- Carl Anderson - Ralph
- Patrick Labyorteaux - Richie Yeager
- Veronica Hamel - Vanessa
- Susan Tyrrell - Annie / Isabelle Oates
- Ralph Nelson - Dr. Greene
- Gordon Jump - Vinnie
- Joseph Ruskin - Rodell
- Severn Darden - Mr. Wheeler
- Richard Romanus - Sonny Watson
- John Alvin - Grocer
- Kenneth Tobey - Andy Wilkins
- Dianne Kay - Joanna Haymes
- Melanie Griffith - Julie
- Jean Hagen - Belle Kates
- Michael V. Gazzo - Joe Durniak
- Al Ruscio - Roper
- Philip Michael Thomas - Kingston St. Jacques
- Bill Duke - Officer Dryden
- Edward James Olmos - Julio Gutierez
- Shizuko Hoshi - Mrs. Hong
- Priscilla Barnes - Lisa Kendrick
- Roger E. Mosley - The Baron
- Stan Shaw - Leotis
- Raymond Singer - Emile Parouch
- Lola Albright - Lola Turkel
- Gary Graham - Freddy
- Richard Venture - Hilliard
- Paul Hecht - D.A. Coleman
- Eugene Roche - Dr. George Stegner
- Richard Lynch - Lionel Fitzgerald II
- Lynn Hamilton - Edith Dobey
- Blackie Dammett - Sugar
- Rebecca Balding - Mickie Marra
- Art Hindle - John Colby
- Alex Rocco - Thomas Callendar
- Marc Alaimo - Daimler
- Cliff Emmich - Marshall 'Moo-Moo' Caifano
- Lana Wood - Sidney 'Sid' Archer
- Quinn Cummings - Toni McDermott
- Lynn Borden - Roxy
- Kristy McNichol - Joey Carston
- Morgan Woodward - Clay Zachary
- Dave Shelley - Lee Bristol
- Frank Marth - Dr. Meredith
- Heather MacRae - Debra
- Dan Vadis - Cardwell
- Danny DeVito - John John the Apple / John DeAppoliso
- Peter Brandon - Warren G. Karpel
- Jack Ging - Ray Pardee
- Helen Martin - Vivian Fellers
- Jamie Tirelli - Cabbie
- Herb Voland - Joe Haymes
- Richard Derr - Francis Bacon Stockwood
- Jerry Hardin - Psychiatrist
- Jack DeLeon - Herman Bessinger
- Ann Prentiss - Mrs. Carston
- Michele Carey - Catlin
- James B. Sikking - Ted McDermott
- Carl Weathers - Mitzi Graham
- Linda Kelsey - Ellie Cole
- Dennis Burkley - Eddie Bell
- Charles Napier - Sheriff Joe Tyce
- Charles Napier - John Brown Harris
- R. G. Armstrong - 'Dad' Watson
- Nora Marlowe - Diedre
- John Ritter - Tom Cole
- Allan Miller - Joe Collandra
- John Tuell - Gate Guard
- Karen Carlson - Christine D. Phelps
- Robert Loggia - Ben Forest
- John Carradine - The Professor
- James Hong - Su Long
- Connie Sawyer - Nurse
- Connie Sawyer - Manager
- M. Emmet Walsh - Freddie
- M. Emmet Walsh - Lloyd Herman Eckworth
- Dave Madden - Phil Hill
- Martin Kove - Jimmy Lucas
- Mark Gordon - John Carelli
- Liz Torres - Anita
- Sheila Larken - Nancy Blake
- Roberto Rodriquez - Mike Todesco
- Carmine Caridi - Eberly
- Patricia Pearcy - Gail Harcourt
- Jan Smithers - Sharman Crane
- Mary Jo Catlett - Terrible Tessie
- Robyn Hilton - Miss O'Toole
- Marki Bey - Officer Minnie Kaplan
- Hank Stohl - Police Officer #1
- Lindsay Bloom - Officer Dee O'Reilly
- Liberty Godshall - Katie
- J.R. Miller - Stevie Spencer
- Skip Young - Bartender
- Richard Dimitri - Duran
- Wendell Wright - Officer
- Pat Morita - Jewelry Store Owner
- Anthony Geary - Delano
- Lynne Marta - Helen Carnahan
- Lynne Marta - K.C. McBride
- Lynne Marta - Cheryl Waite
- Bill McKinney - Johnny Bagley
- Mare Winningham - Joey Carston
- Kaz Garas - Eddie Carlyle
- Peter Mark Richman - Avery Schiller
- Sylvia Anderson - Charlie Sireen
- Jon Korkes - Terry Nash
- Connie Hoffman - Orange (as Connie Lisa Marie)
- Susan Gailey - Karen Karpel
- Tom Clancy - Sonny McPhearson
- Quinn K. Redeker - Deputy Police Chief Reasonor
- Quinn K. Redeker - Dr. Melford
- Dale Robinette - J.D. Turquet 'Turkey'
- Jerrold Ziman - Paul Rizzo
- Madison Arnold - Karl Regan
- Lee McLaughlin - Al O'Riley
- Nick Holt - Frankie
- Patrick Wright - Tony
- Gino Conforti - Mickey
- Janet Margolin - Dr. Judith Kaufman
- Jean Allison - Helen Yeager
- Paul Kent - Lt. Anderson
- Walter Mathews - Lt. Jake Donner
- Natalie Norwick - Virginia Donner
- Ernesto Macias - Waiting Man
- James Oliver - Thief
- Jordan Michals - Airport Attendant
- Angelo Rossitto - Big Ben
- Kenneth Menard - Airport Guard
- Tiffany Peters - Magda
- Ron Manning - Tow Driver
- Clint Young - Truck Driver
- Michael Payne - Secretary
- Robert Viharo - Jack Cunningham / John Gallagher
- Toni Kalem - Molly Bristol
- Richard LePore - Frank Carroll
- Jack O'Leary - Joe Garras
- Michael Lerner - Fat Rolly
- Michael Delano - Roger
- Gerry Black - Policeman
- Gerry Black - Sergeant
- Sheila Frazier - Dr. Sammie Mason
- Dorothy Meyer - Mrs. Walters
- Fuddle Bagley - Dewey
- W.K. Stratton - Officer Raymond T. Andrews
- Maurice Sneed - Maurice
- Stan Haze - Train
- Chuck Hicks - Clayborne
- Kenneth White - Hobart
- Mary Steelsmith - Ginger
- Leonard P. Geer - Truck Driver
- Eldon Burke - Gambler
- Victoria Wells - Barmaid
- A. Michael Baldwin - Boy on Dock (uncredited)
- George Loros - Little Huey Chaco
- Richard Karron - Hammerlock Grange
- Susan Heldfond - Melanie
- Sherril Lynn Rettino - Mary (as Sherril Lynn Katzman)
- Taylor Lacher - Hank Ward
- Robert Sutton - Cabot (as Robert Raymond Sutton)
- Deborah Zon - Julie
- Jere Rae Mansfield - Tricia (as Jeri Lea Ray)
- Patricia Wilson - Rachel Tyce
- Lark Geib - Lizzie Tyce
- Floyd Levine - Boyle
- Alex Courtney - Officer Simonetti
- Joanne Strauss - Dr. Morgan
- J. Jay Saunders - Jackson Walters
- J. Jay Saunders - Sgt. Mike
- Suzanne Somers - Jane Hutton
- Suzanne Somers - Sally Ann Sloane
- Suzanne Somers - Linda Offenbecker
- John Saxon - René Nadasy
- Vincent Schiavelli - Weeze
- Paul Bryar - Security Guard
- John J. Fox - Grover
- Christopher Lofton - Kevin Mackey
- Maida Severn - Maggie
- Ed Vasgersian - Mr. Cavanaugh
- Carole Cook - 'Scorchy'
- Darrell Zwerling - Stu Basset
- Darrell Zwerling - Man
- Samantha Eggar - Charlotte
- Craig Stevens - Walter Healy
- Louis Nye - Jerry
- Joan Collins - Janice
- Carl Betz - Father Ignatius
- Jason Bernard - R.C. Turner
- John McLiam - Lionel 'Gramps' Fitzgerald Sr
- Susan Kellermann - Monique
- Freeman King - Danny Deveen
- Ric Carrott - Officer Baker
- Bob Basso - Joseph 'Joe' Riley Benson
- Geoffrey Lewis - Monk
- Peter MacLean - Professor Gage
- Peter MacLean - Judge Raymond McClellan
- Jerome Guardino - M.E. Carboni
- Jerome Guardino - McDevlin, Bus Driver
- Macon McCalman - Officer Bernie Glassman
- Karen Morrow - Mitzi Graham
- Paul Picerni - Patsy Cairo
- Paul Picerni - Johnny Doors
- G.W. Bailey - Slade
- G.W. Bailey - Hotel Clerk
- Arthur Tovey - Toy Store Customer (uncredited)
- LaWanda Page - Lady Bessie
- Garry Walberg - Earl Banks
- Stefan Gierasch - Arthur Fingal Solkin
- David S. Cass Sr. - Shockley
- James Karen - Carter
- Kay Medford - Edna Zelinka
- Will Geer - Commodore Atwater
- Ron Moody - Derek Stafford
- Robert Walden - Marty Simon
- Ed Begley Jr. - Harv Schwab
- Chuck McCann - Larry Horvath
- Chuck McCann - Wally Stone
- Paul Burke - Lt. Ted Cameron
- Frank Converse - Jack Mitchell
- Joan Blondell - Mrs. Pruitt
- Foster Brooks - Drunk Gambler
- George Dunn - Officer O' Keefe
- Joseph R. Sicari - Ernie Silvers
- Audrey Christie - Ginger Evans
- Sherry Jackson - Denise Girard
- Ramon Bieri - Bo Rile
- Joel Fabiani - Alexander Drew
- Bob Harks - Bailiff (uncredited)
- Bob Harks - Guest (uncredited)
- Bob Harks - Restaurant Patron (uncredited)
- Tim Thomerson - Phil
- Charles Cyphers - Arthur Cole
- Charles Cyphers - Medical Examiner Delaney
- Charles Cyphers - Detective Webster
- Barbara Babcock - Ellen Forbes
- Wynn Irwin - Al Taft
- Charlie Picerni - Nicky Cairo
- Charlie Picerni - Thug #1 (uncredited)
- Thayer David - George Felton
- Robert J. Wilke - Mac Johnson
- Rory Calhoun - Steve Hanson
- Read Morgan - 'Blackie'
- Kathleen Miller - Joanne Mello / Linda Williams
- Jeff Corey - Andrew Mello
- Joseph Bova - George
- E.J. André - Jenson
- Robert Nadder - Cook
- Mary-Margaret Lewis - Terry Evers
- Trish Mahoney - Young Woman
- Ben Marino - Phelps
- Bobby Bass - Thug #2 (uncredited)
- Louie Elias - Assassin (uncredited)
- Howard Honig - Chuckles
- Val Bisoglio - James Balford
- Robert Emhardt - Harry Trask
- Leonard Goldberg
- Aaron Spelling
Danny DeVito interpreta a John John the Apple / John DeAppoliso en la serie.
Edward James Olmos interpreta a Julio Gutierez en la serie.
M. Emmet Walsh interpreta a Lloyd Herman Eckworth en la serie.
Carl Weathers interpreta a Mitzi Graham en la serie.
Bill Duke interpreta a Officer Dryden en la serie.
R. G. Armstrong interpreta a 'Dad' Watson en la serie.
Vincent Schiavelli hace el papel de Weeze.
Michael V. Gazzo interpreta a Joe Durniak en la serie.
Robert Loggia interpreta a Ben Forest en la serie.
Michael Lerner hace el papel de Fat Rolly.
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