- Melissa Ponzio - Melissa McCall
- JR Bourne - Chris Argent
- Colton Haynes - Jackson Whittemore
- Crystal Reed - Allison Argent
- Crystal Reed - Marie-Jeanne Valet
- Madison McLaughlin - Paige Krasikeva
- Mason Dye - Garrett
- Eaddy Mays - Victoria Argent
- Adam Fristoe - Adrian Harris
- Felisha Terrell - Kali
- Brian Patrick Wade - Ennis
- Max Carver - Aiden Steiner
- Alicia Coppola - Talia Hale
- Todd Stashwick - Henry Tate
- Doug Jones - William Barrow
- Brandon Boyce - Dr. Vandenburg
- Cary-Hiroyuki Tagawa - Katashi
- Max Lloyd-Jones - Chris Argent
- Ivonne Coll - Araya Calavera
- Ivo Nandi - Severo Calavera
- Glenn McCuen - Sean Walcott
- Joseph Gatt - The Mute
- Lily Mariye - Satomi Ito
- Samantha Logan - Violet
- Ashton Moio - Donovan Donati
- Jackson Heywood - Merrick
- Art Kulik - Kassian
- Tonantzin Carmelo - Dark Night
- Zedrick Restauro - Preston
- Daniel Bonjour - Marcel
- Lili Bordán - Colette
- Chris Gann - Driver
- Charles Fathy - Bernard
- Ana Mulvoy Ten - Carrie Hudson
- Neil Napier - Rene
- Froy Gutierrez - Nolan
- Ross Butler - Nathan
- B.J. Clinkscales - Cameraman
- Tanner Stine - Jake
- Benjamin Wadsworth - Alec
- Milissa Sears - Mara
- Jessica Bues - Deputy Morrow
- Sibongile Mlambo - Tamora Monroe
- Brandon Stoughton - Tucker Cornish
- Brad James - Vice Principal
- John Atwood - Math Teacher
- Vince Pisani - Ref
- John Curran - Garrison Myers
- Brian Bascle - Janitor
- Adam C. Edwards - Tyhurst
- Desiree Hall - Jennifer
- Stephen David Calhoun - Marcus
- Joe Knezevich - Omega
- Jamila Thompson - Harley Harlowe
- Jeff Rose - Mr. Martin
- Akeem Smith - Bennett
- Morgan Ayres - Sean Long
- Robert Pralgo - David Whittemore
- Andrea Laing - Kara Simmons
- John Wesley Shipp - Mr. Lahey
- Bianca Lawson - Marin Morrell
- Gage Golightly - Erica Reyes
- Stephen Ford - Matt Daehler
- Caitlin Custer - Heather
- Lauren McKnight - Emily
- Aaron Thornton - Mr. Strauss
- Aaron Thornton - Deputy Strauss
- Anton Starkman - Billy
- Zelda Williams - Caitlin
- Sinqua Walls - Vernon Boyd
- Patrick Gorman - Tolbert
- Patrick Gorman - Elias Stilinski
- Adelaide Kane - Cora Hale
- Vernee Watson-Johnson - Eichen House Attendant
- Matt Shively - Oliver
- Gina Holden - Claudia Stilinski
- Geno Segers - Kincaid
- Skyler Maxon - Corporal Rhys
- Josh Duvendeck - Hayes
- Daniel Sharman - Isaac Lahey
- Jeff Skowron - Briggs
- Nichole Sakura - Rinko
- Brent King - Demarco Montana
- Josh Wingate - Fahey
- Nicole Pulliam - Dr. Wentz
- Lou Ferrigno Jr. - Mr. Haigh
- Catherine Black - Maddy
- Mark Elias - Patrick Clarke
- Dakota Gorman - Kalissa
- Gabriel Hogan - Belasko
- Salvator Xuereb - Mr. Stewart
- Eddie Ramos - Lucas
- Marcy Goldman - Lorraine Martin
- Billy Snow - Phil
- Tom Choi - Ken Yukimura
- Peter Katona - Vadim
- Lexi Ainsworth - Beth
- Lachlan Buchanan - Henri Argent
- Steven Brand - Gabriel Valack
- Maya Eshet - Meredith Walker
- Meagan Tandy - Braeden
- Kelsey Asbille - Tracy Stewart
- Gilles Marini - Sebastien Valet
- Marisol Nichols - Corinne
- Henry Zaga - Josh Diaz
- Benita Robledo - Valerie Clarke
- Jordan Fisher - Noah Patrick
- Rio Mangini - Alex
- Rahnuma Panthaky - Ms. Fleming
- Gabrielle Elyse - Jayden
- Tamlyn Tomita - Noshiko Yukimura
- Mieko Hillman - Deputy Tara Graeme
- Mieko Hillman - Tara Graeme
- Alisha Boe - Gwen
- Taj Speights - Okafur
- Ryan Malgarini - Trent
- McNally Sagal - Lenore
- Jennifer Say Gan - Sandra Hugo
- Mason McNulty - Caleb
- Shelby Steel - Tara Raeken
- Susan Walters - Natalie Martin
- Joey Honsa - Claudia Stilinski
- Pete Ploszek - Garrett Douglas
- John Posey - Conrad Fenris
- Lily Bleu Andrew - Lorilee Rohr
- Meghan McGarry - Lenore
- Seth Gilliam - Alan Deaton
- Brandon Soo Hoo - Jiang
- Christian Taylor - Principal Thomas
- Ellery Sprayberry - Tierney
- Mike C. Manning - Deputy Farrell
- Victoria Moroles - Hayden Romero
- Clayton Froning - Schrader
- Cody Saintgnue - Brett Talbot
- Aaron Hendry - Brunski
- C.J. Hoff - Edgar
- Todd Williams - Mr. Geyer
- Michelle Clunie - Mrs. Finch
- Casey Deidrick - Halwyn
- Rhenzy Feliz - Aaron
- Gonzalo Menendez - Gilberto
- Sloane Avery - Ashley
- Charlie Carver - Ethan Steiner
- Ian Nelson - Derek Hale
- Matthew Del Negro - Rafael McCall
- Michael Hogan - Gerard Argent
- Haley Webb - Julia Baccari
- Orny Adams - Bobby Finstock
- Khylin Rhambo - Mason Hewitt
- Gideon Emery - Deucalion
- Jill Wagner - Kate Argent
- Claire Andrew - Sydney
- Lucy Loken - Quinn Finch
- Andrew Callahan - Gabe
- Jesy McKinney - Kyle
- Rob Mars - Bouncer
- Eric Wallace
- Marty Adelstein
- Liz Gateley
- René Echevarria
- Joseph P. Genier
Tamlyn Tomita interpreta a Noshiko Yukimura en la serie.
Tyler Posey hace el papel de Scott McCall.
Dylan O'Brien interpreta a Stiles Stilinski en la serie.
Holland Roden hace el papel de Lydia Martin.
Shelley Hennig interpreta a Malia Tate en la serie.
Dylan Sprayberry interpreta a Liam Dunbar en la serie.
Linden Ashby interpreta a Noah Stilinski en la serie.
Melissa Ponzio hace el papel de Melissa McCall.
JR Bourne hace el papel de Chris Argent.
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