- Cassie Clare - Young Helen
- Stuart Davidson - Private Ambulanceman
- Stuart Davidson - Coastguard Rescue Officer
- Stuart Davidson - Salsa Dancer
- Robert Morgan - Joseph Gravelle
- Archie Rush - Steve Kernan
- Imogen Waterhouse - Sophie Bailey
- Andrew Whipp - Phillip Bailey
- Sophie Duval - May Kernan
- Simon Meacock - John Kernan
- Phoebe Thomas - Dora Horton
- Howard Coggins - Bill Jeffries
- Alex Ferns - Nolan Prince
- Jenny Galloway - Ethel Blackstone
- Delroy Brown - Harvey Campbell
- Tilly Blackwood - Una Drake
- Rupert Procter - John Holland
- Ronan Vibert - Gavin Drake
- Molly Hanson - Hannah Drake
- Leon Ockenden - Danny Ball
- Claire Price - Joy Bradshaw
- James Buller - Peter Bradshaw
- James Weber Brown - Brian 'Digger' Digsby
- Bill Buckhurst - DI Ben Marshall
- Alex Felton - Michael Larkin
- Simon Armstrong - Errol Prowse
- Katy Brand - Debs Luscombe
- Sam Stockman - Anthony Light
- Alex Avery - Ray Mason
- Georgia Henshaw - Amelia Prowse
- Gerald Kyd - Prof. Tal Greening
- Charles Babalola - Ian Igby
- Florence Hall - Abby Naseby
- David Westhead - Grantham Naseby
- Naomi Ryan - Andrea Matteo
- Alan Williams - Keegan Brubaker
- Paul Hawkyard - Brent Hess
- Richard Huw - Peter Walker
- Gyuri Sarossy - George Flemington
- Christopher Villiers - Tim Morris
- Maya Gerber - Lily Sidwell
- Timothy Carlton - Donald Sidwell
- Amy Marston - Olivia Sidwell
- Alun Raglan - Terence Brooks
- Andrew Havill - Edward Sidwell
- Peter Gunn - Robert Talbot
- Emma Campbell-Jones - Christine Talbot
- Oliver Bennett - Andrew Talbot
- Hazel Ellerby - Rose Porter
- Alice Henley - Lucy Everidge
- Carla Mendonça - Paula Barranco
- Gabriela Montaraz - Issabella Martinez
- Lucy Phelps - Gemma Duffy
- Ben Turner - Dr Mel Siddiqui
- David Corbett - Rafe Phelps
- Simone McAullay - Jess Phelps
- Tupele Dorgu - Lori Fletcher
- Robin Laing - Eddie Landman
- Rupert Lazarus - Anthony 'Stix' King
- Adie Allen - Karen Shaw
- Peter McNeil O'Connor - Lee Millar
- Dean Williamson - Phil Tate
- Michael Culkin - Charles Gower
- Heather Peace - Chrissy Woodward
- Ben Caplan - Phillip Spence
- Nellie Burroughes - Erica Ryland
- Stephen Marcus - Gobby Mitchell
- Percelle Ascott - Jake Taylor
- Nick Brimble - Bob Fountain
- Dario Coates - Ben Fairhead
- Nicola Duffett - Amy Penketh
- Paul Copley - John Roxwell
- Kirsty Oswald - Gemma Roxwell
- Joe Dixon - Samuel Mansfield
- Vincenzo Nicoli - Tam Bryant
- Matthew Houston - Scott Poole
- Susy Kane - Claire Bryant
- Kate Maravan - Roz Bryant
- Nigel Betts - Brian Teddern
- Charlotte Randle - Yvonne Marks
- Matthew Marsh - Sidney Sutton
- David Schofield - Ben Arnold
- Ryan Calais Cameron - Malik Negasi
- Michele Austin - Maggie Fordham-Bryce
- Daisy Beaumont - Anna Daniels
- Louis Tamone - Jason Daniels
- Will Austin - Steve Johnson
- Cassie Bradley - Jinty Morgan
- Iain Batchelor - Jerry Foxby
- Suzette Llewellyn - Helen Boyd
- Francis Magee - George James
- Sandra Voe - Peggy Winterson
- Chris Larkin - Oliver Foxby
- Susan Vidler - Antonia Foxby
- Alexandra Evans - Young Antonia
- James Barriscale - Dick Hamilton
- Ramon Tikaram - Don Shapur
- Emma Stansfield - Ruby Hamilton
- Aaron Phagura - Kass Shapur
- David Sterne - John 'Blackbeard' Fraser
- Macy Nyman - Ellie Patterson
- Emma Handy - Debbie Patterson
- Kate Miles - Cath Lowe
- Chloe Hannaford - Megan Chapman
- James Redmond - Dean Lowe
- Jack Loxton - Alex Lowe
- Ian Barber
- Piotr Szkopiak
- Niall Fraser
- Adrian Bean
- Matt Carter
- Dan Muirden
- Al Smith
- David Bowker
- Mark Hiser
- Bridget Colgan
- Sally Abbott
Sandra Voe hace el papel de Peggy Winterson.
David Schofield interpreta a Ben Arnold en la serie.
Stephen Marcus hace el papel de Gobby Mitchell.
Claire Goose interpreta a Jane Kennedy en la serie.
Matt Bardock interpreta a DS Davey Higgins en la serie.
Oliver Gomm hace el papel de Clint Holman.
Beatie Edney interpreta a Judith Kennedy en la serie.
Ivan Kaye interpreta a Mick Sturrock en la serie.
Grace Hogg-Robinson hace el papel de Beth Kennedy.
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