- Don Cheadle - Cousin D
- Krysten Leigh Jones - Tasha
- Andre Jamal Kinney - Todd Miller
- Arjay Smith - Reggie
- Tommy Davidson - Lou
- Pat O'Brien - Pat O'Brien
- Orlando Jones - Max Trotter
- Greg Germann - Marcus
- David Faustino - Droobie
- Mo'Nique - Lynette
- Brenda Song - Shannon
- Isaac Hayes - Isaac Hayes
- Mablean Ephriam - Judge Mablean Ephriam
- JoJo - Michelle Cooper
- Karen Malina White - Denise
- Jamil Walker Smith - Skateboarder
- Dan Gilvezan - Marshall
- Sugar Ray Leonard - Sugar Ray Leonard
- Alexa PenaVega - Jill
- Ashton Kutcher - Ashton Kutcher
- Roxanne Beckford - Pregnant Woman
- Marcus Allen - Marcus Allen
- Jules Sylvester - Jules Sylvester
- Danielle Panabaker - Chelsea
- Harry Groener - Dr. Lyons
- Rif Hutton - Guy near Animal Control Center
- Serena Williams - Serena Williams
- Richard Lawson - Bishop
- Christopher Darga - Appliance Man
- Don Franklin - Mr. Diggs
- Phil Reeves - Mickey
- Shaquille O'Neal - Shaquille O'Neal
- Khleo Thomas - Curtis
- Nate Hartley - Samuel
- Amy Hill - Teacher #2
- Dennis Dun - Doctor
- Steven Williams - Lloyd
- Ellen DeGeneres - Ellen DeGeneres
- Michael Cornacchia - Norman
- June Squibb - Nun
- Art LaFleur - Stan
- Sugar Shane Mosley - Sugar Shane Mosley
- Shania Accius - Dosha the Assistant
- Ice Cube - Ice Cube
- Theresa Saldana - Lydia
- Reynaldo Rey - Deacon
- Niecy Nash-Betts - Benita
- Matt Besser - Brad Cooley
- Irma P. Hall - Aunt Liva
- Carter Jenkins - Michael
- Naya Rivera - Donna
- Shar Jackson - Valerie
- Lee Weaver - Schooney
- Dick Butkus - Dick Butkus
- Judith Scott - Patricia
- Phil McGraw - Dr. Phil
- Jay Leno - Jay Leno
- Kristin Herrera - Sophia
- Michael Hitchcock - Father Roger
- Matt Damon - Matt Damon
- Wesley Snipes - Duke
- Kyle Kaplan - David Wasserstein
- Penn Jillette - Penn
- Don Rickles - Don Rickles
- Billy Jayne - Coach
- Charles Barkley - Charles Barkley
- India.Arie - India.Arie
- Denise Dowse - Doctor
- A. Russell Andrews - Deacon
- Raquel Lee - Vanessa's Friend
- Cleavant Derricks - Willie
- Teller - Teller
- Chris Rock - Chris Rock
- Adam Carolla - Adam Carolla
- Flavor Flav - Flavor Flav
- Andrew McFarlane - Michael
- Angela Bassett - Angela Bassett
- Richard Erdman - Frank
- Omarion - Shonte
- Craig Robinson - Wayne
- Carl Gilliard - Mike
- Halle Berry - Halle Berry (uncredited)
- Rhyon Nicole Brown - Chrissie
- Brian Posehn - David
- June Kyoto Lu - Sister Kim
- Nancy Lenehan - Sister Lane
- Hugh Hefner - Hugh Hefner
- Roy Abramsohn - Cowen
- Miguel A. Núñez Jr. - Clyde
- Ashley Monique Clark - Teri
- Janet Hubert - Leora
- Lucy Lawless - Lucy Lawless
- Michael Dempsey - Store Clerk
- Bebe Drake - Mama Lena
- Cleo King - Cheryl
- Davenia McFadden - Molly
- Simbi Khali - Therapist
- Maetrix Fitten - Soccer Dad (uncredited)
- Taylor Lautner - Aaron
- Jascha Washington - Rich
- Paula Abdul - Paula Abdul
- Randy Jackson - Randy Jackson
- Rick Hoffman - Jerry Best
- Wade Williams - Father Cronin
- Steven Gilborn - Mr. Malvert
- Phil LaMarr - Orlando
- Reginald Ballard - W.B.
- Lombardo Boyar - Chuy
- Michael Ralph - Kelly
- Jill C. Klein - Sister Eileen
- Alexis Fields - Adult Bryana
- Chelsea Handler - Doris Flynt
- Lily Goff - Brooke
- Kelly Perine - Friend
- Carlos Mencia - Chuy
- Matt Winston - Airport Official
- Ed Cambridge - Grandfather at Airport
- Daniel E. Smith - Grandson at Airport
- Philip Bolden - Little Boy
- Paul Butcher - Sneezing Boy
- Kate Fuglei - Kristen's Mom
- Meagen Fay - Joan Lefko
- Meagen Fay - Teacher
- Lloren Zeigler - Bryana's Friend
- Luck Hari - Pharmacist
- Luck Hari - Saleswoman
- Erik Walker - Bully
- Nico Woulard - Bully
- Judy Prescott - Tracy
- Jeanine Jackson - Carrie
- Victoria Garcia-Kelleher - Renee
- Jack Ong - Dr. Kim
- David Wells - Man Standing in Queue
- Vikrum Shah - Milkshake Guy
- RuDee Sade - Allison
- Paul Parducci - Coach
- Victor Nelli Jr. - Richard
- Pete Gardner - Doctor
- Cindy Lu - Shannon's Mother
- Cindy Lu - Susan
- Johanna McKay - Ref
- Rashaan Nall - Basketball Player
- Eileen April Boylan - Shannon
- Thomas Vincent Kelly - Police Officer
- Jason Matthew Smith - Cop
- Danielle Nicolet - Cheryl
- Danielle Nicolet - Shirley
- Tzi Ma - Ed
- Emmy Yu - Shannon
- Robert Vito - Brian
- Chad Einbinder - Phil
- John Prosky - Father
- Nick Toth - Alarm Guy
- Billy Crystal - Self
- Troy Curvey Jr. - Rev. Bell
- Gregg Daniel - Funeral Director
- Jesika Reynolds - Antonitta
- Joel McCrary - Ted
- Kinna McInroe - Pat
- Kimberly Brooks - Stevie's Mom
- Faruq Tauheed - Skater
- Reggie Gaskins - DJ
- Ruthie Bram - Sarah
- Lauren Summers - Girl #1
- Jack Donner - Jeremiah
- Howard Mann - Mel
- Garcelle Beauvais - Vicki
- Deborah Dir - Deborah
- Wendy Hammers - Parent #1
- Jan Linder - Parent #3
- Tony Winters - Robert
- Benjamin Brown - Orderly
- Gil Christner - Mazer
- Julanne Chidi Hill - Nurse
- Aria Wallace - Riley
- Aria Wallace - Lara
- Fawn Irish - Leggy Cocktail Waitress
- Carl Reiner - Carl Reiner
- Carl Reiner - Neighbor
- Julie Wittner - Flight Attendant
- Anthony Griffith - M.C.
- Susan Boyajian - Housekeeper
- Keisuke Hoashi - Soccer Dad
- Faith Shin - Soccer Twin
- Mary Boucher - Nun
- Mary Boucher - Sister Arlene
- Mary Boucher - Sister Mary
- Darnell Suttles - Coach
- Joe Guzaldo - Classmate's Parent
- Duane Carnahan - Billy
- Brendan Hill - Kid #2
- Chris J Nelson - Bully
- Guilford Adams - Video Store Clerk
- John Balma - Mr. Grafton
- Rebecca Corry - Marianne
- Matthew Henerson - Salvation Army Santa
- Karen Bankhead - Nurse
- Shane Baumel - Billy
- Charles Robinson - Earl Davis
- Christopher Gerse - Brett
- Anna Maria Horsford - Aunt Sis
- Glynn Turman - Carl
- Kennedy McCullough - Lauren
- Denver Dowridge - Usher
- Allie Carieri - Bird Call Kid
- Ron Fassler - Car Salesman
- Gino Montesinos - Juan the Caddy Salesman
- Dagney Kerr - Teacher Ruth
- Audrey Wasilewski - Kathy Alhorn
- David St. James - Headmaster
- Dan Warner - Coach
- Hannah Leigh - Mandy
- Anthony Skillman - Timmy
- Brian Callaway - Pool Boy
- Jennie Fahn - Pool Lady
- Christian Copelin - Boy #2
- Carla Renata - Mrs. Borsik
- George Clinton - George Clinton
- Daniella Monet - Karen
- Sally Brooks - Sister Patrice
- Sally Brooks - Sister Mary Pete
- Jeris Poindexter - Bum
- Jill Talley - Diane
- Harrison Samuels - Birthday Boy
- Tembi Locke - Mrs. Diggs
- Ryan Napier - Kenny
- Snoop Dogg - Calvin
- Ryan Cutrona - Gym Teacher
- Kate Flannery - Christpher's Mom
- Matt McKenzie - Christopher's Dad
- Jordan Orr - Christopher
- Hunter Allan - Henry
- Justin Martin - School Kid
- Tierra Abbott - Tasha
- Brooke Burke - Reporter
- Dennis Hunter - Stage Manager
- Janel Parrish - Laura
- Vernee Watson-Johnson - Aunt Sis
- Cedric Yarbrough - Monroe
- Chancellor Miller - Norman
- Colby Paul - Drew Benson
- Sam Feuer - Bill Brewer
- Travis T. Flory - Poker Playing Boy
- Shelley Berman - Shelley Berman
- Donna Lynn Leavy - Adrian
- Claudette Roche - Connie French
- Davetta Sherwood - Sherry
- Gus Hoffman - Mason
- Warren Hutcherson - Security Guard
- Khadijah Haqq McCray - Lady
- Giovonnie Samuels - Lady
- Bee-Be Smith - Lady
- Mark Arnott - Teacher
- Liza del Mundo - Ticket Agent
- Nefetari Spencer - Nef
- Nefetari Spencer - P.E. Teacher
- Diane Sellers - Mrs. Ware
- Jane Edith Wilson - Woman
- Scott Atkinson - Burt
- Stephanie Patton - Girl Allergic to Things
- Stephanie Patton - Brooke
- Eric Lange - Tony
- Laivan Greene - Nef
- Paul Lévesque - Triple H
- T.J. Beacom - School Athlete
- Ryan Jinn - Boy
- Abhi Sinha - Aneesh
- Cody Weiant - Girl #2
- Josh Blaylock - Todd
- Loren Freeman - "Mr. Meanie" Martin
- Nicholas S. Morrison - Jason
- Anthony Anderson - Bryan
- Lewis Dauber - Priest
- Sarah Lilly - Piano Teacher
- Steve Austin - Steve Austin
- Mike Coleman - Coach Rogers
- Andrew Lewis Caldwell - Wrestler
- Ellen Woglom - Saleswoman
- Justin Lee - Killa From Manilla
- Mike Batayeh - Man
- Rick Cross - Serge
- Necar Zadegan - Sales Associate
- Joel Weiss - Man
- Sean Shanks - Concert Goer #1
- Doug Williams - Alex - Repairman
- Kiyano La'vin - RoRo
- Windell Middlebrooks - Boogie
- Don Oscar Smith - Animal Control Guy
- David Downing - Father
- Cooper Thornton - Stan
- Clint Culp - Carnie
- Yasmin Spain - Prom Date(uncredited)
- Aaron Grady - DeSean
- Wendle Josepher - Nurse
- Yvonne Farrow - Teacher
- Jernard Burks - Southside
- Pat Finn - Zalinski
- Susan Dalian - Sales Rep
- Jeff Marlow - Photographer
- Chuck Kovacic - Mr. Duft
- Phil Diskin - Rabbi #2
- Roger Marks - Rabbi #1
- Chris Warren - Jason
- Cleavon McClendon - Derek
- Marque Richardson - Tyrone
- Robin Ray Eller - Mrs. Scott
- Rodney J. Hobbs - Mr. Scott
- Bahni Turpin - Kai
- Aree Davis - Mean Friend
- Dan Brinkle - Dan
- Michael Colyar - Man
- Dior Raye - Pam
- Judith Moreland - Customer
- Scott Michael Morgan - Cable Guy
- Philip Anthony Traylor - Nigel
- Creed Bratton - Funeral Home Employee
- David Ursin - Car Mechanic
- Kriss Turner
- Teri Schaffer
- Ken Kwapis
- Bernie Mac
- John Riggi
- Steve Tompkins
Ellen DeGeneres hace el papel de Ellen DeGeneres.
David St. James interpreta a Headmaster en la serie.
Chris Rock hace el papel de Chris Rock.
Matt Damon hace el papel de Matt Damon.
Carl Reiner interpreta a Carl Reiner en la serie.
Don Cheadle interpreta a Cousin D en la serie.
Bernie Mac hace el papel de Bernie 'Mac' McCullough.
Lee Weaver interpreta a Schooney en la serie.
Halle Berry interpreta a Halle Berry (uncredited) en la serie.
Jeremy Suarez interpreta a Jordan Thomkins en la serie.
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