- Griffin Matthews - Shane Evans
- Merle Dandridge - Kim Hammond
- J. J. Soria - Esteban Diaz
- Cheryl Hines - Dot Karlson
- Nolan Gerard Funk - Van White
- Rosie Perez - Megan Briscoe
- Luke Gulbranson - Ethan
- Elly Han - Karaoke Woman #2
- Shiloh Verrico - Erika
- Jo Yang - Housekeeper
- Jo D. Jonz - Air Marshal
- Florence Regina - TSA Woman
- Chanicha Shindejanichakul - FA #3
- Kumron Jivachat - Hotel Staff Member
- Lawrence de Stefano - British Hotel Staff Member
- Peter Mele - Older Man
- Cindy Cheung - Jean Miller
- Anne O'Sullivan - Woman Smoking in Bar
- Hannah Tinker - Gillian
- Shyaporn Theerakulstit - Bartender
- Edan Heymann - Mason
- Julia Harnett - Cyclist
- Ann Magnuson - Janet Sokolov
- Michael Bryan French - Edward Sokolov
- Jared Reinfeldt - Hot Cater Waiter
- Niceto Darcey Festin - Janet's Assistant
- Christian Felix - Associate #1
- Jason Nuzzo - Associate #2
- Kresh Novakovic - Associate #3
- Isha Blaaker - Nate
- William DeMeritt - Rick Green
- Alyssa Cheatham - Eve Bowden-Green
- Barbara Kingsley - Ms. Hassler
- Caitlin Cisco - Waitress
- Matt W. Cody - Maitre'd
- Amelia Windom - 911 Operator
- Mary Jo Mecca - Assistant
- Teresa Meza - Transit Cop #1
- Ryan Scott Thomas - Transit Cop #2
- Archie Kao - The Client
- Bruce Baek - Hak Oh-Seong
- Ann Harada - Fuku Suzu
- Bebe Neuwirth - Diana Carlisle
- Samsara Yett - Maya Bowden-Green
- Rob Leo Roy - Doorman
- Jason Furlani - Detective O'Brien
- Adam Ratcliffe - Prison Guard
- Joe Pallister - Jozef Jasar
- Christine McBurney - Aquarium Patron (uncredited)
- Sherin Shetty - Jennifer
- Owen Asztalos - Young Davey
- Morgan Hallett - Lisa Bowden
- Soara-Joye Ross - Waitress
- Jonas Cohen - Nurse
- Rachel Paula Green - Guard
- Edward Mawere - Mick the Bartender
- Mark Fichera - Pale Blue Eyes
- Terry Serpico - Bill Briscoe
- Christina Shea-Wright - Sarah
- Carla Oudin - Sam
- Anita Zagaria - Enrico's Nonna
- Brandon Morris - Agent Chavez (Checkered Tie Guy)
- Brandon Morris - Agent Chavez
- Yasha Jackson - Jada Harris
- Audrey Grace Marshall - Young Cassie
- Jason Jones - Hank Bowden
- Stephanie Koenig - Sabrina Oznowich
- Ritchie Coster - Victor
- Tim Rogan - Agent Kendrick
- MaryAnn Hu - CIA Director
- Briana Cuoco - Cecilia
- Jennifer Betit Yen - Gate Agent
- Roberto De Felice - Man
- Alberto Frezza - Enrico
- Alberto Vazquez - Bodega Owner
- Mae Martin - Grace St. James
- Santiago Cabrera - Marco
- Jessie Ennis - Jenny
- Shohreh Aghdashloo - Brenda
- Kayvon Esmaili - Will Kotov
- Erik Passoja - Jim Jones
- Erica Ibsen - Cassie Double #2
- Kate Cochran - Cassie Double #3
- Janine Theisen - Cassie Berlin Double
- Konstantin Gries - Front Desk Clerk #1
- Jonathan von Mering - Front Desk Clerk #2
- Lea Beie - Police Officer
- Alyssa Preston - Female Clerk
- Monika Anna Wojtyllo - Housekeeper
- Scott Rosendall - Ted
- Annie Heller - Meeting Leader
- Mike Aviles - CIA Officer
- Gabrielle Conforti - Woman in Elevator
- Gayle Samuels - Business Woman
- Margaret Cho - Utada
- Guðfinna Rúnarsdóttir - Female British Birdwatcher
- Graham Littlewood - Male British Birdwatcher
- Jason Wong - Marty Chang
- Angela Matemotja - Beatriz Salazar
- Michael D'Amore - Liam Berger
- Olivia Cordell - Receptionist
- Rob James - Security Guard
- Arabella Grant - Franny
- Katie Self - Perky Mom
- Sanjay Rao - Waiter
- Patrick Quinlan - Artisinal Cheesemaker
- Alanna Ubach - Carol Atkinson
- Victoria Garcia-Kelleher - Sara Park
- Joseph Kamal - Demir
- Salma Khan - Gate Agent
- Davíð Þór Katrínarson - Jimmy
- PeiPei Alena Yuan - North Korean Henchwoman
- Izabella Miko - Cherri
- Betsy Moore - Wanda
- Kara Luiz - Woman
- Sharon Stone - Lisa Bowden
- Tiffany Adams - Female Cop
- Kylie Pavlich - Ride Operator
- Lon Gowan - Officer
- Carrie Madsen - Older Flight Attendant
- Carlos Ragas - WITSEC Agent
- Silver Tree
Terry Serpico interpreta a Bill Briscoe en la serie.
Kaley Cuoco hace el papel de Cassie Bowden.
Zosia Mamet hace el papel de Annie Mouradian.
Deniz Akdeniz hace el papel de Max Park.
Mo McRae interpreta a Benjamin Berry en la serie.
Callie Hernandez interpreta a Gabrielle Diaz en la serie.
Griffin Matthews interpreta a Shane Evans en la serie.
J. J. Soria hace el papel de Esteban Diaz.
Cheryl Hines hace el papel de Dot Karlson.
Rosie Perez hace el papel de Megan Briscoe.
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