- Joseph Campanella - Dr. Curt Connors (voice)
- Joseph Campanella - Dr. Curt Connors / Lizard (voice)
- Joseph Campanella - Lizard (voice)
- Edward Mulhare - Spencer Smythe (voice)
- Alyson Court - Jubilee (voice)
- Edward Albert - Matt Murdock / Daredevil (voice)
- Rue McClanahan - Mrs. Hardy (voice)
- Rob Paulsen - Morrie Bench / Hydro-Man (voice)
- John Vernon - Doctor Strange (voice)
- Lenore Zann - Rogue (voice)
- Nichelle Nichols - Miriam (voice)
- Amy Hill - Susan Choi (voice)
- George Takei - Wong (voice)
- Tim Russ - Hobie Brown / Prowler (voice)
- Stan Lee - The Man (voice)
- Nita Talbot - Anastasia Hardy (voice)
- John Beck - Frank Castle / Punisher (voice)
- John Phillip Law - John Hardesky / The Cat (voice)
- Cam Clarke - Reed Richards / Mr. Fantastic (voice)
- Dimitra Arliss - Anastasia Hardy (voice)
- Alison Sealy-Smith - Storm (voice)
- Walker Edmiston - Bob Frank / Whizzer (voice)
- Roger Kern - Gecko (voice)
- Carl Ballantine - Lenny Luntz (voice)
- Robert Axelrod - Microchip (voice)
- Alfonso Ribeiro - Randy Robertson (voice)
- Telma Hopkins - Mrs. Farrell (voice)
- Mira Furlan - Silver Sable (voice)
- Gail Matthius - Sue Richards / Invisible Woman (voice)
- Norm Spencer - Cyclops (voice)
- Toby Scott Ganger - Billy Connors (voice)
- Michael Des Barres - Jackson Weele (voice)
- Lawrence Mandley - Iceberg (voice)
- Sandra Bernhard - Sarah Baker (voice)
- Philip Abbott - Nick Fury (voice)
- Philip Abbott - Wardell Stromm (voice)
- Nell Carter - Glory Grant (voice)
- Quinton Flynn - Johnny Storm / The Human Torch (voice)
- Catherine Disher - Jean Grey (voice)
- Stanley Ralph Ross - Joey Nails (voice)
- George Buza - Beast (voice)
- Alan Johnson - Arthur Avis / Young Vulture (voice)
- Alan Johnson - Vulture (voice)
- Patrick Pinney - Ben Grimm / The Thing (voice)
- Martin Landau - Scorpion (voice)
- Martin Landau - Mac Gargan / Scorpion (voice)
- Bob Bergen - Ned Leeds (voice)
- Oliver Muirhead - Whistler (voice)
- Oliver Muirhead - Dr. Jonathan Ohn / The Spot (voice)
- Paul Winfield - Omar Mosley / Black Marvel (voice)
- Dee Bradley Baker - Young Destroyer (voice)
- Tom Kane - Doctor Doom (voice)
- Iona Morris - Storm (voice)
- Iona Morris - Martha Robertson (voice)
- Joseph Ruskin - Lewald (voice)
- Laurie O'Brien - Genevieve (voice)
- Anne-Marie Johnson - Mousie (voice)
- Anne-Marie Johnson - Angela (voice)
- Brian Keith - Uncle Ben (voice)
- Cedric Smith - Xavier (voice)
- Chris Potter - Gambit (voice)
- Beverly Garland - Miranda Wilson (voice)
- Gregg Berger - Kraven (voice)
- Gregg Berger - Mysterio (voice)
- Gregg Berger - Quentin Beck / Mysterio (voice)
- Townsend Coleman - Young Silvermane (voice)
- Townsend Coleman - Middle-Aged Silvermane (voice)
- Ken Chandler - Sam (voice)
- Ken Chandler - Security Guard (voice)
- Michael Horton - John Jameson (voice)
- Cal Dodd - Wolverine (voice)
- Warren Sroka - Young Peter Parker (voice)
- Neil Ross - Norman Osborn (voice)
- Neil Ross - Norman Osborn / Green Goblin (voice)
- Neil Ross - Green Goblin (voice)
- Malcolm McDowell - Whistler (voice)
- Roy Dotrice - Keene Marlowe / Destroyer (voice)
- Roy Dotrice - Keene Marlowe (voice)
- Michael Rye - Dr. Farley Stillwell (voice)
- Matthew McCurley - Young Boy Silvermane (voice)
- Caroline Goodall - Vanessa Fisk (voice)
- Susan Beaubian - Dr. Mariah Crawford (voice)
- Susan Beaubian - Dr. Mariah Crawford / Calypso (voice)
- Peter Mark Richman - Old Peter Parker / Old Spider-Man
- Earl Boen - Red Skull (voice)
- Earl Boen - Beyonder (voice)
- Kathy Garver - Madeline Joyce / Miss America (voice)
- Kathy Garver - Gila (voice)
- Billy 'Pop' Atmore - Robert Farrell / Rocket Racer (voice)
- Scott Cleverdon - Cletus Kasady / Carnage (voice)
- Scott Cleverdon - Michael Pingree (voice)
- James Avery - Jim Rhodes / War Machine (voice)
- Wanda De Jesus - Dr. Sylvia Lopez (voice)
- Lois Nettleton - Nora (voice)
- Frankie Crocker - Jimmy Dugan (voice)
- Leigh-Allyn Baker - Alisa Silver (voice)
- Leigh-Allyn Baker - Alisa Silvermane (voice)
- Giselle Loren - Margaret Connors (voice)
- Ed Gilbert - Dormammu (voice)
- Ed Gilbert - Mary Jane's Father (voice)
- Dorian Harewood - Tombstone (voice)
- Cannon Young - Child Silvermane (voice)
- Eddie Albert - Adrian Toomes / Old Vulture (voice)
- Hank Azaria - Eddie Brock / Venom (voice)
- Hank Azaria - Eddie Brock (voice)
- Jim Cummings - Shocker (voice)
- Jim Cummings - Man-Spider (voice)
- Jeff Corey - Silvermane (voice)
- Marla Rubinoff - Liz Allen (voice)
- Mark Hamill - Hobgoblin (voice)
- Mark Hamill - Jason Phillips / Hobgoblin (voice)
- Mark Hamill - Jason Phillips (voice)
- Barbara Goodson - Dr. Ashley Kafka (voice)
- Don Reed - Clay Marks (voice)
- Edie Mirman - Illyena (voice)
- Nick Jameson - Michael Morbius (voice)
- Nick Jameson - Morbius (voice)
- Nick Jameson - Richard Fisk (voice)
- Nick Jameson - Dr. Groitzig (voice)
- Jack Angel - Nick Fury (voice)
- Don Stark - Rhino (voice)
- Brett King - Young Thunderer (voice)
- Cain Devore - Young Whizzer (voice)
- Jonathan Harris - Miles Warren / The Professor (voice)
- David Warner - Landon (voice)
- Dawnn Lewis - Detective Terri Lee (voice)
- David Hayter - Captain America (voice)
- David Hayter - Brace Huntington (voice)
- Richard Moll - Scorpion (voice)
- Liz Georges - Debra Whitman (voice)
- Nicky Blair - Hammerhead (voice)
- Efrem Zimbalist Jr. - Doctor Octopus (voice)
- Efrem Zimbalist Jr. - Otto Octavius / Doctor Octopus (voice)
- Hansford Rowe - Thunderer (voice)
- Phil Proctor - Kragov (voice)
- Phil Proctor - Kragov / Electro (voice)
- Robert Hays - Tony Stark / Iron Man (voice)
- Tony Jay - Baron Mordo (voice)
- Patrick Labyorteaux - Flash Thompson (voice)
- J.D. Hall - Blade (voice)
- Joan Lee - Madame Web (voice)
- Mary Kay Bergman - Gwen Stacy (voice)
- Maxwell Caulfield - Alistair Smythe (voice)
- Maxwell Caulfield - Ultimate Slayer Smythe (voice)
- Majel Barrett - Anna Watson (voice)
- Stan Lee
- Steve Ditko
- Avi Arad
Mark Hamill interpreta a Jason Phillips / Hobgoblin (voice) en la serie.
Paul Winfield hace el papel de Omar Mosley / Black Marvel (voice).
David Warner hace el papel de Landon (voice).
Sandra Bernhard interpreta a Sarah Baker (voice) en la serie.
Martin Landau interpreta a Scorpion (voice) en la serie.
Earl Boen interpreta a Beyonder (voice) en la serie.
Roy Dotrice hace el papel de Keene Marlowe / Destroyer (voice).
George Takei interpreta a Wong (voice) en la serie.
Nichelle Nichols interpreta a Miriam (voice) en la serie.
Majel Barrett hace el papel de Anna Watson (voice).
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