- Quincy Dunn-Baker - Kev
- Adam DeCarlo - Guy on the Street
- Adriane Lenox - Roberta
- Alexander Blaise - Investor #2
- Evan Zes - Investor #1
- Sting - Sting
- Jonathan Burke - Waiter
- Meredith Holzman - Anita
- Jacob Ming-Trent - Lucien
- Roy Wood Jr. - Vaughn
- Eric R. Williams - Cashier Doug
- Esteban Benito - Tavo Mora
- Dana Kreitz - Manda
- Jimmy Fallon - Jimmy Fallon
- Mandy González - Silvia Mora
- Robert G. McKay - Detective Jurgenson
- Salem Murphy - Conductor
- Julian Cihi - Tim Kono
- Maximilian Lee Piazza - Young Tim Kono
- Zainab Jah - Ndidi Idoko
- Jeena Yi - Amy Huang
- Anthony Ruiz - José Torres
- Maulik Pancholy - Arnav Kapoor
- Seth Andrew Bridges - ESU Cop
- Ava Eisenson - Brazzos Producer
- Kirk Kelly - Neighbour
- Matthew Lamb - Little Charles
- Ben Livingston - Charles’ Father
- Amy Schumer - Amy Schumer
- Jackie Hoffman - Uma Heller
- Walker Hare - TV Detective
- Damani Varnado - Liam Grimsby
- Steven Strickland - Coffee Vendor
- David T. Patterson - Jared McGregor
- Latrisha Talley - Brazzos P.A.
- Samuel Farnsworth - Young Oliver
- Oliver Fequiere - Henry Putnam
- Dave Marr - Young Teddy
- ChaCha Shen - Little Dorothy
- Jane Lynch - Sazz Pataki
- Wakeema Hollis - Naomi Jackson
- Johnny Hopkins - Jimmy Russo
- Andrea Martin - Joy Payne
- Dipa Anitia - Quik Helix Technician
- Charles Everett - Police Officer
- Francisco Javier González - Luis
- Ade Otukoya - Brazzos Director
- James Caverly - Theo Dimas
- Mark Consuelos - Mabel's Dad
- Da'Vine Joy Randolph - Donna Williams
- Tieisha Thomas - Subway Rider
- Caroline Valencia - Young Mabel
- Daniel Oreskes - Marv
- Jaboukie Young-White - Sam
- Zoe Colletti - Lucy
- Marie-Françoise Theodore - Roberta
- Vanessa Aspillaga - Ursula
- Teddy Coluca - Lester
- Christine Ko - Nina Lin
- Ariel Shafir - Ivan
- Ali Stroker - Paulette
- Orson Hong - Grant
- Russell G. Jones - Grover Stanley
- Ned Noyes - Frank
- Tina Fey - Cinda Canning
- Jayne Houdyshell - Bunny Folger
- Nathan Lane - Teddy Dimas
- Ryan Broussard - Will Putnam
- Adina Verson - Poppy White
- Michael Rapaport - Detective Kreps
- Shirley MacLaine - Rose Cooper
- Jason Veasey - Jonathan Bridgecroft
- Bob Ari - Becky's Dad
- Kathryn Boswell - Reporter
- Margaret Reed - Stage Manager
- Meryl Streep - Loretta Durkin
- Allison Guinn - KT Knoblauer
- Linda Emond - Donna DeMeo
- Lisa Kron - Casting Director
- Ashley Park - Kimber Lee
- Jeremy Shamos - Dickie Glenroy
- Wesley Taylor - Clifford DeMeo
- Jesse Williams - Tobert
- Noma Dumezweni - Maxine Spear
- Adrian Martinez - Gregg Rivera
- Caitlin Hammond - Girl Cop
- Jay Aubrey Jones - Usher
- Gerrard Lobo - Detective Biswas
- Galway McCullough - Friend of Ben's
- Harry Sutton Jr. - Doctor Douglas
- Joel Waggoner - Tom
- Paul Rudd - Ben Glenroy
- Paul Rudd - Glen Stubbins
- Sas Goldberg - Realtor
- Peter Bartlett - Jerry Blau
- Matthew Broderick - Matthew Broderick
- Mel Brooks - Mel Brooks
- Gina Naomi Baez - Young Mother
- Scott Robertson - Another White-Haired Actor
- Sprague Theobald - White-Haired Actor
- Taylor Colwell - Young Loretta
- Bret Shuford - Director
- Emilie Kouatchou - Ensemble #2
- Kelvin Moon Loh - Ensemble #4
- Marylouise Burke - Trixie
- Wai Ching Ho - Mei Mei
- Ashanti J'Aria - Dr. Turbovsky
- Makia Martin - Security Guard
- Mike Smith Rivera - Doctor
- Ian Lowe - Piano Bar Accompanist
- Zach Galifianakis - Zach Galifianakis
- Eugene Levy - Eugene Levy
- Eva Longoria - Eva Longoria
- Scott Bakula - Scott Bakula
- Catherine Cohen - Trina Brothers
- Jin Ha - Marshall P. Pope
- Molly Shannon - Bev Melon
- Marc Bovino - Sal Snyder-Bernsdore
- Danny Breslin - Young Guy
- Jennifer Castillo - Young Girl
- Alan Heitz - Cart Vendor
- Kurt Maloney - Guy on Street
- Eric William Morris - Todd Shettinger
- Jackie Zebrowski - Lady Out a Window
- Desmin Borges - Alfonso
- Richard Kind - Vince Fish
- Kumail Nanjiani - Rudy Thurber
- Daphne Rubin-Vega - Inez
- Vinny DeGennaro - Stunt Guy #2
- Michael McFadden - Bartender
- Veanne Cox - Dr. Maggie
- Jeanette Branch - Stunt Guy #1
- Robert Lil Bob McCall - Stunt Guy #3
- John McEnroe - John McEnroe
- Melissa McCarthy - Doreen
- Griffin Dunne - Professor Milton Dudenoff
- Elliot Frances Flynn - Student Film Woman #1
- Acelynn Jennings - Young Tawny
- Jason Kravits - Big Mike
- Alberto Bonilla - Clerk
- Alexandra Templer - Helga
- Rae Bell - Blue-Haired Kid
- Adam Enright - 1st AD
- Ron Howard - Ron Howard
- Selena Gómez
Michael Rapaport interpreta a Detective Kreps en la serie.
Matthew Broderick interpreta a Matthew Broderick en la serie.
Sting interpreta a Sting en la serie.
Shirley MacLaine interpreta a Rose Cooper en la serie.
Steve Martin hace el papel de Charles-Haden Savage.
Martin Short interpreta a Oliver Putnam en la serie.
Michael Cyril Creighton interpreta a Howard Morris en la serie.
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