- Bruce Greenwood - Seth Griffin
- Eric Laneuville - Luther Hawkins
- Howie Mandel - Wayne Fiscus
- Kim Miyori - Wendy Armstrong
- Cindy Pickett - Carol Novino
- David Morse - Jack Morrison
- Ed Flanders - Donald Westphall
- Christina Pickles - Helen Rosenthal
- David Birney - Ben Samuels
- Kavi Raz - Vijay Kochar
- Cynthia Sikes - Annie Cavanero
- Nancy Stafford - Joan Halloran
- Denzel Washington - Philip Chandler
- Stephen Furst - Elliot Axelrod
- Stephen Furst - Dr. Elliot Axelrod
- Terence Knox - Peter White
- Terence Knox - Dr. Peter White
- France Nuyen - Paulette Kiem
- France Nuyen - Dr. Paulette Kiem
- Dee Hoty - Dr. Patricia Meldrum
- Paul Linke - Dr. Herb Benzig
- Christopher Guest - H.J. Cummings
- Frances Lee McCain - Mrs. Reinhardt
- David Packer - Willie Andrews
- Helen Page Camp - Mrs. Deangelis
- Molly Cheek - Leslie Stevenson
- Peter Brocco - Thomas Lazarus
- Ray Liotta - Murray
- Harold Gould - Melvin Millstein
- Karen Austin - Dr. Mary Woodley
- Stephen Shortridge - ER Patient
- Ed Lauter - Stan Morgen
- Laraine Newman - Jane Zontell
- Norman Burton - Monsignor Senti
- Jane Wyatt - Katherine Auschlander
- Alan Arkin - Jerry Singleton
- Wil Wheaton - Owen Drimmer
- Richard Gilliland - Tim Fitzsimmons
- Jeannie Elias - Marcy Eisenberg
- Oliver Clark - John Doe #6
- Barbara Tarbuck - Agnes Najinsky
- Anne Haney - Mrs. Clifford
- Rosalind Chao - Mary Wilson
- Nan Martin - Mrs. Stevenson
- Patricia Wettig - Joanne
- Sagan Lewis - Jacqueline Wade
- Sagan Lewis - Dr. Jacqueline Wade
- Lycia Naff - Maddy
- Jennifer Savidge - Lucy Papandrao
- Jennifer Savidge - Nurse Lucy Papandrao
- Steve Allen - Lech oseransky
- Tim Robbins - Andrew Reinhardt
- Lance Guest - Orderly Rooney
- Linda Carlson - Janet Dalton
- Jack Bannon - Stephen MacAllister
- Tim Van Patten - Dean
- Bette Ford - Pat Kroll
- Melinda Culea - McPhail
- Jamie Rose - Dr. Birch
- Rosemary DeCamp - Amy Jeffries
- Jean Bruce Scott - Roberta Sloan
- Peter Maloney - Dr. Burgess
- Kate Mulgrew - Helen O'Casey
- Herb Edelman - Richard Clarendon
- Helen Hunt - Clancy Williams
- Macon McCalman - Henry Judson
- Robert Costanzo - Mr. Broadwater
- Adam Rich - Louis Appleton
- Ramon Bieri - Gene Galecki
- Fran Bennett - Nurse Julie Attucks
- Dick O'Neill - Mr. O'Connor
- Deborah White - Nina Morrison
- Chad Allen - Tommy Westphall
- Rafael Campos - Ramon
- John Schuck - Andrew Wegener
- Florence Halop - Mrs. Hufnagel
- Peggy McCay - Claire Fields
- Richard Marcus - Ralph Selover
- Ann Hearn - Andrea Fordham
- Jonathan Goldsmith - Dr. Julius Markes
- Bruce Wright - Paramedic
- Jeremy Licht - Robbie Durant
- Lois Foraker - Masha
- Paula Hoffman - Caitlin McFadden
- John Dennis Johnston - Nick Moats
- Millie Slavin - Maggie
- Valerie Wildman - Woman in Bar
- Bruce Gray - Col. Harvey Blackwell
- Piper Laurie - Fran Singleton
- John Mahon - Police Officer
- Henry Beckman - Mr. Benville
- Frances Bay - Mrs. Renninger
- Leo Gordon - Bjorn Johnston
- Bob Harks - Restaurant Patron (uncredited)
- Bill Macy - Hershel Millstein
- Joan Hotchkis - Dr. Mary Carlisle
- Penny Santon - Frannie Catalano
- Charles Bouvier - Appliance Repairman
- David Knell - Matthew Brody
- Martin Garner - William Bonwit
- Allyn Ann McLerie - Roxanne Reed
- Jean Allison - Marie Benzinger
- Michael Sharrett - Donald Westphall
- Tom Atkins - Bob Lonnicker
- Anita Gillette - Maureen Westphall
- Earl Boen - Walter Lankau
- Janis Paige - Dee Mackaluso
- Arthur Taxier - Dr. Morton Chegley
- John McIntire - Harry Cragen
- Jeanette Nolan - Sophia Pavlon
- Judith Barsi - Debbie Oppenheimer
- Alan Haufrect - Albert Runneger
- Arlen Dean Snyder - Sidney
- Barbara Perry - Dietician
- Channing Gibson
- John Masius
- Abby Singer
- Tom Fontana
- Bruce Paltrow
- John Falsey
Frances Lee McCain interpreta a Mrs. Reinhardt en la serie.
Alan Arkin interpreta a Jerry Singleton en la serie.
Wil Wheaton interpreta a Owen Drimmer en la serie.
Jane Wyatt hace el papel de Katherine Auschlander.
Tim Robbins interpreta a Andrew Reinhardt en la serie.
William Daniels interpreta a Mark Craig en la serie.
Norman Lloyd hace el papel de Daniel Auschlander.
Ronny Cox interpreta a John Gideon en la serie.
Bonnie Bartlett interpreta a Ellen Craig en la serie.
Ed Begley Jr. hace el papel de Victor Ehrlich.
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