- Jeannie Wilson - Janet Fowler
- Eddie Barth - Myron Fowler
- Tim Reid - Marcel "Downtown" Brown
- Tim Reid - Lt. Marcel 'Downtown' Brown
- Henry Darrow - Manuel Fernandez
- Lucille Benson - Mrs. Dorothy Bartlett
- Theresa Saldana - Mrs. Karnofsky
- Charles Cyphers - Sergeant Lester
- John Larch - Deputy Sheriff John Burns
- Peter Hansen - Wells
- Joseph Sirola - Matthew Haskell
- Clarence Gilyard Jr. - Wally Stokes
- John Aprea - Sidney Gretchen
- Mark Casella - Kurt
- Ronny Graham - Rick's Lawyer
- William Lucking - Police Det. Frank Lunden
- Charlie Dell - Russell Tiegs
- Ed Lauter - Col. Lawrence Grayson
- Dean Stockwell - Dr. Griss
- Stacey Nelkin - Linda Sanborn
- John Hostetter - Police Sgt.
- Thom Christopher - Priest
- William Smith - Cady
- Sharon Acker - Sandra Jefferson-Delaporte
- Richard McGonagle - FBI Man #1
- Fran Bennett - Wanda Tale
- Donald O'Connor - George Decova / Barnaby the Great
- Kurt Smildsin - Coronor's Man
- Harry Townes - Dr. Cliff Gabriel
- Dan Lauria - Artie Karnovsky / Art Kaufman
- Robert Donner - Cody Dexter
- Victoria Bass - Insurance Investigator Michelle Naughton
- Anne Schedeen - Bailey Randall
- Alex Henteloff - Ditto
- Paul Willson - Rob
- Lance LeGault - Colonel Paul Stark
- Pat Buttram - Jonathan Evans
- Gary Lockwood - Daniel C. Thacker / Eddie Blair
- Jock Mahoney - Oldtimer #1 in Saloon
- Sheila Larken - Attorney Patricia Rieger
- Sunset Carson - Yancy Carlson
- Nicholas Kadi - Assad
- Carmine Caridi - Mr. Agonistes
- Colin Campbell - John Abbott
- Prince Hughes - Fat Johnny (as Prince A. Hughes)
- Kat Sawyer-Young - Sheila
- BD Wong - Counterboy (as Bradd Wong)
- Liberty Godshall - Christy Huggins
- Ian Patrick Williams - Robin Davis
- Thomas A. Geas - Thug #2
- Kathryn Holcomb - Sandra Flank
- Virginia Vincent - Toni Myers
- Rebecca Clemons - News Anchor Terry Aames
- George P. Wilbur - Kaydon's Hood / Thug
- Kim Sudol - Eve Brandt
- Stuart Whitman - Buck Yancy / The Rough Rider
- Joan Sweeny - Lila Simpson
- Stevie Sterling - Carmen
- Kenneth Danziger - Leon Masters
- Sheila Rogers - Dolores Gabriel
- Geof Prysirr - Adams
- Chuck Sloan - Reeder
- Kay Henley - Jean
- Judy Kain - Sandy
- Ted Gehring - Driver of County Truck
- John Nolan - Player #2
- John Nolan - Passenger in county truck
- Darrell Zwerling - Akins
- Ed Morgan - Guard
- Tom Hallick - Doug Sullivan
- Dick O'Neill - Jake Boyle
- Michael Forest - Marvin Kent
- H.M. Wynant - Leo Graves
- Lawrence Hilton-Jacobs - Gordon Tate
- Bridget Hanley - Shelby Barnett
- Don Stroud - Arnold
- Alan Hale Jr. - Bartender
- John Russell - Oldtimer #2 - in Saloon
- Jackie Joseph - Lila Hackett
- Marty Brill - P.R. Rep
- Doris Dowling - Annette - Boutique Owner
- Barrie Ingham - Zoltan
- Gino Conforti - Maurice Lebow
- James Karen - Insurance Agent
- Bill Zuckert - Dooley
- Steve Franken - Tunridge
- Read Morgan - Agent #1
- Peter White - Chef Sebastian
- Brooke Bundy - Jan Reynolds
- Bruce Gray - Paul Costa
- Lawrence Doheny
- Christian I. Nyby II
- Vincent McEveety
- Bob Sweeney
- Bernard L. Kowalski
- Don Weis
- James Crocker
- Michael Piller
- Richard C. Okie
- Rogers Turrentine
Dean Stockwell hace el papel de Dr. Griss.
Jameson Parker interpreta a A.J. Simon en la serie.
Gerald McRaney hace el papel de Rick Simon.
Mary Carver interpreta a Cecilia Simon en la serie.
Joan McMurtrey interpreta a Abigail Marsh en la serie.
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