- Cesar Romero - Pat De Carlo
- Peter Falk - Jack
- Stephen Elliott - Mike Dundee
- Abe Vigoda - Old Train Passenger
- Helmut Dantine - Dr. Roland Maradick
- Christopher Plummer - Dick
- Paul Lukas - Captain Lindemann
- J.M. Kerrigan - Pether Flynn
- Thomas Mitchell - Jack Guzzow
- Madeleine Sherwood - Rose
- Larry Gates - Clayman
- Vaughn Taylor - Prof. Henry Lempkin
- Rudy Bond - Peter D'Agostino
- Jack Lemmon - Charlie Bemis
- Leo G. Carroll - Bellingham
- Pat O’Brien - Mike Waterson
- Lee Remick - Elaine Bayley
- Arthur O'Connell - Manachi Conners
- Patrick McVey - Mike
- Edward Binns - Joe Doyle
- Orson Bean - Charlie Digger
- Charles Bronson - Cal
- Richard Bright - Ditch
- Boris Karloff - Professor Koernig
- Elsa Lanchester - Jenny Pratt
- Jack Carson - Harry Breen
- Lloyd Bridges - Pike
- Miriam Hopkins - Theresa Durand
- Herbert Marshall - Colonel Beaumont
- Robert Loggia - Lieutenant Joe Crane
- Norman Lloyd - O'Leary
- Miriam Colon - Mrs. Talavera
- Leonard Stone - Detective Farrow
- George Peppard - Kenny Chance
- Patricia Neal - Caroline Mann
- Denholm Elliott - Eric Inwood
- Martin Balsam - Francis Toohey
- Peter Capell - Paul
- Don Fellows - Turney
- Jason Robards - Walter Osgood
- Lois Smith - Lisa Molloy
- Michael Higgins - Sergeant James Sheeley
- Ralph Bellamy - Walter Preston
- Doreen Lang - Clara Breedlove
- James Dean - Hotel Bellboy (uncredited)
- Stanley Ridges - Police Chief Scott Anderson
- Gena Rowlands - Betty
- Eli Wallach - Peter Hendon
- Albert Dekker - Billy Bones
- Jack Palance - Arky
- Natalie Wood - Jen Potter
- Sal Mineo - Dino Manetta
- Jim Backus - Tim McTaggart
- William Shatner - Kenneth Preston
- DeForest Kelley - Bob Philo
- Pat Hingle - Maj. Bergman
- Dennis Hopper - Harry Wales
- Ian Wolfe - Guthrie
- Grace Kelly - Freda Clark
- Otto Kruger - Spencer de Witt Roland
- Worthington Miner
Cesar Romero hace el papel de Pat De Carlo.
Peter Falk interpreta a Jack en la serie.
Stephen Elliott interpreta a Mike Dundee en la serie.
Abe Vigoda hace el papel de Old Train Passenger.
Helmut Dantine interpreta a Dr. Roland Maradick en la serie.
Christopher Plummer interpreta a Dick en la serie.
Paul Lukas hace el papel de Captain Lindemann.
J.M. Kerrigan interpreta a Pether Flynn en la serie.
Thomas Mitchell hace el papel de Jack Guzzow.
Madeleine Sherwood hace el papel de Rose.
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