- Tanuj Mahashabde - Krishnan Subramaniam Iyer
- Jheel Mehta - Sonalika Aatmaram Bhide (Sonu)
- Palak Sidhwani - Sonalika Aatmaram Bhide (Sonu)
- Nirmal Soni - Dr. Hansraj Baldevraj Hathi
- Kavi Kumar Azad - Dr. Hansraj Baldevraj Hathi
- Ambika Ranjankar - Komal Hansraj Hathi
- Kush Shah - Gulabkumar Hansraj Hathi (Goli)
- Gurucharan Singh - Roshan Singh Harjeet Singh Sodhi
- Laad Singh Maan - Roshan Singh Harjeet Singh Sodhi
- Balwinder Singh Suri - Roshan Singh Harjeet Singh Sodhi
- Jennifer Mistry Bansiwal - Roshan Daruwala Kaur Sodhi
- Samay Shah - Gurucharan Singh Sodhi (Gogi)
- Ghanashyam Nayak - Natwarlal Prabhashankar Undhaiwala (Nattu Kaka)
- Azhar Shaikh - Pankaj Diwan Sahay (Pinku)
- Shyam Pathak - Patrakaar Popatlal Bhagwatiprasad Pandey
- Tanmay Vekaria - Bagheshwar Dadukh Undhaiwala (Bagha)
- Bhavya Gandhi - Tipendra Jethalal Gada (Tapu)
- Sunayana Fozdar - Anjali Taarak Mehta
- Dilkhush Reporter - Roshan Daruwala Kaur Sodhi
- Sharad Sankla - Abdul Nawab Miyaa
- Sachin Shroff - Taarak Mehta
- Mayur Vakani - Sundar
- Kiran Bhatt - Nattu Kaka
- Rakesh Bedi - Taarak’s Boss
- Nitish Bhaluni - Tipendra Jethalal Gada (Tapu)
- Daya Shankar Pandey - Inspector Chalu Pandey
- Monika Bhadoriya - Bawri Dhondulal Kanpuria
- Navina Wadekar - Bawri Dhondulal Kanpuria
- Munmun Dutta - Babita Krishnan Iyer
- Harshad Joshi
- Raju Odedra
Dilip Joshi hace el papel de Jethalal Champaklal Gada.
Disha Vakani interpreta a Daya Jethalal Gada en la serie.
Raj Anadkat interpreta a Tipendra Jethalal Gada (Tapu) en la serie.
Amit Bhatt hace el papel de Champaklal Jayantilal Gada.
Shailesh Lodha hace el papel de Taarak Mehta.
Neha Mehta interpreta a Anjali Taarak Mehta en la serie.
Nidhi Bhanushali interpreta a Sonalika Aatmaram Bhide (Sonu) en la serie.
Tanuj Mahashabde hace el papel de Krishnan Subramaniam Iyer.
Mandar Chandwadkar hace el papel de Aatmaram Tukaram Bhide.
Sonalika Joshi hace el papel de Madhavi Aatmaram Bhide.
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