- Kara Zediker - T'Pau
- Peter Weller - John Frederick Paxton
- Gregg Henry - Zho'Kaan
- Dennis Christopher - Danik
- Wade Williams - Garos
- Becky Wahlstrom - Vissian Cogenitor
- Daniel Dae Kim - Corporal Chang
- William Utay - Vulcan Captain Vanik
- Clancy Brown - Zobral
- Stephanie Niznik - The Wraith
- Clint Howard - Muk
- Keone Young - Hoshi's Father
- Scott Klace - Firek Goff
- Kellie Waymire - Crewman Elizabeth Cutler
- Roxann Dawson - Repair Station Computer (voice)
- Glenn Morshower - MacReady
- Brigid Brannagh - Ruby
- Maury Sterling - Tarquin
- Bruce French - Vulcan Elder
- John Vickery - Prosecutor Orak
- Larry Cedar - Tessic
- Robert O'Reilly - Kago-Darr
- William Lucking - Harrad-Sar
- Guy Siner - Stuart Reed
- Bruce Davison - Menos
- Robert Rusler - Orgoth
- Erick Avari - Jamin
- Aaron Lustig - Guri
- Brian Reddy - Dr. Temec
- Roger Cross - Tret
- Bill Cobbs - Dr. Emory Erickson
- Marina Sirtis - Counselor Deanna Troi
- Paul Wight - Orion Slaver
- Holmes Osborne - Enolian Official
- D.C. Douglas - Zepht
- Marco Sanchez - Corporal Romero
- Kristin Bauer - Lt. Laneth
- Michael Sussman - Dead Crewman
- Lee Arenberg - Ambassador Gral
- Terrell Tilford - Marab
- Golden Brooks - Alicia Travers
- Peter Mensah - Daniel Greaves
- Nicole Forester - Nora
- Zach Grenier - Renth
- Lawrence Monoson - First Officer Matthew Ryan
- Ann Cusack - Maggie
- Robert Pine - Tavin
- Cyia Batten - Navaar
- Brent Spiner - Dr. Arik Soong
- Keith Szarabajka - Damrus
- René Auberjonois - Ezral
- Steven Culp - Major Hayes
- Renée Elise Goldsberry - Crewman Kelly
- Leland Orser - Loomis
- Ethan Phillips - Ulis
- Jessica D. Stone - Narra
- Rudolf Martin - Ravis
- John Cothran - Gralik Durr
- Diane DiLascio - Riann
- Alex Nevil - Menk Man
- Charles Dennis - Chancellor Trelit
- Casey Biggs - Illyrian Captain
- Cullen Douglas - Suliban Soldier
- Brett Rickaby - Yedrin Koss
- Christopher Darga - Klingon Captain Vorok
- Tim Kelleher - Lieutenant Pell
- Leslie Silva - Danica Erickson
- Jane Carr - Mary Reed
- Jeffrey Combs - Commander Shran
- Jeffrey Combs - Krem
- Lindsey Stoddart - Indava
- Sean Whalen - Zoumas
- Padma Lakshmi - Kaitaama
- Emily Bergl - Bethany
- Jonathan Frakes - Commander William T. Riker
- Henri Lubatti - Crewman Ethan Novakovich
- Melinda Page Hamilton - Feezal
- Steven Flynn - Maklii
- Ed O'Ross - Gaavrin
- Larissa Laskin - Calla, Vissian Engineer's Wife
- Julia Rose - Corporal McKenzie
- Tucker Smallwood - Xindi-Primate Councilor
- Christopher Neame - German General
- Harry Groener - Nathan Samuels
- Philip Anthony-Rodriguez - Juan
- Richard Riehle - Dr. Jeremy Lucas
- Julianne Christie - Ah'Len
- Karl Wiedergott - Larr
- Enrique Murciano - Tolaris
- Hank Harris - Jack
- Jordan Lund - Skalaar
- Scott Burkholder - Tagrim
- Joan Pringle - Rianna Mayweather
- Keith Carradine - A.G. Robinson
- Richard Lineback - Kessick
- Paula Malcomson - Madeline Reed
- Andreas Katsulas - Vissian Captain Drennik
- Brian Thompson - Admiral Valdore
- Geno Silva - Senator Vrax
- Annie Wersching - Liana
- Dey Young - Keyla
- Suzie Plakson - Tarah
- Kieran Mulroney - Shaw
- Dean Stockwell - Colonel Grat
- Randy Oglesby - Degra
- Randy Oglesby - Trena'L
- Francis Guinan - General Gosis
- Michael Ensign - Dr. Oratt
- Menina Fortunato - Maras
- David Andrews - Lorian
- Taylor Sheridan - Jareb
- Bonita Friedericy - Rooney
- John Schuck - Antaak
- David Kagen - Major Klev
- Geoff Meed - Dee'Ahn Male
- Mary Mara - Sphere-Builder Presage
- Dan Warner - Officer #2
- Crystal Allen - D'Nesh
- Laura Interval - Veylo, Vissian Tactical Officer
- Kaj-Erik Eriksen - Smike
- Alec Newman - Malik
- Robert Foxworth - Administrator V'Las
- Claudette Sutherland - Maya
- Bobbi Sue Luther - Orion Slave Woman
- Bruce Gray - Surak
- John Harrington Bland - Kov
- John Rosenfeld - Mark Latrelle
- Jeff Kober - Traeg
- Ricky Luna - Carlos
- Dayo Ade - Klingon Tactical Officer
- Michael Nouri - Arev / Syrran
- Diane Klimaszewski - Dancer
- Alexandra Lydon - Jhamel
- Kate McNeil - Commander Collins
- DonnaMarie Recco - Dee'Ahn Female
- Matt Kaminsky - Crewman
- Matt Kaminsky - Cunningham
- Stephen McHattie - Alien Foreman
- Rick Worthy - Jannar
- Sonny Surowiec - German Soldier
- Dayna Devon - N.D. Engineer
- Brad Greenquist - Rigelian Kidnapper
- Brad Greenquist - Captain Khata'n Zshaar
- Michael Krawic - Stron
- Marc Worden - Klingon Prisoner
- Van Epperson - Alien Man
- Patrick Fischler - Mercer
- Larc Spies - Stel
- Abby Brammell - Persis
- Barbara Tarbuck - Chancellor Kalev
- Bruce Thomas - Xindi-Reptilian Soldier
- Elaine Klimaszewski - Dancer
- Josh Holt - Ensign Masaro
- Joel West - Raakin
- Todd Stashwick - Talok
- Dave Power - Ensign Jeffrey Pierce
- Bob Morrisey - Dr. Strom
- Bob Morrisey - Xindi-Reptilian Captain
- Joseph Ruskin - Suliban Doctor
- Gary Kasper - Orion Slaver
- Jim Beaver - Admiral Daniel Leonard
- Joel Swetow - Andorian Ambassador Thoris
- Paul Hayes - Businessman
- Wilda Taylor - Woman
- James Avery - General K'Vagh
- Wayne Grace - Fleet Admiral Krell
- Chelsea Bond - Alien Mother
- Ethan Dampf - Alien Child
- Ron King - Farmer
- James Horan - Humanoid Figure
- Melinda Clarke - Suliban Sarin
- Tommy Lister Jr. - Klaang
- Mark Moses - Henry Archer
- Peter Henry Schroeder - Klingon Chancellor
- Regi Davis - Klingon First Officer
- Mike Baldridge - Dillard
- John Cragen - Crewman
- Drew Howerton - Steward
- Mary Carver - Nadet
- Brian Jacobs - Athan
- Richard Tanner - Vulcan Initiate
- Jamie McShane - Tactical Crewman
- Charlie Brewer - Alien/Akaali #1
- Tom Bergeron - Coridan Ambassador
- Tom Bergeron - Alien Trader D'Marr
- Charles Lucia - Captain Keene
- D. Elliot Woods - Nausicaan Prisoner
- J.G. Hertzler - Advocate Kolos
- J.G. Hertzler - Klingon Captain
- Michael O'Hagan - Captain Fraddock
- Joseph Hindy - Prah Mantoos
- Leonard Kelly-Young - Sonsorra
- Lamont Thompson - N.D. Alien Pilgrim
- Robert Mammana - Engineer
- David A. Kimball - Esaak
- Christopher Rydell - Alien Astronaut
- Granville Van Dusen - Andorian General
- Granville Van Dusen - Klingon Magistrate
- Michelle Bonilla - Bu'kaH
- Seth MacFarlane - Engineer
- Seth MacFarlane - Ensign Rivers
- Matt Malloy - Grish
- Rudolph Willrich - Captain Kuulan
- Gregory Itzin - Admiral Black
- Gregory Itzin - Captain Sopek
- Fionnula Flanagan - Vulcan Ambassador V'Lar
- Dennis Howard - Vulcan Captain
- Stephen Wozniak - Latia Male
- Brandon Karrer - Alien Man
- James Ingersoll - Risan Man
- Conor O'Farrell - Burzaan
- Conor O'Farrell - Pri'Nam D'Jamat
- Danny Goldring - Alien Captain
- Danny Goldring - Nausicaan Captain
- Stephanie Erb - Receptionist
- John Rubinstein - Minister Kuvak
- John Rubinstein - Mazarite Captain
- John Fleck - Silik
- Keith Allan - Suliban Commander Raan
- Michael Kosik - Suliban Soldier
- Clay Wilcox - Billy
- Ron Marasco - Captain Tellus
- Mark Rolston - Kuroda Lor-ehn
- Mark Rolston - Captain Magh
- David Selburg - Vulcan Captain
- Tim Glenn - Med Tech
- Bari Hochwald - E'lis
- Jesse Rutherford - Q'Ell
- Christopher Shea - Sajen
- Christopher Shea - Andorian Captain Telev
- Robertson Dean - Captain Korok
- Wayne A. King - Klingon
- Peewee Piemonte - Klingon
- Stephen Mendillo - Vulcan Captain Tavek
- J. Paul Boehmer - Mestral
- J. Paul Boehmer - SS Agent
- J. Paul Boehmer - Officer
- Richard Wharton - Jossen
- Coleen Maloney - Vulcan Officer
- David Richards - Dockmaster
- Vincent Hammond - Huge Alien
- Dennis Cockrum - Alien Barkeep
- Jason Waters - Soldier
- Morgan H. Margolis - Crewman Baird
- Thomas Kopache - Vulcan Attaché Tos
- Thomas Kopache - The Alien
- Carly Thomas Smith - Alison
- Gary Riotto - Alien
- Ric Sarabia - Alien
- Leland Crooke - Firek Plinn
- Scott Rinker - Pilot
- Scott Rinker - Gareb
- Brian Cousins - Alien Lieutenant
- Sean Smith - Alien Crewman
- Jeff Hayenga - Dr. Yuris
- Lee Spencer - Vulcan Doctor
- Eric Pierpoint - Harris
- Eric Pierpoint - Shiraht
- John Balma - Muroc
- Zane Cassidy - Andorian Soldier
- Michael McGrady - Nausicaan Prisoner
- Brian Morri - Enolian Guard
- Joseph Will - Crewman Michael Rostov
- Steven Allerick - Cook
- Alexander Chance - Crewman
- Valarie Ianniello - Crewman
- Victor Talmadge - Asahf
- Helen Cates - Klingon First Officer
- D.J. Lockhart-Johnson - Cell Guard
- Corey Mendell Parker - Paul Mayweather
- Adam Paul - Nichols
- Ken Feinberg - Alien Captain
- Henry Stram - Hudak
- Mark Chaet - Yolen
- Laura Putney - Trevix
- Jamison Yang - Crewman
- F.J. Rio - Vissian Chief Engineer
- John Short - Drake
- Christopher Wynne - Dr. Moninger
- Paul Anthony Scott - Foster
- Adam Harrington - Researcher
- Mark Chadwick - Male Tarkalean
- Daniel Riordan - Duras
- Bruce Wright - Dr. Fer'at
- Josh Cruze - Captain Ramirez
- Dan Desmond - Klingon Chancellor
- David Figlioli - Klingon Crewman
- Gary Bullock - Klingon Council Member
- Louis Ortiz - Klingon Warrior
- Michael Canavan - Vulcan
- Victor Bevine - Flight Controller
- Chris Freeman - Alien Head Guard
- Nathan Anderson - Sergeant Kemper
- Kenneth White - Engineering Crewman
- J. Michael Flynn - Nijil
- J. Michael Flynn - Mazarite Official
- Ryan Honey - Guard
- Troy Mittleider - Palmer
- Brian J. Williams - Alien Decon Agent
- Nikita Ager - Rajiin
- Steve Larson - Zjod
- Vaughn Armstrong - Admiral Maxwell Forrest
- Vaughn Armstrong - Kreetassan Captain
- Vaughn Armstrong - Captain Maximilian Forrest
- Vaughn Armstrong - Klingon Captain
- Dell Yount - B'Rat
- Philip Boyd - Com Officer
- Adam Taylor Gordon - Young Trip
- Adam Taylor Gordon - Sim Trip at 8
- Ken Lally - Security Guard
- John Eddins - Xindi-Reptilian
- Amir Aboulela - Sloth
- Sam Witwer - Sloth
- Richard Anthony Crenna - Guard
- James Parks - Deputy Bennings
- Steven Klein - Draysik
- Paul Rae - Bartender
- Gary Bristow - Stablehand
- Jeff Ricketts - Keval
- Jeff Ricketts - Alien Captain
- Alexandria M. Salling - Skagaran Girl
- Shane Sweet - Sim Trip at 17
- Maximillian Kesmodel - Sim Trip at 4
- Donna DuPlantier - Prostitute #2
- Christopher Goodman - Thalen
- Vince Grant - Yarrick
- David Youse - Nalbis
- Gregory Wagrowski - Ceris
- Matt Huhn - ND Triannon
- Josh Drennen - Degra's Assistant
- Josh Drennen - Thalen
- Noa Tishby - Amanda Cole
- Paul Eliopoulos - Crewman
- Kipleigh Brown - Taylor
- Tom Schanley - Greer
- Sean McGowan - Corporal Hawkins
- Josette DiCarlo - Sphere-Builder Woman
- Josette DiCarlo - Sphere-Builder
- Scott MacDonald - Commander Dolim
- Ruth Williamson - Sphere-Builder Primary
- Andrew Borba - Xindi-Reptilian Lieutenant
- Gunter Ziegler - Doctor
- Joe Maruzzo - Sal
- Tom Wright - Ghrath
- John Harnagel - Joe Prazki
- Matt Winston - Temporal Agent Daniels
- Steve Schirripa - Carmine
- Jack Gwaltney - Vosk
- David Pease - Technician
- Jim Fitzpatrick - Commander Williams
- Joe Chrest - Bar Patron
- Thom Williams - Klingon Soldier
- Jordan Orr - Young Malik
- Gary Graham - Ambassador Soval
- Gary Graham - Crewman Soval
- Amy Wieczorek - Pilot
- Kevin Foster - Security Guard
- Kris Iyer - Deputy Director of Cold Station 12
- Jack Donner - Vulcan Priest
- Michael Reilly Burke - Koss
- Kristen Ariza - Augment
- Joanna Cassidy - T'Les
- Molly Brink - Lieutenant Talas
- Kevin Brief - Naarg
- Ada Maris - Captain Erika Hernandez
- Derek Magyar - Commander Kelby
- Derek Magyar - Ensign Kelby
- John Mahon - Admiral Gardner
- Pat Healy - Alien Slave
- David Sobolov - Slar (voice)
- Adam Clark - Josiah
- Steve Rankin - Colonel Green
- Johanna Watts - Gannet Brooks
- Christine Romeo - Khouri
- Jasmine Jessica Anthony - Talla
- Mike Fincke - Engineer
- Jonathan Schmock - Alien
- Michael Garvey - Capt. Goroth
- Jeffrey Dean Morgan - Xindi-Reptilian
- Adam Grimes - Lokesh
- Michael Childers - Strode
- Majel Barrett - Defiant Computer (voice)
- Billy Mayo - Officer #1
- Erin Cummings - Prostitute #1
- Erin Leigh Price - Elizabeth Tucker (uncredited)
- Stacie Lynn Renna - Traistana
- Manny Coto
- Brannon Braga
- Rick Berman
- Michael Sussman
- Merri D. Howard
- John Shiban
Holmes Osborne interpreta a Enolian Official en la serie.
Josh Cruze hace el papel de Captain Ramirez.
Joanna Cassidy hace el papel de T'Les.
Jonathan Frakes interpreta a Commander William T. Riker en la serie.
LeVar Burton interpreta a Himself en la serie.
Marina Sirtis interpreta a Counselor Deanna Troi en la serie.
Richard Lineback hace el papel de Kessick.
Robert Foxworth interpreta a Administrator V'Las en la serie.
Christopher Wynne interpreta a Dr. Moninger en la serie.
Dean Stockwell hace el papel de Colonel Grat.
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