- Michael J. Fox - Mike Flaherty
- Victoria Dillard - Janelle Cooper
- Jennifer Esposito - Stacey Paterno
- Carla Gugino - Ashley Schaeffer
- Carla Gugino - Ashley Schaeffer (archive footage)
- Mark Linn-Baker - Dr. Benjamin
- Marla Maples - Jennifer
- Raúl Esparza - Reporter
- Brian Van Holt - Brent
- Susan Floyd - Lisa
- Meredith Baxter - Macy
- Ed Koch - Ed Koch - The Judge
- Scott Bryce - Jay
- Sam Lloyd - Walter
- Yasiin Bey - Monty
- Jimmy Fallon - Photographer
- Ned Romero - Chief
- Steve Ryan - Fred
- Anthony Mangano - Robber
- Noelle Beck - Kaari the Magician
- Amy Poehler - Susan
- Milo O’Shea - Father Larry
- Deborah Rush - Helen
- Gretchen Mol - Gwen
- George Wendt - Dan Donaldson
- Woody Harrelson - Tommy Dugan
- J. Smith-Cameron - Lisa
- Ken Marino - Dan
- Constance Marie - Gabby
- Luke Perry - Spence Kaymer
- George Stephanopoulos - George Stephanopoulos
- Jorge Garcia - Cabbie
- Queen Latifah - Robin Jones
- David Shatraw - Kyle
- Shawn Christian - Santa Claus
- Martin Sheen - Ray Harris / Ray Crawford
- Nancy Valen - Ashley
- John Francis Daley - Spencer
- Larry Elder - Larry Elder
- Sung Kang - Jordan
- Lydie Denier - Mademoiselle Simone, Paris Delegate
- Bob Gunton - Governor Riley
- Judith Light - Christine
- Michael Gaston - Detective
- Chris Berman - Chris Berman
- Todd Stashwick - Television Director
- Justin Theroux - Pete
- Richard Hamilton - Alfred
- Lorri Bagley - Mitsy
- Jenna Stern - Nina Lawrence
- Peter Krause - Casey McCall
- Carrie Preston - Gayle
- Joseph Sirola - Mario Forcini
- Jon Stewart - Mitch Parker
- Kevin Carolan - Reporter
- Kimberley Davies - Inga
- Geoff Stults - Blake
- Joel McKinnon Miller - George
- Francis Guinan - Priest #2
- Samm Levine - Young Paul
- Eddie McClintock - Robert
- Dakota Fanning - Cindy
- Barry Melrose - Barry Melrose
- Sally Wheeler - Susan
- Kaitlin Hopkins - Anne Bondek
- Branden Williams - Trent
- Alex Kapp - Karen
- Blake Clark - Claremont
- Roy Firestone - Roy Firestone
- Vanessa Marcil - Kara
- Beth Riesgraf - Waitress
- Roger Clemens - Roger Clemens
- Nipsey Russell - Nipsey Russell
- Matt Besser - The Director
- Boomer Esiason - Boomer Esiason
- Julius Carry - Nick Mitchell
- Amy Irving - Lindsay Shaw
- John McMartin - Senator Joseph Grady
- Gordon Joseph Weiss - Homeless Guy
- Christine Taylor - Catherine Moore, Caitlin's Sister
- Star Jones - Star Jones
- Alice Drummond - Sondra Spencer
- James Patrick Stuart - Alex
- Kevin Mambo - Smooth Daddy
- Cody Arens - Kid #1
- Judah Friedlander - Flirtatious Man in Bar
- Michael Gross - Dr. Peterson
- Tom Amandes - Julian Wheeler
- Lori Loughlin - Michelle
- Sam Robards - Arthur
- Deirdre Lovejoy - Reporter
- Peter Jacobson - Greg
- Kathie Lee Gifford - Kathie Lee Gifford
- Geneva Carr - Kathy
- Donald Trump - Donald Trump
- Josh Stamberg - Phil
- David Lee Russek - Stripper
- Karen Shallo - Mourner
- Bray Poor - Yale
- Andy Daly - Payroll Guy
- Kim Dickens - Veronica
- Isaac Mizrahi - Isaac Mizrahi
- Minae Noji - Tai Chi Instructor
- Kathryn Joosten - Sister Agnes
- Sean Whalen - Caitlin's Cousin Stevie
- Elizabeth Mitchell - Nancy Wheeler
- Matt Corboy - Boyfriend
- Amy Jo Johnson - Stephanie
- Diana Kauffman - Victoria's Secret Model
- Pat Kilbane - Pete
- Mark Valley - Joseph Maxwell
- Conan O'Brien - Conan O'Brien
- C.S. Lee - Reporter
- Joe Torre - Joe Torre
- Ric Stoneback - Ken Payson
- Nelson Landrieu - Pedro Ramirez
- Marcia Cross - Joan Calvin
- Dabbs Greer - Dr. Marsh Laughlin, DDS
- Kevin Ruf - Attendant
- Stuart Fratkin - Producer
- Sarah Shahi - Bachelorette
- Alex Rice - Native American Representative
- Rusty Joiner - Man in Store
- Jason Priestley - Scott
- Sam McMurray - Alexander Bryant
- Josh Braaten - Carson
- Jack Knight - Commissioner O'Brien
- Kelly Monaco - Nurse
- Frank Santorelli - Second Doorman
- Lisa Ling - Lisa Ling
- John C. Vennema - Co-Op President
- Farrah Fawcett - Judge Claire Simmons
- Raquel Welch - Abby Lassiter
- Regis Philbin - Regis Philbin
- David Aaron Baker - Jason
- Jennifer Van Dyck - Interviewer
- Stephen Colbert - Frank
- Ken Thorley - Delivery Guy
- Michelle Phillips - Jane Moore
- Peter James Smith - Host
- Roger Lodge - Roger Lodge
- Barry Corbin - Peter Noland
- Barry Corbin - Peter Noland (archive footage)
- Robert Hays - Los Angeles Mayor Stone Taylor
- Gerry Becker - Dr. Cosimi
- Mike Lupica - Mike Lupica
- John Bedford Lloyd - Wayne Sheridan
- John Bedford Lloyd - Dr. Bronsteen
- William Christian - Man
- Eric Stonestreet - The Photographer
- Kal Penn - Buddy
- Lou Diamond Phillips - Nate
- Lou Diamond Phillips - Nate (archive footage)
- Landry Allbright - Susie
- Seth Meyers - Doug
- Bob Costas - Bob Costas (voice)
- Priscilla Presley - Marie Paterno
- Priscilla Presley - Marie Paterno (archive footage)
- Christopher Lloyd - Owen Kingston (archive footage)
- Christopher Lloyd - Owen Kingston
- Jack McGee - Officer Greenfield
- Robert Maschio - Bingo's Partner
- Robert Maschio - Officer Carney
- James Carville - James Carville
- Marceline Hugot - Doggie Day Care
- Meredith Vieira - Meredith Vieira
- Brad Raider - Hey Guy
- Rachel Jacobs - Tina
- Scott Wolf - Tim Connelly
- John Callahan - Edmund
- Stephen Kunken - Doctor
- Richard Portnow - Mr. Paterno
- Ted Shackelford - Barry Simmons
- Henri Lubatti - Chef Jean Pierre
- Philip Bosco - Randall Winston, Sr. (archive footage)
- Bill Maher - Bill Maher
- Chrissie Carnell Bixler - Sheila
- Dave Allen - Crackpot
- Adam Wylie - Kid
- Jenna Fischer - Waitress
- Kim Raver - Jeannie
- Jennifer Garner - Becky
- Tim Allen - Rags (voice)
- Beth Littleford - Deirdre West
- Beth Littleford - Deirdre West (archive footage)
- Clayton Prince - Bennet Jones
- Chad Cox - Young Chad
- Maria Tucci - Mrs. Paterno
- Anne Twomey - Holly
- Todd Barry - Doug the Tour Guide
- Serah D'Laine - Jenny
- Erin Murphy - Julie
- Jonathan Walker - Neil, Nikki's date
- Jonathan Walker - Neil (uncredited)
- Jay Russell - Reporter
- Jason Antoon - Abdul
- Jason Antoon - Cab Driver
- Rena Sofer - Sam
- Eva La Dare - Yoga Instructor
- Robert Trumbull - Priest
- Jimmy Palumbo - Bartender
- Michael Goldfinger - First Union Guy
- Eric Slovin - Man In Hallway
- Welker White - Maria
- Edmund Ikeda - Mr. Fong
- Bill Boggs - Talk Show Moderator
- Tom Lacy - Mayor Garfield
- William Bogert - Priest
- Jane Cecil - Marge
- Claudia Rocafort - Beautiful Woman
- Brian Tarantina - First Homeless Man
- John Sobestanovich - Second Homeless Man
- William Preston - Older Homeless Man
- Jerry Adler - Police Commissioner
- Tom Riis Farrell - UPS Guy
- Eric Kushnick - Pizza Guy
- Iraida Polanco - Cleaning Lady
- Dan Dierdorf - Dan Dierdorf
- Taylor Stanley - Karen
- Tom Shillue - Man in Hall
- Frank Gifford - Frank Gifford
- Anney Giobbe - Melissa
- Wilson Jermaine Heredia - Wilson Jermaine Heredia
- Larry King - Larry King
- Al Michaels - Al Michaels
- Anthony Rapp - Anthony Rapp
- Daphne Rubin-Vega - Daphne Rubin-Vega
- Judy Krause - George Stephanopoulos' Secretary (uncredited)
- Amanda Peet - Shelly
- Gabriel Macht - Naked Guy
- Cynthia Watros - Gayley
- Marlee Matlin - Sarah
- J.K. Simmons - Kevin
- Sam Seder - Bogus Temp
- Sam Seder - George
- Frank Dattolo - Second Dinner Guest
- Charle Landry - Tommy
- Kathleen Chalfant - Mother Superior
- Anna Holbrook - Heidi Longley
- Ellen Bethea - Reporter
- Rachel York - Beautiful Woman
- Marin Hinkle - Carolyn
- Marcia DeBonis - Ticket Agent
- Timothi-Jane Graham - Waitress
- Nancy Giles - Social Worker
- Paula Abdul - Paula Abdul
- Tracy Pollan - Renee
- Courtney Thorne-Smith - Danielle Brinkman
- Daphne Zuniga - Carrie
- Paula Marshall - Laurie Parres
- Heidi Klum - Heidi Klum
- Heidi Klum - Heidi Klum (archive footage)
- Blanca Camacho - Flower Woman
- Melinda Wade - Nadine (voice)
- Gerry Red Wilson - Andrew 'Drew' West
- Gerry Red Wilson - Shock Jock (archive footage)
- Mia Matthews - Bartender
- Zandy Hartig - Katie
- Manuel E. Santiago - Councilman Rodriguez
- David Letterman - David Letterman
- David Letterman - Rags (uncredited) (voice)
- Dennis Paladino - Sergeant
- Bradley White - Stephen
- Hope Chernov - Bridget
- Whitney Allen - Cathy
- Jan Owen - Mrs. Walker
- Brette Taylor - Susan
- Sylvia Kauders - Roberta
- Paul Romero - Bully
- Peggy Shay - Little Old Lady
- Mitch Rouse - Steve and Mr. Bungle
- Curt Chaplin - The Court Reporter
- Alyssa Milano - Meg Winston
- Scott Terra - Justin
- Julia Gibson - Justin's Mom
- James Harder - Old Santa
- Wendy Marlow - Catering Girl
- Leslie Barrett - Wilson
- Reathel Bean - John
- John Elsen - Cop (voice)
- Matt Malloy - Ben
- Margaret Reed - Candice
- Rod McLachlan - Reporter
- Chris Tallman - Bouncer
- Natalie Venetia Belcon - Waitress
- Jay Potter - Press Secretary
- Sue Cremin - Nurse June
- David Tawil - Millionaire
- Joe Urla - Daniel
- Raymond Anthony Thomas - Joe
- Andrew Weems - Televangelist
- Tom McCarthy - Priest
- Lee Bryant - Linda, Kaari's Mom
- Mike Royce - Christopher, Carter's date
- Ned Van Zandt - Mr. Anderson
- Barbara Gulan - Tina
- Stewart J. Zully - Reporter
- Sue Jin Song - Reporter
- Marion McCorry - Patricia Murell
- Rohan Quine - Party-goer obstructing Flaherty
- Bobby Reed - Fashion Stylist
- Heather Gottlieb - Erika
- Russell G. Jones - Wakim
- Willie C. Carpenter - Nigerian Delegate
- Andy Fowle - Baby Reporter
- Andy Fowle - Bully Reporter
- Frankie Muniz - Derek Evans
- Dina Pearlman - Tour Guide
- Geoffrey Wigdor - Butch
- Jeff Gordon - Jeff Gordon
- Mary B. McCann - T.V. Reporter
- Mike Hodge - Lloyd Drum
- Judy Toma - The Senator
- Scott Decker - Rick
- Tony Devon - FBI Man #1
- Joe Zaloom - Hot Dog Vendor
- Richard Thomsen - Judge
- Charles White - Hank Dorsett
- Oliver Solomon - Reporter
- Oliver Solomon - Worker
- George Sarris - Game Show Contestant
- Buzz Bovshow - Rabbi Judson
- Kathleen Goldpaugh - Woman in Bar
- Dar Billingham - Mayor's Office Employee
- Bourke Floyd - Irate Yankees Fan
- Christopher Lucas - Billy
- Christopher Lucas - Caddy
- Cassandra Kubinski - Student
- Michael McElroy - Gym Manager
- Malea McGuinness - Woman
- David Ilku - Reporter
- Tony Rigo - Manny
- Sean Michael Arthur - Nude Male Model
- Jeffrey Donovan - Tom
- Alfonse D'amato - Alfonse D'amato
- Mark Mortimer - Vendor
- Conor Dubin - Intern Scott Crane
- Omar Scroggins - Second Kid
- Sabrina Gennarino - Reporter
- Christopher Innvar - Fireman
- Danny Mastrogiorgio - First Rescue Worker
- Mark Kenneth Smaltz - Reporter
- Kal Cauthen - Second Rescue Worker
- William Hill - Doorman
- Faith Prince - Claudia Sachs
- Faith Prince - Claudia Lassiter
- Thomas Lyons - Reporter
- Nick Sullivan - Photographer
- Dael Orlandersmith - Ethel Finney, Impound Clerk
- Patrick Boll - Rob
- William Charlton - Depressed Guy
- Anne Shropshire - Nikki's grandmother
- Amir Darvish - Cabbie
- John Seidman - Art Instructor
- Dean Strange - Jason
- Michael Charles Roman - Devin
- Wills Robbins - Technician
- Joy Behar - Joy Behar
- George Ede - Elderly Man
- Cynthia Vance - Hometown Reporter
- Lori Tan Chinn - Samaritan Nun
- Robb Pruitt - Samaritan Doctor
- Peter Arpesella - Italian Actor #1
- Paolo Pagliacolo - Italian Actor #2
- John Ellison Conlee - Mr. Stepnowski
- John E. Mack - Manager
- John E. Mack - Man in Bar
- Ron Crawford - Judge
- Kim Sykes - Reporter
- Mark Nelson - Therapist
- Patrick Welsh - Father
- Traci Ann Wolfe - Hot Grieving Chick
- Geoffrey Ewing - Agent Duncan
- Sarah Knowlton - Janine Solfort
- Sara Ramirez - Carol Quinn
- Wali Collins - Cab Driver
- Blaise Hemingway - Forrester
- Patrick Ewing - Patrick Ewing
- Maurice Godin - Trevor Wolfe
- Peter Hermann - Ed
- Nicholas Wyman - Executive
- Elaina Erika Davis - Reporter
- Bill Kux - Doctor
- Michael Aronov - First Protester
- Timm Sharp - Second Protester
- Victor Verhaeghe - Employee
- Nahanni Johnstone - Stewardess
- Ryan Marsini - Davey
- Richard Robichaux - Bellhop
- Stephanie McVay - Tour Guide
- Mario Brassard - French Construction Guy (uncredited) (voice)
- Scott Robertson - Camera Man
- Peter Rini - Tony DiMarco
- Anne Bellamy - Grandma
- Andrew Fried - Guy
- Jim Ortlieb - Ian
- Charlie Hartsock - Reporter
- Jay Montalvo - Teacher #2
- Zaid Farid - Foreman
- Michael Gelman - Gelman
- Willie Garson - Ned
- Charles C. Stevenson Jr. - Priest
- William Mesnik - Rabbi Elgar
- Caroline Keenan - Mindy
- Troy Martin - Mayor's Bodyguard
- Armando Pucci - Armande
- Joanna Canton - Woman
- Doug Spinuzza - Stoner Guy
- Greg Wrangler - Delivery Guy
- Erika L. Holmes - Tonya
- Harper Roisman - Mr. Kaplan
- Ruth Rudnick - Manager
- Linda Porter - Woman #2
- Carlos Jacott - Lloyd
- Richard Penn - Doctor
- Ryan Culver - Jock
- William Turner - Carlos
- Ashley Gardner - Judith
- Kevin R. Kelly - A.V. Nerd
- Bonita Friedericy - Edith Connelly, Housekeeper
- Michael C. McCarthy - Father
- John David Conti - Deli Guy
- Judith Drake - Sample Woman
- Charlie Curtis - Beautiful Lady
- Magdalena Zmrzla - Tatiana
- Monique Edwards - Focus Group Woman #1
- Joanna Going - Julia Rhodes
- Rosie O'Donnell - Rosie O'Donnell
- Kevin Rankin - Kurt
- Clement Blake - Richard Hayden
- Lisa Dinkins - Reporter
- Jill Tracy - Debbie
- Jill Tracy - Muriel
- Sean Smith - Maitre D'
- Paul Hungerford - Husband
- Terry Walters - Wife
- Ben Livingston - Lee
- Nik Wilcox - Kissing Waiter
- R.F. Daley - Golf Father
- Brian Tahash - Huge Guy
- Darryl Theirse - Security Officer Mike Viola
- Rick Cramer - Vince
- Tara Mercurio - Jessica
- Tara Mercurio - Girlfriend
- Antonio Todd - First Base Umpire
- Steve Lindsay - Baseball Player
- Marc Lynn - M.C.
- Torrey Dickinson - Sci-Fi Kid
- Christiane Eden - Women Smoker
- Marquita Terry - Sherri Fields
- Paul Tigue - Marcus
- Christine Romeo - TV Anchorwoman
- David Doty - Fake Doctor
- Doug Ballard - Chad
- Mim Drew - Judy
- Scott McAfee - Young Mayor
- Olivia d'Abo - Allison Wright
- David Hayman - George Washington #1
- Gelbert Coloma - George Washington #3
- Michael Raysses - Man in Bar
- Lou Cutell - Shelly Hallerman
- Jeff Corbett - John, Lawyer
- Julie Dretzin - Jill
- Dan Kinsella - Equipment Manager
- Dan Kinsella - Police Dispatcher
- Dan Kinsella - Subway Conductor
- Dan Kinsella - Bingo Announcer
- Dan Kinsella - Jason
- Helen Siff - Woman on TV
- Nate Reese - Man on TV
- Lynne Marie Stewart - Adoption Woman
- David Starwalt - Jerry Flynn
- Barry Wiggins - Bartender
- Krista Allen - Jesse
- Melissa Jones Harper - Shopper #1
- Julie David - Shoplifter
- Steve Hosford - Scrawny Guy
- Jonathan Nail - Priest
- Judith Moreland - Elsa Kirkpatrick
- Melinda Bennett - Caitlin's Cousin Marsha (Bride)
- Russell Duncan - Wedding Guest
- Nick Soderblom - Juice Bar Attendant
- Denise Richards - Jennifer Duncan
- Roma Torre - Roma Torre
- Pat Kiernan - Pat Kiernan
- Jennifer Ritchkoff - TV Reporter
- Howard Mann - Anthony DeMatt
- Jack Wright - George Washington #2
- Jack Wright - Radio Technician
- Paul Schulze - Steven
- Courtney Gebhart - Waitress
- David Jahn - Eric
- Chi Muoi Lo - Walter
- Bree Turner - Tracy Crandall
- Marielle Heller - Carrie
- Richard Kuhlman - Martin Davis
- Derek Waters - Bungee
- Tom Silardi - Police Officer
- Perry King - Tom Crandall
- Chris Elwood - Doug Smuckers
- René Ashton - Tiffany
- Jerry Giles - Advisor
- Johnny Hawkes - Chad
- Sabrina Speer - Britney
- Rudy Ruggiero - Journalist
- Jayson Williams - Jayson Williams
- John Scurti - Reporter
- Joel Hurt Jones - Reporter
- Bob Glouberman - Reporter
- Myrna Niles - Aunt Syl
- John Harrington Bland - Reporter
- Jack Kerrigan - Man in Copy Room
- Paul Eric Jerome - Nathan
- Marie Gabrielle - Reporter
- Michael Longfield - Messenger
- Deborah Zoe - Carla Hayes
- Lisa Louise Langford - Reporter
- Cynthia Huerta - Mayor of San Antonio
- Avery Glymph - Reporter
- Amy Hohn - Reporter
- Kim Yancey - Reporter
- Lizzie Murray - Foster Care Lady
- André Gordon - Security Guard
- Stacey Logan - Nurse
- Anne James - Nurse
- Michael J. Fox
- Gary David Goldberg
- Chris Henchy
- David S. Rosenthal
Willie Garson interpreta a Ned en la serie.
Brian Tarantina interpreta a First Homeless Man en la serie.
Christopher Lloyd interpreta a Owen Kingston (archive footage) en la serie.
Amanda Peet hace el papel de Shelly.
Yasiin Bey interpreta a Monty en la serie.
Richard Portnow interpreta a Mr. Paterno en la serie.
Bob Gunton hace el papel de Governor Riley.
Dakota Fanning interpreta a Cindy en la serie.
John Scurti interpreta a Reporter en la serie.
Charlie Sheen interpreta a Charlie Crawford en la serie.
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