- Lee Patrick - Mrs. Endicott
- James Whitmore - Philip Selby
- Florida Friebus - Lois Halsey
- Marion Ross - Ann Bell
- Yvonne Craig - Carolyn
- Sylvia Field - Mrs. Emerson
- Mark Goddard - Peter Montopolis
- Wesley Lau - The Ranger
- Wesley Lau - Lieutenant Crane
- Ellen Corby - Maria
- Abby Dalton - Karen Prescott
- Bruce Gordon - Lt. Spear
- Margaret Hayes - Muriel Girard
- Joan O'Brien - Susan Hudson
- Agnes Moorehead - Elizabeth Marshall
- Bert Freed - Lt. Columbo
- Duncan McLeod - Dave Gordon
- Mimi Walters - Miss Petrie
- Bess Flowers - Woman at Airline Counter (uncredited)
- Larry Blyden - Peter Meinecke
- Betsy von Furstenberg - Susan Jerome
- Paul Mazursky - Danny
- Paul Mazursky - The Waiter
- Paul Mazursky - Reporter
- David White - Charley Frey
- Midge Ware - Edna Flynn
- Amzie Strickland - The Landlady
- Peg La Centra - Mrs. Denham
- Bob Duggan - The Sergeant
- Jean Carson - Donna
- Alan Hewitt - Mr. Fifer
- John Hoyt - Arnold Bellson
- Sandy Kenyon - Eddie
- Fred Beir - Bob Field
- Bobby Driscoll - Fred Forbes
- Ruth Ford - Julie McCormick
- Paul Langton - Dr. Walter Halsey
- Ross Elliott - Dr. Reinecke
- Ross Elliott - Ernie Valentine
- Patty McCormack - Dotty Halsey
- Zachary Scott - Damian Shea
- Diana Lynn - Charlotte Bell Wheeler
- William Bassett - Dr. Roger Waring
- Mona Freeman - Avery Dow
- Arthur Franz - Simon Dow
- Fay Roope - Dow
- Peter Walker - Lieutenant Girard
- Peter Walker - John Jerome
- Vincent Price - Self - Host
- Vincent Price - Michael Seemes
- Doreen Lang - Marge Montopolis
- Barbara Stuart - Claire
- Barbara Stuart - Florence
- Barbara Stuart - Claire Fleming
- Barbara Stuart - Alice Chatillon
- Arthur Batanides - Manny
- William Boyett - Policeman
- Robert Culp - Abel
- Anne Seymour - Emily Bell
- Anne Seymour - Hazel
- Lyle Latell - Hannegan
- Doris Dowling - Madame
- Doris Dowling - Genevieve Benoit
- Joe De Santis - Al Scheuber
- Joe De Santis - Paul Otis
- James O'Rear - Vatsek
- Dane Clark - Dr. Joseph Teague
- Margarita Cordova - Esperanza
- John Hackett - Andrew Glenn
- Everett Sloane - Bartholomew Malthus
- Everett Sloane - Alfred Emerson
- Everett Sloane - Francis Rushmore
- Everett Sloane - Lt. Malotte
- Thomas Nello - Manny
- Thomas Nello - Dan
- Thomas Nello - Tommy
- Pepe Hern - Mercado
- Helene LeBerthon - Carla
- Tony Maxwell - Felipe
- George Brent - Fred Girard
- Tracey Roberts - Claire Bradford
- Tracey Roberts - Buff
- Susan Davis - Jerry
- Berry Kroeger - General Bell
- Berry Kroeger - Commissioner of Police
- Berry Kroeger - Colonel Geraldine
- Berry Kroeger - Bermudez
- Charles Meredith - Judge Bascomb
- Charles Meredith - Gentry
- Hugh Sanders - Lt. Burdick
- Hugh Sanders - Lt. Hallaran
- Hugh Sanders - Edward Bennett
- Vinton Hayworth - Madigan
- Warren Stevens - Jim Powell
- Chet Stratton - Whitman
- Chet Stratton - Joe
- Chet Stratton - Arnold Beschamps
- Dehl Berti - Jerry
- Jerome Cowan - Harry Holmes
- Jerome Cowan - Mr. Vandiver
- June Blair - Colette Dufour
- Erin O'Brien-Moore - Mme. Petit
- Nelson Olmsted - Arthur Chandler
- Nelson Olmsted - Felix McMahon
- Jack Cassidy - David Townsend
- John Alderman - Randolph Marshall
- John Alderman - Edson
- Doris Lloyd - Nora Roberts
- Vanessa Brown - Carol Penn
- Betty Garde - Mrs. Andrews
- Jeff Morrow - John Clayton
- Carol Ohmart - Diane
- Janet Blair - Lisa Townsend
- John Ericson - Ray
- Joan Evans - Blanche
- Cesar Romero - Prince Florizel
- Dan Tobin - Club President
Cesar Romero hace el papel de Prince Florizel.
Vincent Price interpreta a Michael Seemes en la serie.
Doreen Lang interpreta a Marge Montopolis en la serie.
Walter Slezak interpreta a Host en la serie.
Capítulo disponible en las siguientes plataformas:
