- Rick Springfield - Self
- Peggy Noonan - Self
- George Wendt - Santa
- Al Franken - Self
- Bob Costas - Self
- Cokie Roberts - Self
- Annie Duke - Self
- Stephanie Tubbs Jones - Self
- Fareed Zakaria - Self
- Greg Behrendt - Self
- Barbara Boxer - Self
- Mark Cuban - Self
- Harry Smith - Self
- Jane Fonda - Self - Guest
- Leslie Feist - Self
- Jon Stewart - Self
- Dermot Mulroney - Self - Guest
- Katrina vanden Heuvel - Self
- Malcolm Gladwell - Self
- Lisa Loeb - Self
- Cornel West - Self
- Stone Phillips - Self
- David Gergen - Self
- Jeff Daniels - Self
- Paul Dinello - Tad
- Tim Robbins - Self
- George Stephanopoulos - Self
- Robin Givhan - Self
- Ron Suskind - Self
- Andrew Sullivan - Self
- Gary Sinise - Self
- Kareem Abdul-Jabbar - Self
- R. James Woolsey, Jr. - Self
- Toby Keith - Self
- Hillary Clinton - Self
- William Rieflin - Self
- Nina Totenberg - Self
- Frank McCourt - Self
- Björk - Self - Musical Guest
- Tom Vilsack - Self
- Julie Andrews - Self - Grimm Colberty Tales
- Neil Young - Himself
- Anderson Cooper - Self (archive footage)
- Anderson Cooper - Self
- Michelle Obama - Self
- Jack White - Self
- Tavis Smiley - Self
- Al Sharpton - Self
- Al Sharpton - Self (archive footage from Rosa Parks funeral)
- George Saunders - Self
- Carl Wilson - Self - Guest
- John McCain - Self
- Elvis Costello - Self
- John Legend - Self
- Grover Norquist - Self
- Thomas L. Friedman - Self
- Lou Dobbs - Self
- Lou Dobbs - Self (archive footage)
- Charlize Theron - Self (archive footage from North Country)
- Arianna Huffington - Self
- Arianna Huffington - Self - Guest - The Huffington Post
- Harry Belafonte - Self - Guest
- David Copperfield - Self (archive footage)
- David Gregory - Self
- Bradley Whitford - Self
- Sarah Vowell - Herself
- Helen Thomas - Self
- Keith Olbermann - Self
- John Edwards - Self
- Ken Burns - Self
- Steven Van Zandt - Self
- Ralph Nader - Self
- Gary Hart - Self
- John Oliver - Self
- Andrew Young - Self
- Michael Stipe - Self
- Carl Bernstein - Self
- Michael Smerconish - Self
- Mike Mills - Self
- Peter Buck - Self
- Scott McCaughey - Self
- Bill Berry - Self
- Sarah Palin - Herself
- Jamie Oliver - Himself
- Jeffrey Tambor - Himself
- Lynn Sherr - Herself
- Carol Burnett - Herself
- Robert Plant - Himself
- Walter Isaacson - Himself
- Justin Simien - Himself
- Meredith Vieira - Herself
- Jill Lepore - Herself
- Eva Longoria - Herself
- Alexandra Pelosi - Self
- Alan Dershowitz - Self
- Paul Begala - Self
- Eliot Spitzer - Self
- Michael Jackson - Self (archive footage)
- Martin Bashir - Self (archive footage)
- Mary Elizabeth Donaldson - Self (archive footage)
- Katie Holmes - Self (archive footage)
- David Cross - Russ Lieber (voice) (uncredited)
- David Cross - Self
- Juliet Huddy - Self (archive footage)
- Mike Jerrick - Self (archive footage)
- Saddam Hussein - Self (archive footage)
- Jim Cramer - Self
- Kay Bailey Hutchison - Self (archive footage from Meet the Press 10/24/2005)
- Neil deGrasse Tyson - Self
- Patrick Fitzgerald - Self (archive footage from a press conference 10/28/2005)
- Ken Mehlman - Self (archive footage from Meet the Press 10/30/2005)
- Camilla Shand - Self (archive footage)
- Tom Cruise - Self (archive footage)
- Tom Cruise - Maverick (archive footage)
- Eric Drysdale - Bobby (uncredited)
- Harry Reid - Self (archive footage)
- Bruce Feiler - Self
- Kelly Wallace - Self (archive footage)
- Drew Rosenhaus - Self (archive footage from news conference 11/08/2005)
- Terrell Owens - Self (archive footage from news conference 11/08/2005)
- Juan Gabriel - Self (archive footage , fall from stage)
- Matt Taibbi - Self
- Brian Greene - Self
- Barney Frank - Self
- Barney Frank - Self (archive footage from The Colbert Report 10/27/2005)
- Jerry Mitchell - Self
- Tom Skerritt - Viper (archive footage)
- Lesley Stahl - Self
- Larry Craig - Self (uncredited)
- Charlie Crist - Self
- Jerry Nadler - Self
- Jackie Speier - Self
- Chris Dodd - Self
- Chris Dodd - Self (archive footage)
- Robert F. Kennedy Jr. - Self
- John Dingell - Self
- Judy Woodruff - Self
- Kendrick Lamar - Self
- Seth Rogen - Self
- James Corden - Self
- Barack Obama - Self
- Paul Farmer - Self
- Christopher Nolan - Self
- Sister Rosemary Nyirumbe - Self
- Deanna Storey
- Jim Hoskinson
- Jay Katsir
- Bobby Mort
- Laura Krafft
- Peter Gwinn
- Michael Brumm
- Frank Lesser
- Mark Therrien
- Julia Lipkins
- Kate Sunbury-Shupp
- Rebecca Rosenberg
- Joshua Bell
- Ben Karlin
Tom Skerritt interpreta a Viper (archive footage) en la serie.
Katie Holmes interpreta a Self (archive footage) en la serie.
Jeffrey Tambor interpreta a Himself en la serie.
Stephen Colbert hace el papel de Self - Host.
David Cross interpreta a Russ Lieber (voice) (uncredited) en la serie.
Tom Cruise interpreta a Maverick (archive footage) en la serie.
Tim Robbins hace el papel de Self.
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