- Charlee Kaye - Military Kid
- Mark Anthony Vazquez - Drill Sergeant
- Tien Tran - Sheila Cholosternin
- Kaitlin Olson - Edison Jaymes
- Janina Gavankar - Hannah Howard
- Rahul Nath - Dr. Chandreshekar
- Samuel Hardie - Marcus (voice)
- Exie Booker - Dr. Carter
- Paul Jurewicz - Dewey Pantowski
- Francesca Lombardo - 6 Year Old Erin
- Spencer House - Duncan Tabner
- Ginger Gonzaga - Anabela 'AYC' Ysidro-Campos
- Alan Blumenfeld - Schugler
- Concetta Tomei - Rep. Pitosi
- Tommy Cook - Rep. Bob White
- Jenny Tran - Congressional Aide
- Asif Ali - Captain Dave Powers
- Michael Hitchcock - Jerome Lalosz
- Alice Wetterlund - Major Jane Pike
- Pedro Lopez - Pizza Hut Guy
- Roy Wood Jr. - Liaison Bert Mellows
- Punkie Johnson - Staff Sergeant Kiki Rhodes
- Dmitrious Bistrevsky - Airman #1
- Scott Michael Morgan - Convenience Store Clerk
- Scott Michael Morgan - Emmett Buntyn
- John Hartmann - Chambers
- Alex Quijano - Jim
- Алексей Воробьёв - Yuri 'Bobby' Telatovich
- Tiffany Yvonne Cox - Journalist
- Nancy Lantis - Dr. Wolf
- Fred Willard - Fred Naird
- Landon Ashworth - Gabe Ely
- Marc-Sully Saint-Fleur - Jean Baptiste Bosou
- Nicole J. Butler - Prisoner
- Vivis - Hilde
- P.L. Brown - Officer Smith
- Bruce Locke - General Tsengjun
- Megan Grano - Reporter #2 (Meredith)
- Thomas Ohrstrom - Dr. Vandeveld
- Mike Park - Reporter #1
- Dan Bakkedahl - John Blandsmith
- Jessica St. Clair - Kelly King
- Amanda Lund - Anna
- Ian Abramson - Participant #1
- Bil Dwyer - Participant #3
- Noah Emmerich - General Kick Grabaston
- Jessica McKenna - Participant #2
- Punam Patel - Ranatunga
- Ted Cole - General #1
- Brandon Molale - Clarke Luffinch
- Carolyn Wilson - Louise Papaleo
- Bronwen Smith - Panel Member
- Mel Tuck - Gus Kelly
- Patrick Warburton - General Dabney Stramm
- Diedrich Bader - General Rongley
- Jane Lynch - Admiral Maywheather
- Larry Joe Campbell - Admiral Louis Biffoont
- Patton Oswalt - Captain Lancaster
- Terry Crews - General Neyman Aggroad
- Jon Lovitz - Sal Scarapiducci
- Tim Meadows - Secretary of Defense
- JayR Tinaco - Xyler
- Aparna Nancherla - Pella Bhat
- Ellie Harvie - Tina - Bean Counter
- David Herman - Albertson
- Sophie Lui - Reporter #2
- Tiffany Mo - Briget
- Natalie Moon - Interviewer
- Shanel Pratap - Reporter #1
- Richard Ouyang - Dr. Zhang
- Tim Chiou - Dr. Lim
- Kelvin Han Yee - General Gao
- Hector Duran - Julio Diaz-Jose
- Derek Kwan - Chinese F. Tony
- Brandy Le - Zhang's Assistant
- Kelly Metzger - Ms. Deaver
- Lisa Kudrow - Maggie Naird
- Owen Daniels - Obie Hanrahan
- Bob Balaban - Ron (voice)
- Valencia Budijanto - Small Girl
- Sarah Hayward - Professor Yaffe
- Cari Leslie - Mad Buff
- Nick Preston - Cameraman
- Anita Brown - Catherine Foothead
- Amro Majzoub - Jay Collins
- Joel McVeagh - Photographer
- Brendan Riggs - Doctor
- Kate Berlant - Sal Scarapiducci Jr. (voice)
- Chris Gethard - Eddie Broser
- Thomas Ma
- Caroline Battista
- Michelle Canart
- Eliason Aboukassam
- Hannah Christine Kess
- Christopher Langston
- Jimmy O. Yang
- Kim Tran
- Esmé Park
- Sarah Moses
- Mamoudou N’Diaye
- Lauren Houseman
- Nick Vassil
- Jayson Snyman
- David Magee
- Jeanne McCarthy
- Sandra-Ken Freeman
- Garrett McElver
- Roger Roscoe
- Gabriel Law
- Randy Babajtis
- Miriam Cole
- Ben Wilkins
Jimmy O. Yang hace el papel de Dr. Chan Kaifang.
Steve Carell interpreta a General Mark R. Naird en la serie.
John Malkovich hace el papel de Dr. Adrian Mallory.
Ben Schwartz hace el papel de F. Tony Scarapiducci.
Diana Silvers interpreta a Erin Naird en la serie.
Tawny Newsome interpreta a Captain Angela Ali en la serie.
Don Lake interpreta a Brig. Gen. Brad Gregory en la serie.
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