- Pat Harrington, Jr. - Peter Stowe
- Brenda Benet - Brenda
- Victoria Vetri - Dolly Daly
- Karin Wolfe - Etta
- Lynn Fields - Heidi
- Ann Prentiss - Kerry Allen
- Diana Muldaur - Lynn Bardman
- Richard Steele - Dick (uncredited)
- Richard Steele - Dick
- Ann Marie - Hildy
- Ann Marie - Model
- Bill Dana - Policeman
- Pat Morita - Duke Komosori
- Miko Mayama - Kendis Komosori
- Sabrina Scharf - Diane Kirby
- Ron Ely - Ronald
- Cicely Tyson - Betty Kelly
- Jodie Foster - Joey Kelly
- David Ketchum - Joe Kelly
- Arlen Stuart - Mrs. Stuart
- George Takei - Mr. Sato
- Claudia Bryar - Mrs. Thaler
- Warren Berlinger - Harvey Henshaw
- Jean Marie Ingels - Doreen
- Linda Meiklejohn - Jeri
- Hans Moebus - Bar Patron (uncredited)
- Jonathan Daly - Dr. Bob Lockwood
- Teddy Quinn - Danny Lockwood
- Tani Guthrie - Barbara Harris
- Gwynne Gilford - Mrs. Baldassare
- Diana Hale - Mrs. Basimson
- Francine York - Kate Landis
- Lisa Gerritsen - Alice
- Darleen Carr - Waitress (uncredited)
- Erin Moran - Emily Ruth Gustafson
- Ruth McDevitt - Miss Bristol
- Martha Scott - Grandmother
- Meg Wyllie - Miss Harriet Ritter
- James Cole - Max Kelly
- James Cole - Ralphie
- Tippi Hedren - Cissy Drummond-Randolph
- Yvonne Craig - Maryanne Atwater
- Robert Hitchcock - Bar Patron (uncredited)
- Murray Pollack - Bar Patron (uncredited)
- Murray Pollack - Maitre D' (uncredited)
- Suzanne Pleshette - Valerie Bessinger
- Patrick O'Moore - Senator Goldrich
- Natalie Masters - Mrs. Goldrich
- Lee Joe Casey - Bobby Brownbear
- Will Geer - Harry I. Madison
- Lori Saunders - Cynthia Kurland
- Cosmo Sardo - Maitre d' (uncredited)
- John Fiedler - The Mild Man
- Bruce Kirby - Officer Gifford
- Bruce Kirby - Harry
- David Armstrong - Party Guest (uncredited)
- Peter Eastman - Party Guest (uncredited)
- Dennis Fimple - Party Guest (uncredited)
- Andrew Prine - Dr. Hal 'Speed' Gould
- Barbara Clarke Chisolm - Female Technician
- Catherine Ferrar - Miss Fern
- Pat Delaney - Harriet
- Rosemary Edelman - Carol Fleischman
- Lew Horn - Bob Fleischman
- Ed Hall - Ted Wilson
- Gordon Cooper - Gordon Cooper
- Bill Fiore - Mr. Weston
- Hal Cooper - Gus (uncredited)
- Hal Cooper - Gus
- Claire Brennen - Sherry Barnes
- Robert Burton - Brian Frisbee
- Lisa Kirk - Mrs. Rickles
- Chris Woodley - Miss Huffman
- Vincent Van Patten - Mark
- Jeff Williams - Mike Riley
- Tiger Williams - Lester Riley
- Angus Duncan - John Buckner
- Kirk Mee - Mr. Taggart
- Virginia Hawkins - Mrs. Kensington
- Allen Joseph - Mr. Wertz
- Richard X. Slattery - Xander Malloy
- Ivor Barry - Major Pritchett
- Ivor Barry - The Englishman
- Lou Jacobi - Frank Hausman
- Alan Oppenheimer - Sy Freeman
- Frank Corsentino - Marvin Flair
- William Lanteau - Vincent Pryor
- William Lanteau - Gus the Waiter (uncredited)
- Ned York - Alex
- Ronny Graham - Burgess 'Buzz' Carew
- Willie Aames - Harold O'Brien
- Willie Aames - Scott
- Madlyn Rhue - Dolores Carew
- Jason Karpf - Jimmy
- Daniel Elam - Bar Patron (uncredited)
- Carol Lawrence - Irena Kosnova
- Vic Tayback - Bernie
- Sally Struthers - Katie O'Hara
- Allan Drake - Prescott
- Allan Drake - Mr. Prescott
- Trisha Noble - Dr. Liz Park
- Hal Baylor - Mr. O'Brien
- Jerry Stiller - Paul Sterling
- Jerry Stiller - Mr. Landon
- Anne Meara - Annie Dempsey
- Anne Meara - Bunny Sterling
- Ed Parker - Self
- Bill M. Ryusaki - Bill - Karate Instructor
- Larry Delaney - Mr. Lindley
- Eve McVeagh - Lorraine Karn
- Sammy Davis Jr. - Rodney River Jr.
- Lou Cutell - Samson
- Suzanne Taylor - Miss Silo
- Barbara Cason - Irma Handily
- Michael Link - Bruce
- Michael Morgan - Steve
- Yvonne Wilder - Kathy
- James Komack
Jodie Foster interpreta a Joey Kelly en la serie.
George Takei interpreta a Mr. Sato en la serie.
Bruce Kirby hace el papel de Officer Gifford.
Eve McVeagh hace el papel de Lorraine Karn.
Bill Bixby interpreta a Tom Corbett en la serie.
Brandon Cruz interpreta a Eddie Corbett en la serie.
Miyoshi Umeki hace el papel de Mrs. Livingston.
Kristina Holland interpreta a Tina Rickles en la serie.
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