- Terence Morgan - Sir Francis Drake
- Terence Morgan - Hugh Graveney
- Alex Scott - Don Pedro
- John Bennett - Tomas
- William Lucas - Count Julio
- Warren Mitchell - Roberto
- John Welsh - Governor Walters
- Alfred Burke - Sir Amyas Paulet
- Richard Pearson - Sir Richard Bosanquet
- Delphi Lawrence - The Countess
- Clive Morton - English Ambassador
- Brian Cant - Corporal
- Barry Morse - Governor
- Mark Eden - Agila
- Ferdy Mayne - Joos
- Anthony Bushell - Tom Doughty
- Kieron Moore - Sir Thomas Stukeley
- Patrick McAlinney - Skipper Staunton
- Gerard Heinz - Alva
- Zena Marshall - Maria
- Patrick Allen - Navarre
- Robin Hughes - Adam Forrester
- Marne Maitland - Uluch Ali
- Michael Anderson Jr. - John Harrington
- Laurence Naismith - Sir Miles Burns
- Bryan Coleman - Sir Thomas Wenham
- Ronald Leigh-Hunt - Hawkins
- Nanette Newman - Yana
- Frederick Jaeger - Vicary
- Andrew Keir - Flavel
- Elspeth March - Grace O'Malley
- Pamela Brown - Catherine De Medici
- Basil Dignam - Duke Of Alva
- Eileen Way - Pastora
- Bernard Archard - Sir Christopher
- Nigel Davenport - Don Miguel de Cervantes
- Brian Bedford - Estaban
- Raymond Huntley - Doctor Dee
- Peter Stephens - Counsellor
- John Moffatt - Spanish Captain
- Patrick Wymark - Captain Williams
- Robert Rietti - Captain Riccardo
- Susan Hampshire - Celia
- Martin Boddey - The Colonel
- Neil McCallum - Sir Martin
- David McCallum - Lord Oakeshott
- Patrick Holt - Lord Westbrook
- Michael Bell - Captain Of The Guard
- Patrick Troughton - Gazio
- Gabriella Licudi - Lady-in-Waiting
- Arnold Diamond - Governor
- Natasha Parry - Countess Inez
- Clifford Elkin - Don Antonio
- Peter Hempson - Pedro
- Olive McFarland - Jenny
- Barry Foster - Tom Brewster
- Fred Johnson - Parson Main
- Ruth Lodge - Mistress Seaton
- Robert Cawdron - Crombie
- Victor Maddern - Ship's Cook
- Victor Maddern - Brewer
- Charles Lloyd Pack - Daniel Peters
- John Arnatt - Duke of Cordova
- John Arnatt - Spanish Ambassador
- Wensley Pithey - Davey Preston
- Grazina Frame - Bess Pierpont
- Harvey Hall - Thomas Phillips
- Noelle Middleton - Mary Queen of Scots
- Reginald Jessup - Sergeant
- Howard Greene - Sentry
- Michael Golden - Rafe
- Edward Cast - Captain of the Guard
- Michael Peake - Spanish Governor
- Joanne Dainton - Laura
- Henri Vidon - The Prefect
- Roger Delgado - Mendoza
- Roger Delgado - The Governor
- Roger Delgado - Spanish Ambassador
- Isobel Black - Sophia
- Glynn Edwards - Martin
- Glynn Edwards - Will Martin
- Glynn Edwards - Martin Armstrong
- Gordon Gardner - Lacey
- Francesca Annis - Mariella
- Katherine Woodville - Anne Wenham
- Katherine Woodville - Little Dove
- Joseph Cuby - Don Carlos
- Michael Ripper - Almighty Jones
- Michael Ripper - Caylus
- Emrys Leyshon - Major-Domo
- Zia Mohyeddin - King Philip of Spain
- Helen Christie - Lady Amyas
- William Dexter - Lambert
- Reginald Hearne - Gomez
- Richard Huggett - Alonzo
- Patrick McLoughlin - Richard Trevelyan
- Marie Burke - Dona Inez
- Pauline Letts - Dona Clara
- Will Stampe - Don Gonzalo
- Dallas Cavell - Lieutenant
- Catherine Finn - Governor's Wife
- Colin Rix - Prisoner
- Marshall Jones - Cooper
- Marshall Jones - Garrett
- Derek Sydney - Governor
- Bob Grant - Clements
- Leon Peers - Alencon
- Leon Peers - Eastwood
- Rory MacDermot - Fletcher
- Charles Hill - Spanish Admiral
- Peter Diamond - Bosun
- Peter Diamond - De Luc
- Walter Randall - Spanish Captain
- Frederick Rawlings - Indian Chief
- Liam Gaffney - Lord O'Neill
- Peter Halliday - Theobald Burke
- John McCarthy - Richard Burke
- Wesley Murphy - The Sergeant
- Gordon Phillott - The Abbot
- Ewan Roberts - Munro
- Ewan Roberts - Morton, Earl of Lenox
- Michael Forrest - Jan
- David Grahame - Banker
- George Little - Lieutenant
- Tom Bowman - Mate
- David Davies - Sykes
- Stanley Morgan - Lieutenant
- Richard Shaw - Vanderhof
- Anthony Bate - Tilsto
- Dennis Edwards - De Vazim
- Bill Nagy - Corsia
- John Ronane - Spanish Officer
- Katharine Blake - The Dark Lady
- Lawrence Davidson - Lord Marmont
- Philip Guard - Johnnie Factotum / William Shakespeare
- Barry Shawzin - Chamberlain
- Larry Taylor - Twisted Face
- Richard Warner - Walsingham
- Yvonne Buckingham - Heloise
- Susan Burnet - Lady Elena
- Vicki Woolf - Prisoner
- Vicki Woolf - Lady in Waiting
- John Dunbar - Major-Domo
- Nancy Egerton - Gretchen
- Andrew Faulds - Count Toledo
- Kenneth Gilbert - Sergeant
- Tom Kempinski - Spanish Officer
- Mary Merrall - Duchess
- Sarah Branch - Sara
- William Abney - Don Pedro
- Larry Burns - Obadiah
- Christopher Carlos - Baltasar
- Harry Lockart - Rafael
- Charles Carson - Spanish Admiral
- Colin Jeavons - Spanish Officer
- Michael Mellinger - Servant
- Edward Woodward - Spanish Captain
- Guy Deghy - Zarque
- Waveney Lee - Olwen
- Jack Melford - Sir Owen Tudor
- Norman Scace - Stephens
- Paul Stassino - Hassan Bey
- Kim Tracy - Zaharra
- Jean Kent - Queen Elizabeth I
- Milton Reid - Diego
- Michael Crawford - John Drake
- Reginald Beckwith - Sir Henry Rainsford
- Endre Muller - Black Eagle
- Charles Heslop - Withers
- Barry Keegan - Gomez
- Howard Lang - Grenville
- Leslie Harris
Terence Morgan interpreta a Sir Francis Drake en la serie.
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