- Susan Ruttan - Horsemama
- Judith Hoag - Charlotte Dent
- Daniel Cosgrove - John Lucas
- Darlene Vogel - Sally Benedict
- Aisha Tyler - Lydia Townsend
- Michael Reilly Burke - Coach Flynn
- Gideon Emery - Sean Hennessey
- James Van Der Beek - Judd Shaw
- Isabella Hofmann - Principal
- Michael Arden - James Poole
- Barry Bostwick - Bill Ramey
- Nicholas Gonzalez - Detective Garza
- Eddie Kaye Thomas - Brice Walden
- Christina Chang - Claire Post
- Lauri Johnson - Delores
- Benito Martinez - Police Chief
- Chad L. Coleman - Ray Perkins
- Jesse Head - Jamie Roscoe
- Eyal Podell - Perry Hughes
- Cameron Goodman - Brandi
- Tania Raymonde - Sarah Poole
- William R. Moses - Sam Denver
- Kerr Smith - Patrick Dent
- Deirdre Lovejoy - Zoe Jenks
- Elizabeth Sung - Mei Chen
- Matthew Humphreys - Ben Sheppard
- Geoff Meed - Oscar Temple
- Curtis Armstrong - Louis
- Daniel Travis - Greg Beaudette
- Gail O'Grady - Kerry Denver
- Joey Luthman - Matthew Clarke
- Elizabeth Bogush - Greta Wilkes
- Haley Hudson - Punk Girl
- Colby French - Jerry Powell
- Kelvin Yu - Quon Wen
- Scott Michael Campbell - William Hollander
- Aimee-Lynn Chadwick - Jessica
- Devon Gummersall - Clay Thornton
- Gina DeVivo - RDO Sales Clerk
- Matt Lauria - Eric / John Doe
- Steven Skyler - Stephen
- Brandon Mychal Smith - Billy York
- Candice Patton - Kelly
- Sonya Leslie - Hannah
- Ellen Marlow - Amy Benedict
- Carlos Sanz - Restaurant Owner
- Rebekah Brandes - Tracy Benedict
- Jake Dogias - Chicago PD Tech
- John Charles Meyer - Quint
- Paunita Nichols - Drugstore Clerk
- Lily Rains - Monica
- Lou Richards - Mr. Simmons
- Rando Thomas - Gas Station Cashier
- Jona Xiao - Female Med Student
- Nicole Cannon - Ellen Quinn
- Mitchell Fink - Ed Warren
- Sandra Purpuro - Helen Vicks
- Vyto Ruginis - Robert Dent
- John Walcutt - Henry James
- Adrian Alvarado - Valet Manager
- Todd Eric Andrews - Hotel Manager
- Susan Carol Davis - Karen James
- David Stanford - Paul Grant
- Jarrod Bunch - Coach Tom Bryant / John Doe
- Christopher Stapleton - Wayne Wilmers
- Joel Swetow - Chiropractor
- Natalia Castellanos - Waitress
- Kelsey Crane - Female Bartender
- James Giordano - Super
- Ian Gregory - Coach Simms
- Blair Hickey - Ken Newman
- Mike Mauloff - Ralph the Trivia Guy
- Aedin Mincks - Walter, Jr.
- Oren Skoog - Jason Latimer
- James Wellington - Logan Clark
- Gary Carlos Cervantes - Roger Turow
- Tina Ivlev - Dana Hayes
- Matthew Alan - Dylan Dreslyn
- Chuck Ashworth - Officer
- Blair Bess - Hal Gordon
- Jeff Blum - Student
- Cindy Chiu - Li Wen / Jane Doe
- Vivan Dugré - Stephanie
- David Haley - Robert Turow
- Samantha Krutzfeldt - Kate
- Kyle Justin Leatherberry - Skateboard Kid
- Talbott Lin - Young Chef
- Ailsa Marshall - Erin Ingalls
- Eugene Shaw - Jin Lao
- Francesca P. Roberts - Flora Williams
- Craig Barnett - Officer Gillespie
- Bianca Christians - Yoga Supervisor
- Jasper Cole - Desk Clerk
- Stephen Gabriel - Theo
- John Griffin - Travis
- Kanin Howell - Frank Breen
- Erika T. Johnson - Female Resident
- Nelson Mashita - Nerdy Supervisor
- David Mendenhall - Newsstand Clerk
- Erin Raftery - CSU Tech
- Tahmus Rounds - Jack Carson
- Ellery Sprayberry - Claire Morse
- John T. Woods - John Doe / Henry Morse
- Conor Dubin - Michael Axton
- Anil Raman - Victor Gupta
- Jud Tylor - Layla Demchak
- Michael DiBacco - Officer
- Gwen Holloway - Molly Winston
- Sterling Jones - Sheriff Booth
- Caitlin Keats - Becky Lucas
- Jillian Nelson - Julianne
- James Preston - Bill
- Vick Sabitjian - Landlord
- Terry Woodberry - Stew Green
- Tim DeZarn - Frank Sanders
- Caleb Lane - Daniel Harris
- Sarah Domin - Amy Sanders / Jane Doe
- Deborah Geffner - Dr. Sharon Walker
- Jack Guzman - Motorcycle Cop
- Joe Keyes - Detective Dunlap
- Lisa Long - Helen
- Mallory Low - Teenage Barista
- Courtney Merritt - Meghan
- Erika Ringor - Carla
- J. Michael Silver - Keith Gibson
- Samantha Sloyan - Nurse
- Sewell Whitney - Julius Eddleston
- Skoti Collins - officer Anderson
- Edward Kerr - George Steele
- Aldis Hodge - Donny Rowe
- Joel Polis - Judge Cooperman
- Tom Schanley - Jack Driscoll
- Don Wallace - Chris Rowe
- Stacy Arnell - Woman
- Douglas Bennett - Mickey Boyd
- J. Paul Boehmer - Frank Scola
- Kim Chase - Carol
- Cathy Fithian - Clerk
- Gilbert Garcia - Coffee Guy
- Willow Hale - Secretary
- Lyn Alicia Henderson - Diana
- Nadji Jeter - Football Kid
- Will McFadden - David Andrews
- Molly Morgan - Andi
- Bobby Nish - Miko
- Dennis Oh - Handsome Man
- Teri Reeves - Jane Doe / Ashley Kemp
- Mark Weiler - Det. Keller
- George Williams - Judge
- Sam Maccarone - Joseph Tomly
- Evan Arnold - Medical Examiner / Gavin Spencer
- Joan McMurtrey - Andrea Hudson
- Jeffrey Buckner Ford - Don McGuffy
- Emily Happe - Nurse
- Christopher Hoffman - Clayton Riggs
- Fitz Houston - Clerk
- Matthew Jones - ESU Leader
- Elaine Mani Lee - Hostess
- Alice Rietveld - Dealer
- Jules Willcox - Olivia Hatton
- Kevin Weisman - Ziipper
- Cullen Douglas - 208
- Peter O'Meara - Conner Hennessey
- Saxon Anderson - Hot Boy
- Rachel Bernstein - Sexy Woman
- Emerson Brooks - Detective
- Jessie Camacho - Taffy
- Cindy Clark - Desk Lady
- Avery Clyde - Jane Doe / Julia
- Mike Foy - Danny Walker
- Allen Lulu - Gary
- John Marzilli - Salesman
- 'Big' LeRoy Mobley - Bodyguard / Man
- Brett Wagner - Roadie
- Christopher Baskerville - Detective Barns
- Blake Robbins - Dr. Max Rayburn
- Dahlia Salem - Dr. Mallory Messenger
- Carl Ciarfalio - Eric Boden
- Alexis DeLaRosa - Andy Santiago / John Doe
- Laura Gardner - Trudy Stutler
- Wayne Lopez - Scoopa Rooter Guy
- Rocky McMurray - Brian McKinney
- Summer Perry - Emo Girl
- Alesha Rucci - Corinne
- Keong Sim - Robert Chung
- Billy Tyler - Big Guy
- Elisha Cuthbert - Maxine Denver
- John Burke - Mitch
- Vedette Lim - Sandra
- Oliver Trevena - Worker
- Baron Davis - Terrence King
- Mary Anne McGarry - Carol Scott
- Markus Baldwin - Eric Fountain
- Christopher DerGregorian - John Torres
- Sally Elphick - Front Desk Clerk
- Taymour Ghazi - Jimmy 'Strip Club Manager'
- Todd Julian - Gavin Boyle
- Mack-b - Black Suit Man
- Katie Malia - Kissing Hot Girl
- Gathering Marbet - Wendy Scott / Jane Doe
- Jonathan Strait - Nathan Potter
- Glenn Taranto - 'Gus' Diner Manager
- Dan Thiel - Bruce the Waiter
- Chacko Vadaketh - Bellhop
- Stephen Wastell - Tommy the Bartender
- Steve Wilcox - Jonas Barham
- Sam Anderson - Train Driver
- Claire Jacobs - Dierdre Clark
- Tom Astor - Chris
- Mara Casey - Woman in Neck Brace
- Tom Choi - Rufus
- Brandon Ford Green - EMT
- Camilla Luddington - Emma Clark / Jane Doe
- Janora McDuffie - Doctor
- Steven Shaw - Barry
- Mathew Dunlop - Bartender
- Karis Campbell - Karen Summers
- Jadin Gould - Lucy Donovan
- Jake Borelli - High School Guy
- Brady Hender - Troy Pearl
- Pilar Holland - Denise
- Jessica Lancaster - Lisa Price
- Enrique Almeida - Fernando Diaz
- Paul Anderson - Hat Guy
- James C. Burns - David Hansen
- Ellyn Daniels - Chloe Devereux
- Yan Feldman - Jonathan Teague
- Wesley John - Ian Whitman
- Rod Keller - Scott Walder
- Jessica Tomé - Francesca Jordan
- Karissa Vacker - Vanessa
- Gregory Zarian - Thomas Jordan
- Takayo Fischer - Ruth Nakagawa
- Charles Parnell - Dan Freeman
- Lanny Joon - Asian Cop
- Chuck Kelley - Arlen Sullivan
- Scotty Leavenworth - Will Rosemount
- Tony Sancho - Darryl Diaz
- Shauna Stoddart - Dr. Tracy Holden
- Charlie Weirauch - Usher
- Bill Zasadil - Sam Becker
- Jerry Bruckheimer
- Danny Cannon
Christian Slater interpreta a Alex Donovan en la serie.
Rochelle Aytes hace el papel de Grace Russell.
Bob Stephenson interpreta a Walter Bailey en la serie.
Heather Stephens hace el papel de Lindsey Drake.
Michelle Borth interpreta a Candace Butler en la serie.
Anthony Carrigan hace el papel de Tyler Davies.
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