- Liz Truss - Self
- Joe Lycett - Self
- Gordon Brown - Self
- Theresa May - Self
- Caroline Kennedy - Self
- Jacinda Ardern - Self
- Sheikh Hasina - Self
- Kwasi Kwarteng - Self
- Nicola Sturgeon - Self
- Douglas Henshall - Self
- Matt Hancock - Self
- Uğur Şahin - Self
- David Harewood - Self
- Zachary Quinto - Self
- Ed Miliband - Self
- William Shatner - Self
- Hannah Fry - Self
- Kate Winslet - Self – Actor and producer
- Jimmy Wales - Self
- Stuart Rose - Self
- Justin Welby - Self
- Nicholas Soames - Self
- Brian Cox - Self – Actor
- Grant Shapps - Self – Defence Secretary
- Beeban Kidron - Self - Chair, 5Rights Foundation
- Beeban Kidron - Self
- Liz Kendall - Self – Shadow Work and Pensions Secretary
- Oliver Dowden - Self – Deputy Prime Minister
- Oliver Dowden - Self
- John Kerry - Self – US Special Envoy for Climate
- John Kerry - Self
- Humza Yousaf - Self – First Minister of Scotland
- Valerie Amos - Self – Master, University College Oxford
- Valerie Amos - Self – Former head of the UN's agency relief programme
- Keir Starmer - Self – Leader, Labour
- Keir Starmer - Self
- Keir Starmer - Self - Prime Minister
- Michael Gove - Self – Levelling Up and Housing Secretary
- Michael Gove - Self
- Michael Gove - Self – Levelling Up, Housing and Communities Secretary
- Jaan Tallinn - Self
- David Cameron - Self – Foreign Secretary
- David Cameron - Self
- Rishi Sunak - Self
- Rishi Sunak - Self – Prime Minister
- Simon Sebag-Montefiore - Self – Author and historian
- Simon Sebag-Montefiore - Self
- Iain Duncan Smith - Self
- Iain Duncan Smith - Self – Conservative
- Penny Mordaunt - Self – Former Conservative Leader of the House of Commons
- Jeremy Hunt - Self – Chancellor of the Exchequer
- Jeremy Hunt - Self
- Jeremy Hunt - Self – Shadow Chancellor of the Exchequer
- Rachel Johnson - Self
- Rachel Johnson - Self – Presenter, LBC
- Nadine Dorries - Self – Former Culture Secretary
- Nadine Dorries - Self
- Simon Schama - Self – Historian
- Simon Schama - Self
- Amanda Pritchard - Self – Chief Executive, NHS England
- Michael Mosley - Self – TV Presenter
- Bill Browder - Self – Author and CEO, Hermitage Capital
- Sharon White - Self – Chair, John Lewis Partnership
- Sharon White - Self
- Sharon White - Self – Chair, John Lewis
- Stewart Purvis - Self – Former Chief Executive of ITN
- Timothy Spall - Self – Actor
- Irvine Welsh - Self – Playwright and author
- Susanna Reid - Self – Broadcaster
- Susanna Reid - Self
- Yánis Varoufákis - Self – Former Greek Finance Minister
- Victoria Derbyshire - Self – Presenter and Interviewer
- Victoria Derbyshire - Self – Presenter and interviewer
- Helen Mirren - Self – Actor
- Jon Culshaw - Self – Comedian
- Brian Blessed - Self – Actor
- Alan Cumming - Self – Actor
- Malcolm Rifkind - Self – Former Foreign Secretary
- Naftali Bennett - Self – Former Prime Minister of Israel
- Jeremy Bowen - Self – International Editor
- David Davis - Self – Former cabinet minister
- Jane Moore - Self – Journalist and broadcaster
- Jane Moore - Self – Broadcaster
- Alex Karp - Self – CEO and co-founder, Palantir Technologies
- Michael Howard - Self – Former Conservative leader
- Sarah Snook - Self – Actor
- Michael Grade - Self – Chair, Ofcom
- Sophie Raworth - Self
- Joanna Scanlan - Self – Actor
- John McDonnell - Self – Former Shadow Chancellor
- Lucy Powell - Self - Leader of the House of Commons
- Andrew Mitchell - Self – Shadow Foreign Secretary
- Piers Morgan - Self – Broadcaster
- Piers Morgan - Self – Presenter, TalkTV
- Piers Morgan - Self - Broadcaster
- Simon Reeve - Self – Broadcaster
- Richard Allan - Self – Liberal Democrat Peer and former Facebook executive
- Ralph Fiennes - Self – Actor
- Stephen Fry - Self – writer and comedian
- Stephen Fry - Self – Writer and comedian
- Tracy-Ann Oberman - Self – Actor
- Matt Smith - Self – Actor
- Nigel Farage - Self – Leader, Reform UK
- Nigel Farage - Self - Leader, Reform UK
- Justin Currie - Self – Del Amitri frontman
- Charles Spencer - Self
- Theo Paphitis - Self – Entrepreneur
- Patricia Clarkson - Self – Actor
- Clive Myrie - Self
- Imran Ahmed - Self – CEO, Center for Countering Digital Hate
- Hugh Fearnley-Whittingstall - Self – Chef and campaigner
- Hugh Fearnley-Whittingstall - Self – Chef and broadcaster
- Hugh Fearnley-Whittingstall - Self – Chef
- Hugh Fearnley-Whittingstall - Self – Green activist
- Ruby Wax - Self – Author and broadcaster
- Steve Coogan - Self
- Steve Coogan - Self – Actor
- Lyse Doucet - Self – Chief International Correspondent
- Chris Packham - Self – Nature presenter and conservationist
- Chris Stark - Self – CEO, Climate Change Committee
- Andy Burnham - Self – Mayor of Greater Manchester
- Andy Burnham - Self – Greater Manchester Mayor
- Nancy Pelosi - Self – Former US House of Representatives Speaker
- Jacqui Smith - Self – Former Labour cabinet minister
- Harriet Harman - Self – Labour
- Harriet Harman - Self – Labour MP
- Tina Brown - Self – Journalist, author and editor
- Dominic West - Self
- Joanna Lumley - Self
- Leonid Volkov - Self – Former chief of staff to Alexei Navalny
- Mikaela Loach - Self – Climate justice activist and author
- Alan Johnson - Self – Author and former Home Secretary
- Amber Rudd - Self – Former Home Secretary
- Peter Mandelson - Self – Former business secretary
- Armando Iannucci - Self
- Armando Iannucci - Self – Writer and satirist
- Kelly Somers - Self - England reporter, BBCSport
- Nicola Benedetti - Self – Director, Edinburgh International Festival
- Kit Harington - Self
- Olivia Washington - Self
- Tom Tugendhat - Self – Conservative leadership candidate
- Ben Whishaw - Self
- Lucian Msamati - Self
- Angela Rayner - Self – Deputy Prime Minister
- Vladimir Kara-Murza - Self – Political activist
- Xand van Tulleken - Self – Doctor and Broadcaster
- Priti Patel - Self – Shadow Foreign Secretary
- Damian Lewis - Self
- Meera Thavosothy
- James Wadell
- Meera Thavasothy
- James Waddell
- Janet McAllen
- Harriet Oliver
- Georgia Bell
- Katharine Sharpe
- Oscar Bentley
- Richard Ashton
- Florence Cook
- Chris Evans
- Kieran McAleer
- Sebastian Parris
- Mike Schwartz
- Chris Evans
- Tim Ashburner
Kate Winslet hace el papel de Self.
William Shatner interpreta a Self en la serie.
Brian Cox interpreta a Self – Actor en la serie.
Steve Coogan hace el papel de Self – Actor.
Patricia Clarkson interpreta a Self – Actor en la serie.
Laura Kuenssberg hace el papel de Self - Presenter.
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