- Jenna Coleman - Johanna Constantine
- Jenna Coleman - Lady Johanna Constantine
- Bill Paterson - Dr. John Hathaway
- Laurie Kynaston - Alex Burgess
- Charles Dance - Roderick Burgess
- Benjamin Evan Ainsworth - Alex Burgess (6)
- Stacy Abalogun - Nurse Edmunds
- Nicola Achilleas - Pushy Person #4
- Roger Ajogbe - James Kincaid
- Martin Bishop - Neurologist
- Benedick Blythe - Alex Burgess (70)
- Ione Brown - Sleepwalking Patient
- Clare Buckingham - Sleep-Deprived Patient
- Simon Bundock - Alex Burgess Double (6)
- Tracey Collier - Disciple #2
- Christopher Colquhoun - Paul McGuire (62)
- Sion Alun Davies - Ozzie
- Gus Gordon - Paul McGuire (18 - 42)
- Robert Grose - Disciple #1
- Jordan Long - Guard #10 (Fred)
- Corey Mylchreest - Adonis
- Johnny Palmiero - Guard #2 (Simon)
- Eugene Rangayah - Disciple #3
- Amy Rockson - Margaret Kincaid
- Douglas Russell - Guard #1 (Hugo)
- Sanjeev Bhaskar - Cain
- Ansu Kabia - Ruthven Sykes
- Graham Bohea - Hangman
- Crystal Yu - Jackie
- Meera Syal - Ric the Vic
- Clare Higgins - Mad Hettie
- Eleanor Fanyinka - Rachel
- Hannah van der Westhuysen - The Princess
- Stephen Odubola - Kevin Brody
- Marcus Fraser - Agilieth
- Steve Hutchinson - Alex Logue
- Olu Adaeze - Armed Officer #1
- Sam Donnelly - Armed Officer #2
- Marcus Adolphy - Cab Driver
- Joe Corrigall - Sam
- Sarah Niles - Rosemary
- Martyn Ford - Squatterbloat
- Munya Chawawa - Choronzon
- Sam Strike - Todd
- Niamh Walsh - Young Ethel Cripps
- Joely Richardson - Ethel Cripps
- Emma Duncan - Bette Munroe
- Steven Brand - Marsh Janowski
- Laurie Davidson - Mark Brewer
- Daisy Head - Judy Talbot
- James Udom - Garry Fletcher
- Lourdes Faberes - Kate Fletcher
- David Thewlis - John Dee
- Sarah Quist - Lindy
- Jennifer Armour - Traffic Report Terri
- Kirsten Foster - News Anchor Annie
- Jay Rincon - Meteorologist Mike
- Georgia Goodman - Rebecca
- Walles Hamonde - Jeff
- Ferdinand Kingsley - Hob Gadling
- Samuel Blenkin - William Shakespeare
- Ian McNeice - Tavern Landlord (1989)
- Angus Yellowlees - Kit Marlowe
- Sarah Twomey - Lushing Lou
- Curtis Kantsa - Franklin
- Kieron Moore - Crispin
- Sia Alipour - Aiden
- Jon Rumney - Harry
- Rebecca Night - Esme
- Leemore Marrett Jr. - Tourist Husband Sam
- Harry Burton - Geoffrey Chaucer
- William Chubb - Edmund
- Alex Akindeji - Louis
- Hannah Ankrah - Bar Patron #1 (1989)
- Kevin Brewer - Pub Visitor #5 (1389)
- Paul Cassidy - Pub Visitor #2 (1389)
- Michael Clarke - Pub Visitor #2 (1389)
- Kelsey Cooke - Tara
- Nigel Cooke - Tavern Visitor #1 (1689)
- Nick Cornwall - Pub Visitor #1 (1389)
- Reanne Farley - Tavern Serving Maid (1689)
- Aykut Hilmi - Pub Visitor #4 (1389)
- Ruchika Jain - Clara
- Danielle Kassaraté - Tavern Waitress (1589)
- Angus Kennedy - Tavern Landlord (1789)
- Akil Largie - Bouncer (1689)
- John Leader - Freddie
- Tony Richardson - Man in the Shadows (1689)
- Benjamin Wainwright - Tavern Visitor #2 (1689)
- Asim Chaudhry - Abel
- Donna Preston - Despair
- Nina Wadia - Fate Mother
- Souad Faress - Fate Crone
- Dinita Gohil - Fate Maiden
- Aimée Cassettari - Flight Attendant
- Andi Osho - Miranda Walker
- Sam Hazeldine - Barnaby
- Sacharissa Claxton - Officer Sandra Davis
- Lloyd Everitt - Hector Hall
- Lewis Reeves - Philip Sitz
- John Cameron Mitchell - Hal Carter
- Danny Kirrane - Fun Land
- Mark Hamill - Merv Pumpkinhead (voice)
- Lenny Henry - Martin Tenbones (voice)
- Roger Allam - Azazel (voice)
- Cassie Clare - Mazikeen
- Razane Jammal - Lyta Hall
- Sandra James-Young - Unity Kincaid
- Cara Horgan - Zelda
- Lily Travers - Barbie
- Richard Fleeshman - Ken
- Daisy Badger - Chantal
- Jill Winternitz - The Good Doctor
- Kerry Shale - Nimrod
- Ben Wiggins - Carl
- Stephen Fry - Gilbert
- Peter de Jersey - Mr. Holdaway
- Nicholas Anscombe - Merv Pumpkinhead (Body)
- Ann Ogbomo - Gault
- Eddie Karanja - Jed Walker
- Isla Gie - Child Zelda
- Dickie Beau - The Shredder
- Zora Bishop - Myth America
- Desiree Burch - Grass Widow
- Nalan Burgess - Nurse Sindy
- JP Conway - The Connoisseur
- Jimmy Essex - Carrion
- David Menkin - The Hammer of God
- Kirris Riviere - Adonai
- Matthew Sim - The Crooner
- Daniel Tuite - Hello Little Girl
- Michael Walters - The Water Boy
- Rosie Day - The Tabby Kitten (voice)
- David Gyasi - The Gray Cat (voice)
- Joe Lycett - The Black Cat (voice)
- Neil Gaiman - Crow / Skull Bird (voice)
- James McAvoy - Golden Haired Man (voice)
- David Tennant - Don (voice)
- Georgia Tennant - Laura Lynn (voice)
- Anna Lundberg - Marion (voice)
- Nonso Anozie - Wyvern (voice)
- Diane Morgan - Gryphon (voice)
- Tom Wu - Pegasus (voice)
- Melissanthi Mahut - Calliope
- Arthur Darvill - Richard Madoc
- Amita Suman - Nora
- Derek Jacobi - Erasmus Fry
- Sandra Oh - The Prophet (voice)
- Jeffrey Mundell - Don (Body)
- Louise Williams - Laura Lynn (Body)
- Jessica Murrain - Alisa
- Hopi Grace - Lara
- Merch Husey - Josh
- Fiona Marr - Erin
- Valmike Rampersad - Callum
- Yasmeen Scott - Lottie
- Freddie Stewart - Elliot
- Michael Sheen - Paul (voice)
- Nicole Evans - Marion (Body)
- Robert Ryan - Tavern Patron #1
- Stanley Morgan - Charlie
- Kirby - Death
- Jay Franklin
- Vanessa James Benton
- Mike Dringenberg
- Lauren Bello
- Catherine Smyth McMullen
- Sam Kieth
- Natasha Vincent
- Corrine Millson-Crane
- Jenna Bamberger
- Valentina Novakovic
- Neil Grigson
- Sarah-Kate Fenelon
- Christopher S. Aud
- Aaron Glascock
- Curt Schulkey
- Kasey Truman
- David Buckley
- Paul Munro
Mark Hamill hace el papel de Merv Pumpkinhead (voice).
Charles Dance hace el papel de Roderick Burgess.
Michael Sheen hace el papel de Paul (voice).
Derek Jacobi interpreta a Erasmus Fry en la serie.
Ian McNeice hace el papel de Tavern Landlord (1989).
Tom Sturridge interpreta a Morpheus / Dream en la serie.
Boyd Holbrook hace el papel de The Corinthian.
Vivienne Acheampong interpreta a Lucienne en la serie.
Patton Oswalt interpreta a Matthew the Raven (voice) en la serie.
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