
- Dinarte de Freitas - Pedro
- Jessi Goei - Naya
- Sharif Atkins - Quinn
- Agam Darshi - Benazir
- Gunnar Anderson - Ryan's Assistant
- Rob Demery - Bank Guard
- Steven Sean Garland - Bank Manager
- Andrew Hunter - Activist Mutant
- Kathryn Erbe - Aunt Dane
- Desmond Phillips - Lead Purifier
- Dayo Abanikanda - Security Guard
- Michelle Davidson - News Broadcaster #1
- Jeff Pearson - Protestor #1
- Zachariah Rogers - Protestor #2
- Paul Ryden - News Broadcaster #2
- Susanna Skaggs - Young Polaris
- Kate Burton - Dr. Madeline Risman
- Christopher Cousins - Lawrence Hayes
- Ken Kirby - Noah
- Jason Davis - Mr. Hoover
- Anjelica Bette Fellini - Rebecca / Twist
- Dani Deetté - Sentinel Services Guard
- Anissa Matlock - Porcelain Mutant
- Devin McGee - Mutant Prisoner
- Lily D. Moore - Shawna
- Maureen Mountcastle - Mrs. Hoover
- Che Broadway - Bearded Purifier
- Lowrey Brown - Kyle
- Frances Turner - Paula Turner
- Julia Farino - Andrea Von Strucker
- Marc Farley - Shopkeeper
- Wayne Hughes - Art Rael
- Jon Levine - Administrator
- Dave MacDonald - Officer #1
- Jeffrey Nordling - Danny
- Erinn Ruth - Evangeline
- Leah Lewis - Young Clarice
- Lauren Bonetti - Foster Mom
- Chase Anderson - Young Purifier
- Chase Anderson - Purifier #1
- Christian Finlayson - Young Reed
- Morgan Brown - Grizzled Purifier
- Morgan Brown - Injured Purifier
- Ethan McDowell - Young Otto
- Given Sharp - Lilly
- James Carpinello - Max
- Laysla De Oliveira - Glow
- Olivia Grace Applegate - Pam
- Chase Steven Anderson - Ray
- Athena Maria Bitzis - Mother
- Greg Weeks - Frank
- Greg Weeks - Purifier #2
- Karen Ceesay - Gina
- David Chin - Alexander
- David E. Collier - S.S. Agent
- Jeremy Michael Grey - Mutant Father
- Kat Conner Sterling - Teenaged Daughter
- Carsten Nørgaard - Andreas Von Strucker
- Eric Benson - Chris
- Amber Erwin - Production Assistant
- Jordan Cox - Mason
- Gabriella Garcia - Gabby
- Casey Hendershot - Air Blast Morlock
- Curtis Lyons - Strong Morlock
- Tang Nguyen - Chip
- Christopher C. Padilla - Purifier #1
- Rebecca Ray - Iris
- Fedor Steer - Membrain
- Mark Weinhandl - Cop
- Tom O'Keefe - Officer Wilson
- Chris Claremont - Theorist
- Diana Chiritescu - Worried Morlock
- Clare Margaret Donovan - Clare
- Michael Luwoye - Erg
- Peter Gallagher - Benedict Ryan
- John Crow - Reporter #2
- Tyshon Freeman - Tico
- Alicia Kelley - Human Woman
- Renes Rivera - Bulk
- Jeff Daniel Phillips - Tex / Fade
- Chelle Ramos - Heather
- Drew Youngblood - Young Andy
- Carl Palmer - Agent Myers
- Christian Gabriel Anderson - Rahul
- Ilan Muallem - Interpol Agent
- Tanya Wheelock - Bar Patron (uncredited)
- Kent Wagner - Mutant Prisoner (uncredited)
- Jack Kirby
- Alan Fine
- Lauren Shuler Donner
- Joe Quesada
- Bryan Singer
- Simon Kinberg
- Matt Nix
Stephen Moyer interpreta a Reed Strucker en la serie.
Amy Acker interpreta a Caitlin Strucker en la serie.
Natalie Alyn Lind hace el papel de Lauren Strucker.
Percy Hynes White interpreta a Andy Strucker en la serie.
Sean Teale hace el papel de Marcos Diaz / Eclipse.
Blair Redford interpreta a John Proudstar / Thunderbird en la serie.
Emma Dumont hace el papel de Lorna Dane / Polaris.
Jamie Chung interpreta a Clarice Fong / Blink en la serie.
Skyler Samuels interpreta a Esme Frost / Sophie Frost / Phoebe Frost en la serie.
Coby Bell interpreta a Jace Turner en la serie.
Capítulo disponible en las siguientes plataformas:
