- Sonalika Joshi - Madhavi Aatmaram Bhide
- Jheel Mehta - Sonalika Aatmaram Bhide (Sonu)
- Palak Sidhwani - Sonalika Aatmaram Bhide (Sonu)
- Nirmal Soni - Dr. Hansraj Baldevraj Hathi
- Kavi Kumar Azad - Dr. Hansraj Baldevraj Hathi
- Ambika Ranjankar - Komal Hansraj Hathi
- Kush Shah - Gulabkumar Hansraj Hathi (Goli)
- Gurucharan Singh - Roshan Singh Harjeet Singh Sodhi
- Laad Singh Maan - Roshan Singh Harjeet Singh Sodhi
- Balwinder Singh Suri - Roshan Singh Harjeet Singh Sodhi
- Jennifer Mistry Bansiwal - Roshan Daruwala Kaur Sodhi
- Samay Shah - Gurucharan Singh Sodhi (Gogi)
- Ghanashyam Nayak - Natwarlal Prabhashankar Undhaiwala (Nattu Kaka)
- Azhar Shaikh - Pankaj Diwan Sahay (Pinku)
- Shyam Pathak - Patrakaar Popatlal Bhagwatiprasad Pandey
- Tanmay Vekaria - Bagheshwar Dadukh Undhaiwala (Bagha)
- Bhavya Gandhi - Tipendra Jethalal Gada (Tapu)
- Sunayana Fozdar - Anjali Taarak Mehta
- Dilkhush Reporter - Roshan Daruwala Kaur Sodhi
- Sharad Sankla - Abdul Nawab Miyaa
- Sachin Shroff - Taarak Mehta
- Mayur Vakani - Sundar
- Kiran Bhatt - Nattu Kaka
- Rakesh Bedi - Taarak’s Boss
- Nitish Bhaluni - Tipendra Jethalal Gada (Tapu)
- Daya Shankar Pandey - Inspector Chalu Pandey
- Monika Bhadoriya - Bawri Dhondulal Kanpuria
- Navina Wadekar - Bawri Dhondulal Kanpuria
- Munmun Dutta - Babita Krishnan Iyer
- Harshad Joshi
- Raju Odedra
Dilip Joshi hace el papel de Jethalal Champaklal Gada.
Disha Vakani interpreta a Daya Jethalal Gada en la serie.
Raj Anadkat interpreta a Tipendra Jethalal Gada (Tapu) en la serie.
Amit Bhatt interpreta a Champaklal Jayantilal Gada en la serie.
Shailesh Lodha interpreta a Taarak Mehta en la serie.
Neha Mehta interpreta a Anjali Taarak Mehta en la serie.
Nidhi Bhanushali interpreta a Sonalika Aatmaram Bhide (Sonu) en la serie.
Tanuj Mahashabde interpreta a Krishnan Subramaniam Iyer en la serie.
Mandar Chandwadkar interpreta a Aatmaram Tukaram Bhide en la serie.
Sonalika Joshi interpreta a Madhavi Aatmaram Bhide en la serie.
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