- Blythe Danner - Angie Chafin
- Jorma Taccone - Benjamin Roth
- Richard Schiff - Dean Chafin
- Jason Lee - Kevin
- Will Forte - Reed
- Mary Elizabeth Ellis - Connie
- Michael Leone - Sal
- Tom Virtue - Minister
- Nick Cannon - Calvin
- Matt Lauer - Matt Lauer
- Connie Sawyer - Shopper
- Adam Campbell - Trent
- Matt Braunger - Gene
- Jean Villepique - Terry
- Anahi Bustillos - Mia
- Mary Jo Smith - Helen
- Matthew Jones - Officer
- Jill Matson - Ava's Fan
- Japheth Gordon - Dr. Deon
- Jim Piddock - Matthew Taylor
- Jeff Clarke - Car Deeler
- Eloy Casados - Pete
- Michael Hitchcock - Mr. Bob
- Missi Pyle - Kaye
- Michael King - Bartender
- Sam Page - Dr. Goddard
- Bryan Callen - Marc
- Adam Gregor - Barry
- Jen Kober - Libby
- Licia L. Shearer - Admitting Nurse
- Libby Baker - Surgical Nurse
- Michael Rothhaar - Dr. Jellicourse
- Scott Anthony Leet - Reggie
- Josh Latzer - Putch
- Ryan Salazar - Carlos
- Ray Proscia - Dr. Krueger
- Chris Diamantopoulos - Julien
- Chloe Csengery - McKenna
- Molly Shannon - Nancy
- Kate French - Jessie
- Elle Labadie - Bridget
- Asif Ali - Michael
- Laura Wernette - Beth
- Paul F. Tompkins - Dave
- James Greene - Len
- Scott Beehner - Roger
- Kevin Kirkpatrick - Dad
- Stephanie Jackson - Mom
- Sawyer Ever - Timothy
- Grace Rowe - Customer #1
- Terasa Livingstone - Customer #2
- Gary Kraus - Customer #3
- Julia Fowler - Saleslady #1
- Tara Perry - Saleslady #2
- Reggie Austin - Isaac
- Shane Nickerson - Bart
- Megan Mullally - Shayna
- Emily Rutherfurd - Laura
- Ivo Nandi - Fabian
- Damon Jones - Gary
- Jenn Korbee - Charlotte
- Cary Y. Mizobe - Master Hu
- Simon Rhee - Kung Fu Master
- Alison La Placa - Gail Reinhold
- Dean Winters - Casey Brinkley
- A.J. Tannen - Parent
- Heather Olt - Hopeful Spinster
- Amy Kidd - Pregnant Woman
- Mario Orozco - Tattoo Artist
- Alanis Morissette - Amanda
- Cheryl Francis Harrington - Sharon
- Carla Renata - Security Woman #1
- Sean Carrigan - Craig
- Casey Strand - Flight Attendant
- John Pirruccello - Security Agent
- Dana L. Wilson - Security Woman #2
- Gary Dubin - Passenger
- Larry Dorf - Ned
- Frank Ertl - Old Man Foot Cheese
- Charley Rossman - Bedroom-Bathroom Guy
- Steven Pasquale - Luke Granby
- Eve Best - Yvonne Encanto
- Izabela Vidovic - Tanya Moore
- Ben Falcone - Justin
- Nat Faxon - Lawrence
- Jonathan Adams - Ray
- Drew Droege - Manic Man-Day Singer
- Drew Droege - Driver
- Lyle Kanouse - Hoyt
- Carlee Avers - Luke's Ex-Girlfriend
- Michael Weaver - Hockey Buddy
- Sarah Gilman - Jamie
- Gracie Dzienny - Kylie
- Sharon Osbourne - Sharon Osbourne
- Henry Winkler - Marty Alexander
- Jennifer Say Gan - Linda
- Samantha Futerman - Riley
- Harrison Xu - Danny
- Benjamin Byron Davis - Man at Taco Stand
- Stevie Nicks - Stevie Nicks
- Rajni Kareer - Veterinarian
- Joe Pacheco - Todd
- Joseph DiMasso - Tim's Friend
- Fred Armisen - Gideon Kirk
- Keith Burke - Race Starter
- Ken Narasaki - Silver Fox
- Marion Ross - Gammy
- NRACA - Singer #3
- Whitney Claire Kaufman - Singer #5
- Kyle Dean Massey - Singer #6
- Jeffrey G. Barnett - Funzone Employee
- Jack McGee - Chuck
- Steven M. Gagnon - Ted
- Charlene deGuzman - Assistant
- Marcus Folmar - Security Guard #1
- Nate Shelkey - Security Guard #2
- Sean Hayes - Walter
- Kimberly Wallis - Mom
- Rene Gube - Bryce
- Rachel Dratch - Linda
- Sean Whalen - Todd
- Shantel Wislawski - Charlie
- Sebastien Stella - Dan
- Bruce French - Trapeze Artist / Husband
- Rob Huebel - Jerry
- Brian Leone - Richard
- Hope Levy - Gail
- Laird Macintosh - Jackson
- Stephanie Allynne - Vanessa
- Dioni Michelle Collins - Hilary
- Michael Shepperd - Security Guard
- Tony Hale - Dr. Welborn
- Tymberlee Hill - Nancy
- Craig Frank - Barista
- Roger V. Burton - Wayne
- Ryann Turner - Neighbor Lady #2
- Trevor J. Davis - Neighbor Man
- Ursula Burton - Neighbor Lady #3
- Alek Cole - Kid
- Will Sasso - Paul
- Jayden Maddux - Tim
- Kaliko Kauahi - Patty
- Johnny Ray Meeks - Young Minister
- Karl T. Wright - Volunteer
- Kerry Carney - Diana
- Eugene Cordero - Scott Friend #1
- David Theune - Scott Friend #2
- Azita Ghanizada - Natasha
- David Petruzzi - Teddy
- Romy Rosemont - Jane
- Jerry Lambert - Frank
- Joey Pollari - Max
- Elisha Yaffe - Clerk
- John DiResta - Steve
- Tom Lommel - Dan
- Jessica Kozak - Receptionist
- Jordana Capra - Madame Pomfrey
- Caroline Aaron - Marla
- Mary Pat Gleason - Esther
- D.C. Pierson - Photographer
- Miguel Nájera - Officer Littlejohn
- Clint Culp - Luther
- Bob Gunton - Tom
- Mimi Kennedy - Sally
- Allan Havey - Uncle Dennis
- Andrew Friedman - Cowboy Minister
- Christopher Boyer - Dean
- Jordan Black - Chezeray
- Mitchell Edmonds - Man
- Hannah Kasulka - Cater-Waiter
- Louis Fasanaro - Triangle Faced Neighbor
- Emily Goldwyn - Emily
- Preston Sadleir - Hunter
- Adrian Gonzalez - Besos
- Jonathan Biver - Audience Member
- Stephane Nicoli - Waiter
- Tanya R. Barnes - Party Guest
- Stefan Rollins - Poker player
- Kimberly Quinn - Dawn
- Terron Brooks - Singer
- Bernardo Badillo - Berto
- Andrea du Roi - Lady Kissed by Ava
- Lindsay McGrail - Hairdresser
- Gregory Marcel - Glen
- Ryan Schneider - Ivan
- Ray Pierce - Trapeze Artist
- Michael Cory Davis - Guy
- Jason Williams - Guy
- Dani Danger - Bar Patron
- Mark Kubr - Bouncer
- Billy Merritt - Father
- Paul Mabon - Husband
- Anna Dokoza
- Tim McAuliffe
- Christina Applegate
- Emily Spivey
- Alex Reid
- D.J. Nash
Missi Pyle interpreta a Kaye en la serie.
Caroline Aaron interpreta a Marla en la serie.
Bob Gunton interpreta a Tom en la serie.
Will Arnett interpreta a Chris Brinkley en la serie.
Maya Rudolph hace el papel de Ava Alexander.
Luka Jones interpreta a Scott Chafin en la serie.
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