- Amy Weber - Ruby
- Cullen Douglas - Lazier
- Tom Waite - Spencer
- Britt Robertson - Little Sheena
- Peter J. Lucas - Norliss
- Jeff Moldovan - Henchman
- Jay Amor - Ackerman
- Rus Blackwell - Yozkov
- Jennifer Hammon - Tracy
- Dave Corey - Kumar
- Isaac C. Singleton Jr. - Somali Henchman
- Steve Zurk - Burke
- Chaz Roberson - Villager
- Elizabeth Fendrick - Debra
- Kayla Campbell - Mariah
- Tony Armatrading - M'Buli
- Bob Lipka - Buck
- Tyrone C. Wiggins - M'Buli Rebel
- Carol Grow - Amanda
- Tom Savini - Peter Reynolds
- Bill Cordell - Turner
- Henry Polic II - Professor Barrington
- Hank Stone - Robert Morgan
- Erin Wiley Sands - Jamila
- Romonda Shaver - Thema
- Maury Covington - Cardinal Righetti
- Loren Kinsella - Party Guest
- Cheryl Lewis - Female Mutant
- Leland Crooke - Dr. Daniel Miller
- Antoni Corone - Armstrong
- Avery Clyde - Tourist
- Tom Nowicki - Carlton Rule
- Emilio Plana - Raffeo
- Darryl van Leer - Waddells
- Marc Macaulay - Engleberg
- Patrick Holland - Jeff Davis
- Chandra Leigh - Tourist
- Lamont Lofton - Colonel
- Lamont Lofton - Manir Chief
- Tiffany Phillips - Jade
- Lou Walker - Commandant
- Anthony Hubert - Lassa
- Kurt Smildsin - Orvis McShain
- Sophia M. Crawford - Camilla
- Joe Candelora - Mr. Don
- Nick Meaney - Monty Wilde
- Jane Park Smith - Sims
- Neil Brown Jr. - Nakele
- Neil Brown Jr. - Taya
- Jon Beshara - Ahmad
- Karen Fraction - Masuya
- Karen Fraction - Miku
- Ralph Wilcox - Zanabu
- James Bates Jr. - Meyer
- Paul Townsend - Taylor
- Jan Taylor Hendricks - Selma
- Juliette Jeffers - Dr. Tuli Botika
- Steve DuMouchel - Dr. Ahman
- Keith Hudson - John Smith
- Terry Allen Jones - Doctor
- Ashlee Payne - Tourist
- Grand L. Bush - Kiptalami Chief
- James Edward Coleman II - Tuma
- Tony Major - Aragai Chief
- Peter Onorati - Tyler
- Chet Anekwe - Karnivan
- Cedric Pendleton - Algonquin
- Brian Minyard - Jericho
- L. Warren Young - Danico
- Adam Leadbeater - Olsen
- Andrew B. Clark - Harbormaster
- Rahman Johnson - Gomada
- Jeffrey William Evans - Sy
- Todd Rogers Terry - Theif
- Todd Rogers Terry - Villager
- Tom Hillmann - Ben
- Kent Lindsey - Mark
- James Black - Shakoro
- Joseph Bertót - Keeper of the Key
- Jed Carpenter - Koro
- Cindy Oliver - Elizabeth
- Tim Powell - Hundley
- David Andrew Nash - Soldier
- Tia Marrie - Cult Member
- Peter Reckell - Cody
- Michael Hartson - Carl
- Michael Hartson - Carl Metters
- Quinn Duffy - Nicodemus
- Tom Schuster - Mercenary
- Justine Eyre - Andrea
- Ron Ely - Bixby
- Rick Perkins - Jared
- Robert Herrick - Lou
- J. LaRose - Raoul
- Jimmy Roger - Mitina
- Jimmy Roger - Bakari
- Pete Penuel - Roland
- Afemo Omilami - Kontee
- Peggy Sheffield - English Tourist
- Karen Kim - Cassandra
- Avis-Marie Barnes - Doctor
- Christian Boeving - Devlin
- Andrew Stoddard - Frank Hanson
- Laila Ali - Melina
- Leesa Castaneda - Victoria Stevens
- Yahya McClain - Jim
- Alexandra Tydings - Elena
- Mira Furlan - Yoka Laneesh
- Stacy Meadows - Kwashee
- Stacy Meadows - Man
- Thomas Merdis - Meshudu
- Greg Davis Jr. - Niko
- Greg Sproles - Henry
- Patricia Tallman - Caroline Dula
- Dennis Neal - Gumani
- Simon Needham - Milahn
- Humberto Recio - Gavin
- Yvette Nipar - Amanda Prentiss Cutter
- Steven West - Mbato
- Mel Johnson Jr. - Rabul
- Ronald McCall - Qaba
- Jim R. Coleman - President N'Gama
- Veryl Jones - Rashid
- Rick Worthy - Mako Zabodi
- Kelvin Payton - Aide
- Michele Howard - Sarah Peterman
- Margo Peace - Ethel Ugama
- K. Danor Gerald - Syma
- John Hostetter - Col. Quentin Massey
- Jim Helsinger - Omar Bendix
- James Zelley - Karl Strohm
- Elena Wohl - Rochelle
- Gary Graham - Glenn Pollett
- Brett Rice - Shanahan
- Mark Lainer - Kelstrom
- Megalyn Echikunwoke - Janel
- Dushawn Moses - Nukada
- Kevin J. O'Neill - Vinson
- Ray Fuller - Babsola
- Don McLeod - Gorilla
- Rich Kelley - M'shuma
- Jennifer Bergeron - Samantha
- Reuben Shaw - Kono
- Sean Callery
Isaac C. Singleton Jr. interpreta a Somali Henchman en la serie.
Gena Lee Nolin hace el papel de Sheena.
John Allen Nelson hace el papel de Matt Cutter.
Margo Moorer interpreta a Kali en la serie.
Kevin Quigley hace el papel de Mendelsohn.
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