- Aimee Lou Wood - Aimee Gibbs
- Patricia Allison - Ola Nyman
- Dua Saleh - Cal Bowman
- Mikael Persbrandt - Jakob Nyman
- Chinenye Ezeudu - Viv Odusanya
- Alistair Petrie - Michael Groff
- Rakhee Thakrar - Emily Sands
- Jemima Kirke - Hope Haddon
- George Robinson - Isaac Goodwin
- Anne-Marie Duff - Erin Wiley
- Hannah Gadsby - Celia
- Jim Howick - Colin Hendricks
- Felix Mufti - Roman
- Reda Elazouar - Beau
- Alexandra James - Aisha
- Lowri Palfrey - Simone McAllister
- Tom Mackley - Liam
- Edward Bluemel - Sean Wiley
- Dominic Applewhite - Charlie
- Lu Corfield - Sarah
- Lily Frazer - Tiana
- Jonny Amies - Sam
- Max Boast - Tom Baker
- Samuel Jordan - Simon
- T'Nia Miller - Maxine Tarrington
- Stephen Fry - NSQC Quizmaster
- Jack Bandeira - Eli
- Daniel Betts - Sgt Morris
- Spike Leighton - Luke
- Youssef Kerkour - Nathan
- Alice Hewkin - Tanya
- George Georgiou - Yousef
- Dan Mersh - Harry
- Olive Gray - Kate
- Catriona Knox - Mrs. Gibbs
- Freddie Watkins - Otis' Client Without a Problem
- Anjana Vasan - Abortion Clinic Protestor
- Tom Colley - Thug
- Aurora Burghart - Good Samaritan
- Milly Thomas - Female Client
- Daniel Adegboyega - Rydel
- India Ria Amarteifio - Lizzie
- Dan Renton Skinner - Swimming Instructor
- Kadeem Ramsay - OctoBoy
- Jason Baughan - Military Guy
- Lily Newmark - Ruthie
- Ann Queensberry - Lady in Checkout Line
- Toby Williams - Tim
- Ashna Rabheru - Gwen
- Gbemisola Ikumelo - Huma
- Neil Maskell - Police Officer
- Deobia Oparei - Mr. Effiong
- Tsion Habte - Fiona
- Susan Lynch - Tara Gibbs
- Natasha Joseph - Abortion Clinic Nurse
- Natasha Joseph - Doctor
- Sharon Duncan-Brewster - Roz Marchetti
- Mirren Mack - Florence
- Sindhu Vee - Olivia's Mum
- David Cann - Quiz Moderator
- Femi Elufowoju Jr. - Prophet Joshua
- Andrew Joshi - A&E Doctor
- Dee Ahluwalia - Benvolio
- Lino Facioli - Dex Thompson
- Sarah Durham - Headmistress
- Rosie Dwyer - Dex's Girlfriend
- Maud Druine - Student
- Lisa Palfrey - Cynthia
- Joe Wilkinson - Jeffrey
- David Layde - Roland Matthews
- Armin Karima - Malek Amir
- Kieron Moore - Dylan
- Jojo Macari - Kyle
- Daniel Ings - Dan
- Atilla Akinci - Albert
- Miles Jupp - Obstetrician
- Laurent C. Lucas - French Irate Driver
- Doreene Blackstock - Beatrice Effiong
- George Asprey - Michael Groff's Father
- Jerry Iwu - Oba
- Tomi Ogunjobi - Aunt Beryl
- Rebecca Root - Leanne
- Conor Clarke-McGrath - Courgette Connor
- Jason Isaacs - Peter Groff
- Suzanne Bertish - Dr. Cutton
- Lois Chimimba - Journalist
- Sinna Mogul - The Floor Manager
- George Somner - Joe
- Anna Ruben - Lucy Groff
- Hannah Waddingham - Sofia Marchetti
- Samantha Spiro - Maureen Groff
- Anna Francolini - Gloria
- Bella Maclean - Jem
- Lisa McGrillis - Joanna
- Indra Ové - Anna
- Colin Murtagh - Dog Owner
- Reece Richards - Eugene
- Robert Wilfort - Mark
- Sophie Thompson - Lily's Mum
- Rhoda Ofori-Attah - Dr. O'Dem
- Amar Chadha-Patel - DJ Dave
- Simone Ashley - Olivia Hanan
- Chaneil Kular - Anwar Bakshi
- Judith Cabral - Deriver (voice)
- Noel White - Hugh
- Rupert Frazer - Dog Show Judge
- Andrew Bone - Doctor
- Jack Gleeson - Dodgy Mo
- Dan Levy - Thomas Molloy
- Jodie Turner-Smith - God
- Marie Reuther - Ellen
- Oli Julian
Asa Butterfield hace el papel de Otis Milburn.
Gillian Anderson interpreta a Jean Milburn en la serie.
Ncuti Gatwa interpreta a Eric Effiong en la serie.
Emma Mackey hace el papel de Maeve Wiley.
Kedar Williams-Stirling interpreta a Jackson Marchetti en la serie.
Thaddea Graham interpreta a Sarah 'O' Owens en la serie.
Mimi Keene hace el papel de Ruby Matthews.
Anthony Lexa interpreta a Abbi Montgomery en la serie.
Connor Swindells hace el papel de Adam Groff.
Aimee Lou Wood interpreta a Aimee Gibbs en la serie.
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