- Harrison Ford - Self
- Cynthia Nixon - Self
- Julie Andrews - Self - Guest
- Tonya Harding - Self
- Brendan Fraser - Self
- Colby Donaldson - Self
- Kate Winslet - Self - Guest
- Jessica Alba - Self
- Christian Bale - Self
- Jennifer Hudson - Self
- Katharine McPhee - Self
- Patti LaBelle - Self
- Jessica Simpson - Self
- Bob Barker - Self
- Dennis Haysbert - Self
- Jenna Bush Hager - Self
- Laura Bush - Self
- Erin Moriarty - Self
- Adam Rodriguez - Self
- Halle Berry - Self
- Jason Lewis - Self
- James Franco - Self
- Ben Stiller - Self
- Mary Jo Buttafuoco - Self
- Tina Turner - Self
- Taylor Hicks - Self
- Sarah Jessica Parker - Self
- Seth Rogen - Self
- Fantasia Barrino - Self
- Gabrielle Union - Self
- Kevin Costner - Self
- Ashton Kutcher - Self
- Kim Cattrall - Self
- LL Cool J - Self
- Clive Owen - Self - Guest
- Maya Angelou - Self
- Denzel Washington - Self - Guest
- Gavin DeGraw - Self
- Kyra Sedgwick - Self
- Sara Bareilles - Self
- Blake Lively - Self
- America Ferrera - Self
- Katie Lee - Self
- Jerri Manthey - Self
- Marg Helgenberger - Self
- Trace Adkins - Self
- Luke Wilson - Self
- Christopher Kimball - Self
- Melody Thomas Scott - Self
- Billy Bob Thornton - Self
- Rick Springfield - Self
- Kristin Davis - Self
- Mike Myers - Self
- Sigourney Weaver - Self
- Elisabeth Shue - Self
- Drew Carey - Self
- Melina Kanakaredes - Self
- Katie Couric - Self
- Mark Wahlberg - Self - Guest
- David Duchovny - Self
- Katherine Heigl - Self
- Elizabeth Perkins - Self
- Tim Allen - Self
- Garth Brooks - Self
- Harry Smith - Self
- John Legend - Self
- Will Ferrell - Self
- Julia Stiles - Self - Guest
- Martina McBride - Self
- Masaharu Morimoto - Self
- Sissy Biggers - Self
- Christopher Guest - Nigel Tufnel
- Don Cheadle - Self - Guest
- Solange - Self
- Ashley Tisdale - Self
- Will Dailey - Self
- Ricky Skaggs - Self
- Tony Dungy - Self
- Julia Louis-Dreyfus - Self
- Tom Selleck - Self
- Jeffery Deaver - Self
- Leona Lewis - Self
- Jorja Fox - Self
- Samuel L. Jackson - Self
- Ken Jennings - Self
- Gary Oldman - Self
- Annette Bening - Self
- Jude Law - Self
- Lisa Roberts Gillan - Self
- Hugh Grant - Self
- Eva Mendes - Self
- Richard Gere - Self - Guest
- Emma Roberts - Self
- Farrah Fawcett - Self
- Maria Sharapova - Self
- Jamie Lee Curtis - Self
- Rachel Weisz - Self
- Camryn Manheim - Self
- Jada Pinkett Smith - Self
- Justin Timberlake - Self
- Greg Behrendt - Self
- Donna Summer - Self
- Shia LaBeouf - Self
- Sean Penn - Self
- Yaël Naïm - Self
- Julianne Moore - Self - Guest
- Suzanne Somers - Self
- Gary Sinise - Self
- George Tenet - Self
- Rihanna - Self
- Robin Williams - Self
- Anne Hathaway - Self
- Michelle Ray Smith - Self
- Charlize Theron - Self
- Bill Maher - Self
- Daniel Lue - Self
- Gervase Peterson - Self
- Montel Williams - Self
- Tionne 'T-Boz' Watkins - Self
- Dolly Parton - Self
- Skandar Keynes - Self
- Alana de la Garza - Self
- Matthew Fox - Self
- Patti Smith - Self
- Bryce Dallas Howard - Self
- Johnny Depp - Self
- Kevin Nealon - Self
- Jodie Foster - Self - Guest
- Freddie Highmore - Self
- Lou Dobbs - Self
- Alison Irwin - Self
- Vanessa Redgrave - Self
- Chris Daughtry - Self
- Martin Short - Self
- Tommie Smith - Self
- Anthony LaPaglia - Self
- Greg Kinnear - Self - Guest
- Jennifer Love Hewitt - Self
- Alanis Morissette - Self
- Jami Gertz - Self
- Ringo Starr - Self
- Philip Seymour Hoffman - Self - Guest
- Dionne Warwick - Self
- Cherie Blair - Self
- Robert Downey Jr. - Self
- Jake Gyllenhaal - Self
- John Travolta - Self
- Ivanka Trump - Self
- Shemar Moore - Self
- Bill Clinton - Self
- Tina Wesson - Self
- Monica - Self
- Bethany Hamilton - Self
- Kristin Chenoweth - Self - Guest
- Tyrese Gibson - Self
- Tim Farriss - Self
- Tara Conner - Self
- Donnie Wahlberg - Self
- Emily Procter - Self
- Forest Whitaker - Self
- Jerry Bruckheimer - Self
- Chris O'Donnell - Self
- Tom Cruise - Self - Guest
- Queen Latifah - Self
- Naomi Judd - Self
- Tina Brown - Self
- Randy Jackson - Self
- Adrian Martinez - Self
- Andrew Knowlton - Self
- Viggo Mortensen - Self
- Gloria Vanderbilt - Self
- Leslie Uggams - Self
- George Foreman - Self
- Brad Paisley - Self
- Spike Lee - Self
- Clint Eastwood - Self
- Ashley Judd - Self
- Ewan McGregor - Self
- Kirsten Dunst - Self
- Criss Angel - Self
- Orlando Bloom - Self
- Cynthia Rowley - Self
- George Takei - Self
- Dakota Fanning - Self
- Danni Boatwright - Self
- Ryan Phillippe - Self
- Rachael Ray - Self
- Emily Watson - Self
- Tim McGraw - Self
- R.E. Rodgers - Self
- Sharon Case - Self
- Téa Leoni - Self
- Raquel Welch - Self
- Bryan Adams - Self
- Lindsay Lohan - Self - Guest
- Clay Aiken - Self
- Jermaine Jackson - Self
- Jim Carrey - Self - Guest
- Ingrid Schau - Self
- Olivia Newton-John - Self
- Steven Spielberg - Self
- Matt Damon - Self
- Matt Damon - Self - Guest
- Kelly Clarkson - Self
- Skeet Ulrich - Self
- Damien Fahey - Self
- Darren Hayes - Self
- Jamie-Lynn Sigler - Self - Guest
- Daniel Radcliffe - Self - Guest
- Rose McGowan - Self
- Ray Romano - Self - Guest
- Tommy Lee Jones - Self - Guest
- Gary Hart - Self
- Mandy Moore - Self
- Joel Osteen - Self
- Joyce DeWitt - Self - Guest
- Colin Firth - Self - Guest
- Alexa PenaVega - Self
- Leann Slaby - Self
- Pharrell Williams - Self
- Chris Rose - Self
- Helen Mirren - Self
- Hugh Jackman - Self
- Jennifer Connelly - Self
- Jason Ritter - Self
- Peter O'Toole - Self
- Blake Shelton - Self
- Rupert Grint - Self
- Ed Harris - Self
- Davy Jones - Self
- Tara Lipinski - Self
- Lauren Bacall - Self - Guest
- Mamie Gummer - Self
- John Mayer - Self
- Neil Patrick Harris - Self
- Mike Lupica - Self
- Tobey Maguire - Self
- Naomi Watts - Self
- Jason Schwartzman - Self
- Jeff Foxworthy - Self
- Jeffrey Tambor - Self
- Sarah McLachlan - Self
- Wanda Sykes - Self - Guest
- Cameron Diaz - Self
- Gisele Bündchen - Self
- Jim Nantz - Self
- Leonardo DiCaprio - Self
- Cate Blanchett - Self
- Kobe Bryant - Self
- Haley Joel Osment - Self - Guest
- Carol Higgins Clark - Self
- Will Smith - Self
- Shirley MacLaine - Self
- Hilary Swank - Self
- Jewel - Self
- Lee Ann Womack - Self
- Lily Tomlin - Self - Guest
- Reba McEntire - Self - Guest
- Cobie Smulders - Self
- Tori Spelling - Self
- John Ritter - Self
- Ben Affleck - Self
- Diana DeGarmo - Self
- Sylvester Stallone - Self
- Jason Dean Bennison - Self
- Natalie Cole - Self
- David Caruso - Self
- Liz Tuccillo - Self
- Denis Leary - Self
- Angelina Jolie - Self
- Donald Trump - Self
- Peter Walsh - Self
- Sally Bedell Smith - Self
- Adrien Brody - Self
- Kevin Bacon - Self
- Jimmy Smits - Self
- Kathryn Morris - Self - Guest
- Phil McGraw - Self
- Mia Farrow - Self
- Terry Crews - Self
- Sharon Stone - Self - Guest
- Cole Sprouse - Self
- Dane Cook - Self
- Tyra Banks - Self
- Katie Holmes - Self
- Elizabeth Banks - Self
- Zach Braff - Self
- Drew Barrymore - Self
- Amanda Bynes - Self
- Elton John - Self
- James Taylor - Self
- Michael McKean - David St. Hubbins
- Kelly Rowland - Self
- John Lithgow - Self
- Claire Danes - Self
- Jonathan Togo - Self
- Beyoncé - Self
- Michelle Pfeiffer - Self
- Peter Tork - Self
- Robert Klein - Self
- Jennifer Aniston - Self - Guest
- Jeff Probst - Self
- Bruce Willis - Self - Guest
- Ray Liotta - Self
- Joe Namath - Self
- Jane Fonda - Self - Guest
- Regina Hall - Self - Guest
- Harry Shearer - Derek Smalls
- Rupert Boneham - Self
- Tony Bennett - Self
- Betty White - Self - Guest
- Daryl Sabara - Self
- Micky Dolenz - Self
- Kanye West - Self
- Stanley Tucci - Self
- Don Rickles - Self - Guest
- Tichina Arnold - Self
- Phil Simms - Self
- Diane Keaton - Self - Guest
- Rich Little - Self
- Joe Montana - Self
- Kenny Chesney - Self
- Emma Watson - Self
- Vaughn Lowery - Self
- Scarlett Johansson - Self
- Kenny Loggins - Self
- Bobby Flay - Self
- Jimmy Carter - Self
- Josh Radnor - Self
- Hannah Storm - Self
- Geraldine A. Ferraro - Self
Freddie Highmore interpreta a Self en la serie.
Harrison Ford hace el papel de Self.
Annette Bening interpreta a Self en la serie.
Martin Short interpreta a Self en la serie.
Sarah Jessica Parker interpreta a Self en la serie.
Jodie Foster interpreta a Self - Guest en la serie.
Elizabeth Perkins interpreta a Self en la serie.
Diane Keaton hace el papel de Self - Guest.
Anne Hathaway interpreta a Self en la serie.
Jorja Fox hace el papel de Self.
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