- Lance Gross - Frank Haywood
- 50 Cent - Big Glade
- Chris Tardio - Det. Curtis Gillespie
- John Ashton - Franklin Sherman
- Alex Fernandez - Federico 'Fico' Vasquez
- Nestor Serrano - Xavier Obispo
- George Stults - Langston Sherman
- Ignacio Serricchio - Alejandro Lopez-Fernando
- Annette O'Toole - Elaine Sherman
- Julia Vera - Old Marina
- Jose Pablo Cantillo - Luis Obispo
- Lorraine Toussaint - La Bruja
- Toby Hemingway - Timo Proud
- Michael Des Barres - Icepick
- Mike Starr - Benny Famosa
- Salli Richardson-Whitfield - Athena Brookes
- Lisa Waltz - Karyn Welling
- James Madio - Lazlo Levy
- T.J. Thyne - Jack Hodgins
- Wilson Cruz - Jonni
- Eric Thomas Wilson - Thug #2
- Amy Aquino - Cristina Farrel
- Brett Davern - Cooper Allison
- Eltony Williams - Lt. Sam Royce
- Jaime Murray - Amadea Denaris
- Jim Cody Williams - John Fogerty's Manager
- John Fogerty - Himself
- Roy Werner - Lt. Col. Nick Allison
- Patrick Robert Smith - NTSB Investigator
- Rus Blackwell - Chris Jellicoe
- Michael Gambino - Thug #1
- Richard Augustine - Burly Man
- Timothy E. Goodwin - Trumpet Instructor
- Heather Ashley Chase - Bartender
- Tom Stedham - DEA Agent
- John Francis Daley - Lance Sweets
- Mitch Pileggi - Eddie Ross
- Ryan Cutrona - Henry Coleman
- Greg Evigan - Bronski
- Valarie Pettiford - Chatney Dubois
- Chris Ellis - Warden Nick Larsen
- Brandon W. Jones - Kevin Montgomery
- Blake Shields - Young Eddie Ross
- James Harvey Ward - Young Glen Hogan
- Mario Van Peebles - Fontana
- Katie Garfield - Carmela
- Eric Norris - Dark Figure
- Pearce Blair - Hotel Guest
- Tom Calococci - Sherrif
- Sigrid Lium - Beach Girl
- Jodi Lyn O'Keefe - Lisa
- Ian Reed Kesler - Ira Messing
- Ginger Gonzaga - Therese
- John Sanderford - Nathan Stein
- Kodi Baker - Club DJ
- Charles Justo - Hot Guy / Club Promoter
- Jake Busey - Bobby the Twin
- Amad Jackson - Tyson the Twin
- Mike Bradecich - O'Malley
- Chris Johnson - Marty Nix
- Rick Zieff - Barry Verlinger
- Gregor Manns - Bouncer
- Andres Perez-Molina - Miami-Dade Detective
- Sarah Lynn Dawson - Roulette Dealer
- Rachel Ann Mullins - Waitress
- Jonathan Slavin - Preston Miller
- Joshua Leonard - Derek Towers
- Ever Carradine - Agent Judy Green
- Molly Morgan - Angelica Angel
- Cloie Wyatt Taylor - Teacher
- Christina Rodriguez - Forensic Tech - Feature
- Eric Roberts - Uncle Shadrack
- Jason Beghe - Col. Chuck Bradshaw
- Spencer Garrett - Ed Scanian
- Sebastian Siegel - Hector
- Peta Wilson - Pope
- Sean McGowan - Major Jeremy Wren
- Sumalee Montano - Lee Scott
- JJ Snyder - Reporter
- Juliette Goglia - Melissa Welling
- M.C. Gainey - Pete Steck
- Laura Slade Wiggins - Claire
- Jamila Allen - Renae Francis
- Judy Echavez - Reporter
- Paul Aldanée - Smuggler Fisherman
- Arjay Smith - Trey
- T.J. Myers - Fontana Fan
- T.J. Myers - Sorceress
- Adina Porter - Ms. Estelle
- Jeremy Guskin - DJ W-Squared
- Casey Washington - J-Stryke
- Jacob Latimore - Young Trey
- Shane Edelman - Joe Turnbull
- Charlene Amoia - Annie Turnbull
- David H. Lawrence XVII - Miss-terious
- Christopher Goodman - Bartender
- Lindsay Bushman - Doppelwilla
- Katana Malone - Domino Player
- Mariano Mendoza - Henchman
- Jayvo Scott - Cuban Goon
- Sal Velez Jr. - Miami Hustler
- Kelly Carlson - Gail McHottie
- Mercedes Colon - Marta Abreu
- Yara Shahidi - Adina Abreu
- Patrick Fabian - CEO Dwayne Anderson
- Celestino Cornielle - Carlos Abreu
- Mageina Tovah - Joyce Weatherby
- Michael Irby - Detective Quinones
- Frank Crim - Gary Anthony Jones
- Chris Browning - Ed Beiderman
- William Stanford Davis - Earl
- Maliabeth Johnson - Attractive Woman
- Roderick McCarthy - Policeman
- Michael Lespinasse - Bystander
- Shani Pride - Eliana Obispo
- Arthur Darbinyan - Russian Priest
- Kane Jungbluth-Murry - La Bruja's Son
- Tracy Lee - Club Patron
- Patrick Fischler - Jason Stefanian
- Anne Ramsay - U.S. Marshal Catherine Gibson
- Karina Logue - Alexandra Deering
- Sonya Leslie - Blacksmith
- Aaron Hendry - Bill
- Daniel Forcey - First Man
- Richard Greener
- Hart Hanson
- Barry Josephson
John Ashton interpreta a Franklin Sherman en la serie.
Annette O'Toole hace el papel de Elaine Sherman.
Geoff Stults interpreta a Walter Sherman en la serie.
Maddie Hasson interpreta a Willa Monday en la serie.
Mercedes Mason interpreta a Isabel Zambada en la serie.
Michael Clarke Duncan hace el papel de Leo Knox.
Capítulo disponible en las siguientes plataformas:
