- Michael Boatman - Michael
- Martin Sheen - Martin Goodson
- Denise Richards - Lori
- Cheryl Ladd - Joanne
- Izabella Miko - Mary Kathleen
- Brian Austin Green - Sean
- Sarah Souza - Holly
- Andy Mientus - Andy
- Bob Clendenin - Bob
- Dana Gould - Todd
- Steven Krueger - Ryan Hoggett
- Slash - Lester
- Shel Rasten - Rocker Dude
- Mike Powers - Chad
- Mercedes Mason - Maggie
- Abby Donnelly - Stacy
- Laird Macintosh - Peter
- Alexis Carra - Kelly
- Gina La Piana - Blake
- Christopher Gehrman - Meeting Leader
- Johnny Dowers - Ray James
- Anna Hutchison - Sasha
- Lorin McCraley - Otto
- James Ryen - Travis
- Cee Lo Green - Cee Lo Green
- Lindsay Lohan - Lindsay Lohan
- Nancy DeMars - Bar Patron
- Mikaela Hoover - Daytona
- Kerri Kenney - Mel
- Jay Johnston - Rodney
- Kristen Renton - Allie
- Michael Swan - Victor
- Darius McCrary - Donovan
- Rigo Obezo - Prison Guard
- Alexandra Ella - Athena
- Christine Estabrook - Judy
- Steve Valentine - Dr. Lesley Moore
- Michaela Watkins - Lisa
- Aldo Gonzalez - Ernesto
- James Black - Cleo
- Stephen Monroe Taylor - Wayne
- Ash Williams - Tyler
- Chris Reed - Gene
- Nicole Travolta - Monica
- Bruno Amato - Cop
- Kristine Angela - Sex Therapy Couple
- John Fleck - Dr. Fiedler
- Nadia Bjorlin - Dr. Miller
- Kevin Austin - Pledge
- Michael Chandler - Nice Guy
- Marissa Kai Miluk - Batter's Sister (uncredited)
- Don Stark - Principal
- Marque Richardson - Logan
- Noland Ammon - Batter
- Fredericka Meek - Receptionist
- Greg Cipes - Canvas
- Michael James Bell - Photo Shoot Director
- Laura Keller - Photo Shoot Assistant
- Kenny Ridwan - Dr. Harris (uncredited)
- Kevin Joy - Quinn
- Rebeka Montoya - Carlita
- Tuc Watkins - Jeff
- Davis Desmond - Kid
- Gibson Bobby Sjobeck - Kid
- Brian Posehn - Brian
- Cynthia Sophiea - Manager
- Kamala Jones - Couple Woman #5
- Jason-Shane Scott - Couple Man #5
- Christiann Castellanos - Natalie
- Travis Guba - Couple Man #1
- Heather Joy Sher - Couple Woman #1
- Thomas Crawford - Couple Man #2
- Marypat Farrell - Couple Woman #2
- Leslie Connelly - Couple Woman #3
- Eileen Fogarty - Couple Woman #4
- April Clark - Vicki
- DeForrest Taylor - Steve
- Tony Todd - Prison Guard
- Daniel Issac Alamary - Inmate
- Meredith Salenger - Meredith
- Jen Kober - Little Ed
- Mary K. DeVault - Ginny
- Indira G. Wilson - Kayla
- Carolyn Hennesy - Barb
- Mimi Kennedy - Elaine
- Kate Reinders - Hope
- Amanda Bearse - Rita
- Toby Huss - Tom
- Matt Cedeño - Gonzalo
- Sally Brooks - Karen
- Jason Williams - Handsome Cop
- G. Maximilian Zarou - Bob
- Tom Beyer - Mold Inspector
- Stacy Keach - Ray
- Danielle Bisutti - Kristy
- Rebecca Ann Johnson - Shelley Trahan
- Ken Lerner - Judge
- Brian Palermo - Prosecutor
- Emiliano Díez - Priest
- Schuyler Helford - Sateen
- Bryce Johnson - Mike
- Gregory Marcel - Eric
- Michael Masini - Fireman
- Eddie Shin - Director
- Bob Einstein - Hoffler
- Karen McDougal - Shelly
- Ashley Fink - Donna
- Carla Jimenez - Kim
- Ron Ostrow - Bart
- Jocelyn Ayanna - Missy
- Lynette DuPree - Shonna
- Donnell Turner - Handsome Man
- Jake Rude - Jimmy
- Antonio Todd - Officer Kettles
- Antonio Todd - Guard
- Jim Meskimen - Daniel
- Maxie Solters - Volunteer
- Rodney J. Hobbs - Volunteer
- Marion Ross - Dr. Murphy
- Nate Shelkey - Trivia Master
- Carol Kane - Carol
- Mircea Monroe - Tracy
- Brian Gross - Matt
- Jerry Hauck - Tracy's Dad
- Jennie Kwan - Woman
- Chaley Rose - Barista
- Rizwan Manji - Indian Father
- Richard Moll - Carlos
- Adam Wylie - Winger
- Brian Dare - Crew Member
- Amanda Musso - Gate Agent
- Jay Brian Winnick - Male Interview Subject
- April Audia - Announcer (voice)
- Matt Bush - Kent
- Robert Gant - Dr. Konner
- Jackie Joyner - Nurse
- LeAnn Rimes - Wynona
- Meghan Falcone - Daley
- Seth Coltan - Bruce
- Michael Loftus - $ Man
- Matt Kaminsky - Husband
- Beth Kennedy - Wife
- Kristina Anapau - Erica
- Jeremy Scott Johnson - Dr. Higgins
- John M. Keating - Jack
- Mario Diaz - Prisoner
- Tim Bagley - Zac
- Mark Povinelli - Little Elvis
- Patrick Cox - Bouncer
- Mariko Saito - Contortionist
- Brea Grant - Ellie
- Katherine Von Till - Newscaster
- Katherine Von Till - Crazy Woman
- Shannon McClung - Jack
- Jeff Bowser - Vet
- Michael D'Amore - Vet
- Scott Monahan - College Student
- Kenzie Caplan - College Student
- Laura Bell Bundy - Dr. Jordan Denby
- Ajay Mehta - Sanjay
- Meera Simhan - Mira
- Gina Gershon - Mandy
- Kim Shaw - Vanessa
- Chip Chinery - Jimmy
- Gary Kraus - Burly Man
- Odette Annable - Jamie
- Gail Borges - Judge Reynolds
- Tauvia Dawn - Kiana
- Greta Jung - Quan
- Tiffany Daniels - Janelle
- Brooke Peoples - Janice
- Rachele Brooke Smith - Chelsea
- Briana Lane - Celeste
- Margarita Franco - Woman
- Ron West - Dr. Russell
- George Wyner - Dr. Richter
- John Duff - Bank Security Guard
- Gary Rubenstein - Dr. Jewsenheemer
- Suzanne Whang - Bank Teller
- Lori Hall - Bank Operator Voice
- Angela Landis - Salesgirl
- Masiela Lusha - Molly
- John Ennis - Balloon Guy
- Eugenio Derbez - Eugene
- Duncan Bravo - Hindu Cleric
- Dominic Rains - Mahesh
- Cody Chappel - Worker
- Ana de la Reguera - Livi
- Cheech Marin - Hector
- Soledad St. Hilaire - Carmen
- Tracey Evans - Prison Board Member
- Tracey Evans - Priscilla
- Frederick Keeve - Gay Bar Patron
- Barry Livingston - Stanley
- Barry Livingston - Prison Board Member
- Kevin Dobson - Dr. Cameron
- Carla Gallo - Shannon
- Julia Duffy - Phyllis
- Brooke Lyons - Dr. Everheart
- Jeff Harlan - Richard
- Nikki BreAnne Wells - Amber
- Fred Stoller - Fred
- Bryan Chesters - Harassment Instructor
- Scott Elrod - Tim
- Chasty Ballesteros - Stripper
- Isaiah Mustafa - Paul Wesley
- Louisa Abernathy - Nurse
- Eddie Braun - Bicyclist
- Josh Latzer - Clay
- John Charles Meyer - Jack
- Tiffany Panhilason - Courtney
- Camilla Jackson - Karen
- Don Lake - James
- Jim Turner - Roland
- Shannon Welles - Amelia
- Tom Billett - Cop
- Candace Bailey - Michelle
- Aly Michalka - Lauren
- Brett Zimmerman - Benjamin / Lengerman
- Roy Abramsohn - Jack
- Tiffany Dupont - Jenna
- Phil Abrams - Husband
- Devin Sidell - Wife
- Oscar Magana Jr. - Officer T. Smith
- Kelly Frye - Kayla
- John-Paul Lavoisier - Vance
- Will Harris - Bouncer
- Jesse Mackey - Bouncer
- Robert Maffia - Carl
- Danielle Baker - Stripper
- Jeremiah Benjamin - Homeless Person
- Joe Duffy - Who's Asking, Pussy Face?
- Ginger Gonzaga - Maureen
- Ginger Gonzaga - Vanessa
- John Witherspoon - Will
- T.V. Carpio - Kiri
- Michael Gross - Dr. Randy
- Cedric Sanders - Kwame
- Katherine Bailess - Susie
- Andrew Fromer - Stage Hand
- Elaine Hendrix - Warden Becky Hartley
- Ethan Erickson - Quinn
- Lorna Scott - Secretary
- Nicole J. Butler - Nurse
- Takayo Fischer - Esther
- Dennis W. Hall - Clip Board Man
- Jacqueline MacInnes Wood - Jane
- Ivar Brogger - Mr. Ventura
- Eric Steinberg - Dr. Woo
- Joseph A. Garcia - Guy
- Will Sasso - Jimmy
- Arden Myrin - Paula
- Lance Lim - Milo
- Matt Shea - Mr. Terizian
- Thomas Barbusca - Justin
- Shane Giedraitis - Kid
- Brant Daugherty - Tiffer
- Michele Gomez - Interviewer
- Mitch Silpa - Mr. Hornsby
- Michael Meir Saltzman - Bellman
- Tara Karsian - Phyllis
- Adam Lustick - Vlad
- Suzanne Ford - Doris
- Regi Davis - Dispatcher
- Brandon Morales - Mike
- Carlos Antonio - Dave
- Carla Renata - Angelina
- Paul Rogan - Bobo (voice)
- Paul Rogan - Nigel
- Angela Trimbur - Dillon
- Gloria Garayua - Nikki
- Délé Ogundiran - Claire
- Jill Basey - Shirley
- Tina Ivlev - Tammy
- Lauren Marini - Kimmy
- David Terrell - Cop
- Davenia McFadden - Shirley
- Gilbert Gottfried - Dudley
- Ciara Hanna - Jade
- Andrew Hibbard - Business Man
- Marianne Muellerleile - Dorothy
- DeeDee Rescher - Ellen
- Robin Riker - Terri
- Greg Perrow - Dex
- Ping Wu - Mr. Wangchuck
- Michael Cory Davis - Ballplayer
- Mykayla Sohn - Maisy
- Izabella Alvarez - Myla
- John Henson - Darren
- Angie Simms - Kim
- Ariana Madix - Melanie
- Asante Jones - Officer
- Angelina Assereto - Marissa
- Christine Marzano - Ashley
- Brooke Newton - Eva
- Darnell Suttles - Jerry
- Jeff Doucette - Louie
- Mary-Pat Green - Greta
- Juan Alfonso - Brad
- E.J. Callahan - Sal
- Vee Kumari - Anjali
- Rob Mainord - Lawyer
- Emily Montague - Brianne
- Reggie De Leon - Applicant
- Ben Giroux - Applicant
- Corbin Bernsen - Roger
- Jeff Pierre - Dave Loftus
- Dan Thiel - Jed Zeile
- Joe Roth
Charlie Sheen hace el papel de Charlie Goodson.
Selma Blair interpreta a Kate Wales en la serie.
Shawnee Smith interpreta a Jennifer Goodson en la serie.
Daniela Bobadilla hace el papel de Sam Goodson.
Noureen DeWulf hace el papel de Lacey.
Michael Arden hace el papel de Patrick.
Derek Richardson interpreta a Jack Nolan en la serie.
Barry Corbin hace el papel de Ed.
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