- David Davino - Alberto Benitez
- Iva Franks-Singer - Self
- Neil Johnson - Self
- Charles Parker Newton - Neil Johnson
- Michael Power - Jack Tanner
- Michael Urriquia - Nyah Lee
- Gloria Chung - Kay Xiong
- Jo Young - Middle Sherry
- Brian J. Coffey - Andre
- Raymond Mosser - Jessica's Peepaw
- Matt Garafalo - Joseph Sierra, Jessica's Father
- Allen Enlow - Daniel Young
- Jenna Michno - Jessie Cooper
- Rachel Pirard - Young Jessie
- Kimberly Amato - Sandi Musk
- Grant Williams - Andy Lefleur
- William Otterson - Chief David Weatherwax
- William Otterson - David Haley
- J.D. Brown - Tom Donato
- Vanna Pilgrim - Kristin Donato
- Linda Collins - Kristin's Mother
- Jonah Young - George Long
- Nancy P. Corbo - Cheryl Vivier
- Sean Michael Nugent - Jed Waits
- Michele Ann Suttile - Trisha's Friend
- Madonna - Self (archive footage)
- Joseph Covino - Robert Hoskins
- Gabrielle Ryan - Kaity Sudberry
- Anthony Aroya - Kaity's Dad
- Meredyth Kenney - Dawn Krohn Hillyer
- Preston Christopher Lawrence - Richard Ellerbee
- Patrick Noth - Stanley Decker
- Christy Martin - Self
- Hillary Hamilton - Sherry Lusk
- Mona Depena - Deborah Roberts
- Gianmarco Soresi - Young David Richards
- Trent Lamont Miller - Michael Johnson
- Paul Nielsen - Dave Asmussen
- Mischa Ipp - Kathy Haley
- Maria Mercedes Galuppo - Terri Mendez
- Melina Lekkas - Detective Angela Martinez
- Emily Asaro - Catherine McKinney
- Jonathan Iglesias - Simon Gonzales
- Kelly Madan - Simon's Girlfriend
- Ana Cecilia Stieglitz - Linda Smith
- Max Kolby - Linda's Son
- Samantha Steinmetz - Rachel Wilson
- Abigail Friend - Rachel & Darrell's Daughter
- Jamie Josephs - Linda Ricchio
- Dorothy Meyers - Harvette Williams
- Mark Anthony Hackett - Kevin Gary
- Whitney Kimball Long - Amy Johnson
- Nate Steinwachs - Dustin Hall
- Lisa Richardson
Madonna interpreta a Self (archive footage) en la serie.
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