- Ken Jenkins - Bob Kelso
- Neil Flynn - Janitor
- Sam Lloyd - Ted Buckland
- Robert Maschio - Todd
- Aloma Wright - Laverne Roberts
- Aloma Wright - Nurse Shirley
- Steve Susskind - Mr. Groff
- Christopher Meloni - Dr. Norris
- Heather Locklear - Julie Keaton
- Leslie David Baker - Surgery Patient
- Fred Berry - Fred Berry
- Chad Broskey - Rod
- Cayden Boyd - Hummer
- Biff Yeager - Dr. Walch
- Sarah Lancaster - Lisa
- Richard Kind - Mr. Corman
- Ricky Schroder - Paul
- Erik Estrada - Erik Estrada
- Ed McMahon - Ed McMahon
- Efren Ramirez - Ricky
- Jay Leno - Jay Leno
- Michael Copon - Pedro
- Scott Foley - Sean Kelly
- Nestor Carbonell - Dr. Ramirez
- Colin Farrell - Billy
- Ken Lerner - Mr. James
- Jimmie Walker - Jimmie Walker
- Ted Lange - Mr. Blair
- Loren Lester - Vet
- Cheryl Hines - Paige
- Nadine Velazquez - Nicole
- Dick Van Dyke - Dr. Townshend
- Barry Williams - Barry Williams
- Maree Cheatham - Mrs. Warner
- Kevin Cooney - Mr. Woodbury
- Freddy Rodríguez - Mark
- Bernie Kopell - Mr. Moran
- Jon Polito - Mr. Summers
- John Bennett Perry - Harrison
- Joe Manganiello - Chad
- Keri Russell - Melody
- Brendan Fraser - Ben Sullivan
- Kevin Rahm - Mr. Hutnik
- Sam Jaeger - Steve Larkin
- Benton Jennings - Mr. Hobbs
- Scott Menville - Rabbit (voice)
- Kelli Williams - Kristen Murphy
- Kyle Sullivan - Brian
- Chris Hogan - Mr. Gerst
- Richard Cansino - Dr. Rose
- Susanne Blakeslee - Gayle
- Taran Killam - Jimmy
- Mike Weinberg - Tyler
- Gary Busey - Gary Busey
- Michael Weston - Private Brian Dancer
- Matthew Perry - Murray
- Mary Mouser - Girl
- Mike Henry - Dr. Henry
- David Clennon - Dr. Turner
- Victoria Tennant - Maggie
- Van Epperson - Mr. Mariani
- Mircea Monroe - Heather
- Warren Munson - Mr. Taylor
- Ravi Patel - Intern
- Hattie Winston - Margaret Turk
- Ed Begley Jr. - Dr. Bailey
- Chrystee Pharris - Kylie
- Sean Whalen - Laddy
- Maureen McCormick - Maureen McCormick
- Vanessa Marshall - Becky
- Edith Fields - Mrs. Foster
- Tim Conlon - Dean
- Frank Novak - Pat Rosell
- Paul Dooley - Paul
- Al Harrington - Older Patient
- Ryan Reynolds - Spence
- Julie Warner - Allison
- Common - Common
- Michael Boatman - Ron
- Jay Mohr - Dr. Peter Fisher
- Larry Thomas - Larry
- Reno Wilson - Russell Vaughn
- David Copperfield - David Copperfield
- D.L. Hughley - Kevin Turk
- Louie Anderson - Louie Anderson
- Tara Reid - Danni
- Ed Brigadier - Barber
- Karen Ziemba - Radiologist
- Tim DeKay - Mr. Hill
- Tim Moore - Mr. Gold
- DJ Qualls - Josh
- Eric Bogosian - Dr. Gross
- Femi Emiola - Young Woman
- George Wallace - Minister
- Carole Davis - Rosie
- Glynn Turman - George
- Josh Randall - Jake
- Aziz Ansari - Ed
- Clay Aiken - Kenny
- Jennifer O'Dell - Stunning Woman
- Chuck Woolery - Chuck Woolery
- William Brent - Devin
- Lauren Stamile - Shannon
- Shelley Malil - Bartender
- Zach Mills - Young J.D.
- David Warshofsky - Dave Bradford
- Alan Ruck - Mr. Bragin
- John Ducey - Will Forte
- Time Winters - Jesus
- William Daniels - Dr. Douglas
- Gillian Vigman - Female Patient
- Travis Wester - David Morrison
- Paul Connor - Patient
- Benjamin King - Milos
- Lee Arenberg - Dr. Moyer
- Julianna Margulies - Neena
- Ned Bellamy - Dr. Green
- Mindy Sterling - Mrs. Cropper
- Sarah Ramos - Lindsay
- Paul Collins - Dr. Benson
- Portia Dawson - Mrs. Bell
- Lindsay Hollister - Nell
- Caroll Spinney - Oscar the Grouch (voice)
- John Ritter - Sam Dorian
- Jim Hanks - Dr. Turner
- Barry Bostwick - Mr. Randolph
- Christopher Darga - Homeless Steve
- John Billingsley - Alan
- Michael McMillian - Patrick
- Lee Thompson Young - Derek
- Paul Adelstein - Dr. Stone
- David Weidoff - Intern
- Jason Bateman - Mr. Sutton
- Dayo Ade - Mr. Hovey
- Jeremy Howard - Fat Frank
- Markie Post - Lily Reid
- Sean Hayes - Nick
- Michael Bunin - Jerry
- Steve Tom - Narrator / Doctor
- Jennifer Lothrop - Girl
- Liliana Mumy - Samantha Tanner
- Stephen Furst - Dr. Franklyn
- James Michael Tyler - Therapist
- Mandy Moore - Julie
- Anthony Russell - Mr. Lawton
- Dave Foley - Dr. Hedrick
- Julia Campbell - Mrs. Fremont
- Timothy Davis-Reed - Interviewer
- Trev Broudy - Doctor
- Alexander Chaplin - Mr. Thompson
- R. Lee Ermey - Janitor's Father
- Ellen Albertini Dow - Betty
- Myra Turley - Woman
- Peter Jacobson - Mr. Foster
- Maria Menounos - Tamara
- Carlos Jacott - Dr. No-Shot
- Eric Laneuville - Dr. Lamar
- George Takei - George Takei
- Erica O'Keith - Whitney
- Eric Jacobson - Grover (voice)
- Courteney Cox - Dr. Maddox
- Marisa Petroro - Cavewoman
- Michael Spiller - The Balloon Guy
- Kevin Clash - Elmo (voice)
- Jordan Murphy - Robot Groom
- Scott Weinger - Dr. Kershnar
- Josh Hammond - Razor
- Lane Davies - Simon Reid
- Billy Dee Williams - Billy Dee Williams
- Juanita Jennings - Dr. Munson
- Jerod Mixon - Herbert
- Mike Starr - Mr. Iverson
- Dayna Devon - Nurse
- Michael J. Fox - Kevin Casey
- Embeth Davidtz - Maddie
- Carter Jenkins - Young Todd
- Paul Hipp - Marc
- Meredith Bishop - Melissa
- Michael Patrick McGill - Officer Brady
- Molly Shannon - Denise Lemmon
- Susan Grace - Woman
- Lyla Graham - Old Mother
- Kelly McCracken - Patient
- Erin Carufel - Woman in Tub (uncredited)
- Vaughn Lowery - Tracy
- Candice Coke - Maria Espinosa
- Cynthia Frost - Mrs. Grodberg
- Jordi Caballero - Massimo
- Michael Alaimo - Mr. Radford
- Gene Pompa - Paulo
- Kurt Doss - Ryan Duncan
- Jane Le - Ming
- Larry Sullivan - Eric Coleman
- Jake Fritz - Billy
- Katherine Disque - Waitress
- Mary Gillis - Mrs Pratt
- Timmy Deters - Boy
- Shannon Welles - Old Woman
- Randi Kaplan - Patient
- Jack Walsh - Unconscious Patient
- Max Kerstein - Mr. Bidwell
- Robert Munns - Mr. Kavanaugh
- Alpheus Merchant - Sleeping Patient
- Esther Mercado - Mrs. Guerrero
- Cooper Thornton - Tommy Tanner
- Ray Spinka - Kindly Old Man
- Troy Bishop - College Dude
- Paige Peterson - Shelly
- Paige Peterson - Surgical Nurse
- John O'Brien - Man
- Mark Chaet - Dr. Greenberg
- Gina Morelli - Carla's Mom
- Earl Schuman - Patient
- Mane Andrew - Darryl
- Andy Forrest - Teacher
- John Valdetero - Bartender
- T.J. Hall - Young Turk
- Amelinda Embry - Jennifer
- Drew Wicks - Patient
- Granger Green - Meredith
- Cathy Herd - Mrs. Wheeler
- Joel Hurt Jones - Mr. Wheeler
- Lela Lee - Bonnie
- Lela Lee - Surgical Intern
- Ted Pitsis - Al
- Carrot Top - Carrot Top
- Sean Carrigan - Paul
- Jim Blanchette - Allan
- Brian Catalano - Yuppie
- Myrna Niles - Grandmother
- Timothy Starks - Man
- Leah Rowan - Woman
- Adrian Wenner - Philip Chambers
- Don Chastain - Mr. Chambers
- Steven Shaw - Mr. Sloane
- Eric Saiet - Jerry Donovan
- Alexandra Lee - Young Elliot
- Helen Siff - Patient
- Charles C. Stevenson Jr. - Patient
- P.D. Mani - Dr. Simotas
- Robert Dolan - Mr. Winston
- Steven Hack - Dr. Bobb
- Kymberly Newberry - Dr. Allan
- April Pressel - Denise Bober
- Bob McClurg - Car Driver
- Derek Miller - Orderly
- Derek Miller - Paramedic
- Bonita Friedericy - Nurse
- Amy Tolsky - Nurse
- Marcus Ashley - ER Doctor
- Jill Basey - Mrs. Kellerman
- Brian Powell - Mr. Hogan
- Jeffrey Asch - Dr. Amato
- Brian McGovern - Dr. DiStefano
- Bruce Sledge - Dana Gould
- Rochelle Robinson - Woman
- Cole Williams - Mike
- Theresa Barrera - Gyno Girl
- Richard Livingston - Dad
- Marcy Goldman - Mrs. Watson
- Damara Reilly - Mrs. Koppleman
- Colin Hay - Troubador
- Colin Hay - Colin Hay
- Stacy Barnhisel - Mrs. Marrick
- Don Tiffany - Mr. Marrick
- Trevor Wright - Kid
- Toni Ann Rossi - Sandy Larkin
- Marshall Manesh - Pizza Guy
- Marshall Manesh - Akbar
- Marshall Manesh - Dr. Akbar
- Lenore Thomas - Jenny
- Bergen Williams - Carol Stonewater
- Ron Ostrow - Mr. Foster
- Keith Blaney - Mr. Simms
- Barry Kivel - Mr. Hilliard
- Masi Oka - Franklyn
- Larry Udy - Mr. Weisfelner
- Larry Udy - Mr. Grimmett
- D. Elliot Woods - Security Guard
- Adam Harrington - Jack Moyer
- Jonathan Conrad - Justin
- Danny Swerdlow - Rudy
- Angee Hughes - Nurse
- J.K. Baker - Maintenance Man
- Bronwen Booth - Miss Myers
- Bronwen Booth - Anchorwoman
- Soren Hellerup - Rolf Mueller
- Natalie Farrey - Employee
- Natalie Farrey - Daisy
- Ingo Neuhaus - Hermann Mueller
- Robert Noble - Chaplain
- Gabriel Pimentel - Mike
- Verne Troyer - Small Man at Bar
- Richard Voigts - Mr. Weinberg
- James Henriksen - Husband
- Sarah Lilly - Wife
- Brad Koepenick - Mitchell
- Nicholas DiNardo - Delivery Kid
- Jerry Farmer - Convict
- Michael Hagerty - Will
- Randy Davison - Urine Lab Technician
- Vince Brocato - Patient
- John Hemphill - Patient
- Melody Butiu - Cashier
- Jace Milstead - Jimmy
- Torrey DeVitto - Gorgeous Girl
- Jan Devereaux - Female Resident
- Fred Ornstein - Bus Driver
- Don Perry - Mr. Bober
- Garrett Donovan - Baby Marrick
- Garrett Donovan - Councilman Donovan
- Kaidy Kuna - Father
- Adrian Armas - Handsome Man
- Donald Sage Mackay - Doctor
- Donald Sage Mackay - Dr. Page
- Adam Biesk - Guy
- Yolanda Snowball - Woman
- Sheila Wills - Wife
- Julia Sanford - Catherine
- Larkin Campbell - Maintenance Man
- Larkin Campbell - Guy
- Brogan Roche - Man
- Brogan Roche - Choir Leader
- Brogan Roche - Dr. Lemmon
- Cheryl White - Miss Himsel
- Jessica Kate Meyer - Stephanie
- Joe Sabatino - Cop
- Jordan Feldman - Scott Gerber
- Irene White - Janice
- Susan Slome - Woman
- John Maynard - Doctor
- Lawrence H. Toffler - Todd's Father
- Zaid Farid - Mr. Strauss
- Renee Ryan - Mrs. Janitor
- Paul Tigue - Waiter
- Cathleen Gallagher - Woman
- Michael Edwin - Mr. Bell
- Eamonn Roche - Buzz
- Eamonn Roche - Mr. Clark
- Lindsey Stoddart - Lauren
- Lindsey Stoddart - Nurse Haltson
- Josh David Jordan - Jeff
- Sybil Azur - Mother
- Cheyenne Haynes - Daughter
- Jeffry E. Stein - Patron
- Margaret Easley - J.D.'s Mother
- Mike Coleman - Another Janitor
- Art Bonilla - Priest
- Dougald Park - Mr. Fitzpatrick
- Juan Carlos Cantu - Hector
- Lou George - Tailor
- Andre B. Blake - Paramedic
- Richard Clarke Larsen - Homeless Man
- Bart Sumner - Mr. Blass
- Herman Poppe - Mr. Porter
- Jennie Ventriss - Pat
- Chuck Lacey - Odd Doctor
- Ian Kerr - Chairman of the Board
- Ian Kerr - Mr. Peeps (voice)
- Jody Carter - Mrs. Covello
- Jack Shearer - Aaron Simon
- Carol Herman - Mrs. Carter
- Kevin Lowe - Mr. Daniels
- Elizabeth Bogush - Alex
- Elizabeth Bogush - Alex Hanson
- Wendy Schenker - Mrs. MacCalla
- Jason-Shane Scott - Mike
- Janelle Marra - Nurse
- Janelle Marra - Sheila
- Mercy Malick - Contortionist
- Jeff Witzke - Father
- Andrew Friedman - EMT
- Amy Ferguson - Girl
- William Bassett - Patient
- Terrence Beasor - Man in Bed
- Al Checco - Man in Bed
- Tacey Adams - Woman
- Dutch Hofstetter - Young Dr. Cox
- Alysia Joy Powell - Karen
- David Pressman - Mickey
- Ralph Cole Jr. - Glen
- Bayard Crawley - Dave
- Barry Cutler - Brett
- Brian Kaiser - Emcee
- Adam Bitterman - Worker
- Colin Bain - Steve
- Adam Zolotin - Reuben
- Cullen Douglas - Patrick
- Cullen Douglas - Two O'Clock Man
- Matt Kaminsky - Mr. Milligan
- Randy Crowder - Patient
- Kareem Ferguson - Waiter
- Wells Rosales - Student
- Linda Porter - Old Woman
- Shanola Hampton - Woman
- Reggie Currelley - Man
- Matthew Pohlson - Patient
- Marc D. Wilson - James
- Monica Allgeier - Nurse Tisdale
- Takayo Fischer - Mrs. Cheng
- Gregory Hinton - Bouncer
- Gary Rubenstein - Patient
- Heather Graham - Dr. Molly Clock
- Jennifer Bowman - Nurse Birdie
- Tim Haldeman - Mr. Warner
- Mary-Margaret Lewis - Woman
- Ian Vogt - Father
- Stephanie Brown - Jenny
- Whitney Rydbeck - Dennis
- Sue Ozeran - Lady
- Fred Stoller - Mr. Hoffner
- Larry Marko - Mr. Gilmore
- Hira Ambrosino - Realtor
- John Balma - Owner
- Brandon Waters - Young Janitor
- Stuart McLean - Dr. Gold
- Madison R. Wells - Karen
- Brian Oerly - Angry Neighbor
- Joe Costanza - Mr. Kellerman
- Opender Singh - Omar
- Keli Daniels - Nurse
- Joe Souza - Guy
- J.P. Manoux - Charlie
- Tom Schmid - Fellowship Director
- John Siciliano - Homeless Guy
- Jeff Griggs - Hypnotist
- Matthew J. Evans - Kid
- Kerris Dorsey - Kid
- Duane R. Shepard Sr. - Mr. Morrison
- Geoffrey Wade - Dr. Bailey
- Gary Ballard - Mr. Biegel
- Gary Ballard - Kevin Biegel
- Paul Raci - Drunk Guy
- Carol Hickey - Mrs. Donnelly
- Wesley Leong - Mr. Kwan
- Nami Paix - Mrs. Kwan
- Thomas Crawford - Mr. Peele
- Bill Lawrence - Justice of the Peace
- Bill Lawrence - Cafeteria Client
- Bill Lawrence - Janitor
- Mary Pat Dowhy - Mrs. Peele
- Beverly Polcyn - Dyslexic Woman
- Ric Sarabia - S&M Guy
- India King - Elliot's Intern
- Allison Smith - Millie
- Gerald Downey - Jimmy
- David Doty - Priest
- Jo Deodato Clark - Mrs. Nickels
- Tangelia Rouse - Mrs. London
- Stacey Hinnen - Mr. Morgan
- Dan Sachoff - Matthew
- Dan Sachoff - Professor
- Callard Harris - Guy
- Kellie Madison - Girl
- Jack Yang - Patient
- Greg Allen Johnson - Mr. Bursick
- Greg Allen Johnson - Older Gentleman
- Kareem Abdul-Jabbar - Kareem Abdul-Jabbar
- Nathan Lee Graham - Eric / Devin
- J.B. Ghuman Jr. - Mark
- J.R. Starr - Mr. Burton
- Alicia Fusting - Patient
- Michael Janik - Patient
- Janet Carroll - Mrs. Cooke
- Eve Brent - Mrs. Harris
- Robert Martin Robinson - Mr. Borland
- Monica Garcia Pérez - Sperm Bank Nurse
- Traber Burns - Mr. Russell
- Wes Robinson - Jake
- Mary Kate Schellhardt - Carol
- Ross Mackenzie - Man
- Ross Mackenzie - Patient
- David St. James - Mr. Sommers
- Sabin Rich - Stanley
- Rebecca Metz - Volunteer Woman
- Hans Raith - German Guy
- Weston Nathanson - Old Man
- Noel Arthur - Frat Guy
- Jack Axelrod - Italian Man
- Abigail Droeger - Kid
- Henry LeBlanc - Eric McNair
- Kateri DeMartino - Nurse
- Bill J. Stevens - Board Member
- Deonte Gordon - Orderly
- Deonte Gordon - Mark the Orderly
- Deonte Gordon - Figsack
- Deonte Gordon - Deonte
- Deonte Gordon - Shawn
- Lyn Alicia Henderson - Rebecca
- Michael Cotter - Michael
- Michael Cotter - Doctor
- Michael Cotter - Intern
- Michael Cotter - Resident
- Beans Morocco - Artie
- Rachel Winfree - Jill's Mom
- Patrick Mulderrig - Man
- Ming Lo - Dr. Kim
- Paul Shively - Mr. Ketay
- Mike Peebler - Patient
- Rowbie Orsatti - Pilgrim Kid
- Carole Goldman - Mrs. Goldstein
- Keith Allan - Bartender
- Matt Bush - Teenage Boy
- John David Conti - Patient
- Kris Iyer - Dr. Rotinaj
- Johnny Crear - Mr. Peters
- Dan Ponce - Greaser
- Leon David Franco - Greaser
- Edward Tinney - Dr. Fulton
- Tate Hanyok - Debbie
- Carl J. Johnson - Harvey
- Julian Acosta - Jesus
- Evelina Turen - Blonde
- Danica Sheridan - Woman
- Tom Knickerbocker - Dr. Lemke
- Rachel Avery - Jenny
- Rachel Avery - Katie
- Frank Maharajh - Vijay
- Jerry Kernion - Cotton Candy Man
- Carol Avery - Valerie
- Danielle Weeks - Sarah
- Kevin West - Mr. Mehleison
- Andy Pessoa - Bobby
- Lou Saliba - Phil
- Licia L. Shearer - Lactation Specialist
- Kym Hoy - Patient
- Jennifer Leigh Warren - Patient
- Sulekha Naidu - Janice
- Elizabeth Tippet - Jessica
- Caroline Do - Best Friend
- Rick Irwin - Dr. Mahoney
- Kelli Kirkland - Rochelle
- Spice Williams-Crosby - Donna
- Chris Dougherty - Jerry
- Chris Dougherty - Intern
- Chris Dougherty - Jamie
- Guilford Adams - Intern
- DaJuan Johnson - Intern
- Dean J. West - Intern
- Jerry Shea - Intern
- Glenn Hetrick - Inmate
- Julian Berlin - Anne
- Terrance Christopher Jones - Kenyan Intern
- Mike Schwartz - Lloyd
- Mike Schwartz - Delivery Guy
- Mike Schwartz - Patient
- Jamie Strange - Stacy
- Artie O'Daly - Intern
- Ana Rey - Patient
- Susan Bjurman - Woman
- Jeanette Miller - Betty
- Shaughn Buchholz - Cabbage
- Shaughn Buchholz - Cabbage / Jason
- Shaughn Buchholz - Jason
- Candace Kroslak - Kristin
- Samara Frame - Radiologist
- Boris Kievsky - Elliot Man
- Toshi Toda - Mr. Chuang
- Justin Grafman - Timothy Frances
- Keeshan Giles - Lester
- Troy Kotsur - Mr. Frances
- Maurice Warfield - Laverne's Uncle
- Darlene Kardon - Patient
- Bernie Hourihan - Patient
- Ben Kronen - Patient
- Gina DeVivo - Stephanie
- Randi Cee - Barbara
- J.J. Nolan - Hot Girl
- Peter A. Hulne - Frank
- Elizabeth Banks - Dr. Kim Briggs
- Marjorie Lovett - Mrs. Sheldon
- Bruce Kirby - Mr. Bilbray
- Robert Pierce - Dr. Shapiro
- Leon Simmons - Old MC
- Jeffrey Scott Kelly - Salesman
- Gary Kraus - Salesman
- Stephon Fuller - Salesman
- Craig Patton - Mr. Fulton
- Gail Borges - Woman
- Mary Kathleen Gordon - Mrs. Cole
- Debra Azar - Dr. Donna
- Greg Allan Martin - Tan Doctor
- Arthur Roberts - Board Member
- Aaron Ikeda - Rex
- Andy Kreiss - Man
- Susan Leslie - Mrs. Winston
- Sterling Beaumon - Josh
- Brandon Hancock - Football Guy
- Scott Holroyd - John
- Roshawn Franklin - Olympic Athlete
- Houston Rhines - Brother
- Peter Holden - Mr. Macrae
- Jerry Sherman - Mr. Mandelbaum
- Duke Stroud - Board Member
- Alison White - Butch Doctor
- Christopher Gehrman - Mr. Candy
- Jack Angel - PA System / Announcer
- Edward James Gage - Cop
- Edith Jefferson - Ball-Mart Lady
- Robert Khakh - Empire Burger Manager
- Katie Gill - Marian
- Paul Kwo - Potions Tech
- Eric Artell - Rodney
- Aseem Batra - Josephine
- James Ritz - Mr. Hicks
- Marcus Folmar - Mr. Tillman
- Jennifer Jostyn - Dr. Simmons
- Annie Little - Christine
- Jack Grinnage - Marvell
- Scott Rinker - Mr. Halford
- Cathleen Kaelyn - Mrs. Halford
- Robert Beckwith - Dr. Johnson
- Robert Beckwith - Roy
- Michael Potter - Patient
- David Goryl - Mr. Fremont
- Lewis Dauber - Mr. Vaughn
- Helen Geller - Mrs. Fishman
- Marcy Minton - Nurse Barbara
- Mary Passeri - Nurse Nelly
- Blair Williamson - Craig
- Marcia Ann Burrs - Peggy
- Julie Pop - Lulu Tarasi
- Phoebe Dorin - Mrs. Jensen
- Adam Conger - Charles
- Michael McDonald - Mike Davis
- Michael McDonald - Mr. Cropper
- Michael McDonald - Dr. Toilet (voice)
- Linda Tomassone - Paige
- Betsy Beutler - Dr. Katie Collins
- Debra Fordham - Dr. Fordham
- Jean St. James - Mrs. Powell
- Sara Van Horn - Mrs. Emmett
- Corena Chase - Robyn
- Arleen Grace - Woman
- Johnny Kastl - Doug Murphy
- Stephanie D'Abruzzo - Patti
- Stephanie D'Abruzzo - A.M. Muppet (Ex Ray) (voice)
- Cabot McMullen - Med School Professor
- Randall Keenan Winston - Leonard
- Randall Keenan Winston - Death
- Todd Bosley - Howie
- Nancy Daly - Mrs. Gallin
- Judy Jean Berns - Mrs. Stonewater
- Josh Cooke - Dan
- Charles Rahi Chun - Dr. Wen
- Bob Clendenin - Dr. Zeltzer
- Tom Cavanagh - Dan Dorian
- Phill Lewis - Hooch
- Kathryn Joosten - Mrs. Tanner
- Amy Smart - Jamie Moyer
- Jay Kenneth Johnson - Dr. Matthews
- Joe Rose - Troy
- Michael Learned - Mrs. Wilk
- Nicole Sullivan - Jill Tracy
- Martin Klebba - Randall
- Sonal Shah - Dr. Sunny Day
- Sonal Shah - Sunny Day
- Travis Schuldt - Keith
- Tyler Poelle - Boon
- Katie O'Rourke - Coffee Nurse
- George Miserlis - Crispin
- Philip McNiven - Roy
- Kit Pongetti - Lady
- Kit Pongetti - Dr. Mitchell
- Jill Tracy - Elaine
- Meredith Roberts Quill - Kathy
- Bob Rumnock - Patient
- Bellamy Young - Dr. Miller
- Antonio Sabàto, Jr. - Antonio Sabàto Jr.
- Cecelia Antoinette - Mrs. Duncan
- Kate Micucci - Stephanie Gooch
- Jim Hazelton - David Izzle
- Jeremiah Hu - Student
- Betty A. Bridges - Ms. Simmons
- David Cade - Boots
- Windell Middlebrooks - Captain Duncook
- Windell Middlebrooks - Capt. Duncook
- John Lanz - Eric Puritsky
- Tony Tambi - Joseph
- Tom Ormeny - Arthur
- Walter Addison - Ben
- Art Frankel - Mr. Foster
- Lynne Maclean - Nurse Kearney
- Ginna Rutter - 75-Year Old Lucy
- Matt Winston - Jeffrey Steadman
- Judy Kain - Irene Kelly
- Daniel Edward Mora - Father
- Lily Goff - Gaby
- Matthew Cardarople - Frank
- Peter Choi - Sushi Chef
- Monica Allison - Attractive Woman
- Andrew Miller - Baby Jack
- Christa Miller - Jordan Sullivan
- Nicky Whelan - Maya
- Ryan Biegel - Clint
- Matthew Moy - Trang
- Jeffrey Hutchinson - Dr. Berman
- Michelle Shore - Person in Line #2
- Alisha Gaddis - Nurses Aide (uncredited)
- Hannah Storm - Self (uncredited)
- Steven Wash Jr. - Young Turk
- Jesus Perez - Taco Stand Worker
- John Brantley Cole - Guy
- Harmony Lucas - Man
- Eric Leviton - Bartender
- Phyllis Applegate - Mrs. Kaye
- Jeff Lapensee - Man
- Sam Menning - Mr. Booker
- Oleg Zatsepin - Mover
- Cary Brothers - Cary Brothers
- Tara Callaghan Carr - Mother
- Libby Hudson - Hot Grandma
- Sharline Liu - Nurse
- James Carraway - Patient
- Daniel Graves - Older Buisnessman
- Dylan Bell - Kid
- Ellerine Harding - Old Woman
- Adrian N. Roberts - Security Guard
- Richard Augustine - Inmate
- Paul Webster - Mr. Winston
- Michael Mitchell - Emery
- Ed Marques - Patient
- Bill Lawrence
- Debby Romano
- Brett Benner
- Randall Keenan Winston
- Corey Nickerson
- Prentice Penny
- Peter Nusbaum
- John W. Cook II
Gary Busey hace el papel de Gary Busey.
Michael J. Fox interpreta a Kevin Casey en la serie.
David St. James interpreta a Mr. Sommers en la serie.
Alan Ruck hace el papel de Mr. Bragin.
Ned Bellamy interpreta a Dr. Green en la serie.
Biff Yeager hace el papel de Pathologist.
Cayden Boyd interpreta a Hummer en la serie.
Common hace el papel de Common.
Jon Polito hace el papel de Mr. Summers.
Lee Arenberg interpreta a Dr. Moyer en la serie.
Capítulo disponible en las siguientes plataformas:
