- Christopher Lloyd - Reverend Jim 'Iggy' Ignatowski
- Christopher Lloyd - Reverend Jim Ignatowski
- Carol Kane - Simka Gravas
- Carol Kane - Simka Dahblitz
- Colleen Riley - Muffie
- Ruth Gordon - Dee Wilcox
- Suzanne Kent - Angela Matusa
- Carlos Palomino - Welterweight Champion of the World Carlos Palomino
- Talia Balsam - Cathy Consuelos
- Ron Rich - Attendant
- John Lehne - Hamlet's Owner
- Taurean Blacque - Policeman
- J. Alan Thomas - Jeff Bennett
- J. Alan Thomas - Jeff Bennett (uncredited)
- Robert Phalen - Tom Jeffries
- William Bogert - James Broderick
- Andra Akers - Rita
- Clyde Kusatsu - Paul
- Paula Victor - Mrs. Hazeltine
- Dolph Sweet - Mr. Caruthers
- Sheila Rogers - Mrs. Caruthers
- Arlene Golonka - Sheila Martin
- Joanna Cassidy - Beverly
- Pierrino Mascarino - Stanley Tarses
- Ellen Regan - Suzanne Caruthers
- Ellen Regan - Suzanne Burns
- Angelo Nazzo - George Wilson
- Sandy Holt - Woman
- Marshall Jay Kaplan - Student (uncredited)
- Joyce Mandel - Woman in Bar (uncredited)
- Woody Eney - INS Agent
- Gail Edwards - Denise
- George Reynolds - Cab Driver
- Rusdi Lane - Rudy
- Rusdi Lane - Waiter
- Scoey Mitchell - Robber
- Chris Barnes - Kid
- Rod Browning - Father
- Mandy Patinkin - Alan
- Tom Selleck - Mike Beldon
- Regina Baff - Ruth
- Richard Foronjy - Nick
- Aharon Ipalé - Ramon
- Herb Vigran - Weldon Manning
- John Dukakis - Goodwin
- Fay Hauser - Nurse
- Jeffrey Tambor - Congressman Walter Griswald
- Susan Heldfond - Jill
- Amanda McBroom - Olivia
- Michele Conaway - Actress
- Susan Kellermann - Greta Gravas
- James Staley - Priest
- Byron Webster - Maitre d'
- Mavis Neal Palmer - Restaurant Patron
- Sherrie Wills - Girl in cab
- Martin Mull - Roger Chapman
- Joey Aresco - Michael Patrese
- Gary Imhoff - Richard
- Rik Colitti - Cook
- Christine Dickinson - Lea
- Michael Hershewe - Jason Nardo
- David Knapp - Spelling Bee Moderator
- Carl Byrd - Crista's Father
- Suzanne Carney - Marilu Hartman
- Hervé Villechaize - Hervé Villechaize
- Rhea Perlman - Zena Sherman
- Joan Hackett - Charlotte Reiger
- Jack Gilford - Joe Reiger
- Ian Wolfe - Old Man in the Hospital
- T.J. Castronovo - Tommy Jeffries
- T.J. Castronovo - Tommy Jeffries (uncredited)
- Margaret Ladd - Miss Stallworth
- Richard Beauchamp - Mechanic
- Tom Ewell - Dr. Richmond
- Robert Picardo - Philip Polevoy
- Mary Woronov - Fran Strickland
- William Callaway - Sandor Kovacs
- Michael Horton - Steven Jensen
- Phil Rubenstein - Wayne Hubbard
- Michael Mann - Peter Nicholson
- Michael Mann - Businessman #2
- Constance Forslund - Janet
- Scott Brady - Inspector Melnick
- James Hong - Wealthy Passenger
- Julie Payne - Sister Number One
- Kres Mersky - Sister Number Two
- Fred Stuthman - Blind Passenger
- Jean Hayworth - The Old Lady
- Nancy Steen - Maid
- Dick Butkus - Party Guy
- Dee Wallace - Joyce
- Lenny Baker - Baschi
- Michael Delano - Don Reavy
- Camila Ashland - Mrs. Sherman
- John C. Becher - Mr. Sherman
- Michael V. Gazzo - Vince
- John Dennis - Maintenance Man
- Barbara Stuart - Mrs. Brennan
- Michael Fairman - John Brennan
- Mary Betten - The Maid
- Shane Butterworth - Tommy
- Philip Coccioletti - John Hannon
- Teresa Baxter - Third Woman
- Edith Fields - Fifth Woman
- Susan Sullivan - Nora Chandliss
- Lee Delano - The Maitre D'
- Maryedith Burrell - The Hatcheck Girl
- Beverly Ross - The Instructress
- John Petlock - Waiter
- John Petlock - Chairman of the Board
- Rodney Saulsberry - Carl (uncredited)
- Richard Derr - Buyer #1
- Peggy Stewart - Buyer #2
- Eric Sevareid - Eric Sevareid
- Warren Munson - Customer #1
- Carl Lumbly - Customer #2
- Priscilla Barnes - Tawny
- Richard Minchenberg - Dwight
- Julie Kavner - Monica Banta Douglas
- Andrew Bloch - The French Waiter
- Harvey Miller - The Attendant
- John David Carson - Kirk Bradshaw
- Michael Pritchard - Kenny
- David Daniel - Bar Patron
- Jill Jaress - Airline Attendant
- Jill Jaress - Sally
- Victor Buono - Mr. Caldwell
- Dick Yarmy - Spencer
- John Eames - The Butler
- Gene LeBell - Referee
- Gene LeBell - The Referee
- Sarina C. Grant - The Casting Director
- James Staszkiel - Producer #1
- Michael DeBartolo - Tony Danza Look-Alike (uncredited)
- Ed. Weinberger - Suicidal Man (uncredited)
- Ed. Weinberger - Producer #2
- Ed. Weinberger - Boxing Fan (uncredited)
- Harvey Vernon - The Guide
- Eileen Brennan - Mrs. McKenzie
- Stephen Elliott - Ed McKenzie
- Louis Guss - Maxie Melcher
- Martha Smith - Mary Snyder
- John Yates - The Airline Pilot
- Myron Natwick - The Maitre d'
- John Considine - Michael Edwards
- Al Ruscio - Dr. Webster
- Jesse D. Goins - Shotgun
- Jon St. Elwood - The Boxer
- Vince Delgado - Referee
- Nicholas Hormann - Businessman #1
- Louise Lasser - Phyllis Bornstein Consuelos
- Louise Lasser - Phyllis Reiger
- Carmine Caridi - Lou-Lou Pantusso
- Carmine Caridi - Lou-Lou
- Jim McKrell - The Passenger
- Iris Korn - Edith Tremayne
- Sam DeFazio - Louie's Lawyer
- Jane Brody - Janine
- Joseph G. Medalis - Edith's Lawyer
- Joe 'Flash' Riley - The Judge
- John Harkins - John Bowman
- Robert Balderson - Mr. Barrett
- Alice Hirson - Woman Customer
- John O'Leary - The Priest
- Bill Wiley - George Givens
- Marcia Wallace - Marcia Wallace
- Dana Halsted - Ms. Lang
- Heather Hobbs - Kid #2
- Al Lewis - Security Guard
- Claire Malis - Cynthia
- Michael McGuire - Mr. Gray
- Clint Young - The Guard
- George Wendt - The Exterminator
- Robin Klein - Karen
- J.P. Bumstead - Guy #1
- Bob Larkin - Guy #2
- Dick Miller - Fergie
- Dick Miller - Ernie the Waiter
- Diane Peterson - Peggy
- Kiva Dawson - The Girl Scout
- Reuven Bar-Yotam - Oumas
- Charles Thomas Murphy - Customer
- Charles Thomas Murphy - Restaurant Patron
- Warwick Sims - James
- G. Rockett Phillips - Todd Bentley
- Cassandra Gava - Desiree
- Robert L. Hughes - Waiter
- Patch Mackenzie - Woman on Plane
- Danny Nero - Diner (uncredited)
- Barry Nelson - Dr. Jeffries
- Bernadette Birkett - Doris Marie Winslow
- Wendy Goldman - Lynne
- Martin Short - Mitch Harris
- Melendy Britt - Janine
- Andrea Marcovicci - Emily
- Barbara Babcock - Karen
- Jerry Fujikawa - Itsumi Fujimoto
- Paul Sand - Craig Eagen
- Ernie Hudson - Terry Carver
- John Christy Ewing - Dr. Frazier
- Chuck James - Bill Thompson
- Nat Bernstein - Dr. Stewart
- Howard Gewirtz - Dr. Smith
- Andrew Winner - Dr. Baker
- Allen Williams - Robert
- Noni White - Andrea Stewart
- Stan Rodarte - Doom room friend
- Tony Gaetano - The Waiter
- Charlayne Woodard - Nina Chambers
- John Mengatti - The Boy
- Audrey Berindey - The Girl
- Rebecca Holden - Christina Longworth
- Joel Brooks - Nick Dwyer
- John Calvin - Doug Blakely
- Mark Harrison - Mr. Booth
- Rebecca Clemons - Mrs. Booth
- Candi Brough - Candi Moratta
- Randi Brough - Randi Moratta
- Alex Rodine - The Maitre D'
- Walter Olkewicz - Tom Caldwell
- Walter Olkewicz - Tom
- Ted Danson - Vincenzo Senaca
- Jimmy Lennon Sr. - Ring Announcer
- Jimmy Lennon Sr. - Jimmy Lennon (uncredited)
- Jimmy Lennon Sr. - Announcer
- Jimmy Lennon Sr. - The Ring Announcer
- Ian Praiser - Soap Opera Actor (voice) (uncredited)
- Ian Praiser - Dr. Harmon
- Gela Nash - The Receptionist
- Sam Scarber - The Video Installer
- Karen Anders - The Drunk Woman
- Sari Price - The Customer
- Torill - Woman #2
- Marcia Wolf - Woman #3
- Eugene Jackson - Cabbie (uncredited)
- Paul LeClair - Man in Beauty Salon (uncredited)
- Bubba Smith - Lucius Franklin
- Naomi Stevens - Aunt Lucia
- Fran Ryan - Mrs. Elizabeth Weber
- Nina van Pallandt - Lindsay
- Robert G. Denison - Earl
- Joyce Brothers - Dr. Joyce Brothers
- Vincent Schiavelli - Reverend Gorky
- Peter Elbling - Mascha
- Charles Cioffi - Frank
- Anthony Eldridge - Boy #1
- Wendell Wright - Policeman
- Wendell Wright - Sam
- Tom Hanks - Gordon
- J. Pat O'Malley - Tom
- Wendy Phillips - Heather
- Eugene Roche - Jack
- Matthew Faison - Mr. Thompson
- Melanie Gaffin - Jennifer
- David Mendenhall - Jason
- Max Wright - Mr. Ambrose
- Anne DeSalvo - Vicki De Stefano
- Murphy Cross - Judy Griffith
- Carlene Watkins - Susan McDaniel
- Al Rosen - Cabbie (uncredited)
- Al Rosen - Cabbie
- Dick Sargent - Attorney John Bickers
- F. William Parker - Judge Herring
- Santos Morales - Perez
- Richard Monahan - Winslow
- Anthony Charnota - The Stickman
- Christopher Maher - The Indian
- Keone Young - The Japanese Man
- Carolyn DeMirjian - The Large Lady
- Allyce Beasley - Cindy Bates
- Allen Garfield - Mr. Ratledge
- Martin Garner - The Cabbie
- Matthew Laurance - Allen
- David Paymer - Ned
- Caren Kaye - The Beautiful Actress
- Brian Robbins - Young Man
- Kerry Noonan - Young Woman
- Charlie Stavola - Bartender (uncredited)
- Donnelly Rhodes - Angelo Banta
- Wallace Shawn - Arnie Ross
- Wallace Shawn - Arnie
- Mark Blankfield - Zifka
- Peter Jurasik - Tom Pelton
- Jim Pollack - The Man at Table
- Patrick 'Grampy' Davis - Gramps
- Hillary Carlip - The Fruitcake
- Gayle Hunnicutt - Mrs. Bascombe
- Lois de Banzie - Mrs. Gwinn
- Peter Frechette - Scott
- Paul Napier - Mr. Blount
- Robert Moberly - Waiter
- Robert Moberly - The Waiter
- Nelson Welch - Mr. Parker
- Penny Marshall - Penny Marshall
- Judith Marie-Bergan - Shawn
- John Hancock - Dr. Brandon
- Michael Alldredge - Todd
- Brad Kesten - Bulldog Greg
- Michael Saucedo - Johnny DeCeo
- Martin Azarow - Armed-wrestling Cabbie
- Cathie Shirriff - Diane Mckenna
- David Young - Dr. Gordon
- Wendy Jewell - Woman Cabby
- Keenan Wynn - Leo Goodman
- Charles Bouvier - Customer
- William Hootkins - Liquor Authority Agent
- Peter Iacangelo - Inspector Donovan
- Rose Marie Klespitz - Pretty Blonde
- Sharon Madden - Nun
- Scatman Crothers - Walt
- Tom Villard - Cartoonist
- Tracey Walter - Panhandler
- Howard Witt - Immigration Officer
- Barton Dean
- Michael J. Leeson
- Holly Holmberg Brooks
- Dennis Danzinger
- Ellen Sandler
- Earl Pomerantz
- Stan Daniels
- James L. Brooks
- Ken Estin
- Glen Charles
- Les Charles
- Eileen Brennan
- Bob James
Naomi Stevens hace el papel de Aunt Lucia.
Martin Short interpreta a Mitch Harris en la serie.
Stephen Elliott interpreta a Ed McKenzie en la serie.
Tom Hanks interpreta a Gordon en la serie.
Jeffrey Tambor interpreta a Congressman Walter Griswald en la serie.
Joanna Cassidy interpreta a Beverly en la serie.
Vincent Schiavelli interpreta a Reverend Gorky en la serie.
Michael V. Gazzo interpreta a Vince en la serie.
William Hootkins interpreta a Liquor Authority Agent en la serie.
Allen Garfield interpreta a Mr. Ratledge en la serie.
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