- Quincy Brown - Derek Jones
- Luke James - Noah Brooks
- Lance Gross - Maurice
- Miss Lawrence - Miss Bruce
- Michael Michele - Ayanna Floyd
- Gladys Knight - Gladys Knight
- Jacob Crawford - Medic
- Lenny Kravitz - Roland Crane
- Jussie Smollett - Jamal Lyon
- Ashani Roberts - Nakisha
- Juan Pablo Gamboa - Mr. Smith
- Chad Michael Murray - Xander
- Camila Banus - Nina Ferrera
- Marcus Lewis - Brick
- Patricia Williams - Ms. Pat
- Rayven Symone Ferrell - Rachel
- Travis Quentin - Police Officer 2
- Al Sharpton - Rev. Al Sharpton
- Kayla Smith - Olivia
- Kosine - Lil Dini
- Sidney Starr - Dallas
- Trayce Malachi - Jayden
- Sydney Mitchell - Blogger
- Keke Palmer - Gigi
- Kimberly Elise - Dianne
- Imani Lewis - Karen
- Jack Yang - Elliot Wu
- Justin Marcel McManus - Omari
- TJ Jackson - Director
- KaMillion - Meeka
- Elijah Kelley - Andy
- Stephen Dorff - Brody Dean
- Stormy Merriwether - 10 Year Old Gigi
- Jay Amir - Young 9-Year-Old Noah
- Joseline Hernandez - Michelle
- Brook Todd - Nick
- Given Sharp - Fan Girl
- Jasmine Burke - Danielle
- Andrene Ward-Hammond - Juanita Butler
- Chad James Buchanan - Hunter Morgan
- Darius McCrary - Otis Leecan
- John Michael Weatherly - Cop
- Dawn Halfkenny - Hair Dryer Woman
- Déjá Dee - Ruth-Anne Leecan
- Selah Kimbro Jones - Young Simone
- Valerie Payton - Star's Customer
- Jwaundace Candece - Blind Girl Singer
- Bella Lotz - Young Star
- Tyrese Gibson - Pastor Harris
- Naomi Campbell - Rose Crane
- Helena Kallianiotes - Maggie
- David Gridley - Waiter
- Sharlene Taulé - Eva
- Big Boi - Antwan 'Big Boi' Patton
- Robert Crayton - Bouncer
- Mark Oliver - Dr. Klein
- Brandi Cohen - Dr. McKenzie
- Keith Brooks - Leonard
- Chanté Bowser - Nurse
- Wil J. Jackson - Uni Cop
- Tracey Bonner - Attending Physician
- Caroline Vreeland - Mary
- Angie Dillard - Administrator
- Maurie A. Chandler - Sharron
- Tiny Harris - Emcee
- Monet A. Chandler - Karen
- Sasha Sloan - Young Carlotta
- Gustavo Carr - Young Jahil
- Robert Pralgo - Detective Luke Belkin
- John Winscher - Patrol Officer
- Christopher Bencomo - Photographer
- Kaylan Montgomery - Kaylan
- Juanita Jennings - Ruby
- Porsha Williams - Celebrity
- Gabriel 'G-Rod' Rodriguez - Brute
- Kelly Price - Self
- Alex Van - Ed Morgan
- David Martyn Conley - Chief Warner
- Judd Lormand - Officer Lassiter
- Jason Looney - Officer Swiley
- Rickey Smiley - Self
- Rickey Smiley - M.C.
- Brad Burroughs - Construction Worker
- Linda Shane - Salon Hairdresser
- Missy Elliott - Pumpkin
- Rose Bianco - Judge Diaz
- Brad Brinkley - Guard
- Brian Kurlander - Moses Goldblatt
- Jalyn Hall - 6 Year Old Cotton
- Juan Gaspard - Inmate
- Lory Cox - Coroner
- Joel Ware - Tatted Inmate
- Phillip DeVona - Detective Walter Batista
- Wanita "D. Woods" Woodgette - Chantal
- Adam Levinthal - Customer
- Tasia Grant - Prison Nurse
- Almeera Jiwa - Pakistani Wife
- Nealla Gordon - Arlene Morgan
- Nealla Gordon - Charlene
- Ahmed Lucan - Pakistani Husband
- Eugene H. Russell IV - Mark Henson
- Sylvia Jefferies - Yvonne Turner
- Josh Ventura - Van Evans
- Brooke Butler - Lisa
- Levi Burdick - Dr. Berg
- Jonathan D. Williams - Dr. Mitchell
- Liz McGeever - Nurse Mason
- Adelle Drahos - Nurse
- Taylor M. Dooley - Receptionist
- Juliet Kim - Okiko
- Jose Miguel Vasquez - Cop
- Monica - Announcer
- Quinten Johnson - Stage Hand
- Mike Epps - Jay Holland
- Tasha Smith - Carol Hardaway
- Kareem J. Grimes - Omari
- Lee Daniels - Video Director
- Jason-Jamal Ligon - Trans Prisoner
- Trent Walker - Camera Assistant
- Jaxon Rose Moore - Young Girl
- K. Steele - Guard
- Virginia Kirby - Manager
- Darryl L. Dillard - Prison Guard
- Jeremy Michael Grey - Doctor
- Taj-Naranja Jenkines - Inmate
- Evan Ross - Angel Rivera
- Paris Jackson - Rachel Wells
- Izzy Ruiz - Javier
- Leslie Black - Grace
- Steven Reddington - Engineer
- Camrus Johnson - Director
- Jim R. Coleman - Driver
- Raquel Dominguez - Juvie Girl
- Kaira Akita - Therapist
- Jessica Nicole Brown - Fan Girl
- Maria Legarda - PA
- Annie Jacob - Soraya
- Shayla Love - Pastor Boyd
- Timothy Douglas Perez - Camin
- Dior Choi - Fisher
- Richard Roundtree - Charles Floyd
- Suehyla El-Attar - Nasty Guard
- Terayle Hill - Lucas 'Lucky' Keyes
- Kaye Singleton - Boutique Manager
- Teyana Taylor - Joyce Sheree
- Roxzane T. Mims - Judge
- Beth Keener - Executive
- David Kronawitter - Reporter
- Sarah 'So' Oliver - Monique
- Da Brat - Da Brat
- Mystie Smith - Health Department Inspector
- Ethan McDowell - Doctor Taylor
- Caroline Avery Granger - Nurse
- Mariana Novak - Doctor
- Patti LaBelle - Christine Brown
- Julia Vasi - Fan
- Barry Piacente - Doctor
- Camila Perez - Mariela
- Healy Lange - Romona
- Tiffany Dupont - Lena
- Quavo - Quavo
- La La Anthony - Paola
- Keedar Whittle - Blue Mike
- Meagan Good - Natalie Knight
- Susan Gallagher - Mrs. Smith
- Onye Eme-Akwari - DJ Shorty Kool
- Adriyan Rae - Tammi
- Jennifer Sears - Female Student
- Casey Mills - Tattoo Artist
- DJames Jones - Handsome Man
- Chris Gann - Police Officer
- Angela Davis - Director
- Ashley LeConte Campbell - Dr. Fisher
- T. Love - Gonzo
- Valyn Hall - Paparazzi
- Robert Mitchel Owenby - Paparazzi
- Cindy L. Jefferson - US Postal Worker
- Stevie J - DJ Dash
- Terrence 'T.C.' Carson - Jeff Morgan
- Mark Thompson - Doctor
- Giovannie Cruz - Paparazzi
- Meg Gillentine - Officer
- Charlisa Anderson - Nurse
- Valerie Sue Love - Ticketing Agent
- George Bryant II - Driver
- Harold Perrineau - Bobby Brooks
- Alexis Louder - Bianca
- Furly Mac - Mike Mike
- Gissette E. Valentin - Female Cop
- Katerina Eichenberger - Reporter
- Krish Amrahs - Nurse
- Melissa Saint-Amand - Blaire
- Lyndie Greenwood - Megan Jetter
- HeadKrack - HeadKrack
- HeadKrack - DJ
- Terrence J - Ryan J
- Mimi Faust - Drea
- Stevie Baggs Jr. - Kelvin
- Patrick Lamont Jr. - Branded Guy
- Chase Anderson - Conservative Socialite
- Latarsha Rose - Dr. McDonald
- Olivia D. Dawson - Geraldine
- Kenneth Israel - Chris Mackey
- Max Bickelhaup - Police Officer
- Gabrielle Walsh - Detective Maria Montero
- Justin James Boykin - Reporter
- Sarah Stipe - Reporter
- Michelle Pokopac - Reporter
- Draya Michele - Chloe David
- Savanna Renee - Young Mother
- Terrence Shingler - Goon
- Greg Weeks - Jamal
- Gregory Nassif St. John - Kenneth Anderson
- Ebony N Mayo - Woman
- Lando LaRon - Masked Guy
- Ben Vereen - Calvin
- Kelly Sullivan - Becky
- Peter Anaya - Coyote
- Kaleka - Judge
- Kate Schettler - Paramedic
- Shari Headley - Houston Connelly
- Kathleen Hogan - High Powered Lawyer
- Lesa Wilson - Sales Lady
- Kristen Wharton - CPS Worker
- A. Smith Harrison - Dr. Henderson
- Linda Kang - Reporter
- Zulay Henao - Lucia
- Nelson Bonilla - Camillo
- Bill Winkler - Judge Kallenbach
- Dustin Lewis - Councilman
- Rachael Thompson - Lawyer
- Andre De'Sean Shanks - Maurice's Assistant
- Mona Amein - P.A.
- Tammi Mac - Aunt Ginny
- Asha Kamali - Aunt Missy
- Miya Golden - Bully Prisoner
- Tyvonna Jones - DJ
- Rick Ross - Irv Riddick
- Big Tigger - Journalist
- Cynthia Bailey - Tasha Rae
- Jhoni Davis - Young Gigi's Mom
- David Shae - Thomas King
- Breezy Sharp - Paparazzi
- Ashton B Grooms - Dior
- Kia Shine - Leon
- Ben Peck - Doctor
- Maurii Davenport - Female Inmate
- Flaco Reyes - Poster Man
- Eric Croas - AA Leader
- Glenn Magee - Cousin Duke
- Kinyumba Mutakabbir - Randall Lawson
- Derek Krantz - Mark Newman
- MAJOR. - Cousin Rashad
- Erika Tham - Amber
- Skye Passmore - Bartender
- Nicole Ari Parker - Giselle Simms
- Rob Lawhon - Neckbeard
- Aaron Quick Nelson - John
- Tamara Whatley - Reporter
- Daniel Baldock - Tow Truck Driver
- Kimberly Maxwell - Nurse
- Jason Turner - Doctor
- Veanna Black - Paparazzi
- Paige Hullett - Paparazzi
- Angelo Reyes - Process Server
- Fred Hammond - Minister
- Orelon Sidney - Judge
- Dayo Abanikanda - Bankhead Boy
- Charity Hitchcock - Jennifer
- Walter Burch - Speciality extra
- Effie Brown
- Tom Donaghy
- Lee Daniels
- Charles Murray
- Pamela Oas Williams
Benjamin Bratt hace el papel de Jahil Rivera.
Jude Demorest interpreta a Star Davis en la serie.
Brittany O'Grady interpreta a Simone Davis en la serie.
Ryan Destiny interpreta a Alexandra "Alex" Crane en la serie.
Queen Latifah hace el papel de Carlotta Brown.
Amiyah Scott hace el papel de Cotton Brown.
Matthew Noszka interpreta a Jackson 'Jax' Ellis en la serie.
William Levy hace el papel de Mateo Ferarra.
Brandy Norwood interpreta a Cassandra "Cassie" Brown en la serie.
Quincy Brown interpreta a Derek Jones en la serie.
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