- Freddie Highmore - Self
- Harrison Ford - Self
- Glenn Close - Self
- Annette Bening - Self
- Pierce Brosnan - Self
- AnnaSophia Robb - Self
- Martin Short - Self
- Sarah Jessica Parker - Self
- Michael J. Fox - Self
- Peter Falk - Self
- Paul Reiser - Self
- Ellen DeGeneres - Self - Host
- Jodie Foster - Self
- Peter Boyle - Self
- Brad Garrett - Self
- Heath Ledger - Self
- Allison Janney - Self
- Diane Keaton - Self
- Anne Hathaway - Self
- Linda Cardellini - Self
- Tom Hanks - Self
- Sally Field - Self
- Sean Astin - Self
- Maria Bello - Self
- Dominic Monaghan - Self
- Edward Norton - Self
- Madonna - Self
- Liam Neeson - Self
- Antonio Banderas - Self
- Matt Dillon - Self
- Kim Cattrall - Self
- Bruce Willis - Self
- Rob Lowe - Self
- Emilio Estevez - Self
- Salma Hayek Pinault - Self - Guest
- Michael Douglas - Self
- William H. Macy - Self
- Diane Lane - Self
- Kathy Griffin - Self
- Kiefer Sutherland - Self
- Kim Basinger - Self
- Mekhi Phifer - Self
- Brittany Murphy - Self
- Chris Rock - Self
- Vince Vaughn - Self
- Téa Leoni - Self
- Daryl Hannah - Self
- Anthony Hopkins - Self
- Sharon Stone - Self
- Jeffrey Tambor - Self
- Patricia Arquette - Self
- Michael Rapaport - Self
- Whoopi Goldberg - Self
- Laura Linney - Self
- Carl Reiner - Self
- Don Cheadle - Self
- Robin Williams - Self
- Alan Arkin - Self
- Cate Blanchett - Self
- Reese Witherspoon - Self
- Ben Affleck - Self
- Kanye West - Self
- Orlando Bloom - Self
- Keira Knightley - Self
- Kevin Bacon - Self
- Owen Wilson - Self
- Catherine Zeta-Jones - Self
- Forest Whitaker - Self
- Jake Gyllenhaal - Self
- Dustin Hoffman - Self
- Wentworth Miller - Self
- Jamie Foxx - Self
- S. Epatha Merkerson - Self
- Jennifer Aniston - Self
- Lucy Liu - Self
- Amanda Peet - Self
- Steve Carell - Self
- Matthew Broderick - Self
- Rupert Everett - Self
- Wyclef Jean - Self
- Joely Fisher - Self
- Robert Downey Jr. - Self
- Jessica Capshaw - Self
- Mel Gibson - Self
- Elisabeth Shue - Self
- Naomi Watts - Self
- Adrien Brody - Self
- Treat Williams - Self
- Colin Hanks - Self
- Russell Crowe - Self
- Kyle Chandler - Self
- Fred Savage - Self
- Laura Dern - Self
- Garry Marshall - Self
- Jeff Goldblum - Self
- Tina Turner - Self
- Nicole Kidman - Self
- Catherine Keener - Self
- Jason Alexander - Self
- Samuel L. Jackson - Self
- Michael Keaton - Self
- Penélope Cruz - Self
- Mary McCormack - Self
- Morgan Freeman - Self
- Hilary Swank - Self
- Amy Yasbeck - Self
- Susan Sarandon - Self
- Rosie Perez - Self
- Kate Winslet - Self
- Kirsten Dunst - Herself
- Jeff Bridges - Self
- Jim Carrey - Self
- John Goodman - Self
- Julianne Moore - Self - Guest
- Tara Reid - Self
- William Shatner - Self
- Sting - Self
- Jerry O'Connell - Self
- Stephen Collins - Self
- John Cusack - Self
- Scarlett Johansson - Self
- Rachel Weisz - Self
- Toni Collette - Self
- Halle Berry - Self
- Benjamin Bratt - Self
- Tom Cruise - Self
- Dakota Fanning - Self
- Kevin Costner - Self
- Mickey Rourke - Self
- Andie MacDowell - Self
- Lenn Goodside
- Ellen DeGeneres
- Ryan Raddatz
- Karen Kilgariff
- Michelle Basterrechea
- Joel Thingvall
- Lauren Pomerantz
- Brittany Curran
- Shealeigh
- Kirsten Dunst
Freddie Highmore interpreta a Self en la serie.
Harrison Ford interpreta a Self en la serie.
Glenn Close hace el papel de Self.
Annette Bening hace el papel de Self.
Pierce Brosnan hace el papel de Self.
AnnaSophia Robb interpreta a Self en la serie.
Martin Short hace el papel de Self.
Sarah Jessica Parker hace el papel de Self.
Michael J. Fox interpreta a Self en la serie.
Peter Falk interpreta a Self en la serie.
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