- Loren Avedon - Dennis Wiggins
- Robb Derringer - Logan Spencer
- Josh Henderson - Raine
- Darryl Chan - Chang
- Barry Bostwick - Governor Gary McNamara
- Dee Wallace - Daphne (as Dee Wallace Stone)
- Noelle Evans - Woman #1
- Jennifer Siebel Newsom - Woman #2 (as Jennifer Siebel)
- Joshua Malina - Jimmy Onassis
- John Rubinstein - Senator Thomas Jefferson Mitchell
- George Wyner - Barry Sharpman
- Shane Edelman - Director
- Dwight Hicks - Ed Sharlock
- Dawn Stern - Actress Playing Shane Phillips on Movie Set (uncredited)
- Mim Drew - Katya
- Mindy Sterling - Ylva Gallo
- Karen Huie - Ming
- Osgood Perkins - Karg
- Henry Gibson - Dr. Meelbow
- D'Mitch Davis - Clebert
- Mark Kelly - Bart
- Richard Keats - Butler
- James DiStefano - Augusto Martini
- Gonzalo Menendez - Miguel (uncredited)
- Renee Olstead - Amy Divornak
- Costas Mandylor - Mica Divornak
- Louis Mandylor - Leo Divornak
- Michael Des Barres - Dr. Zirby
- Dylan Neal - Dr. Ellison
- Shaun Toub - Joshua Bick
- Zack Ward - The Thin Man in Black
- Sam Ayers - Big Butt Guard
- Nora Zehetner - Ashley Blaine
- Ray Wise - Ambassador Blaine
- Donald Gibb - Scarface
- Sam Witwer - Jason
- Marcia Moran - Cocktail Waitress (uncredited)
- Molly Morgan - Anarchist (uncredited)
- Andy Rolfes - The Icelandic Man (uncredited)
- Derek Mears - Hairy (uncredited)
- Stephen Snedden - Scott 'Jammer' Barnes
- Keith Szarabajka - Liev Schrieber
- Thomas F. Wilson - Roger 'Rush' Gibson
- Matt Winston - Mel Hoover
- Rhomeyn Johnson - Guy
- Paul Hayes - Guy
- P.J. Marino - Cheesy Guy
- Masi Oka - Guy
- David Raibon - Guy
- John F. Schaffer - Guy
- Robert Alonzo - Ninja #4 (uncredited)
- Diane Hudock - Alysia the Dental Hygenist
- Helen Eigenberg - Agent Beth Wright
- Jon Polito - Edward Malloy
- Todd Stashwick - Agent Trent Kimbrell / The Ice Man
- Jeff Dunham - Elvis Presley Ventriloquist
- Stephen Furst - Mr. Washman / Dental Patient
- Sybil Temchen - Sara Hills
- Jsu Garcia - Antonio Ronoso
- Donna Pieroni - Woman
- Donna Pieroni - Customs Agent
- Stephen Nichols - Kurt Maxim
- Julie Benz - Elaine
- Claudia Christian - Tanya
- Cynthia Beckert - Phillis
- Sonny Mandal - Prince Yuri
- Priscilla Barnes - Warden Stoop
- Dot-Marie Jones - Leon
- Edith Grant - Guard (as EdieMay Grant)
- Annabelle Milne - Female Prisoner
- Liz Coke - Cohort
- Spice Williams-Crosby - Prison Crone #1 (uncredited)
- John Fleck - Martin Bardham
- Brody Hutzler - Brad Cummings
- Andrew Hawkes - Thug / Stanley
- Bryan Friday - Agent #1 / Thug #2 (uncredited)
- Tamara Davies - Natalie
- Liam Waite - Phillip Ascot
- Paul Schackman - Murray Fishman
- Abner Genece - FBI Agent
- Lou George - Vendor (uncredited)
- Ryan Stockstad - Vendor (uncredited)
- Pat Destro - Dr. Danielle Kay
- Elizabeth Bogush - Amy
- Jim Golden - Bartender
- Chris Torres - La Puma (uncredited)
- Jason George - Sammy August
- Jim Pirri - Craig Zinn
- Troy Blendell - Neil Gordon
- Branton Box - Roto Man (as Branton Boxer)
- Lisa Thornhill - Peggy
- Erik Betts - Capman
- Erik Betts - Lead Thug (uncredited)
- Erik Betts - Thug #3 (uncredited)
- Erik Betts - Ninja #1 (uncredited)
- Erik Betts - Henchman (uncredited)
- Eva La Dare - Woman (as Karen Dyer)
- Rick Cramer - Mueller
- Bill Chott - Carter
- David Rasche - Norton Andrews
- Nautica de la Cruz - Secretary
- Petra Sprecher - Secretary (uncredited)
- Hunter Tylo - Dr. Marks / Andres Sarlin
- Tony Crane - Dr. Sidney Fine
- Fritz Coleman - Self
- David Eckstein - Self
- Adam Kennedy - Self
- Fred Roggin - Self
- Stuart Scott - Male Doctor
- Brooke Burns - Nicki Shields
- Jeffrey Combs - Indigo
- Michael Bailey Smith - Lucus Winter
- L. Sidney - Head Guard
- Elizabeth DeCicco - Model (uncredited)
- Musetta Vander - Dr. Weiland
- Mark Kubr - Henchman (uncredited)
- Mark Kubr - Bleacher Man (uncredited)
- Christina Cox - Margo
- Hari Dhillon - Deepak Shoenstein
- Tony Denison - Arthur Nagin
- Samantha Eggar - Huffy English Woman
- Kylie Delre - Mother
- Randall Batinkoff - James Green
- Danny Woodburn - Bob the Sky Marshal
- David DeLuise - The Jeff
- Shelley Malil - Doctor
- Austin Nichols - Fake College Guy
- David Bickford - Teacher
- Tom Bailey - Headset Man
- Carmen Filpi - Elderly Man
- Christopher Michael - Security Guard
- Beverly Polcyn - Old Woman
- Matt Raftery - Todd
- Rory Thost - Robby
- Elle Alexander - Instructor (uncredited)
- Elle Alexander - Secretary (uncredited)
- Elle Alexander - Female Guard (uncredited)
- Carlos Jacott - Jack Wilde
- Charles Shaughnessy - Henry Harrington
- Alimi Ballard - Kelly Sawyer
- Aaron Lustig - Dr. McDonald
- James Lew - Asian Thug / Bodyguard (uncredited)
- Daniel Quinn - Daniel Kovak
- Judith Montgomery - Mother Superior
- Pepper Sweeney - John Miller
- Buddy Sosthand - Prison Guard
- Hans Raith - Drug Lord Hitman (uncredited)
- Deprise Brescia - Anya Dassi / Justine Navarro (as Déprise D. Brescia)
- Deborah Zoe - Erin Weiss
- Rebecca Grant - Athena
- Edward Atterton - Nicholas Largent
- Patrick St. Esprit - Dallas Dassi
- Mitzi Kapture - Charlotte Hill
- Nicole Vanderhoff - Assistant
- Victoria Hoffman - Alice White
- Abigail Revasch - Margaret
- Jaime Gomez - Carlito Rodriguez
- Evan Marriott - Barry Michaels / Jordan Taft
- Daniel Arrias - Trashman
- Daniel Arrias - Terrorist (uncredited)
- Bob Papenbrook - Eli
- Don Franklin - Evan Harris
- Henry Polic II - Michael Osborne
- Daamen J. Krall - Yuri Sarkov (as Daamen Krall)
- David Chokachi - Gordon Braddock / Cable Guy
- Edward Conna - Rent-a-Cop (as Eddie Conna)
- Alexandra Paul - Christine Black
- Michelle Holgate - Cheryl
- Marshall R. Teague - Phoenix (as Marshall Teague)
- John Rosenfeld - Weber
- Brad Hawkins - Josh Townsend
- Ben Hernandez Bray - Digger (as Ben Bray)
- Jeff Henry - Lt. Bradford
- Pamela Bowen - Erica Pierce
- Faith Minton - Jolene
- Phina Oruche - Female Guard
- Jack Conley - John Marshall
- Daniel Zacapa - Warden Antista
- Shaun Duke - Bar Owner
- Pasha D. Lychnikoff - Bar Manager
- John Reilly - Karl Richmond
- Ryan Alosio - Terrence McConnough
- Brian McGovern - Mark Davis
- Jason Blicker - Garrett Collins
- Roz Witt - Roz
- Bruce Boxleitner - The Chairman
- Bruce Boxleitner - The Chairman (uncredited)
- Terence Bernie Hines - John Dalton
- Bru Muller - Guard
- Greg Sproles - Rugby Player
- Shaun Robinson - TV Broadcaster
- Joan Severance - Lauren Drake
- Serena Scott Thomas - Mrs. Porter
- Donna Bullock - Mrs. Cummings
- Jason Carter - Morgan Porter
- Jeffrey Meek - Jonathan Drake
- Michael Young - Tony Lawrence
- Nicholas Guest - Dane
- Luis Garcia - Zavalla
- Greg Wendell Reid - Tech
- Greg Wendell Reid - Federal Agent
- Edward Albert - Beck
- Garry Guerrier - Alexi Russack
- Arloa Reston - Hostess
- James Patrick Stuart - Matthew Starlin
- Andrew Bowen - Wade
- Nicholas Guilak - Kassar
- Mark Withers - Security Guard
- Houshang Touzie - Syrian Commando
- D.J. Lockhart-Johnson - Security Guard #2
- Kat Coiro - Natalie / Princess Marina
- Elaine Klimaszewski - Twin #1
- Diane Klimaszewski - Twin #2
- Natalie Lander - Beach Girl
- Nolan North - Peter
- James Leo Ryan - Bleached Guy
- Steve Monroe - Six-Pack
- Travis McKenna - Guard
- Patti Yasutake - Min-Yung
- Susan Blakely - Katherine McBain
- Adetoro Makinde - Station Nurse
- K.T. Thangavelu - Doctor
- Dana Lee - Martin Kim
- Bill Saito - Store Owner
- Kevin Moon - Korean Thief
- Christopher Corey Smith - British Guard
- Rosalie Ward - Avery Mason
- Julie Michaels - Julie
- Jeff Conaway - Zachary Mason
- Marc Senter - Eddie
- Stephanie Arellano - Faux Alejandra Santiago
- Chay Santini - Alejandra Santiago
- Jill Remez - Rosa Gonzalez
- Patrick J. Dancy - Adrian 'A.J.' Matthews
- Richard Yniguez - Pedro Santiago
- Roberto 'Sanz' Sanchez - Head of Security
- Reagan Gomez-Preston - Kanesha Hamilton
- Anthony Cistaro - Dylan Masters
- Joel Swetow - Gerald the Mortician
- Mark Totty - Chet
- Jeff Chase - Giant Morgue Worker (uncredited)
- Wolf Larson - Justin Decker
- Ammar Daraiseh - Assad
- Barry Livingston - Courier
- Kevin Fry-Bowers - Simms
- Ken Moreno - Co-Pilot
- Ashley Yegan - Chloe
- Mark Humphrey - Joseph Baker
- Jordan Orr - Tyler Baker
- Hector Luis Bustamante - Luis Garcia
- Mark Zecca - Mark
- Jennifer O'Dell - Haley Swann
- Vanessa Branch - Kendall Swann
- Katherine Cannon - Galina West
- David Andriole - Trenton Foster Jr.
- Christopher May - Nathan Foster
- Kevin P. Kearns - Paparazzi Mitch
- Cameron Daddo - Quentin Cross
- Scott Mosenson - Victor Turner
- Raymond Fitzpatrick - Daniel Golden
- Kevin Dunigan - Deputy Sheriff
- Saskia Garel - Gina Dominic
- Nicholas Walker - Dr. Brad
- Rana Alamuddin - Kayla
Thomas F. Wilson hace el papel de Roger 'Rush' Gibson.
Vanessa Branch interpreta a Kendall Swann en la serie.
Jon Polito interpreta a Edward Malloy en la serie.
Musetta Vander interpreta a Dr. Weiland en la serie.
Bruce Boxleitner interpreta a The Chairman (uncredited) en la serie.
Natasha Henstridge hace el papel de Cassie McBain.
Kristen Miller interpreta a DD Cummings en la serie.
Natashia Williams hace el papel de Shane Phillips.
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