- Austin Abrams - Casey
- Alex Brightman - Jesse
- Matt Shively - Ken
- Ally Sheedy - Fiona
- Kristan Lyon - Bridesmaid (uncredited)
- Joanna Strapp - Young Woman
- Mark Webber - Father Eddie
- Raven Goodwin - Eliza
- Blake Clark - Joe
- Connie Britton - Ally
- Kimberley Crossman - Kit-Cat
- Gabrielle Maiden - Regina
- Andi Chapman - Susan
- David De Beck - Richard
- Gonzalo Escudero - Augusto
- Stacey Moseley - Therapist
- Jordana Rose - Young Bridgette
- Jessica Pohly - TSA Officer Hester
- Jimmy Jean-Louis - Henri
- Numa Perrier - Elsie
- Nhadya Salomon - Mindy
- Allyn Rachel - Leslie
- Sisa Grey - Ida
- Adrian Ciscato - Rivers
- Mia Kaplan - Chloe
- Andrea Kostovick - Young Girl
- Celeste Oliva - Kate
- Suzanne Savoy - Mrs. Waterstein
- Kevin Bacon - Kevin Bacon
- Ari Graynor - Emma
- Aaron Dowdy - Marcel
- Caroline Portu - Danielle
- Daniel Washington - Guy 1
- Rory Benjamin Smith - Guy 2
- Graham King - Guy 3
- Joe Chambrello - Guy 4
- Christy Coco - Bridesmaid (uncredited)
- Jamie Ghazarian - Upscale party goer (uncredited)
- Stormy Daniels - Dana
- Lenny Clarke - Zaggy
- Adobuere Ebiama - Leigh
- Jose Guns Alves - Fireman #1
- Eddie Frateschi - Fireman #2
- Dan Aid - Hank
- Sherie Rene Scott - Aunt Jackie
- Gary Anthony Williams - Phillip
- Kecia Lewis - Aunt Renee
- Tonye Patano - Aunt Valerie
- Chelsea Tavares - Bebe
- Evelyn Howe - Johanny
- Ricardo Pitts-Wiley - Uncle Allan
- Aaron Andrade - College Friend #3
- Alanna Logan - Sorority Sister #2
- Kiara Pichardo - Woman (uncredited)
- Lucien Spelman - Joe Jr.
- Molly Hawkey - Martina
- Michael London
- Janice Williams
- Gene Stupnitsky
- Lee Eisenberg
- Daniel Hart
Mark Webber hace el papel de Father Eddie.
Kevin Bacon interpreta a Kevin Bacon en la serie.
Frankie Shaw interpreta a Bridgette Bird en la serie.
Miguel Gómez interpreta a Rafi en la serie.
Samara Weaving hace el papel de Nelson Rose Taylor.
Rosie O'Donnell hace el papel de Tutu.
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